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JURNAL KESEHATAN YAMASI MAKASSAR
Published by Akademi Farmasi Yamasi Makassar
ISSN : 25488279     EISSN : 28091876     DOI : https://doi.org/10.59060/jurkes.v7i1.250
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal ini memuat naskah hasil penelitian dengan kajian ilmiah yang berkaitan dengan bidang kesehatan secara umum dan bidang farmasi khususnya. Sebuah jurnal yang didedikasikan untuk publikasi hasil penelitian seluruh aspek ilmu farmasi sebagai berikut : farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik, namun tak terbatas secara implisit. Jurnal ini terbit dua kali dalam setahun yaitu setiap bulan Januari dan Juli.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 286 Documents
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Uji Mikrobiologi Serum Sarang Burung Walet (Collocalia fuciphaga) Sebagai Agen Aktif Muhammad Tahir; Suhartini; Nur Zam Sabila
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/74z7qk89

Abstract

The demand for safe and effective natural cosmetic products is increasing, one of which is facial brightening serum. Swallow's nest (Collocalia fuciphaga) contains bioactive compounds such as glycoprotein and epidermal growth factor (EGF) which are known to have the potential as skin brightening agents. This study aims to test the effectiveness of facial serum containing swallow's nest extract from South Sulawesi in increasing skin brightness, and to compare it with Niacinamide-based serum. The study was conducted experimentally in the laboratory using 12 male white rats (Rattus norvegicus), which were divided into three treatment groups (concentrations of 10%, 20%, and 30%) and one positive control (Niacinamide). The back area of the rats was pigmented using UV-B and serum was applied for seven days. Brightness measurements were carried out using a skin tone scale. The results showed that serum with a concentration of 30% provided the most significant increase in brightness, with a decrease in skin tone value from 15 to 3, better than niacinamide.
EFFECTIVENESS TEST OF KEPOK BANANA STEM EXTRACT GEL PREPARATION (Musa paradisiaca L.) AGAINST Staphylococcus epidermidisdisiaca L.) TERHADAP Staphylococcus epidermidis Dzulasfi; Erna
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/mqghg355

Abstract

Penenlitian ini bertujuan untuk mengetahui apakah sediaan gel ekstrak batang pisang kepok (Musa paradisiaca L.) memiliki efektivitas terhadap Staphylococcus epidermidis dan pada konsentrasi berapakah ektrak batang pisang kepok paling efektif dalam menghambat pertumbuhan Staphylococcus epidermidis. Metode yang digunakan dalam penelitian ini adalah eksperimental laboratorium untuk mengetahui efektivitas sediaan gel ekstrak batang pisang kepok (Musa paradisiaca L.) terhadap Staphylococcus epidermidis. Hasil penelitian yang telah dilakukan dari sediaan gel ekstrak batang pisang kepok efektif dalam menghambat pertumbuhan Staphylococcus epidermidis dan konsentrasi yang paling efektif dalam menghambat pertumbuhan Staphylococcus epidermidis adalah konsentrasi 3% dengan zona hambatan sebesar 21,41 mm (kuat).
Aktivitas Antiinflamasi Topikal Sediaan Facewash Ekstrak Daun Pepaya (Carica papaya L.) pada Model Edema Terinduksi Karagenan pada Tikus Ananda Ramadani; Ronal Ronal
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/yytsw030

Abstract

Papaya leaves (Carica papaya L.) have long been used as a traditional medicine due to their bioactive compounds that have anti-inflammatory potential. Edema is a form of inflammatory response characterized by fluid accumulation in interstitial tissue due to increased vascular permeability. This study aims to evaluate the anti-edema effect of a facewash containing papaya leaf extract on the back skin of white rats (Rattus norvegicus). This study was a laboratory experimental study with a completely randomized design. Edema was induced using a 3% carrageenan suspension subcutaneously on the back skin of rats. Skinfold thickness was measured using a caliper before treatment (T₀) and after induction at certain time intervals. Rats were divided into several treatment groups given papaya leaf extract facewash with concentrations of 5%, 10%, and 20%. The results showed that the papaya leaf extract facewash had anti-edema activity with a decrease in skinfold thickness compared to the control. The 10% concentration showed the highest edema-reducing effect at 9%, followed by the 20% concentration at 5%, and the 5% concentration at 3%. Based on these results, it can be concluded that the papaya leaf extract face wash has potential as a topical anti-inflammatory agent, with an optimum concentration of 10%.
Uji Aktivitas Antiinflamasi Ekstrak Etanol Biji Buah Gorek (Caesalpinia bonducella L.) Pada Hewan Coba Tikus Putih (Rattus norvegicus) Jantan Erniati Akadir; Sitti Fauziah Noer; Ayu Wandira A.Baso Amri
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/8awjwb12

