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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 771 Documents
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Probiotics for Preventing Relapse in Ulcerative Colitis: A Systematic Review and Bayesian Network Meta-Analysis Alvianto, Steven; Muzellina, Virly Nanda; Widjanarko, Nicolas Daniel; Lee, Yeong Yeh; Wangidjaja, Olivia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025130-142

Abstract

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by periods of relapse and remission. Preventing relapse is critical to improving long-term outcomes. This study aimed to compare the efficacy of probiotics, 5-aminosalicylic acid (5-ASA), probiotics combined with 5-ASA, and placebo in preventing relapse in UC.Methods: A comprehensive search from PubMed, Cochrane Library, MEDLINE, ProQuest, ScienceDirect, Clinical Trials. gov and Google Scholar databases were conducted. The primary outcome was clinical relapse. A Bayesian random-effects model calculated pooled odds ratios (ORs) with 95% CIs and treatment ranks were assessed using the surface under the cumulative ranking curve (SUCRA).Results: Of total 552 initial papers, 37 extracted, and 26 were removed due to exclusion criteria. Eleven RCTs involving 1,099 participants were eventually included for analysis. Probiotics combined with 5-ASA had the highest efficacy (OR = 0.23, 95% CI: 0.027–1.09; SUCRA = 71.43), followed by 5-ASA alone (OR = 0.25, 95% CI: 0.035–0.95; SUCRA = 66.90) and probiotics alone (OR = 0.275, 95% CI: 0.059–0.724; SUCRA = 59.69). Placebo ranked lowest (SUCRA = 1.98). The most commonly used probiotics included E. coli Nissle 1917, Lactobacillus GG, and Bifidobacterium species. The most frequently used 5-ASA preparation was mesalazine. Interventions were generally well-tolerated, with no significant adverse events reported. Conclusion: With the Bayesian NMA, Probiotics plus 5-ASA demonstrates the highest efficacy in preventing relapses in UC. Further research is needed to standardize probiotic regimens and to assess long-term outcomes with the combination approach.
Abscess Formation Secondary to Bowel Perforation as Initial Presentation of Crohn's Disease: A Case Report Renaldi, Kaka; Hidayat, Leonardus Wibowo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025184-187

Abstract

Crohn's Disease is a gastrointestinal disorder that is more prevalent in the Asian population. Clinical features, such as diarrhea, abdominal pain, and hematochezia, are common manifestations of Crohn's Disease. A 23-year-old male patient presented with a 2-month history of abdominal pain and a mass-like appearance in the right flank. A colonoscopy was performed, which suggests Crohn's Disease. Abdominal CT scan revealed abscess formation. Clinical improvement was not achieved despite the optimization of 5-ASA treatment and the addition of steroids. Abscess drainage was performed, which later revealed ileo-colon perforation with severe adhesion, which was treated with ileo-colon resection, followed by double barrel ileo-colostomy. The pain was improved after surgery and optimization of 5-ASA, steroids, and azathioprine. Intestinal abscess formation should be considered one of the manifestations of Crohn's Disease, which also needs to be investigated for possibilities of perforation. Adequate surgical and medical management can be used to achieve and maintain remission and prevent another intestinal complication. This case report aims to raise awareness of intestinal abscesses due to bowel perforation in Crohn's disease patients.
Health Related Quality of Life and Associated Factors of Inflammatory Bowel Disease Outpatient Unit in Dr. Cipto Mangunkusumo Hospital Afistianto, Muhammad Fikri; Simadibrata, Marcellus; Putranto, Rudi; Abdullah, Murdani; Setiati, Siti; Wisnu, Wismandari; Antono, Dono; Susilo, Adityo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025107-113

Abstract

Background: Inflammatory Bowel Disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is an inflammatory digestive tract condition with unknown causes. Its unpredictable symptoms affect quality of life. In Indonesia, the quality of life of IBD patients remains unreported. Factors such as advanced age, long disease duration, active disease, corticosteroid use, comorbidities, unemployment, and poor sleep quality may reduce quality of life. This study aims to assess the quality of life profile of IBD patients and its associated factors.Methods: This cross-sectional study collected data from October to November 2024 through interviews at the outpatient unit of Dr. Cipto Mangunkusumo Hospital (RSCM). Quality of life was measured using the Inflammatory Bowel Disease Questionnaire 9 (IBDQ-9), and sleep quality was assessed with the Pittsburgh Sleep Quality Index (PSQI). Both tools were validated in Indonesian. Eligible participants met inclusion and exclusion criteria. Bivariate and multivariate logistic regression analyses identified factors associated with quality of life.Results: Among 201 participants, 95% reported a good quality of life. Multivariate analysis identified active disease (PR 4.072 [1.133–14.633], p = 0.031) and combination therapy (PR 12.803 [1.423–115.147], p = 0.023) as factors associated with poor quality of life. Age, disease duration, comorbidities, employment status, and sleep quality showed no significant associations.Conclusion: Most IBD patients (95%) in the RSCM outpatient unit reported a good quality of life. Active disease and combination therapy were linked to poorer quality of life.
Real-Life Situation Of Bile Duct Injury Management: Challenges And Lessons From A Tertiary Care Center Pramana, Triyanta Yuli; Adhyaksari, Apriliana; Lee, See Young; Ratanachu-ek, Thawee; Ranty, Stefanus Satrio; Prasetyo, Ari; Darmayani, Aritantri; Prasetyo, Didik; Notonugroho, Anung
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025143-153

