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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 62 Documents
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Search results for , issue "JPS Volume 9 Nomor 1 (2026)" : 62 Documents clear
Analisis Kontaminasi DNA Babi (Sus scrofa domesticus) Pada Produk Olahan Bakso Sapi Dan Ayam di Tuntungan, Sumatera Utara Sandika , Febri; Idami, Zahratul; Idris, Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1374

Abstract

Background: Meatballs are a popular processed meat product in Indonesia. High consumption of meatballs is accompanied by increasing public concern, especially among Muslims, regarding the halal aspect of the product. The potential contamination of pork DNA (Sus scrofa domesticus) in beef and chicken meatballs is a critical issue, whether due to unintentional cross-contamination or adulteration. Tuntungan area, North Sumatra, with its diverse demographic and trading characteristics, is an important location to assess the level of contamination. Objective: This study aimed to detect the presence of pork DNA (Sus scrofa domesticus) contamination in processed beef and chicken meatball products traded in the Tuntungan area, North Sumatra. Methods: Four meatball samples (three chicken meatballs and one beef meatball) were collected from street vendors and meatball stalls at different locations. DNA detection was performed molecularly using the Real-Time Polymerase Chain Reaction (qPCR) method with the *Genechecker UF-300* instrument. The procedure began with sample preparation, DNA extraction using the Genolution tool, master mix preparation, and analysis using the PCR Gen Checker chip. Result validation was based on the Cycle threshold (Ct) value in the target channel (FAM for pork DNA) and the internal control channel (ROX). Results: The analysis results of all four samples showed a FAM Ct value of 0 (not detected), indicating no amplification of specific pork target DNA. Meanwhile, the ROX Ct value (internal control) in all samples was detected in the range of 19.41–20.50, proving that the DNA extraction and amplification process ran optimally without inhibition. The positive control showed valid amplification signals, and the negative control showed no contamination. Conclusion: Based on the molecular detection results, it can be concluded that all tested beef and chicken meatball samples from the Tuntungan area were not contaminated with pork DNA (Sus scrofa domesticus). This finding indicates that traders in the area have applied good processing practices and separated raw materials, so the meatballs sold meet the halal aspect in terms of ingredient authenticity.
Formulasi Granul Effervescent Mengandung Ekstrak Daun Cyclea barbata Miers: Evaluasi Fisik (Sebelum dan Sesudah Rekonstitusi) Endriyatno, Nur Cholis; Oktavian , Rangga
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.893

Abstract

Cyclea barbata Miers leaf extract contains flavonoid compounds that have anti-inflammatory activity. This study aims to determine the effect of variations in citric acid and sodium bicarbonate concentrations on the physical properties of effervescent granules before (organoleptic, flow time, angle of repose, water content, and compressibility index test) and after (organoleptic, dissolve time, foam height, pH, and hedonic) reconstitution. Effervescent granules were formulated using the wet granulation method using varying concentrations of citric acid: sodium bicarbonate, respectively, it is FI (17%: 30%), FII (20%: 27%) and FIII (23%: 24%). Based on the results of the evaluation test of the physical properties of effervescent granules, FI and FII are appropriate for the requirements of each test, while FIII did not appropriate the requirements in the flow time, angle of repose, foam height and pH tests. This study concludes that FI (17%:30%) demonstrated the most optimal physical properties, meeting all evaluation parameters and receiving the highest hedonic score.
Uji Kualitas dan Identifikasi Sabun Padat Komersial Berbasis Lemak Hewan Menggunakan FTIR Pradini, Ni Komang Virginia; Salamah, Nina; Guntarti , Any; Nurkhasanah , Nurkhasanah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1077