Abstract

Biji buah gorek (Caesalpinia bonducella L.) diketahui kaya akan senyawaaktif seperti terpenoid, flavonoid, fenol, tanin, dan saponin. Penelitian inidilakukan untuk mengevaluasi efek antiinflamasi ekstrak etanol biji tanamantersebut pada tikus putih (Rattus norvegicus) jantan. Proses ekstraksimenggunakan pelarut etanol 96% dengan teknik maserasi. Pengujian aktivitasdilakukan melalui induksi edema pada telapak kaki tikus menggunakan karagenan1%. Hasil menunjukkan adanya penurunan udem kelompok Na-diklofenak 0,068mg/kgBB memiliki volume udem (0,10247) tidak menunjukkan perbedaan yangsignifikan dibandingkan dengan dosis 600 mg/kgBB (0,10293) dan 400 mg/kgBB(0,10307). Namun, ketiga kelompok tersebut memiliki perbedaan yang signifikanterhadap dosis 200 mg/kgBB (0,10320) serta kontrol negatif Na-CMC 1%(0,10400). Kesimpulan Hal ini menunjukkan semakin tinggi dosis ekstrak etanolbiji buah gorek maka semakin baik dalam menurunkan volume udema.
PENGARUH METODE EKSTRAKSI DAUN SAGA (Abrus precatorius L.) DENGAN PELARUT NADES TERHADAP KADAR FENOLIK DAN FLAVONOID TOTAL Renny Amelia; Trysha inka Lutfi Pratami; Didi Rohadi; Tomi
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/1d1xbd48

Abstract

Daun saga (Abrus precatorius L.) merupakan tanaman obat tradisional yang mengandung senyawa bioaktif, terutama flavonoid dan fenolik, yang berperan sebagai antioksidan. Pemilihan metode ekstraksi sangat mempengaruhi kadar senyawa yang dihasilkan. Penelitian ini bertujuan untuk membandingkan kadar flavonoid total dan fenolik total ekstrak daun saga menggunakan pelarut ramah lingkungan Natural Deep Eutectic Solvent (NADES) melalui dua metode, yaitu maserasi dan Microwave Assisted Extraction (MAE). Penelitian dilakukan di laboratorium dengan serbuk daun saga yang diekstraksi menggunakan NADES berbasis asam laktat dan natrium asetat. Kadar flavonoid total ditentukan dengan metode AlCl₃, sedangkan kadar fenolik total ditentukan dengan metode Folin-Ciocalteu menggunakan spektrofotometri UV-Vis. Data dianalisis dengan uji normalitas, homogenitas, dan ANOVA. Hasil penelitian menunjukkan bahwa metode MAE menghasilkan kadar flavonoid dan fenolik lebih tinggi dibandingkan maserasi, uji statistik menunjukkan perbedaan signifikan (p > 0,05). Dengan demikian, MAE dapat dianggap memiliki efisiensi lebih baik diibanding maserasi dan berpotensi direkomendasikan sebagai metode ekstraksi senyawa bioaktif daun saga.
EFEK ANTIHIPERURISEMIA EKSTRAK KULIT BATANG SURIAN (Toona sureni (Blume) Merr.) TERHADAP TIKUS PUTIH (Rattus norvegicus) Rina; Ayu Wandira A. Baso Amri; Mustaina
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/c2z6qn20

