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Characteristics of Gastroesophageal Reflux Disease (GERD) Patients at RSUP Dr. M. Djamil Padang Period 2018-2021 Setiawan, Mentari Adinda; Fasrini, Ulya Uti; Amir, Arni; Muchtar, Masrul; Miro, Saptino; Endrinaldi, Endrinaldi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023227

Abstract

Background: Gastroesophageal reflux disease (GERD), a common digestive problem, is increasing and affecting the individual’s quality of life. This study aimed to describe the characteristics of GERD patients at Dr. M. Djamil Central General Hospital.Method: This cross-sectional study used data from patients' medical records that involved 111 GERD patients, excluding chronic disease and pregnancy. The analysis used univariate analysis and performed the data in cross-tables.Results: The results indicated that demographically, nearly all of the samples fall within the range of productive age (94.59%), with a higher proportion of the female gender (54.05%), the majority having a middle education level (72.08%), being housewives (27.92%), and residing in Padang City (35.13%). Most of the main symptoms were heartburn (62.16%), followed by vomiting, nausea, and dysphagia (4.50%, 2.70%, and 1.80%). More patients received outpatient treatment with two visits (18.02%). Clinically, based on the BMI, the obese classification was higher (43.25%). The levels of triglycerides and total cholesterol in the blood of GERD patients were more in the normal category (60.60% and 61.80%), while the levels of HDL and LDL in the blood of GERD patients were in the abnormal category, with lower HDL (97.80%), and a higher LDL (72.70%).Conclusion: The majority of GERD patients were in the productive age group, female, middle level of education, housewives, and resided in Padang. Clinical characteristics of GERD patients included most were categorized as obese according to their BMI, main symptom heartburn, and treated as an outpatient. Triglyceride and total cholesterol were primarily normal; blood HDL and LDL were abnormal.
Peran Reflux Symptom Index dalam diagnostik terapi pasien Laryngopharyngeal Reflux sebelum dan sesudah diberikan Lansoprazole di Poliklinik THT-KL RSUP Dr. M. Djamil Padang.: Indonesia Monica, Febrina; Asyari, Ade; Miro, Saptino
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.58

Abstract

Pendahuluan : Laryngopharyngeal Reflux(LPR) adalah pergerakan retrograde dari isi lambung ke daerah laring, faring, trakea, dan bronkus yang berkontak dengan jaringan pada traktus aerodigestif atas yang dapat menimbulkan jejas. Diagnosis dari LPR dapat ditegakkan dengan tindakan non-invasif yaitu dengan Reflux Symptom Index(RSI) dan Reflux Finding Score(RFS), RSI dapat digunakan dalam membantu dokter untuk menilai tingkat keparahan gejala penderita LPR saat pemeriksaan maupun setelah pengobatan. Metode : Jenis penelitian ini adalah analitik observasional dengan pendekatan studi kohort prospektif melalui observasi pasien yang didiagonosis LPR dari nilai RSI yang didapatkan. Jumlah sampel minimal dari hasil perhitungan uji hipotesis beda rata-rata pada 2 kelompok dependen adalah 18 orang. Hasil : Nilai rata-rata sebelum dan sesudah diberikan terapi PPI 21,50±5,969 dan 15,90±9,008 (me=13,5;min=5;maks=36). Hasil uji Wilcoxon Signed Rank Test didapatkan analisis nilai rata-rata RSI sebelum dan sesudah adalah p=0,002. Kesimpulan : didapatkan perubahan bermakna nilai rata-rata RSI sebelum dan sesudah diberikan PPI pada pasien LPR.Kata kunci: Laryngopharyngeal Reflux, Reflux Symptom Index,Proton Pump Inhibitor
Risiko Perdarahan Saluran Cerna pada Pasien COVID-19 berdasarkan Jenis Obat Antivirus di Rumah Sakit Umum Pusat Dr. M. Djamil Padang Arnelis, Arnelis; Miro, Saptino; Zubir, Nasrul; Yoga, Vesri; Kurniawan, Andry; Kam, Alexander; Rahimi, Abdul Alim; Ranazeri, Jersivindo; Fahrurozi, R. Ifan Arief
Andalas Journal of Health Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2042

