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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
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Search results for , issue "Vol. 10, No. 1" : 9 Documents clear
Vaksin Influenza sebagai Modalitas Pencegahan Kejadian Rawat Inap Akibat Penyakit Kardiovaskular Rusdi, Lusiani; Adnan, Nurhayati; Suhardi, Kevin Fernando
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Sensitisasi Alergen Makanan pada Pasien Kolitis Eosinofilik: Laporan Kasus Zagoto, Agnes Dina Irene Dorithy; Mulya, Deshinta Putri; Ratnasari, Neneng
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Eosinophilic colitis is a very rare disease that can occur in the bimodal population (neonates and young adults) with a prevalence was 2.1/100,000 in overall population and 2.3/100,000 in adults. However, only about 0.1% of cases were diagnosed from biopsy results obtained during colonoscopy. The lack of precise histological criteria for the quantity of eosinophils in the colon mucosa creates a distinct challenge in diagnosing eosinophilic colitis. Eosinophilia in the gastrointestinal tract can be mediated by IgE and non-IgE, but non-IgE tends to be dominant in adults. This report discusses about a case of a 64-year-old male with bloody diarrhea that has been occur for two years. The anamnesis revealed symptoms suggestive of eosinophilic colitis, including complaints of diarrhea with abdominal pain and weight loss. Laboratory tests revealed an increase in peripheral eosinophil count and elevated levels of IgE. A positive skin prick test supported the presence of food allergen sensitization. The endoscopy revealed signs of ulcerative colitis, but the biopsy showed evidence of eosinophilic colitis. Initially, the patient was treated for ulcerative colitis but did not show improvement. Following treatment for eosinophilic colitis, the patient’s clinical status showed improvement. Since eosinophilic colitis can be chronic and recur, an accurate diagnosis and proper management are crucial for achieving complete remission. Keywords: chronic diarrhea, eosinophilic colitis, food allergen sensitization, IgE, peripheral eosinophilia
Profilaksis Pasca Paparan Virus HIV pada Petugas Kesehatan Karjadi, Teguh Harjono
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Health workers (HCWs) are prone to get infected by HIV infection when carrying out their duties. The injuries can be caused by needle sticks, sharp objects (scalpels, lancets, or other) that have been exposed to body fluids or splashes of body fluids onto the body’s mucosa (eyes, nose, mouth) and non-intact skin have the potential to transmit the HIV infection. Post-exposure transmission due to contamination of body fluids to health workers can be prevented by providing post-exposure prophylaxis therapy. Post-exposure prophylaxis (PEP) is given as soon as possible and no later than 72 hours after exposure. Prophylaxis is given to HCWs who are significantly exposed using three antiretroviral drugs. In Indonesia, for adolescents and adults ≥ 10 years old, the main choice is Tenofovir (TDF) + Lamivudine (3TC) + Dolutegravir (DTG). Simultaneously with the administration of ARV drugs, counseling is also carried out regarding side effects of ARV, medication adherence, drug interactions, the possibility of seroconversion, and if necessary, management of anxiety that may arise. ARVs will be given for 28 days. After being given post-exposure prophylactic therapy, monitoring for side effects of ARV drugs must be carried out which are given in the 2nd and 4th week. Re-examination of HIV testing to see the effectiveness of treatment was carried out at 12 weeks and 6 months after exposure. Keywords: HIV infection, PEP of HIV
Efektivitas Ekstrak Strobilanthes crispus terhadap Kadar Glukosa Darah Puasa dan Pasca Tes Toleransi Glukosa Oral pada Rattus norvegicus Diabetes Melitus Gunawan, Alvin; Wihanto, Laura; Muliono, Ari Christy