Abstract

Penelitian ini bertujuan untuk mengetahui efek antihiperurisemia ekstrak etanol kulit batang surian (Toona sinensis) terhadap tikus putih jantan (Rattus norvegicus) yang diinduksi kalium oksonat. Penelitian menggunakan metode eksperimental dengan rancangan acak lengkap (RAL) terhadap 15 ekor tikus putih jantan yang dibagi menjadi lima kelompok, yaitu kontrol negatif (Na CMC 1%), kelompok ekstrak dosis 40 mg/kg BB, 80 mg/kg BB, 120 mg/kg BB, dan kontrol positif (allopurinol). Hiperurisemia diinduksi menggunakan kalium oksonat dosis 300 mg/kg BB. Data dianalisis menggunakan uji normalitas Shapiro-Wilk, uji homogenitas, One-Way ANOVA, dan uji lanjut Tukey HSD. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit batang surian mampu menurunkan kadar asam urat pada tikus hiperurisemia dengan persentase penurunan pada jam ke-6 berturut-turut sebesar 38,51%, 42,64%, dan 54,72% untuk dosis 40 mg/kg BB, 80 mg/kg BB, dan 120 mg/kg BB, sedangkan allopurinol sebesar 67,32%. Hasil One-Way ANOVA menunjukkan adanya perbedaan yang signifikan antar kelompok perlakuan (p<0,05). Dosis 120 mg/kg BB memberikan aktivitas antihiperurisemia terbaik di antara kelompok ekstrak 
PENGARUH NILAI HLB KOMBINASI EMULSIFIER PADA FORMULASI BODY LOTION MENGANDUNG EKSTRAK DAUN PUCUK MERAH (Syzygium myrtifolium Walp.) Bannan Muthi'atul Af'idah
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/r1exqp22

Abstract

The utilization of natural ingredients in cosmetic formulations is continuously increasing due to their perceived higher safety profile. Red lip (Syzygium myrtifolium Walp.) leaves possess potent antioxidant activity, rendering them highly potential for utilization as an active ingredient in cosmetic preparations to promote skin health. This study aimed to formulate a body lotion containing red lip leaf extract and to evaluate the effect of the Hydrophilic-Lipophilic Balance (HLB) values of combined emulsifiers, specifically Tween 80 (HLB = 15) and Span 80 (HLB = 4.3), on the physical quality and stability of the resulting body lotion. The formulations were developed by varying four levels of the combined emulsifier HLB values, ranging from HLB 9 to 12. The evaluated physical quality parameters encompassed organoleptic properties, homogeneity, spreadability, acidity (pH), viscosity, and physical stability utilizing the cycling test method. Statistical analysis demonstrated that variations in the HLB values exerted a significant effect on the spreadability, pH, and viscosity of the formulations. Formula 2 (HLB 10) exhibited the physical characteristics that complied with the SNI 16-4399-1996 standard and demonstrated the best physical stability. This study indicates that the HLB value of the Tween 80 and Span 80 emulsifier combination plays a critical role in maintaining the structural integrity and preserving the physical quality of the lotion formulations.
UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN MELINJO (Gnetum gnemon L) TERHADAP BAKTERI Staphylococcus aureus Rizka Anggreani; Esti Febri Fatwami; Dian Islamiyati
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/tnvdrp59

Abstract

Tujuan penelitian ini adalah untuk menilai seberapa baik gel ekstrak daun melinjo (Gnetum gnemon L.) menghambat perkembangan bakteri Staphylococcus aureus. Preparasi gel dengan kekuatan ekstrak yang berbeda yaitu 5%, 7%, dan 9% dibuat setelah ekstrak daun melinjo disiapkan menggunakan prosedur maserasi dengan pelarut etanol 96%. Dengan menggunakan kloramfenikol sebagai kontrol positif dan basis gel sebagai kontrol negatif, aktivitas antibakteri dinilai menggunakan teknik difusi cakram pada media Nutrient Agar (NA) yang telah diinfeksi dengan mikroorganisme uji. Hasil penelitian menunjukkan bahwa pertumbuhan Staphylococcus aureus dapat dihambat oleh gel ekstrak daun melinjo pada konsentrasi berapa pun. Dengan diameter zona inhibisi rata-rata 16,5 mm, formula gel dengan kandungan ekstrak 9% menunjukkan aktivitas antibakteri terbaik, termasuk dalam kategori kuat. Oleh karena itu, pada konsentrasi ideal 9%, formulasi gel ekstrak daun melinjo berpotensi menjadi agen antibakteri terhadap Staphylococcus aureus. Keywords: Tanaman melinjo (gnetum gnemon L); ekstrak; sediaan gel; aktivitas antibakteri.
KNOWLEDGE OF DRUG MANAGEMENT OFFICERS AND DRUG AVAILABILITY AT PRIMARY HEALTH CENTERS IN MAKASSAR CITY Andi Paluseri; yuniati; Lukman Lukman
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/e10wv796

