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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 164 Documents
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Recent progress in immunotherapy for skin cancer Mughni, Fadhli Aulia; Astriningrum, Rinadewi; Hoemardani, Aida SD; Bramono, Kusmarinah; Sampurna, Adhimukti T.; Sutarjo, Agassi Suseno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Skin cancer is a global health concern due to its growing incidence and high mortality rate. The most common therapeutic modalities in skin cancer include surgery, radiotherapy, and chemotherapy. However, those therapies do not specifically target cancer cells and may damage healthy tissues. Cancer induces immune response by releasing soluble antigens and danger signals caused by tumor cellular stress or death, while the immune system continuously monitor and control malignant proliferation through cancer immunoediting. Therefore, targeting this mechanism is a promising approach to manage cancer, especially those unresponsive to conventional therapies. Immunotherapy is a specific therapy that manipulates the immune system to fight the disease. Previous studies have shown promising results in its clinical use in melanoma and non-melanoma skin cancer (NMSC). However, its potential toxicity and tolerability may pose significant obstacles in developing effective cancer immunotherapy. Biomedical, immunological, and clinical research in skin cancer is still needed to elaborate further on its pathogenesis and design safe and effective therapy for each skin cancer.
The vaginal microbiota Kencana, Indah; Yenny, Satya Wydya
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Abstract

The vagina is an ecosystem consisting of various species of microorganisms (microbiota) that play important role in maintaining vaginal health. The vaginal ecosystem includes a variety of species classified into aerobic and anaerobic microorganisms which are vaginal microbiota (VMB). In the vagina of a healthy woman, 70% of normal microbiota is dominated by the Lactobacillus species. Lactobacillus is a Gram-positive, anaerobic bacterium, and belongs to the group of lactic acid bacteria (LAB). LAB produces lactic acid which plays a role in maintaining vaginal acidity at pH
Non-pustular annular psoriasis with signs of high disease activity Yasnova, Nevi; Budianti, Windy Keumala; Andardewi, Melody Febriana
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 2
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Abstract

Background: Non-pustular annular psoriasis is a rare condition in which a type of plaque psoriasis appears with ring-like lesions and a clearer central appearance. The disease activities in psoriasis may be evaluated clinically. It is essential to provide a more meaningful approach to treatment management. Case illustration: A 33-year-old woman complained of a one-year history of multiple erythematous, scaly, and annular plaques with central clearing. Some lesions were surrounded by discrete pinpoint papules on several parts of her body. The lesions worsened during seven weeks of topical and systemic therapy. Discussion: Psoriasis is a chronic, multisystem inflammatory disease with predominantly skin and joint involvement. High disease activity or unstable psoriasis was defined as recent exacerbations showing pinpoint papules developing around established and erythematous borders of the lesions. The active severe disease may present with systemic involvement due to the production of pro-inflammatory chemokines and cytokines in the skin lesions and circulation. Conclusion: A complete clinical history and physical examination can help the clinician diagnose non- pustular annular psoriasis. Several factors may cause worsening disease activity in a patient with psoriasis. Distinguishing between stable and unstable plaque psoriasis is essential to obtain information on psoriasis pathomechanism related to systemic involvement and managing therapeutic strategies. A multidisciplinary approach must be conducted in the management of a patient with high disease activity.
An overview of risk factors for androgenetic alopecia among women at Pasar Ambacang, Kuranji, Padang Sugma, Lidya Aprilia; Yenny, Satya Wydya; Rasyid, Roslaili
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Background: Androgenetic alopecia (AGA) is a patterned hair loss due to chronic and progressive miniaturization of hair follicles. Hair represents femininity and self-confidence in women. Therefore, AGA may affect the quality of life and psychology in women. This study aims to describe the risk factors for AGA in women living in Pasar Ambacang Sub-district, Kuranji District, Padang City. Method: This was a descriptive, cross-sectional study that included 40 women with AGA. Interviews with subjects were conducted. This study was approved by the Health Research Ethics Committee at Universitas Andalas (252/UN.16.2/KEPK-FK/2021) Results: AGA was mostly found on patients aged >65 years old (32.5%), married with childbearing (87.5%), overweight (32-5%), had a family history of AGA from the patient’s father (57.5%,) and a family history of AGA from the patient’s mother (75%). According to their medical history, respondents mostly had no hypertension (65%), type-2 diabetes mellitus (DM) (92.5%), and polycystic ovarian syndrome (PCOS) (100%). Most respondents had menarche at (95%), regular menstrual cycles (95%), and were non- menopausal (67.5%). The most common type of AGA was the type I Ludwig Classification (67.5%). Conclusion: Among women, AGA mostly occurred in patients with the following conditions: aged >65 years old, overweight, married with childbearing, had menarche at old, regular menstrual cycles, non- menopausal, and paternal or maternal history of AGA. AGA risk factors, such as hypertension, DM, and PCOS, were slightly found. The most common type of AGA was the type I Ludwig Classification.
