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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 164 Documents
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Noninvasive diagnostic modality for skin cancer Siregar, Remenda; Nurhayati, Raja; Oentari, Widyaningsih; Sari, Ari Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
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Histopathological examination is the gold standard for the diagnosis of nonmelanoma and melanoma skin cancer, but it is an invasive procedure that consumes time and requires large costs. The average cure rate for skin cancer is high with early detection and appropriate treatment. This is an article review that was made through findings from several scientific articles. There are several noninvasive imaging modality choices that can be used for screening at low cost, high quality, and faster result, which includes dermoscopy, optical coherence tomography, reflectance confocal microscopy, electrical impedance spectroscopy, multispectral imaging, and SIAscopy®. These imaging modalities can assist in the detection of skin cancer using a combination of high-quality computer science, mathematics, and optics. This can improve the efficiency of diagnosis and management, reduce treatment costs, and increase patient satisfaction while utilizing teledermatology.
Clinical characteristics and treatment regimen of pemphigus patients: A retrospective study Budianti, Windy Keumala; Fitri, Eyleny Meisyah; Meilinda, Puti Rineska; Novianto, Endi; Anindya, Shafira; Debinta, Arlha Aporia
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
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Background: Pemphigus is a potentially life-threatening autoimmune bullous disease. In pemphigus, the therapeutic options are based on the clinical characteristics of each patient. However, other than corticosteroids, most therapeutic options for pemphigus are currently limited. Steroid-sparing agents might be considered since the initiation of therapy to prevent the side effects of corticosteroid. The objective of this study is to identify the clinical characteristics and therapy of choice in patients with pemphigus at Dr. Cipto Mangunkusumo General Hospital. Method: All cases of pemphigus from 2016 to 2018 at Dermato-Allergo-Immunology Clinic, Department of Dermatology and Venerology Dr. Cipto Mangunkusumo General Hospital were included in this study. Data were collected from medical records, including patient’s demographics, clinical data, and therapy. Data were analyzed using SPSS 20. Results: There were 24 new pemphigus cases from 2016 to 2018. Female to male ratio was 3.8:1 with median age of onset of 37.5 (16-73)years old. Pemphigus vulgaris was the most common subtype of pemphigus (75%), followed by pemphigus foliaceus. Number of patients with oropharyngeal mucosal involvement was found higher in pemphigus vulgaris compared to pemphigus foliaceus (p=0.012). Systemic steroid was given in 86.9% patients while the rest were treated with topical corticosteroid only. Steroid-sparing agents were given in 58.3% patients. Remission was achieved in 42.3% cases in average 5 (2-28) months. Conclusion: Pemphigus vulgaris is the most common subtype of pemphigus and corticosteroid remains to be its treatment of choice. The steroid-sparing agents most commonly used in this study are mycophenolate mofetil and azathioprine.
Prevalence of Cutibacterium acnes and Staph spp. in the lesions of acne vulgaris in Jakarta Hermawan, Melyawati; Tjoa, Enty; Hidajat, Inneke J.; Teressa, Maria; Layadi, Eka B.; Wolter, Alegra
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
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Background: Acne vulgaris (AV) is a chronic skin disorder that is commonly seen in young adults. Recent studies have shown that bacteria other than Cuticubacterium acnes found in the skin microbiota also play vital roles in the pathogenesis of AV. Understanding the skin microbiota and its disruption in patients with AV is paramount in treating patients with AV. Methods: Samples were obtained from 36 subjects to evaluate the proportion of Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus in lesions of AV by means of bacterial culture. Results: There were 69 specimens collected from the 36 subjects with AV. The most abundant type of bacteria that was successfully isolated in the cultured AV lesions was Staphylococcus epidermidis(46.4%), followed by Cutibacterium acnes(14.5%), and Staphylococcus aureus(2.9%). Conclusion: Staphylococcus epidermidis,the major species of human skin flora, is the most abundant microorganism found in AV. The development of AV is not necessarily associated with the high proportion of Cutibacterium acnes. More pathogenic bacteria, such as Staphylococcus aureusis also not always found in the AV lesions. These findings may provide the basis for the clinicians to determine which types of antibiotics to prescribe for the treatment of AV.
A comparison of single-dose versus divided-dose of metronidazole on bacterial vaginosis among female sex workers in Surakarta Damayanti, Willa; Hastuti, Rini; Triana, Agung; Yuliarto, Danu; Ayu, Ardelia Dyah; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
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Background: Bacterial vaginosis (BV) is the most common vaginal infection in sexually active women. Metronidazole (MTZ) is still one of the recommended regimens for BV either as a single-dose or divided-dose. In addition to its affordability and availability, oral metronidazole also produces fewer adverse effects. This study aimedto determine the efficacy of single-dose versus divided-dose metronidazole for BV among female sex workers (FSWs) in Surakarta. Methods: A single-blind randomized clinical trial was conducted in Surakarta. FSWswith BV (⩾3 Amsel criteria) were enrolled. The subjects were grouped into two, and treated with MTZ either as a single-dose of 2 gr (single-dose group) or 500 mg twice daily for one week (divided-dose group). After two weeks, we performed second vaginal swabs and reassessed the Amsel criteria, complaints and adverse events. Results: Out of 75 FSWs, 30 (42%) were diagnosed with BV. The efficacy between two groups was not significantly different. However, patients in the single-dose group were 2 times more likely to develop recurrent BV (OR = 2.000; 95% CI 0.146 – 27.447), and 1.5 times more likely to have vaginal discharge complaints (OR = 1,500; 95% CI 0,181-12,459) than divided-dose group. Conclusion: Single-dose and divided-dose metronidazole produce similar efficacy for treating BV in sexually active women. Single-dose metronidazole has a higher risk of BV recurrence and vaginal discharge complaint. Divided-dose metronidazole is recommended for treating BV.