Abstract

Background: Solid soap is produced by saponification of fatty acids with strong bases, and its quality is influenced by the type of fat used. Objective: This study aims to evaluate the physical and chemical quality of solid soap made from beef tallow and lard and to identify compound profiles using Fourier Transform Infrared Spectroscopy (FTIR). Method: The methods include dry-rendering fat extraction, solid soap formulation, and soap quality tests (organoleptic properties, pH, moisture content, and foam height). FTIR analysis was conducted to compare the absorption spectra of each soap. Results: The results showed that soaps derived from both fat sources met all quality requirements specified in the Indonesian National Standard (SNI). FTIR analysis revealed generally similar spectral patterns; the lard solid soap exhibited a characteristic absorption band at approximately 3009 cm⁻¹, corresponding to =C-H stretching vibrations of unsaturated fatty acids. In contrast, this band was not detected in the solid soap made from beef tallow. In addition, the CH₂ rocking vibration around 720 cm⁻¹ was more pronounced in the beef tallow solid soap, indicating a higher proportion of long-chain saturated fatty acids. Conclusion: FTIR effectively identifies fat types and can be used in raw material authentication, especially in product halalness.
Potensi Interaksi Obat Pasien Penyakit Saraf di Rumah Sakit X Kabupaten Pidie Aceh: studi deskriptif kuantitatif Lubis, Salmah Handayani; Hasanah, Fenny; Siahaan, Desy Natalia; Intan, Cut
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1100

Abstract

Background: Drug interactions can increase the risk of side effects and reduce the success of therapy, especially in neurological patients who often receive polypharmacy. Objective: This study aims to determine the effect of administering a combination of drugs as a trigger for potential drug interactions based on their classification (minor, moderate, major) in patients with neurological diseases. Methods: This study is a retrospective quantitative descriptive study with a cross-sectional design. The sample consisted of outpatient neurological patients who received more than two drugs that met the inclusion criteria. Potential drug interactions were analyzed using the https://www.drugs.com/drug_interactions.html. Results: The highest category of drug interactions was moderate (n= 52; 75%) with the following drug combinations: (amlodipine and bisoprolol); (Simvastatin + Miconazole); (Simvastatin + Omeprazole); (Hydrochlorothiazide + Codeine); (Codeine + Amitriptyline). In addition, a major drug interaction category (n=28; 25%) was found in the administration of drug combinations (simvastatin and amlodipine) causing liver damage; (Alprazolam + Codeine); (Diazepam + Codeine); (Codeine + Gabapentin) each of these three drug interactions can cause CNS depression, (Furosemide + Gentamicin) causes additive nephrotoxicity and ototoxicity. Conclusion: Moderate-category interactions were the most common (amlodipine and bisoprolol). These drug interactions included pharmacodynamic interactions, and the combination of these drugs could cause clinical risks (hypotension, bradycardia). These findings indicate the need for pharmacists to perform clinical pharmacy services related to prescription review and drug therapy monitoring for patients receiving more than two drugs, as well as providing information to patients on the appropriate timing and dosage of their medications to avoid moderate and major drug interactions in neurological patients in hospitals.
Analisis Kadar Alkaloid Ekstrak Dan Fraksi Biji Trembesi (Samanea saman Merr.) Berdasarkan Kepolaran Pelarut Menggunakan Spektrofotometri UV-Vis Qolbi, Raihan Ahista; Al Azzahra, Yunita
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1101

Abstract

Samanea saman (Merr.) seeds are plant parts that have not been extensively studied, despite their potential as a source of bioactive compounds, particularly alkaloids. Alkaloid compounds are known to possess various pharmacological activities, such as antimicrobial, anticancer, and analgesic effects, making them promising candidates for the development of natural medicines. This study aimed to analyze the alkaloid content in the extract and fractions of S. saman seeds using solvents with different polarity levels,namely n-hexane (non-polar), ethyl acetate (semi-polar), and distilled water (polar). Extraction was carried out using the Ultrasound Assisted Extraction (UAE) method, while quantitative analysis of alkaloid content was performed using UV-Vis spectrophotometry with caffeine as the standard solution. Qualitative testing showed that the ethyl acetate and aqueous fractions were positive for alkaloids. Quantitative analysis of the extract revealed that S. saman seed extract contained alkaloids at a concentration of 142.59 mgCE/g extract. Further analysis of the fractions indicated that the ethyl acetate fraction had the highest alkaloid content 77.34 mgCE/g fraction, compared to the aqueous fraction 24.65 mgCE/g fraction and the n-hexane fraction 45.7 mgCE/g fraction. These findings suggest that semi-polar solvents are the most effective for extracting alkaloid compounds from S. saman seeds, thereby highlighting their potential for further development as raw materials for phytopharmaceuticals or natural-based herbal preparations.
Hubungan Karakteristik Pasien dengan Kepatuhan Minum Obat pada Pasien Hipertensi Berdasarkan Skala MMAS-8 Apriani, Aida; Sirait , Tri Susanti; Silitonga , Desni Rinanda; Zawita, Zawita
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1153