Abstract

Coronavirus disease 2019 (COVID-19) has become a global pandemic to date. Some studies reported gastrointestinal tract (GIT) bleeding occurs in several patients hospitalized with COVID-19. Medications known to be associated with an increased risk of GIT bleeding were not associated with GIT bleeding in COVID-19 patients. Objectives: To examined the risk of gastrointestinal tract (GIT) bleeding in COVID-19 patients based on antiviral drugs at Dr. M. Djamil General Hospital Padang. Methods: A nested cohort study was conducted in Dr. M. Djamil General Hospital Padang from May until October 2021. All COVID-19 patients who received antiviral drugs with GIT bleeding with onset days 0 - 7 were included. COVID-19 was confirmed by RT-PCR swab. Data entry and analysis were conducted by computerized. Results: 30 patients were involved in this study. 43,3% COVID-19 Moderate stage and 56,7% Severe stage. 63,3% were treated with remdesivir and 36,7% were treated with favipiravir. Onset on GIT tract bleeding at day 4 (23,3%), day 5 (26.7%), day 6 (30%), and day 7 (20%). The Chi-square test to determine the factors associated with GIT bleeding in COVID-19 patients including COVID-19 severity, type of antiviral drugs, anticoagulant, and corticosteroid revealed that none of all potential factors above related to GI bleeding. Conclusion: The type of antiviral drugs was not related to GIT bleeding in COVID-19 patients.Keywords: antiviral drugs,  COVID-19, gastrointestinal tract bleeding
Korelasi Lama Menjalani Hemodialisis dengan Kualitas Hidup Pasien Penyakit Ginjal Kronik di RSUP Dr. M. Djamil Padang Rashieka, Shaydi Amala; Rasyid, Rosfita; Miro, Saptino; Yulia, Dwi; Ilmiawati, Cimi
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1081

Abstract

Latar Belakang: Penyakit ginjal kronik (PGK) adalah suatu kondisi adanya gangguan struktur dan gangguan fungsi ginjal yang dapat dilihat melalui pemeriksaan laboratorium ataupun pencitraan dan terjadi lebih dari tiga bulan. Pada pasien PGK yang sudah mencapai tahap akhir akan memerlukan terapi pengganti ginjal. Terapi pengganti ginjal yang sering diberikan pada pasien PGK di Indonesia adalah hemodialisis. Akan tetapi pada hemodialisis terdapat beberapa komplikasi yang dapat menurunkan kualitas hidup pasien. Penurunan kualitas hidup pada pasien PGK juga dapat sebagai prediktor dari angka kesakitan dan kematian pada pasien PGK. Objektif: Penelitian ini bertujuan untuk mengetahui korelasi lama menjalani hemodialisis dengan kualitas hidup pasien PGK di RSUP Dr. M. Djamil Padang Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional dengan jumlah sampel yaitu 93 pasien PGK yang menjalani hemodialisis. Instrumen penelitian yang digunakan yaitu kuesioner KDQOL SFTM 1.3. Uji Statistik yang digunakan yaitu korelasi Spearman. Hasil: Jumlah pasien yang menjalani hemodialisis yang kecil atau sama 60 bulan sebanyak (84,9%) dan setengah dari pasien tersebut (50,5%) mempunyai kualitas hidup yang baik. Pada penelitian ini didapatkan hubungan yang bermakna antara kualitas hidup dan lama hemodialisis dan korelasi yang bernilai positif (r=0,263; p=0,017). Kesimpulan: Semakin lama pasien menjalani hemodialisis maka kualitas hidup pasien akan semakin baik.
Hubungan Tingkat Aktivitas Penyakit Lupus Eritematosus Sistemik dengan Derajat Gangguan Fungsi Ginjal pada Pasien Lupus Eritematosus Sistemik Nabila, Fathiya Sarah; Miro, Saptino; Effendi, Rinal; Almurdi, Almurdi; Yulia, Dwi; Putra, Syandrez Prima
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 2 (2024): Juni 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i2.1103