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. The 2018 Riskesdas data shows that the prevalence of diabetes mellitus is increasing each year. Strobilanthes crispus leaves are known for lowering blood glucose levels. This study aimed to determine the difference in the effectiveness of S. crispus leaves ethanolic extract on fasting blood glucose (FBG) and post-oral glucose tolerance test (OGTT). Methods. True experimental study using post-test only control group design and Rattus norvegicus as experimental animals. Rattus norvegicus were selected by random sampling which were then divided into 4 groups (K, P1, P2, P3), each group consisted of 5 animals. The animals were subsequently induced with diabetes mellitus via a single injection of 160 mg/kgBW/IP alloxan. Group K was given 0.5% NaCMC solution at a dose of 1 ml/200 g BW/day/oral/day. Group P1, P2, and P3 received extract at a dose of 100, 400, 600 mg/kg BW/oral/day for 21 days using oral gavage. Statistical analysis was performed using ANOVA, Tukey, Brown-Forsythe, and Kruskal-Wallis tests. Results. Mean FBG level in group K, P1, P2, P3 were 338.40 mg/dL, 270.80 mg/dL, 200.00 mg/dL, and 138.60 mg/dL, respectively. Mean value of 60 minutes OGTT blood glucose level in group K, P1, P2, P3 were 355.60 mg/dL, 289.00 mg/dL, 188.00 mg/dL, and 164.40 mg/dL, respectively. Meanwhile, mean value of 120 minutes OGTT blood glucose level in group K, P1, P2, P3 were 346.60 mg/dL, 236.20 mg/dL, 175.40 mg/dL, and 117.20 mg/dL, respectively. The hypothesis test results showed a significant difference in 120 minutes OGTT blood glucose level (p= 0.031). Conclusion. The use of ethanol extract from S. crispus leaves is more beneficial in reducing blood glucose levels in 120 minutes OGTT compared to FBG level and 60 minutes OGTT level, with the highest reduction observed in the group given a dose of 600 mg/kgBW/oral/day compared to control. Keywords: DM, fasting blood glucose, OGTT, Rattus norvegicus, Strobilanthes crispus
Gambaran Risiko Post-Traumatic Stress Disorder (PTSD) pada Penyintas COVID-19 di Rumah Sakit Universitas Andalas Wahyuni, Sri; Widya Murni, Arina; Indra, Beni; Gusya Liza, Rini; Koerniati, Isnindiah; Sauma, Eldi
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. The COVID-19 pandemic has a negative impact on life where sufferers can experience emotional problems such as despair, deep sadness, helplessness, anxiety, and depressive symptoms. Especially in hospitalized COVID-19 survivors, there are sequelae in the form of anxiety, depression, and Post-traumatic Stress Disorder (PTSD). PTSD experienced by COVID-19 survivors will affect the patient’s quality of life in the future. This study aimed to assess the risk of PTSD in COVID-19 survivors who had been hospitalized at Andalas University Hospital. Methods. A cross-sectional descriptive study was conducted among COVID-19 survivors aged ≥15 years who had been hospitalized at Andalas University Hospital. Samples were selected by using total sampling method with inclusion criteria included experiencing mild, severe, or critical clinical symptoms during COVID-19 infection, being discharged from Andalas University Hospital for six months or more, and willing to participate in the study by signing an informed consent. Samples who have met the inclusion criteria completed the Bahasa Indonesia version of PCL-5 (PTSD Checklist for DSM-5) questionnaire which has been tested for its validity and reliability. Respondents were categorized as having PTSD risk if the questionnaire results showed a score of ≥23. The collected data were subsequently analyzed using univariate analysis. Results. A total of 75 respondents were included in the study, of which 9.3% (7) were found to be potentially or at risk of PTSD. The group of respondents who were at risk of PTSD was mostly comprised of females, and all of them experienced the four PTSD symptoms (intrusion/re-experiencing, avoidance, negative alterations in cognition and mood, and hyperarousal). The most common trigger that causes PTSD among respondents was the experience of a previous life-threatening traumatic event (71.43%). In addition, the most frequent clinical symptoms of COVID-19 in the PTSD risk group were severe clinical symptoms (71.43%). Conclusions. COVID-19 survivors who have the potential to experience PTSD are predominantly female survivors with severe clinical symptoms, experiencing all four PTSD symptoms, and having a traumatic life-threatening experience during COVID-19 hospitalization. Keywords: COVID-19 survivors, hospitalization, risk of PTSD
Modulasi Mikrobiota untuk Memperbaiki Laju Filtrasi Glomerulus, Toksin Uremik, dan Penanda Inflamasi pada Gagal Ginjal Kronik: Telaah Sistematik dan Meta-Analisis Gunawan, Burhan; Purwata, Raymond Sebastian; Hidayat, Syarif; Pandapotan, Roy Akur; Jennifer, Jennifer