Abstract

Background: Hypertension is classified as a non-communicable disease with a relatively high prevalence and poses a significant risk of various complications if not properly managed or controlled. Medication adherence plays a crucial role in determining the success of antihypertensive therapy. Objective:This study aimed to analyze the level of medication adherence among hypertensive patients at Pidie Jaya General Hospital using the Morisky Medication Adherence Scale (MMAS-8) instrument. Methods:This research employed a descriptive-analytic design with a cross-sectional approach involving 98 hypertensive patients selected using the Slovin formula. Data were collected using the MMAS-8 questionnaire and analyzed using the Chi-square test with a significance level of p < 0.05. Results:The findings showed that medication adherence among respondents was categorized as adherent (26.5%), moderately adherent (58.2%), and non-adherent (15.3%). There were no significant associations between adherence and sex, age, education, occupation, duration of treatment, number of medications, or family support (p > 0.05). However, a significant relationship was found between medication adherence and the distance from the patient's residence to the healthcare facility (p = 0.001). Conclusion: Distance to treatment affects the level of compliance of hypertensive patients with medication. Therefore, strategies are needed to improve access to healthcare services, including optimizing clinical pharmacy services to monitor patient compliance.
Sediaan Larutan Nanopartikel Dari Fraksi Etil Asetat Daun Sungkai (Peronema Canescens Jack) Hartesi , Barmi; Ratih, Hestiary; Nugraha , Sabina Azahra
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1158

Abstract

Sungkai leaves (Peronema canescens Jack) are known to contain secondary metabolite compounds such as alkaloids, polyphenols, flavonoids, quinones, and steroid-triterpenoids, which have potential as immunostimulants. This study aims to determine the effect of the ratio of chitosan and NaTPP on the stability of nanoparticle solutions from the ethyl acetate fraction of sungkai leaves. Sungkai leaves were extracted using the maceration method with 70% ethanol, then fractionated using the liquid-liquid estraction method using n-hexane, ethyl acetate, and n-butanol solvents. The ethyl acetate fraction selected to be made into nanoparticle solutions used the ionic gelation method with variations in the ratio of chitosan:NaTPP consisting of 3 formulas, namely F1 (5:1), F2 (10:1), F3 (20:1). Characterization of the nanoparticle solution was carried out by organoleptic testing, measuring % transmittance, particle size with a Particle Size Analyzer (PSA), and measuring the zeta potential value. The results showed that F3 (Chitosan:NaTPP 20:1) produced an average particle size of 953.6 nm, a polydispersity index of 0,338, and a zeta potential of 43.2 mV, indicating relatively better stability compared to the other formulas. However, the percent transmittance obtained was still below the optimum (80-100%), which was 68.88%. In conclusion, increasing the chitosan:NaTPP ratio affected the environmental stability of the nanoparticles, and formula. F3 was the most stable formula in this study.
Analisis Kandungan Merkuri dan Hidrokuinon dalam Krim Pemutih Wajah Daring Menggunakan Spektrofotometer Serapan Atom dan Kromatografi Cair Kinerja Tinggi Kusmiyati, Mimin; Tronovani , Elvi; Sulaeman , Agus; Musyarrofah, Laila; Fitriani , Hani Sri; Khotimah , Enung Nur; Mirta, Surya Bin
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1176