Abstract

Adequate drug availability at primary health centers (Puskesmas) is a key indicator of effective drug management and may be influenced by the knowledge of drug management officers. This study aimed to examine the relationship between officers’ knowledge and drug availability at selected Puskesmas in Makassar City. A descriptive analytical observational study with a cross-sectional design was conducted on May 16–17, 2025, at Paccerakkang, Mamajang, Pattingalloang, and Mangasa Puskesmas, which were selected using cluster random sampling. All eligible drug management officers were included through total sampling, resulting in seven respondents. Knowledge was assessed using a 20-item questionnaire with excellent reliability (Cronbach’s alpha = 0.9675), while drug availability was evaluated using 2024 Drug Usage and Request Reports (LPLPO) for 40 indicator drugs. Data were analyzed using the Shapiro–Wilk normality test and Pearson’s correlation test. The mean knowledge score was 90%, categorized as good; six respondents had good knowledge and one had sufficient knowledge. Drug availability varied across facilities: one Puskesmas was categorized as good (69.87%), while three were categorized as sufficient, with an average availability of 46.29%. Pearson’s correlation showed no significant relationship between officers’ knowledge and drug availability (r = -0.853; p = 0.147). These findings suggest that drug availability is likely influenced more by procurement policies, distribution systems, and health budget allocation than by officers’ knowledge alone.
FORMULASI DAN UJI KESTABILAN FISIK BISKUIT DARI TEPUNG KULIT BUAH LABU KUNING (Cucurbita moschata) Besse Yuliana; Jelisa Ruru kambuno
Jurnal Kesehatan Yamasi Makassar Vol 10 No 2 (2026): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/hf30qr43

Abstract

Pumpkin peel (Cucurbita moschata) contains various beneficial compounds, including carotenoids (α-carotene, β-carotene, and xanthin), pectin, vitamins A and C, and minerals. The utilization of pumpkin peel as a functional food ingredient can be achieved by processing it into biscuit products. This study aimed to determine whether pumpkin peel flour (Cucurbita moschata) can be formulated into physically stable biscuits and to identify the concentration that produces the best characteristics. This study was an experimental study using four biscuit formulations, namely F1 (20%), F2 (24%), F3 (30%), and F4 (34%) pumpkin peel flour. Evaluations included organoleptic testing, fat content, ash content, moisture content, and carbohydrate content. Organoleptic data were analyzed using the Kruskal–Wallis test, while physicochemical data were analyzed using One-Way ANOVA followed by Duncan's multiple range test.The results of the Kruskal–Wallis test showed that different concentrations of pumpkin peel flour had no significant effect on organoleptic parameters, including color (p=0.407), aroma (p=0.348), taste (p=0.848), and texture (p=0.357). Physicochemical analysis indicated that fat content (p=0.122), ash content (p=0.913), and moisture content (p=0.542) did not differ significantly among the formulations. In contrast, carbohydrate content showed a significant difference (p=0.018), and Duncan's test revealed that F1 differed significantly from F3 and F4. Furthermore, organoleptic evaluation showed that F1 obtained the highest mean preference scores for color (3.63), aroma (3.57), taste (3.37), and texture (3.67).In conclusion, pumpkin peel flour (Cucurbita moschata) can be formulated into biscuits with stable physicochemical characteristics. Formula F1 containing 20% pumpkin peel flour was identified as the best formulation because it achieved the highest panelist preference scores for color, aroma, taste, and texture. Keywords: biscuits, pumpkin peel, Cucurbita moschata, physicochemical properties, organoleptic evaluation.

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