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. Dysbiosis microbiota is considered as one of the consequences and impacts of high uremic toxins in patients with Chronic Kidney Disease (CKD), which can lead to an increased risk of progression and mortality. The aim of this systematic review and meta-analysis was to perform quantitative effect of microbiota modulation for estimated Glomerular Filtration Rate (eGFR), uremic toxin (total-p cresyl/total pCS), and inflammatory marker (hs-CRP) outcome among CKD patients. Methods. Article searches were conducted from PubMed, ScienceDirect, and Cochrane Library data sources from 2010-2022. Assessment of article quality follows the rules of PRISMA (Preferred Reporting Items in Systematic Review and Meta-Analysis). Only randomized controlled trial (RCT) articles investigating the effect of symbiotic, prebiotic, of probiotic for CKD were included in the analysis. Effect size quantify from Standardized Mean Difference (SMD), using a continuous random effect model and described in the forest plot model. Results. A total of 17 RCT studies with a total 867 CKD stage 1-5 subjects (440 subjects in the intervention group and 427 subjects in the control group). The intervention duration ranging from 1-12 months. The studies included had varied on methodologies, with significant heterogenicity (I296,96%, p Conclusions. The administration of probiotic/prebiotic/symbiotic supplements to CKD patients resulted in significant improvements in e-GFR and reductions in total pCS. These results suggest the potential of symbiotic, prebiotic, and probiotic supplementation to improve CKD outcome. Keywords: Chronic kidney disease, e-GFR, hs-CRP, prebiotic, probiotic, uremic toxin
Performa Diagnostik Global Leadership Initiative on Malnutrition (GLIM) dibandingkan dengan Malnutrition Nutritional Assessment (MNA) dalam Pengkajian Malnutrisi pada Pasien Geriatri di Rawat Inap Leoni, Astrine Permata; Amelia, Wita Rizki; Laksmi, Purwita Wijaya; Syauqy, Ahmad
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. As many as 76.6% of patients aged 60 years and above (elderly) are malnourished or at risk of malnutrition based on MNA within the first 48 hours of hospital admission. The prevalence of malnutrition varies widely depending on the population studied, the healthcare setting and the tools used for the assessment. To date, SGA is widely used in the diagnosis of malnutrition for adults and MNA for elderly patients. Recently, experts proposed empirical consensus of GLIM criteria for determining the diagnosis of malnutrition in adults. This study aimed to investigate the diagnostic performance of GLIM criteria as a new consensus in determining the diagnosis of malnutrition in comparison to MNA as a semi-gold standard for nutritional assessment in the elderly. Methods. A cross-sectional study was conducted from January to April 2022 on 103 consecutively recruited elderly patients aged ≥60 years in the Internal Medicine Wards at Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. Results. There were 91.3%, 57.3% and 54.4% malnourished elderly patients upon admission to the hospital, based on GLIM criteria, MNA-SF and MNA-LF, respectively. GLIM has good accuracy compared to both MNA-SF and MNA-LF, as long as the category of malnourished in MNA is a combination of malnutrition and at risk of malnutrition. GLIM had 97.9% sensitivity, 87.5% specificity, AUC 0.93, 98.9% PPV, 77.8% NPV, 7.83 positive LR and 0.02 negative LR towards MNA-SF, and a sensitivity value of 98.9%, specificity 88.9%, AUC 0.94, PPV 98.9%, NPV 88.9%, positive LR 8.91, and negative LR 0.01 towards MNA-LF. Conclusion. GLIM showed good diagnostic accuracy to determine nutritional status in the elderly, especially upon admission to the hospital, so that appropriate early nutritional interventions can be given. Keywords: diagnostic performance, elderly, GLIM, malnutrition, MNA
Penilaian Domain Pengkajian Paripurna Pasien Geriatri (P3G) sebagai Faktor yang Berpengaruh terhadap Kejadian Pneumonia Nosokomial pada Pasien Usia Lanjut yang Dirawat di Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo Victor, Hildebrand Hanoch; Wahyudi, Edy Rizal; Rumende, C. Martin; Soejono, C. H.; Rooshoeroe, A. G.; Shatri, Hamzah; Nainggolan, Leonard; Irawan, Cosphiadi
