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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 771 Documents
 74   75   76   77   78 
Histopathological Spectrum of Gastrointestinal Polyps: A Retrospective Study at a Tertiary Care Hospital Sahu, Ruby; Singh, Shashikant; Ahuja, Arvind
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/26120254-9

Abstract

Background: Gastrointestinal polypoidal lesions are commonly encountered lesions on endoscopic examination. The histopathological examination categorises these lesions into neoplastic and non-neoplastic since these have the potential to get transformed into malignancy. This study aimed to assess the clinical profile as well as the histopathological spectrum of gastrointestinal polyps observed during endoscopic evaluation.Methods: This study was a retrospective cross-sectional observational study conducted in the department of pathology at a tertiary care centre. All the histologically diagnosed gastrointestinal polypoidal lesions over a period of eight years were retrieved from the archives. Immunohistochemistry was applied as and when necessary. Univariate analysis was performed. Categorical variables were presented in number and percentage (%), and continuous variables were presented as mean. Appropriate descriptive statistics and graphical displays for different types of data have been presented. Result: Two hundred cases of gastrointestinal tract polypoidal lesions were included. The age of the patients ranged from 8 months to 90 years. Juvenile rectal polyp was the most frequently encountered non-neoplastic lesion constituting 42.5 %( 85/200) and conventional adenoma was the commonest neoplastic lesion constituting 17.5 %(35/200) of cases. Most of the polypoidal lesions were less than 1 cm; however, in 6.5 %( 13/200) cases, it was larger than 1cm in size.Conclusion: The gastrointestinal tract had a diverse range of non-neoplastic and neoplastic polyps. Histopathology is important in obtaining at a final diagnosis since it allows for a detailed investigation of occurrences and aids in distinguishing non-neoplastic disorders from those with clinical manifestations of malignancy. Keywords: Gastrointestinal polyps, hyperplastic polyp, conventional adenoma                                                                                      
Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model Blandina, Maria Bernadetta Nadya; ., Vetinly; Djuartina, Tena; Tenggara, Riki; Budianto, Iskandar R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202536-42

Abstract

Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats. Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole). Results:  It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent.Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract.Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells
Current Diagnosis and Treatment of Irritable Bowel Syndrome Suprapto, Akmal Primadian; Idrus, Muhammad Firhat
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202576-83

Abstract

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by a combination of symptoms, including abdominal pain, bloating, and altered bowel habits, often without any identifiable organic cause. The diagnosis of IBS typically involves a thorough clinical evaluation, including a detailed patient history and symptom assessment, often guided by the Rome IV criteria. Laboratory tests and imaging studies are generally employed to rule out other conditions. Current treatment strategies for IBS are multifaceted, aiming to alleviate symptoms and improve quality of life. They include dietary modifications, pharmacological treatment for symptoms management, and psychological interventions. Emerging therapies, such as microbiome modulation and novel pharmacologic agents, are under investigation and hold promise for future management of IBS. Overall, an individualized approach to treatment, considering both physiological and psychological factors, is essential for optimal patient outcomes.Keywords: Irritable bowel syndrome, diagnosis, treatment
Eruptive Xanthoma in Acute Pancreatitis: A Systematic Review of Case Reports Yonatan, Eric Ricardo; Alexander, Leonardo; ., Valencia; Wijaya, Lorettha
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202510-18

Abstract

Background: Eruptive xanthoma is a skin lesion caused by localized lipid deposits in the dermis, characterized by an eruption of yellow papules typically present on the buttocks, shoulders, and extensor skin surfaces of the extremities. Eruptive xanthoma is associated with acute pancreatitis as a result of hypertriglyceridemia or other lipid disorders. This study aims to discuss several case reports of patients with eruptive xanthomas and acute pancreatitis to provide descriptions and similarities between cases.Methods: This systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Case reports about eruptive xanthoma and acute pancreatitis are included in this systematic review. The literature search was done using PubMed, EBSCOHost, ProQuest, and Google Scholar. Critical evaluation for case reports by Joanna Briggs Institute is used for risk of bias assessment.Results: A literature search identified 6 case reports after eliminating irrelevant and duplicated studies. All assessed case reports reported similar dermatologic manifestations of eruptive xanthoma. Majority of patients reported severe acute abdominal pain as the main symptom of acute pancreatitis. All studies showed an increased level of lipid profiles, and other diagnostic workups support the diagnosis of eruptive xanthoma and acute pancreatitis. Risk of bias in case reports included was acceptable.Conclusion: Eruptive xanthomas can be found in patients with acute pancreatitis with correlation to hypertriglyceridemia and lipid disorders. Proper recognition, diagnosis, and treatment for eruptive xanthoma and acute pancreatitis should be kept in mind for practitioners.Keywords: Eruptive xanthoma, acute pancreatitis, systematic review
Clinical Study of DLBS2411, a Mucoprotector and Proton Pump Inhibitor Bioactive Fraction Derived From Cinnamomum burmanii, on the Intragastric Acidity Tjandrawinata, Raymond Rubianto; Abdullah, Murdani; Simadibrata, Marcellus; Susanto, Liana W; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202543-54