Intense pulsed light (IPL) as adjuvant therapy for acne vulgaris: A case series Oentari, Widyaningsih; Sutrisno, Angie Regina; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicle with polymorphic clinical manifestation typically found on facial, neck and/or back area. The pathogenesis is complex and multifactorial. Management of acne vulgaris is determined based on its severity. Adjuvant therapies, such as intense pulsed light (IPL), have been described in accelerating the healing process during treatment. Case Illustration: We report two cases regarding the usage of IPL as adjuvant therapy in acne vulgaris. Both patients were diagnosed with moderate acne vulgaris. The first patient was given topical adapalene 0.1% gel every night and sunscreen in the morning, and the other patient was given clindamycin gel applied twice a day, benzoyl peroxide 2.5% cream applied once a day at night, and sunscreen in the morning. Both patients were treated using IPL as their adjuvant therapy every three weeks, with a total of 2 IPL sessions in 2 months. Evaluation using clinical and ultraviolet-induced red fluorescence (UVRF) examination showed gradual improvement. Discussion: IPL as an adjuvant therapy of acne vulgaris has been thought to interfere with the function of the sebaceous glands by its direct phototoxic effects and thermal damage. It also has bactericidal effects on C. acnes through the formation of free radicals. The combination of topical treatment and IPL yielded clinical improvements in both patients.Conclusion: IPL may be beneficial as adjuvant therapy in acne vulgaris in this case series.
Dermoscopic features of uncomplicated tinea versus steroid-modified tinea: An observational study in Indian patients Gadekar, Mithila Ninad; Syed, Nausheen; Chate, Ashutosh; Save, Sushrut
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Tinea is one of the most common superficial fungal skin infections. Steroid-modified tinea infections may present with atypical morphology. This study aims to observe the difference between dermoscopic features of uncomplicated dermatophytosis and steroid-modified dermatophytosis.Methods: This observational study was conducted in 60 patients with tinea cruris, tinea corporis and tinea faciei in the outpatient dermatology department of a tertiary care center. Patients were divided into group A and group B. Group A included 30 patients with no history of steroid use in the past three months. Group B included 30 patients with a history of steroid usage in the past three months. Dermoscopy was performed in both groups using a USB 2.0 dermoscope (Dino-Lite Premier AM3113T®, Magnification – 20x to 50x and 200x) to study the characteristic features in tinea infections. Chi-square test and Fisher’s exact test were applied as applicable.Results: Out of 60 cases of dermatophytosis, 20 cases were of tinea corporis, 28 cases of tinea cruris, and 12 cases of tinea faciei. Dermoscopic features of hair follicular involvement (perifollicular scale, follicular micropustules, the involvement of vellus hair, yellow hair, morse code hair, and transparent hair) were significantly more common in group B than in group A (P = 0.004, P = 0.039, P = 0.0001, P = 0.01, P = 0.03, P = 0.002, respectively for each feature).Conclusions: All dermatophytosis patients with a history of steroid use showed characteristic signs on dermoscopic examination irrespective of their morphologic appearance. Thus, dermoscopy can be used as a rapid diagnostic method for steroid-modified cases of tinea.
The differences of blood type in relation to psoriasis and its onset: Cross sectional study Dharmawan, Nugrohoaji; Widhiati, Suci; Oktavriana, Triasari; Harahap, Irene Jessica Pinarsinta
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Psoriasis is a chronic skin disease caused by inflammatory response and attacks 2% of population, with the prevalence influenced by age, geographical location, and genetic background. Until this day, there are several studies that discuss about the relationship between blood type with disease. However, discussion about the difference between blood type and the relationship with skin disease remains limited. The objective of this study is to know the relationship between blood type, psoriasis, and onset of psoriasis.Methods: This study adopted cross-sectional design of analytic observational study. The subjects of this study were patients in Department of Dermatology and Venereology at Dr. Moewardi General Hospital and UNS Hopital in Surakarta. The blood types were determined by two methods; by using ABD-Pad measurement tools that able to see the reaction of antigen and antibody in short time and by using the hospital’s laboratory facility where sample was taken. Anamnesis were done to collect data about the onset of psoriasis. Chi-square (X2) statistical test was used to analyze the data.Results: Total sample of this study were 62 people with 31 subjects (50%) were psoriasis patients and 31 others (50%) are non-psoriasis patients. Chi-square test (X2) between blood type with psoriasis and blood type with the onset of psoriasis are p = 0.269 and p = 0.188 respectively. Conclusion: The significance level used was p < 0.05, therefore there’s no significant correlation between blood type with psoriasis and the onset of psoriasis.