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Introduction. Nosocomial pneumonia is a lung infection that occurs after the patient is hospitalized for more than 48 hours, without any signs of pulmonary infection at the time of treatment. When compared with young individuals, elderly individuals are more likely to have community-sourced and nosocomial infections with worse outcomes. Comprehensive Geriatric Assessment (CGA) domains are expected to explain the factors that contribute to nosocomial pneumonia in elderly patients. This study aimed to determine the proportion of elderly treated at Dr. Cipto Mangunkusumo National Central General Hospital who experienced nosocomial pneumonia and whether the CGA domains influence the occurrence of nosocomial pneumonia. Methods. A retrospective cohort study was conducted by analyzing the medical records of patients aged 60 years or older who were hospitalized in the medical ward of Geriatric Internal Medicine at Dr. Cipto Mangunkusomo National Central General Hospital in January – September 2019. We also collected secondary data from the geriatric division’s research. The sample consisted of inpatients aged ≥60 years who were hospitalized for more than 48 hours. Those who died within the first 48 hours of hospitalization and subjects with incomplete CGA domain data were excluded from the study. The criteria for nosocomial pneumonia used in this study followed the CDC’s pneumonia criteria for geriatric patients. Data processing was conducted using the application of Statistical Product and Service Solutions (SPSS) 16. Results. Of 228 subjects, the proportion of nosocomial pneumonia in elderly patients hospitalized was 31,14%. The mean age was 69 years with the subject’s age range between 60-89 years. Nutritional status (OR 2.226; CI95% 1.027-4.827) and functional status (OR 3.578; 95%CI 1.398-9.161) are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Conclusions. The proportion of elderly patients with nosocomial pneumonia was 31.14%. Nutritional status and functional status are factors that influence the incidence of nosocomial pneumonia in elderly patients who are hospitalized at Dr. Cipto Mangunkusumo National Central General Hospital. Keywords: Comprehensive geriatric assessment, elderly, nosocomial pneumonia
Vaksinasi Influenza sebagai Prediktor Terjadinya Kejadian Rawat Inap Akibat Kejadian Kardiovaskular pada Pasien dengan Riwayat Penyakit Jantung Koroner: Suatu Laporan Kasus Berbasis Bukti Koesnoe, Sukamto; Johan, Alvin; Dewanta, Widhi; Ekanara, Nabilla Gita; Hermanadi, Muhammad Ikrar
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
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Influenza is known to worsen cardiovascular events in patients with a history of coronary heart disease. However, the effectiveness of influenza vaccination in reducing hospitalization due to cardiovascular disease is not clearly known. We aim to determine the effect of influenza vaccination on hospitalization rates due to cardiovascular disease in patients with a history of coronary heart disease. Relevant literature was searched on four electronic databases: MEDLINE, EMBASE, SCOPUS, and Cochrane Library, using predetermined keywords. Critical review of the studies was done using the Center of Evidence Based Medicine (CEBM) University of Oxford assessment tool. The search yielded six articles, and critical review was done based on validity, importance, and applicability. Three studies showed that influenza vaccination in patients with coronary heart disease would reduce hospitalization rates due to cardiovascular disease within 12 months after vaccination. Three studies did not show any effect of influenza vaccination on hospitalization rates due to cardiovascular disease. The samples in the three studies that found a protective effect of the influenza vaccine were older and at higher risk of experiencing cardiovascular events. Based on our review, we conclude that influenza vaccination can be given to prevent hospitalization due to cardiovascular disease in patients with a history of coronary heart disease, especially in high-risk patients. Keywords: Coronary heart disease, hospitalization, influenza vaccination

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