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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Uji skrining fitokimia dan pengukuran kadar total flavonoid pada ekstrak paku (Nephrolepis biserrata) dengan fraksi n-heksana, etil asetat, dan air Razoki; Ruth Gaby Syahanaya Butar-Butar; Elfia Neswita; Novitaria Br Sembiring; Erida Novriani; Nerly Juli Pranita Simanjuntak; Enni Halimahtussa’diyah Pakpahan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.185

Abstract

Nephrolepis Biserrata, including ferns and lycophytes, are a group of plants that have been around for a long time on Earth, with more than 12,000 different species. Ferns have an important role in the ecosystem, such as helping to form humus, protect the soil from erosion, maintain soil moisture, and act as pioneer plants in the early stages of forest ecosystem succession. Phytochemical screening tests can identify bioactives that are not yet visible through bags or tests that can quickly separate natural ingredients that contain certain phytochemicals and those that do not. Extraction is the activity of withdrawing soluble chemical compounds so that they are separated from insoluble materials. Extraction can be done in various ways including n-hexane which aims to remove fat, ethyl acetate which can extract semi-polar compounds, and water which is a universal solvent.The methods used in this study include maceration, phytochemical screening, fractionation, and data analysis. The results of this research conclude that secondary metabolite compounds are present in the leaves of the Nephrolepis Biserrata fern, based on positive phytochemical tests for alkaloids, phenolics, flavonoids, tannins, and triterpenoids in the ethanol fraction. The n-hexane fraction contains alkaloids, phenolics, flavonoids, tannins, steroids, and triterpenoids. The ethyl acetate fraction contains alkaloids, phenolics, flavonoids, saponins, and tannins, while the water fraction contains alkaloids, phenolics, flavonoids, and tannins. The total flavonoid content is 17.615 mg QE/g of extract. UV-Vis spectroscopy identification results indicate the presence of ???? → ????* and n→ ????* transitions.
Drug-related problem (DRP) penggunaan antidiabetik oral dan insulin pada pasien diabetes melitus tipe II rawat inap di RSU Royal Prima Medan Elfia Neswita; Brian Elberth Halu; Razoki; Asyrun lkhairi Lubis; Muhammad Yunus; Nurasni; Octavian Ashido Nababan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.186

Abstract

Diabetes mellitus is a group of metabolic disorders characterised by hyperglycemia which is the cause of death of up to 80% in low- and middle-income countries. Type 2 diabetes mellitus is the most common form of diabetes. The goals of managing type 2 diabetes mellitus therapy are to reduce the risk of microvascular and macrovascular complications, reduce mortality, and improve quality of life. Treatment of diabetes mellitus requires a long time. Problems arising from complications in diabetes mellitus will increase the difficulty in treating patients. This can potentially cause issues related to Drug Related Problems (DRP). Drug-Related Problems refers to unexpected events experienced by patients and can interfere with the success of the drug therapy given. The research method in this study was to determine the drugs to be evaluated in the form of oral antidiabetic drugs used while undergoing type 2 diabetes mellitus therapy and insulin therapy. The results showed that 26 patients experienced Drug-Related Problems or not (50%). Six patients experienced actual Drug Related Problems (10.2%). In comparison, those who experienced Potential Drug Related Problems were 24 patients (46.15%) of a total of 52 patients with type 2 diabetes mellitus who were the sample of this study. Two categories of Drug Related Problems occur, namely Drug Related Problems related to additional drug therapy with a total of 2 incidents (2.17%) and Drug Related Problems related to unwanted drug reactions (Adverse Drug Reactions) with a total of 4 incidents (7,7%).  
Standardization of specific and non-specific parameters of sambiloto (Andrographis paniculata. Burm.f) ethanol extract as standardized herbal medicine Heldi Candra; Indri Ayu Ningsih; Claudia Angelina Kurnia Bat
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.187

Abstract

This study's objective is to ascertain how to make Sambiloto simplicia that is good and right according to the second edition of the 2017 herbal pharmacopoeia standards, to find out non-specific and specific parameters, which consist of tests for water content, ash content, drying shrinkage, water-soluble extract content, and extract content. Soluble ethanol in Sambiloto simplicia and knowing the secondary metabolites of Sambiloto simplicia. This study employed a qualitative and quantitative observational methodology. The research object was the Sambiloto plant (Andrographis paniculata. Burm.f) which was planted within the home's yard in the Sungai Lekop Plot, Sungai Lekop Village, Sagulung District, Batam City. The results showed that Sambiloto extract contains secondary metabolites of tannins, alkaloids, saponins, terpenoids and flavonoids. Sambiloto viscous extract obtained by 5 ml from 500 ml extract parameter values for non-specific and specific test water content of Sambiloto is 9%, drying shrinkage is 18.5%, total ash content is 10%, water-soluble extract is 12.96%, and ethanol-soluble extract 8%, specific and non-specific parameter tests met the requirements for the 2017 herbal pharmacopoeia, the results showed that Sambiloto simplicia fulfilled the requirements as a standardized herbal medicine.  
Uji antidiabetes kombinasi ekstrak daun insulin (Tithonia diversifolia (Hems.) A.Gray) dan daun ubi jalar (Ipomoea batatas (L.) Lam) ungu pada tikus jantan akibat induksi streptozotocin Octavianing Yosephine; Galih Samodra; Khamdiyah Indah Kurniasih
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.189