Abstract

Background: DLBS2411, A bioactive fraction derived from the bark of Cinnamomum burmanii has been developed to address acid-related gastrointestinal disorders. This study evaluated the pharmacodynamic effect of DLBS2411 on the 24-hour intragastric acidity in healthy adults.  Methods: In a 3-arm, parallel, double-blind, randomized, placebo-controlled clinical trial, healthy subjects received a single dose of DLBS2411 (250 mg or 500 mg) or placebo. Gastric pH was monitored, analyzed and profiled over 24 hours. Results: Of a total of 54 enrolled male subjects, 47 subjects (87.04%) were eligible for the analysis. The mean 24-hour intragastric pH for DLBS2411 250 mg and 500 mg was 2.29 ± 0.42 and 2.13 ± 0.50, respectively, both higher than placebo (1.93 ± 0.70). Differences were more pronounced during the first 12 hours (daytime). DLBS2411 250 mg and 500 mg reached a gastric pH 4 significantly faster (129.9 ± 128.2 and 92.9 ± 106.8 minutes) compared to placebo (196.9 ± 99.7 minutes). No serious adverse events occurred. All adverse events were mild and had been resolved by the end of study, confirming the safety and tolerability of DLBS2411 at the dose of 250 and 500 mg. Conclusion: DLBS2411 effectively suppressed the intragastric acidity and demonstrated a good safety profile in healthy adults. These findings warrant further studies of DLBS2411 in patients with gastric acid-related disorders. Keywords: Alternative medicine, DLBS2411 cinnamomum burmanii, healthy volunteers, intragastric-acidity, proton pump inhibitors
Gastrointestinal Bleeding in Small Bowel Arteriovenous Malformation: A Case Report Renaldi, Kaka; -, Aisyah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202584-87

Abstract

Arteriovenous malformations of the gastrointestinal tract (AVM) can occasionally result in gastrointestinal bleeding. Less than 5% of nonvariceal upper gastrointestinal bleeding is caused by gastrointestinal AVMs, a relatively uncommon cause of GI bleeding. Clinical symptoms that they might present include intussusception, persistent anemia, overt or obscure GI bleeding, and abdominal pain. A 41-year-old male patient presented with a 7-year history of recurrent melena. An initial enteroscopy showed spurting bleeding in the jejunum with histological examination showing AVM with ectopic pancreas. The patient underwent laparotomy with resection, anastomosis, and the construction of a new duodenojejunostomy. The patient complained of recurrent melena during three years of postoperative follow-up. The patient underwent laparotomy resection of the ileum to ascending colon, ileostomy, and splenectomy. Histological examination of the bleeding duodenal mucosa confirmed an arteriovenous malformation. The patient then underwent endoscopic hemostasis using hemoclips and was treated with coil embolization. In abdominal CT, angiographic evaluation showed no visible picture of vascular malformations. Intestinal AVMs are rare but should be considered as the differential diagnosis in patients with recurrent gastrointestinal bleeding. Endoscopic hemostasis, surgical resection, and angiographic intervention can be considered as treatments for AVM.Keywords: Arteriovenous malformation, gastrointestinal bleeding, small bowel
The Association of Anxiety and Depression with the Quality of Life of Inflammatory Bowel Disease Patients Simanjuntak, Tiroy Sari Bumi; K, Marcellus Simadibrata; Shatri, Hamzah; Abdullah, Murdani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202519-27

Abstract

Background: Inflammatory Bowel Disease (IBD), which is chronic and often recurrent, causes psychological changes in patients. This puts IBD patients at a higher risk of developing various mental disorders, especially anxiety and depression. IBD patients who had symptoms of anxiety or depression tended to show a lower quality of life than patients without those symptoms.Methods: This research uses a cross-sectional design. Data collection was carried out using primary data obtained through interviews with IBD patients who were undergoing outpatient treatment from October to December 2023. Anxiety and depression were measured using the Hospital Anxiety Depression Scale (HADS) and quality of life for IBD patients was measured using the Inflammatory Bowel Disease Questionnaire 9 (IBDQ-9). These questionnaires have been translated into Indonesian and validated. The research sample is an accessible population that has passed the inclusion and exclusion criteria using unpaired numerical analytical sample calculations. The sample used in this research was 172 subjects.Results: In the multivariate analysis, after controlling for confounding variables, the fully adjusted prevalence ratio (PR) for anxiety symptoms was 1.182 (CI: 1.061–1.317, p = 0.002). Similarly, the fully adjusted PR for depression symptoms was 1.221 (CI: 1.075–1.386, p = 0.002).Conclusion: Anxiety and depression are more strongly associated with a decline in the quality of life of IBD patients based on the IBDQ-9 after controlling for confounding variables.Keywords: Anxiety, depression, IBD, quality of life
Cardiopulmonary Complications During and After Endoscopy in Elderly Patients:a Prospective Study Yusuf, Sabrina Munggarani; Dwimartutie, Noto; Maulahela, Hasan; Harimurti, Kuntjoro; Rinaldi, Ikhwan; Yunihastuti, Evy; Fauzy, Achmad; Putranto, Rudi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025120-129