Abstract

Background: Bile duct injury (BDI) is a serious complication of cholecystectomy, particularly with the widespread adoption of laparoscopic cholecystectomy (LC). Currently, a wide spectrum of multidisciplinary interventions with different degrees of invasiveness is indicated for BDI management. This study evaluates reallife clinical experiences in managing post-cholecystectomy BDIs in Central Java, Indonesia. We aim to discuss the prevention of BDI further and find out the most effective management and timing of interventions for BDI based on these analyses.Methods: Twenty-seven cases with iatrogenic BDI following cholecystectomy were classified according to BDI Strasberg classification, repair procedures, mortality and success rate procedures, onset of BDI, and timing of repair procedures. The correlation analyses were performed using the Contingency Coefficient Correlation Test.Results: Of the 27 patients, BDIs were detected in 33.3% of patients within two weeks of surgery. Major BDIs (Strasberg E) often required biliodigestive surgery, with variable outcomes. The overall mortality rate was 29.6%, mainly due to biliary sepsis. ERCP success was significantly associated with less severe BDI (p=0.018). This study stated that the type of previous cholecystectomy, timing of BDI diagnosis, and duration of BDI to repair procedures did not statistically influence mortality (p=0.822, p=0.551, p=0.958, respectively).Conclusion: Prevention of BDI is paramount, emphasizing surgical training, careful patient selection, and the critical view of safety technique. Early detection, multidisciplinary management tailored to the injury’s severity improve outcomes. While minimally invasive approaches are preferred for minor BDIs, major injuries necessitate surgical intervention by experienced hepatobiliary surgeons.
A Case Report of Untreatable Complication of Umbilical Hernia in Cirrhosis: A Flood Syndrome Tan, Christine; Audi Yanto, Theo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025188-194

Abstract

Flood syndrome is a rare, life-threatening complication of end-stage liver disease, characterized by the spontaneous rupture of an umbilical hernia. It frequently presents with sepsis, peritonitis, and bowel incarceration, carrying a high mortality rate. The lack of standardized treatment guidelines and the complexities of advanced liver disease make management particularly challenging. We report a case of a 53-year-old woman with decompensated hepatitis B-related cirrhosis (Child-Pugh Class C, MELD score of 26) and refractory ascites, who developed Flood syndrome. She presented with a ruptured umbilical hernia leaking ascitic fluid, accompanied by sepsis, diabetic ketoacidosis, acute kidney injury, and hypoalbuminemia. Surgical intervention was deemed high-risk, and conservative management was undertaken, focusing on infection control, wound care, and medical stabilization of her comorbidities. Despite a multidisciplinary approach, the patient succumbed to the cumulative effects of her advanced disease and associated complications. This case highlights the complexities of managing Flood syndrome, particularly in patients with advanced liver disease. The absence of standardized treatment protocols necessitates a multidisciplinary, individualized approach. Key considerations include managing ascites, preventing infection, optimizing glycaemic control, and carefully evaluating the risks of surgical intervention. This case report illustrates the clinical course, management challenges, and outcomes of Flood syndrome in a patient with advanced cirrhosis, in order to highlight key considerations for clinicians and underscore the urgent need for further research to establish evidence-based guidelines for managing this rare but life-threatening condition.
A Rare Case Of Acute Pancreatitis Cause by Newly Diagnosed Graves’ Disease: A Successful Therapeutic Option Abubakar, Azzaki; Yusuf, Fauzi; Maghfirah, Desi; Gunawan, Andrie; Zufry, Hendra; Edward, Meutia Nailan; Ho, Khek Yu
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025195-200

Abstract

Acute pancreatitis is a frequent disorder whose severity level varies from mild to life-threatening. This condition is characterized by abrupt inflammation of the pancreas. A 53-year-old male was having upper right abdominal pain and epigastric pain which began four hours after hospitalization. This case highlights the complexities of managing acute pancreatitis in a patient with Graves' disease, where hyperthyroidism may worsen pancreatitis and vice versa. Graves' disease is an autoimmune disorder causing hyperthyroidism, which can complicate pancreatitis management, particularly when treated with methimazole, which has been associated with acute pancreatitis. This case suggests a potential link between untreated Graves' disease and idiopathic acute pancreatitis. In patients presenting with unexplained pancreatitis, evaluation for hyperthyroidism may be warranted. The novelty of this case lies in the exclusion of all conventional etiologies and the possible role of autoimmune thyroid disease in pancreatic inflammation.
Analysis of Factors Related to Stigma of Health Worker and Medical Personnel Towards Hepatitis B at RSUDZA Banda Aceh Bakar, Azzaki Abu; Yusuf, Fauzi; Renaldi, Teuku; Salawati, Liza; Mahesa, Pocut Diva; Edward, Meutia Nailan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025154-159