Abstract

Abstrak Latar Belakang: Evaluasi fungsi ginjal dan pemantauan aktivitas penyakit pada pasien lupus eritematosus sistemik (LES) diperlukan untuk mendeteksi penyakit LES secara dini. Penilaian aktivitas penyakit juga berperan penting dalam memandu pemberian terapi yang tepat agar memberikan hasil yang lebih baik. Objektif: Mengetahui hubungan antara tingkat aktivitas penyakit LES dengan derajat gangguan fungsi ginjal pada pasien LES. Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan cross-sectional menggunakan data sekunder dari rekam medis pasien LES di Departemen Penyakit Dalam RSUP Dr. M. Djamil Padang. Teknik pengambilan sampel adalah consecutive sampling dengan total sampel 70 pasien LES. Analisis data dilakukan dengan menggunakan chi-squared test. Hasil: Terdapat 98,6% pasien berjenis kelamin perempuan, 48,9% pasien berada pada kelompok usia 17–25 tahun, rerata kadar serum kreatinin 1,756±3,3437 mg/dl, 65,7% pasien memiliki fungsi ginjal normal, 70% pasien memilliki tingkat aktivitas penyakit LES sedang, dan hasil uji statistik antara tingkat aktivitas penyakit LES dengan derajat gangguan fungsi ginjal pada pasien LES adalah menunjukkan nilai p=0,081. Kesimpulan: Mayoritas pasien berjenis kelamin perempuan, kelompok usia terbanyak yaitu usia 17 – 25 tahun, rerata kadar serum kreatinin 1,756±3,3437 mg/dl, mayoritas memiliki derajat fungsi ginjal yang normal, tingkat aktivitas penyakit LES sedang, dan tidak terdapat hubungan yang signifikan antara tingkat aktivitas penyakit LES dengan derajat gangguan fungsi ginjal pada pasien LES. Kata kunci: tingkat aktivitas penyakit, derajat gangguan fungsi ginjal, lupus eritematosus sistemik Abstract Background: Evaluation of kidney function and monitoring the disease activity in patients with systemic lupus erythematosus (SLE) are necessary for early detection of the SLE disease. Assessment of disease activity also plays an important role in providing a better therapy. Objective: This study aims to determine the relationship between SLE disease activity and the stages of kidney disease in SLE patients. Methods: This study is an analytical study with a cross-sectional approach using secondary data from the medical records of SLE patients in the Internal Medicine Department of Dr. M. Djamil Padang Hospital. The sampling technique is consecutive sampling with a total sample of 70 SLE patients. Data analysis was performed using chi-squared test. Results: There were 98.6% of the patients were female, 48.9% of the patients were in the age group of 17–25 years, the mean serum creatinine level was 1.756±3.3437 mg/dl, 65.7% of the patients had normal kidney function, 70% of the patients had a moderate level of LES disease activity, and the results of a statistical test between the level of activity of LES disease and the stages of kidney disease in SLE patients showed a value of p=0.081. Conclusion: The majority of patients were female, the largest age group was 17-25 years old, the average serum creatinine were 1,756±3,3437 mg/dl, majority of patients had a normal kidney function, had a moderate level of SLE disease activity, and there was no significant relationship between level of SLE disease activity and stages of kidney disease in SLE patients. Keyword: disease activity, stages of kidney disease, systemic lupus erythematosus
Crohn’s Disease with Comorbidites of Syndrome of Inappropriate Anti Diuretic Hormone (SIADH) caused by Pulmonary Tuberculosis Steven, Rios; Miro, Saptino; ., Arnelis; Yoga, Vesri; Viotra, Deka; Elvira, Dwitya; ., Wahyudi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202588-92