Abstract

Background: The high incidence of gastrointestinal and pancreaticobiliary diseases among elderly has led to increased endoscopic procedures in this population. Previous studies indicate a higher risk of cardiopulmonary complications during and after endoscopy in elderly patients compared to younger individuals. This study investigated the incidence and contributing factors of endoscopy-related cardiopulmonary complications in elderly patients.Methods: A prospective cohort study was conducted on 194 patients aged ≥ 60 years undergoing endoscopy at the Gastrointestinal Endoscopy Center, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, from August to October 2023. Consecutive sampling method was used. Multivariate analysis with logistic regression was conducted. Results: Among the 194 patients included, 49.52% experienced cardiopulmonary complications. The most common complications were tachycardia (23.20%), hypoxemia (15.03%), and hypotension (6.20%). Multivariate analysis identified the complexity of the procedure (ASGE level ≥ 3) as a significant risk factor (RR 1.505, 95% CI 1.039-2.179; p=0.03), while mild-moderate sedation was associated with a reduced risk of complications (RR 0.668, 95% CI 0.458-0.975; p=0,037). Conclusion: The incidence of cardiopulmonary complications during and after endoscopy is high among Indonesian elderly. Procedure complexity is an independent risk factor, whereas mild-moderate sedation mitigates the risk. In opposite, advanced age, multimorbidities, high ASA class, long duration of procedure, poor nutritional and functional status, and type of procedure did not affect outcomes
Updated Management of Ulcerative Colitis Prabowo, Muhamad Reza; Fauzi, Achmad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025160-167

Abstract

Ulcerative Colitis (UC) is a chronic disorder of Inflammatory Bowel Disease (IBD) which showed pathological changes of mucosa (symmetrical, diffuse) that involving rectum and may be extended to proximal colon. In general, target of the treatment quite indistinguishable to Crohn’s Disease (CD), such as improving quality of life, treating the acute condition, maintaining remission status, preventing complications, and achieving adequate nutritional status. Nowadays, there are so many therapeutic agents which were more effective than previous drugs. Another reason we should have left prior medicine is the safety of newer agents are promising. Today’s technology advances make gastroenterologist easier to give more treatment choice to every spectrum of ulcerative colitis. This review aims to provide an updated overview of ulcerative colitis management.
The Neutrophil Percentage-to-Albumin Ratio (NPAR) is Associated with In-Hospital Mortality in Patients with Liver Cirrhosis Lastiana, Ni Made Putri; Mariadi, Ketut; Sindhughosa, Dwijo Anargha; Kumar, Manoj
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 2 (2025): VOLUME 26, NUMBER 2, AGUSTUS, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2622025101-106

Abstract

Background: Studies show that the Neutrophil Percentage-to-Albumin Ratio (NPAR) predicts mortality in a number of illnesses. On the other hand, there is currently limited clinical support for using NPAR in liver cirrhosis patients. Investigating the associated of NPAR and hospital mortality outcome patients with liver cirrhosis is the goal of this study.Methods: All cirrhosis patients who were admitted to the hospital were included in this retrospective cohort analysis. The percentage of neutrophils and albumin levels on the first day of hospitalization were compared to determine the NPAR. Data were analyzed using the Mann-Whitney test, operating curve (ROC) analysis, and Kaplan-Meier survival curves. P-value 0.05 was considered statistically significant. Results: This study included 98 patients with liver cirrhosis. It was found that NPAR had a high incidence of patient mortality compared to surviving patients who were hospitalised (35.13 vs. 25.33, p 0.001). The median overall survival for all subjects was 10 days, indicating that 50% of the subjects had died within 10 days. According to ROC analysis, NPAR has an ideal cutoff value of 29.63 and can be utilized as a predictor of in-hospital mortality (sensitivity 74.1%, specificity 72.7%, AUC 0.8, p 0.001). Survival analysis stratified by NPAR showed that patients with NPAR ≥ 29.63 had a lower median survival compared to those with NPAR 29.6.Conclusion: In patients with liver cirrhosis, the Neutrophil Percentage-to-Albumin Ratio (NPAR) is a metric that can be used to assess in-hospital mortality outcomes

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