Abstract

Background: Hepatitis B is one of the infection disease that attacks liver and is often accompanied by stigma including among health worker and medical personnel. This research aiming for analyze related factors with the stigma of health worker and medical personnel towards Hepatitis B at RSUDZA Banda Aceh. Methods: This study was an observational analytics with design cross sectional. Data collection was conducted on November 19-29 at RSUDZA. The sample consisted of from 452 health workers and medical personnel at RSUDZA Banda Aceh which was selected use method accidental sampling. Results: Research results shows 49.6% health worker and medical personnel at RSUDZA Banda Aceh has high (i.e.: negative or discriminatory) stigma towards Hepatitis B. The results of data analysis using the Chi-square test with 95% CI and α 0.05 showed level of knowledge, profession and services have significant relationship with stigma towards hepatitis B, while age, gender, length of service, and training did not show a significant relationship.Conclusion: It can be concluded that there is a relationship between the level of knowledge, profession, and service with the stigma of health workers and medical personnel towards Hepatitis B. And there is no relationship between factors of age, gender, length of service and training with stigma towards Hepatitis B
Clinical Outcomes of Cholangioscopy as a Minimally Invasive Intervention for Common Bile Duct Stones Putri, Septy Rianty Salsabilla Dwi; Wahyudi, Reza Rizwandipa; Prameswari, Devi Shanti; Dwiandika, Rizky Ary; Tahriani, Ridha; Salsabila, Ruhania Najwa; Sena, Cantika Brilian; Jibriel, Diaz Azhalea; Budyono, Catarina
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025176-183

Abstract

Choledocholithiasis is a condition of obstruction in the bile duct due to stones, which is classified into primary and secondary. Primary choledocholithiasis occurs due to obstruction of bile flow that triggers stone formation, while the secondary form is caused by gallstones that have formed previously and moved to the common bile duct, causing obstruction. This condition can cause various serious complications that require different treatments. This article discusses the role of cholangioscopy as a minimally invasive intervention in the diagnosis and therapy of choledocholithiasis. The results of the study showed that cholangioscopy plays an important role in endoscopic therapy and lithotripsy. However, the availability of cholangioscopy equipment in Indonesia is still limited, so its current use is more as a supporting procedure for Endoscopic Retrograde Cholangiopancreatography (ERCP). The purpose of this study was to evaluate the clinical effectiveness of cholangioscopy in the treatment of choledocholithiasis, especially in complex cases that are difficult to treat with conventional methods.
Correlation of Alpha-Fetoprotein Levels with ThreePhase Contrast CT-Scan Finding in Hepatocellular Carcinoma Patients at Dr. Mohammad Hoesin General Hospital Palembangin 2022 – 2023 Nainggolan, Florence Tania; Suprianto, Imam; ., Legiran
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025114-119

Abstract

Background: Hepatocellular carcinoma (HCC) is the primary liver tumor, accounting for 90% of liver tumor cases. Currently, laboratory tests are needed to monitor tumor progression, predict prognosis, and determine appropriate therapy without radiological examinations, one of which is Alpha-Fetoprotein (AFP). This study aims to determine the correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang.Methods: This was a cross-sectional design observational analytic study, using secondary data from medical records that included patient demographics, AFP, ALT, AST, direct bilirubin, indirect bilirubin, and three-phase contrast CT-Scan findings covering nodule size, nodule number, and metastasis in HCC patients treated at Dr. Mohammad Hoesin General Hospital Palembang from January 2022 – December 2023, meeting inclusion and exclusion criteria. Data were analyzed using SPSS version 22. Results: A total of 71 samples met the inclusion and exclusion criteria. Univariate analysis showed the majority were male (83.1%), aged 50–59 years (35.2%), with elevated ALT (59.2%), AST (94.4%), direct bilirubin (91.8%), indirect bilirubin (54.1%), AFP ≥200 ng/mL (77.5%), nodule size ≥30 mm (87.3%), multiple nodules (67.6%), and no extrahepatic metastasis (74.6%). Bivariate analysis showed a significant correlation between AFP levels and nodule size on three-phase contrast CT-Scan (p-value = 0.031).Conclusion: There is a significant correlation between AFP levels and three-phase contrast CT-Scan findings in HCC patients at Dr. Mohammad Hoesin General Hospital Palembang in 2022–2023.
Alpha-Fetoprotein : Its Diagnostic Role in Hepatocellular Carcinoma Bayupurnama, Putut
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/262202599-100

Abstract

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