Abstract

The skin is the outermost organ of the human body and plays an important protective and physiological role. Currently, fair skin is often regarded as a beauty standard desired by both men and women. Mercury and hydroquinone are active ingredients commonly used in whitening products due to their ability to inhibit melanin formation; however, their use can cause serious toxic effects. This study aimed to determine the presence of mercury and hydroquinone qualitatively and quantitatively in facial whitening creams sold online in Bandung City. Samples showing positive results were further analyzed quantitatively to determine their concentrations. For mercury analysis, samples were digested using a microwave digestion method to eliminate organic substances. The color reaction test for mercury employed KI 0.5 N, HCl 6 M, and NaOH 2 N reagents. Based on qualitative testing, samples labeled D and N were positive for mercury. Quantitative determination of mercury was conducted using Atomic Absorption Spectrophotometry (AAS) at a wavelength of 253.7 nm. For hydroquinone analysis, qualitative color tests were carried out using FeCl₃ 5%, phenanthroline, and Benedict reagents, while quantitative analysis was performed using High-Performance Liquid Chromatography (HPLC). Of the 17 samples tested, two (D and N) contained mercury at concentrations of 2,776 ±  0,036 μg/g and 4,277 ± 0,021 μg/g, respectively, and two others (E and H) contained hydroquinone 2,3745% and 2,4798%.
Teh Herbal Daun Kelakai (Stenochlaena palustris) sebagai Potensi Fitoestrogen Untuk Produksi ASI : Terinspirasi dari Kearifan Lokal Suku Anak Dalam Jambi Intami, Eprina; Mustakim , Ardi; Rahmadevi, Rahmadevi; Mulyati , Sri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1177

Abstract

This study was conducted in response to the problem of low breast milk production among some breastfeeding mothers, which may adversely affect infant growth and development. One approach to enhancing breast milk production is the utilization of natural substances containing phytoestrogens. Kelakai leaves (Stenochlaena palustris) are a plant traditionally used by the Suku Anak Dalam community as part of local wisdom to support maternal health during the postpartum period. This study aimed to develop kelakai leaf herbal tea as a natural source of phytoestrogens with potential to support increased breast milk production. The research employed a quasi-experimental design using a one-group pre-test and post-test with control group approach, complemented by laboratory analyses including identification of active compounds, simplicia processing, herbal tea formulation, phytochemical screening, and phytoestrogen content analysis. The results demonstrated that kelakai leaves contain flavonoids, saponins, and phytoestrogenic compounds that may contribute to the stimulation of prolactin and oxytocin secretion. Statistical analysis revealed a p-value of 0.000 (p < 0.05), indicating a significant effect of kelakai herbal tea administration on breast milk production among breastfeeding mothers. Based on these findings, it can be concluded that kelakai herbal tea has potential as an alternative herbal beverage derived from local wisdom that may support the success of exclusive breastfeeding programs.
Interaksi Obat Pada Pasien Geriatri: Kajian Berbasis Evidence Tentang Kombinasi Antihipertensi dan Obat Non Steroidal Anti-Inflammatory Alya, Rahma; Khuriyah, Khuriyah; Ananda, Meisya Dwi; Putra, Hasan Etanov; Adzkia, Muhammad Adit; Putri, Mukarromah Dita; Hilmi, Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1182

Abstract

The number of elderly individuals continues to increase globally, accompanied by a high prevalence of chronic diseases, particularly hypertension and musculoskeletal disorders. This condition makes geriatric patients vulnerable to polypharmacy, which increases the risk of drug interactions, one of which is between antihypertensives and non-steroidal anti-inflammatory drugs (NSAIDs). Such interactions can potentially reduce therapy effectiveness, cause electrolyte disturbances, and lead to acute kidney injury (AKI). This study aims to comprehensively examine the interaction between antihypertensives and NSAIDs in geriatric patients and its impact on therapy safety. The method used is a literature review by selecting national and international articles published between 2015 and 2025, written in either Indonesian or English, specifically investigating interactions between antihypertensives (β-blockers, ACE inhibitors, ARBs, diuretics, and CCBs) and NSAIDs. The review results indicate that most interactions are pharmacodynamic, involving either antagonism or negative synergism. NSAIDs can reduce the effectiveness of antihypertensive therapy through mechanisms such as sodium retention, afferent arteriolar vasoconstriction, and decreased renal perfusion. In certain combinations, such as the triple whammy phenomenon (NSAIDs, diuretics, and RAAS inhibitors), the risk of AKI and hyperkalemia increases significantly. This risk is higher in geriatric patients with decreased kidney function, comorbidities, and concurrent use of multiple drugs. In conclusion, the interaction between antihypertensives and NSAIDs in the elderly population is an important clinical issue. Therefore, close monitoring of kidney function and electrolytes, using the lowest effective dose for the shortest possible duration, and patient education to avoid self-medication are necessary to ensure therapy safety.

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