Abstract

Crohn's disease is an inflammatory condition of the intestines characterized by lesions that can affect the entire digestive tract from the mouth to the anus. Globally, the prevalence of inflammatory bowel disease has increased over the past 20 years, rising from 3.32 million cases in 1990 to 4.9 million cases in 2019. Previously, the management of Crohn’s disease followed the step-up therapy approach; however, this method led to higher recurrence rates. The current approach utilizes top-down therapy, as research data indicate that the remission rate is 57% with top-down therapy compared to 25% with step-up therapy. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) can be caused by pulmonary tuberculosis. A 44-year-old male patient was diagnosed with Crohn’s disease based on a colonoscopy examination, which suggested chronic active colitis with mild activity and crypt distortion consistent with Crohn’s disease. An esophagogastroduodenoscopy (EGD) revealed chronic gastritis, while a histopathological examination of the colon confirmed findings consistent with Crohn’s disease. The diagnosis of pulmonary tuberculosis was established using a rapid molecular test (TCM) with positive results. Hyponatremia with hypoosmolar euvolemia was diagnosed based on serum sodium levels of 128 mmol/L, serum osmolality of 269 mosmol/L, urine osmolality of 288 mosmol/L, and urine sodium of 73 mosmol/L. Treatment included 5-ASA and anti-tuberculosis medications. Crohn’s disease increases morbidity rates and is not limited to developing countries. It is caused by immune system dysregulation, which can predispose patients to secondary infections such as tuberculosis. Pulmonary tuberculosis, in turn, can lead to SIADH.Keywords: Crohn’s disease, pulmonary tuberculosis, SIADHTop of Form
PENGARUH PEMBERIAN N-ACETYLCYSTEINE (NAC) TERHADAP KADAR MALONDIALDEHYDE (MDA)  PADA PENDERITA DIABETES MELITUS TIPE 2 Putri, Athifa Alya; Yerizel, Eti; Miro, Saptino
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1836

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Several classifications of diabetes mellitus include type 1 diabetes, type 2 diabetes, gestational diabetes, and other types of diabetes. Type 2 diabetes is caused by insulin resistance. Hyperglycemia in type 2 diabetes patients causes cell and tissue damage through oxidative stress processes. One of the main biomarkers of oxidative stress levels that can be analyzed is malondialdehyde levels. To reduce ROS levels, a definitive therapy is needed, which is the administration of exogenous antioxidants, one of which is N-Acetylcysteine (NAC) therapy. NAC works by forming glutathione antioxidants, which aim to fulfill the body's natural antioxidant deficit in overcoming hyperglycemia conditions. This study was a true experimental research study with a pre-posttest research design. The sample used was 20 patient blood serum samples, which were measured for MDA levels before NAC administration. Then, NAC therapy was administered at a dose of 3X400 mg per day for 5 weeks, and MDA levels were measured after the therapy using the Thiobarbituric Acid Reactive Substance (TBARS) method. The results of the study showed that the mean MDA level after NAC administration and the mean MDA level before NAC administration were 2.76 ± 0.251 nmol/ml and 3.28 ± 0.427 nmol/ml, respectively. There was a significant decrease in MDA levels in the blood serum of type 2 diabetes patients with a value of p = 0.000 (p <0.5). Thus, it can be concluded that the use of NAC has an effect on reducing MDA levels in type 2 diabetes mellitus patients
HUBUNGAN STADIUM CHRONIC KIDNEY DISEASE DENGAN HIPERTENSI PADA PASIEN CKD DEWASA DI RSUP DR. M. DJAMIL PADANG TAHUN 2020-2021. Putri, Viona Salsabila; Miro, Saptino; Irawati, Lili; Fadrian, Fadrian; Hamdani, Rita; Rasyid, Rosfita
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1845

Abstract

Chronic Kidney Disease (CKD) is a condition where there is structural or functional damage to the kidneys for more than 3 months with or without being followed by a decrease in the estimated Glomerular Filtration Rate (eGFR) and is progressive and irreversible. Hypertension is the most common comorbidity found in patients with CKD which can increase the progression of kidney damage. Objective: To determine the relationship between the stage of CKD and hypertension and the distribution of the frequency of patients with CKD based on age, sex, eGFR value, and hypertension. Methods: This research was an observational analytic study with a cross-sectional design. The research was conducted at the Medical Record Installation of RSUP Dr. M. Djamil from December 2022 - March 2023 used a purposive sampling technique and obtained 33 samples. The research data was secondary data in the form of blood pressure and serum creatinine and then analyzed using the Chi-Square test with a degree of confidence of 95% and p-value <0,05. Results: This study showed that most cases of CKD occurred in the age group 41-65 years (54,5%) and mostly found in men (57,6%). In this study, stage 5 CKD was the most common (72,7%) and the majority of patients with CKD suffered from hypertension (69,7%). The results of data analysis obtained p = 0,090 (p> 0.05). Conclusion: There was no significant relationship between the stage of CKD and hypertension (P=0,090) in adult patients at Dr. M. Djamil Padang in 2020–2021.
PERBANDINGAN KADAR PROTHROMBINE TIME DAN ACTIVATED PARTIAL THROMBOPLASTINE TIME PADA PASIEN DM TIPE 2 KAKI DIABETIK DENGAN TANPA KAKI DIABETIK DI RSUP DR. M. DJAMIL PADANG TAHUN 2019 Decroli, Rezeki Penta; Yulia, Dwi; Miro, Saptino
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 3 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, September 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i3.1846