Plasma malondialdehyde levels related to acne vulgaris severity Puspita, Fitri; Jusuf, Nelva Karmila; Yosi, Ariyati
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Acne vulgaris (AV) is a multifactorial disorder characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. Oxidative stress plays a role in the pathogenesis of AV. Reactive Oxygen Species (ROS), especially lipid peroxides (LPO), plays a role in mediating acne inflammation. Malondialdehyde (MDA) is one of the byproducts of LPO commonly used as a biomarker of cell damage.Methods: This cross-sectional analytic study consisted of sixty patients with AV. The samples were taken from the blood plasma of AV subjects. An enzyme-linked immunosorbent assay (ELISA) examination was performed. The normality of data distribution was determined using the Kolmogorov-Smirnov test and the differences of plasma MDA levels based on the severity of AV were determined using the Kruskal-Wallis test. P valueResults: Acne vulgaris was predominantly found in women (70%), age group of 18 – 25 years old (73,33%), and patients with family history of AV (61,67%). Higher plasma MDA levels were found in women [5,5 (2,53 – 77,6) nmol/mL], age group of 26 – 35 years [5,66 (2,73 – 25) nmol/mL], and subjects with family history of AV [5,49 (2,53 – 77,6) nmol/mL]. Based on the severity of AV, the severe AV group had highest plasma MDA [13,85 (2,69 – 77,6) nmol/mL], followed by moderate AV group [4,46 (2,53-14,3) nmol/mL] and mild AV [3,78 (2,47-6,88) nmol/mL]. There were differences in plasma MDA level based on the severity of AV (p<0,001).Conclusion: There were differences in plasma MDA levels based on the severity of AV.
Indonesian clinical practice guidelinesfor systemic and biologic agents for adults with plaque psoriasis E, Novianto; WK, Budianti; EM, Fitri; BE, Wiryadi; RW, Soebaryo; EHD, Pusponegoro; EH, Effendi; G, Rahmayunita
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: In response to various biologic and non-biologic systemic agents available in Indonesia, proper and accredited treatment guidelines are required to ensure patient safety. Appropriate treatment is crucial and may affect remission time and morbidities. These guidelines were developed by the Indonesian Society of Dermatology and Venereology – Kelompok Studi Psoriasis Indonesia (INSDV-KSPI) to provide updated decision-making algorithms for the biologic and non-biologic systemic agents for the treatment of adult patients with plaque psoriasis. Methods: Experts from twelve institutions across Indonesia were involved in developing the guidelines. Subsequently, a focus group discussed various journals, researchable questions, eligibility criteria, and outcomes of various treatments options. Results: Modified evidence to decision framework of treatment choices were constructed to aid dermatovenerologists across Indonesia in making a clinical judgment on the size of treatment options of biologic and non-biologic systemic agents for psoriasis treatment in Indonesia. Conclusion: These clinical practice guidelines, accepted and acknowledged by the Indonesian Society of Dermatology and Venereology - Kelompok Studi Psoriasis Indonesia (INSDV-KSPI), have been developed to present the latest and concise evidence- and experience-based guideline targeted towards dermatovenereologists in Indonesia on the management of adult plaque psoriasis.
Platelet-rich-fibrin for venous leg ulcer therapy Rachmani, Karin; Suseno, Lis Surachmiati; Ramadhiani, Mutiara
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Venous leg ulcer (VLU) is a chronic condition in the chronic venous insufficiency clinical spectrum. It’s becoming a burden because of its chronicity, slower wound healing, accumulated high cost, and treatment is a challenging task. Platelet-rich-fibrin (PRF) is one of the newer modalities available for treating VLU. Previous studies have shown successful results by using PRF in leg ulcers. We reported a case of venous leg ulcer treated with PRF.Case Illustration: A 47-year-old male came with an ulcer on the lower left leg for one year. The ulcer was preceded with a reddish, tender nodule with a pustule, which then ruptured, resulting in a wound. There was intermittent pain at the lesion with a limb cramp. The patient had used compression stocking, leg elevation, normal saline compress, and topical antibiotics with no improvement. PRF was given for 12 weeks along with compression stocking and leg elevation, which resulted in a clinically improved lesion. Discussion: Wound therapy has greatly improved over the past decades. The interest in the wound care field has led to advancements in biological products as one of its modalities. Platelet-rich-fibrin is an autologous platelet and leucocyte-rich fibrin material which forms an organized network where the platelets and leucocytes are concentrated, leading to the sustained release of various growth factors, and promoting wound healing. Previous studies have shown PRF to be effective and low-cost for VLU.Conclusion: The use of PFR on VLU is an alternative method, low cost, and simple technique with good healing potential.

Page 10 of 17 | Total Record : 164

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