Scientometric evaluation of the global research in acne disease Khakimova, Aida; Zolotarev, Oleg; Senel, Engin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Background: Although acne is one of the most common diseases, medical literature lacks a scientometric analysis relevant to this disorder. In the present study we aimed to perform a scientometric evaluation of literature related to acne. Methods: Publications were identified by searching for the term «acne» in PubMed. Papers from different countries were then identified by using the Advanced Search Builder. The indicators for evaluating of the absolute and relative increase in number of articles were proposed. Results: Dynamic publication of activity is compared according to our proposed indicator - The Average Relative Growth Rate. After 1945 an acceleration of the annual increase in articles was 2.7 times for acne, 1.3 times for acne vulgaris. For acne inversa, hidradenitis suppurativa, keloidal acne from 1985 the growth rate increased in 10-20 times. The other terms are characterized by a constant linear type of increase in publications. The United States has the most publications. Germany and the UK were in the second and third place. By the number of publications per million persons the leaders are Denmark, Israel, Georgia. The research productivity is weakly influenced by Gross Domestic Product. In developed countries the leaders are United States, Germany, Great Britain. In transition countries - China, Poland, Georgia. In developing countries - Turkey, India, Iran. Conclusion: Research activity in acne disease depends on the period of time and GDP of country. Such countries as Georgia, China, Turkey make an active contribution in acne research despite adverse socioeconomic factors.
Lucio phenomenon in pregnancy: A histopathology review Fiqnasyani, Siti Efrida; Oktavriana,, Triasari; Rosmarwati, Ervina; Novriana, Dita Eka; Mudigdo, Ambar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Background: Lucio phenomenon (LP) is a reaction occurring in lepromatous, non-nodular, diffuse leprosypatients who have not received multidrug therapy (MDT). The diagnosis of LP are based on clinical features and supported by histopathological examination. This report was conducted to establish a diagnosis of LP byhistopathological examination, considering that cases of LP in pregnancy are quite rare so that clinicians can be more precise. Case: A 35-year-old pregnant woman complained of extensive ulcers on her hand and legs. Madarosis, saddle nose, and earlobes were found A slit skin smear examination showed a bacterial index of +4 and a morphological index of 20%. A skin biopsy from a leg ulcer with HE staining revealed thinning of the epidermis,foamy macrophages, inflammatory cell infiltrate in the dermis and subcutaneous layers, necrotizing vasculitis with thickening of blood vessel walls, and perivascular lymphohistiocytic infiltrate. Histopathological examination of auricular infiltrate showed basket weave type hyperkeratosis, grenz zone, lymphohistiocytic inflammatory cell infiltrates, foamy and touton cells. Histopathological examination by FF staining showed a heavy M. leprae invasion. Discussion: Histopathological characteristics of LP in this patient found flattened epidermis, subepidermal grenz zone, aggregates and sheets of foamy macrophages admixed with predominantly huge numbers of acid-fast bacilli, foamy macrophages and touton cells. The main microscopic features also found subcutis necrotizing vasculitis. Histopathological examinations are essential to diagnose LP. Conclusion: Histopatholgy of Lucio Phenomenon found grenz zone, inflammatory cell infiltrate and foamy cells. This histopatholgy will support the diagnosis and best treatment for LP patient.