Abstract

Diabetic Foot Ulcers are one of the most common, serious, and costly complications of type 2 diabetes mellitus. Diabetic Foot Ulcers have become more common in tandem with the rising prevalence of type 2 diabetes mellitus. Changes in many hematological parameters, such as Prothrombine Time and Activated Partial Thromboplastine Time, are influenced by the mechanism of diabetic ulcer occurrence. Understanding the various aspects of hematological parameters will help in the prevention and treatment of diabetic foot ulcers. This study aims to determine the comparison in the hematological profile in type 2 DM patients with and without diabetic foot ulcers at Dr. M. Djamil Padang hospital in 2019.  This type of research is an observational analytic study with a retrospective design using medical record data of patients at Dr. M. Jamil Padang hospital from August 2020 to March 2021. The sample consisted of the medical records of patients with type 2 diabetes mellitus with foot ulcers and without foot ulcers, respectively, as many as 60 subjects. Bivariate analysis using independent t-test or Mann Whitney test.  The results showed that the mean PT level of type 2 DM patients with diabetic foot ulcers was 12.8417 ± 2.36939, without diabetic foot ulcers 11.997 ± 1.8325 (p <0.001). The mean aPTT of patients with diabetic foot ulcers was 41.2733 ± 35.1686, without diabetic foot ulcers 32.912 ± 13.1263 (p <0.001).  This study concludes that there are significant in between type 2 DM patient with foot ulcer and without foot ulcers.
Hubungan Nonalcoholic Fatty Liver Disease (NAFLD) dengan Kolesterol Darah Pasien Kolesistolitiasis Dilaparoskopi Kolesistektomi F, Annisa Maida; Yerizel, Eti; Saputra, Deddy; Miro, Saptino; Irwan; Alioes, Yustini
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 3 (2025): September 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i3.1347

Abstract

Latar Belakang: Kolelitiasis atau batu empedu menjadi salah satu masalah bagian gastrointestinal paling umum yang memengaruhi sekitar 10-20% populasi dunia. Kejadian kolelitiasis dikaitkan dengan Non Alcoholic Fatty Liver Disease (NAFLD) dan kadar profil lipid. Objektif: Tujuan penelitian ini untuk mengetahui hubungan NAFLD dengan kadar profil lipid pada pasien kolelitiasis yang dilakukan laparoskopi kolesistektomi. Metode: Penelitian ini merupakan penelitian analitik dengan desain cross sectional dengan data sekunder dari rekam medis pasien kolelitiasis yang dilaparoskopi kolesistektomi di ruang operasi IBS RSUP Dr. M. Djamil Padang. Teknik pengambilan sampel adalah purposive sampling yaitu jumlah sampel yang memenuhi kriteria inkulsi dan ekslusi sebanyak 40 pasien. Hasil: Hasil penelitian ini menunjukkan pasien kolelitiasis yang dilakukan laparoskopi kolesistektomi terbanyak adalah pasien dewasa yaitu 19-59 tahun (72,5%). Sebagian besar pasien berjenis kelamin perempuan (67,5%) dan indeks massa tubuh terbanyak adalah obesitas tipe 1 (35%). Kebanyakan pasien mengalami NAFLD (77,5%) dengan terbanyak adalah grade 2 (37,5%). Hasil uji statistik menunjukkan bahwa tidak terdapat hubungan antara NAFLD dengan kolestserol total (p>0,05), kolestserol HDL (p>0,05), kolesterol LDL (p>0,05), maupun trigliserida (p>0,05). Kesimpulan: Tidak terdapat hubungan antara NAFLD dengan kadar profil lipid pada pasien kolelitiasis yang dilakukan laparoskopi kolesistektomi.