Therapy selection for tinea corporis and cruris with commorbidity: 3 case series Yefta, Yefta; Winarni, Dwi Retno Adi; Siswati, Agnes Sri
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Background: Dermatophytosis is a superficial (skin, hair and nails) fungal infection caused by dermatophyte group fungi (Trichophyton, Epidermophyton and Microsporum). Immunocompromised conditions cause fungal infections to become more widespread and require consideration of therapy. Case Illustration: This case series represented three cases of tinea corporis and tinea cruris in patients with comorbidities. The first case was tinea corporis and tinea cruris in a patient with congestive heart failure with oral terbinafine therapy. The second case was tinea corporis and tinea cruris in a patient with bilateral fourth degree hydronephrosis with oral griseofulvin therapy. The third case was tinea corporis in a patient with autoimmune hemolytic anemia with oral itraconazole therapy. A two-week post-systemic antifungal evaluation gave good results in all of the patients. Discussion: Selection of antifungals in dermatophytosis cases considering the patient's condition (contraindications and side effects that can be caused) provides a good outcome in patients with comorbidities. Conclusion: Dermatophytosis (tinea corporis and tinea cruris) is common in immunocompromised patients. This is due to decreased immunity causing dermatophytes to develop easily on the skin. Selection of the right therapy, considering comorbid conditions is important in order to get the best results for the patients.
Challenges in Diagnosing Staphylococcal Scalded Skin Syndrome in Children with Kwashiorkor: A Case Report Hamdali, Christie; Sirait, Sondang; Rusvita, Adria; Bhakti, Bawono
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Staphylococcal scalded skin syndrome (SSSS) is a type of exfoliating skin disease with high incidence in children. This condition can cause serious morbidity and even mortality with certain comorbid diseases such as malnutrition. Malnutrition could mask the diagnosis of SSSS because of its similarity to numerous differential diagnoses. Accuracy of clinical diagnosis is then essential to determine the proper initial management. This case report presents a 6-month-old male baby with staphylococcal scalded skin syndrome and kwashiorkor. The patient presented with complaints of multiple erythematous plaques and widespread vesicular lesions that subsequently ruptured, resulting in erosions. Physical examination revealed edema, coarse hypopigmented hair, multiple erythematous plaques, erosion, along with scales and crusts. Laboratory examination showed leukocytosis. The patient was administered intravenous ampicillin and chloramphenicol, along with wet dressings. The skin lesions showed improvement, but unfortunately, the patient passed away due to septic shock. Differential diagnoses of the skin lesions are also described, along with clinical signs to help differentiate. Proper diagnosis can help decide the correct early management and improve patient prognosis.
The effect of topical oatmeal (Avena sativa) on hydration-related skin disorders: A systematic review Sugondo, Karenina Novani; Hermawan, Melyawati
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Background: In recent years, interest in developing cosmetics and beauty products based on natural ingredients has increased. The addition of herbal extracts to products could improve the effectiveness of therapy. One of the natural ingredients that can be found is oatmeal. Oatmeal has been used for a long time and has been approved by the U.S. Food and Drug Administration as a skin protective agent since 2003. This study aims to systematically review the literature to determine the effect of topical oatmeal (Avena sativa) on hydration-related skin disorders. Methods: A total of 9,538 studies were found in the database sources such as PubMed, ProQuest, Clinical Key, Cochrane, Clinical Trial, and EBSCO. The inclusion criteria were all randomized controlled trials published from 2010 to 2020 that evaluated the effect of oatmeal-contained moisturizers on hydration-related skin disorders. The risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials (RoB2). Result: A total of five studies were included in this systematic review. These studies were published in 2015-2020. The forms of oatmeal in the five studies differ, such as emollient, lotion, and cream extracts. The skin disorders in the literature also vary, such as chronic pruritus, uremic pruritus, atopic dermatitis, irritant hand eczema, and dry skin. Conclusion: Although the form of oatmeal, skin disorders, and age range in each literature differ, it can be concluded that an oatmeal-contained moisturizer could improve the clinical assessment and the objective measurement of various hydration-related skin conditions.
The effectivity of ultrasound-guided platelet-rich plasma perineural injection in improving leprosy sensory peripheral neuropathy Brahmanti, Herwinda; Widiatmoko, Arif; Widasmara, Dhelya; Sari, Diane Tantia; Kurniawan, Shahdevi Nandar; Santoso, Widodo Mardi; Laksono, Ristiawan Muji; Gofur, Abdul
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
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Abstract

Background: Sensory nerve damage is the earliest leprosy sign which can lead to disability. Previous studies showed that autologous platelet-rich plasma (PRP) perineural blind injection can stimulate leprosy sensory nerve regeneration. Our study provided a safer and more accurate PRP agent delivery method through ultrasound-guided injection and was the first to compare PRP versus standard neuropathy treatment, the neurotropic vitamin. This study aimed to determine the effectiveness of combination therapy of ultrasound-guided PRP perineural injection and oral vitamin B complex compared to single oral vitamin B complex in sensory peripheral neuropathy of posterior tibial nerve in leprosy patients.

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