Abstract

Diabetes mellitus is a condition in which blood glucose levels are high enough in the body. Insulin leaves contain tannins, flavonoids and saponins which play a role in fighting free radicals. Purple sweet potato leaves have anthocyanin and phenolic flavonoid compounds that function as anti-diabetics. The combination of the two is expected to produce a synergistic effect to increase the effectiveness of antidiabetics. This research aims to find out the antidiabetic effect and the effective dose of a combination of insulin leaf extract and purple sweet potato leaves. This study used 25 rats as test animals which were divided into 5 groups. The blood glucose levels of the rats were measured using the GOD-PAP method. The results showed that the combination dose of insulin leaf ethanol extract 30 mg/kgBB and purple sweet potato leaves 120 mg/kgBB (combination group 2) had an anti-diabetic effect, an average of 97.49 and a positive control (glibenclamide) mean of 116.83 in reducing blood glucose levels in streptozotocin-induced mice. The research show that based on the One Way ANOVA analysis, the sig. ie 0.000 <0.05, then in conclusion the average of the five test groups has a significant difference.
Faktor-faktor yang berhubungan dengan kejadian malaria Kecamatan Tanjung Tiram Kabupaten Batubara tahun 2023 Khodijah Tussolihin Dalimunthe; Tina Meirindany; Mutiara Nauli
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.190

Abstract

Malaria is an infectious disease transmitted to humans by the bite of a female Anopheles mosquito infected with a protozoan parasite of the genus Plasmodium. One of the determinants of the spread of malaria by the host is community knowledge and the behavior of using house wire screens. his type of quantitative research is with a cross-sectional design and will be carried out from April to June 2023 in Hamlet XII, Suka Maju Village, Tanjung Tiram District, Batubara Regency. The research sample was 72 respondents with a purposive sampling technique. Test analysis using chi-square and simple logistic regression. The results showed that there was a relationship between the two categories studied <0.05. There is a relationship between the use of wire gauze and the incidence of malaria with a value of p=0.004, as well as a relationship between knowledge and the incidence of malaria with a value of p=0.03. The incidence of malaria that occurred in Batu Bara was due to knowledge and behavior factors of not using wire mesh at home. It is necessary to carry out counseling about malaria and the importance of using wire gauze.  
Uji aktivitas antibakteri ekstrak daun ceremai (Phyllanthus acidus (L.) Skeels) terhadap Staphylococcus aureus Alya Nafis; Dia Septiani; Jekmal Malau
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.192

Abstract

Staphylococcus aureus is a bacterium capable of causing pneumonia. However, the frequent occurrence of antibiotic resistance necessitates the exploration of alternative plant-based antibiotics as natural antibacterial agents. This study aims to analyse the antibacterial activity and chemical compound classes in the ethanol and methanol extracts of Phyllanthus acidus (L.) Skeels leaves, commonly known as ceremai leaves, exhibit antibacterial properties. Chemical compound classes were determined using the TLC method. The 96% ethanol extract of ceremai leaves contained flavonoids, alkaloids, triterpenoids, steroids, and phenols. On the other hand, the methanol extract contained flavonoids, alkaloids, steroids, and phenols. The antibacterial activity was evaluated using the Kirby-Bauer agar diffusion method. The testing revealed that ethanol and methanol extracts of ceremai leaves at concentrations of 15%, 20%, 25%, 30%, 40%, and 50% exhibited antibacterial activity against Staphylococcus aureus bacteria. The 50% concentration showed the highest inhibition zone value, with the ethanol extract (96%) measuring 3.86 ± 0.11 mm and the methanol extract measuring 2.73 ± 0.24 mm falling into the weak category
Profil penggunaan analgesik oral pasien ERACS salah satu rumah sakit swasta kota Semarang tahun 2022 Rissa Maharani Dewi; Nindita Sari Nastiti; Risa Wuriana Mawardi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.193

Abstract

Enhanced Recovery After Caesarean Surgery (ERACS), the new Sectio Caesarea (SC) delivery protocol, is considered to reduce pain and speed up recovery. Oral analgesics are used to relieve post-ERACS pain. The purpose of this study was to determine the profile of the use of oral analgesics in ERACS patients at a private hospital in the city of Semarang in 2022. This study has an observational descriptive design. Data were collected retrospectively from the medical records of ERACS patients in 2022 who used oral analgesics. The results of this study analysed the use of oral analgesics in the form of the percentage of groups and types of oral analgesics used. The study data included the patient's age, gestational age, and socioeconomic status. The results showed the profile of oral analgesic use of 809 non-opioid drugs (91.93%), 43 opioid drugs (4.89%) and Fixed Dose Combination (FDC) opioid/non-opioid 28 drugs (3.18%). The types of analgesics used were Mefenamic Acid 328 (37.27%), Paracetamol 205 (23.30%), Diclofenac Sodium 192 (21.82%), Tramadol 43 (4.89%), FDC Paracetamol/Tramadol 28 (3.18%), Celecoxib 27 (3.07%), Dexketoprofen 22 (2.50%), Ibupro fen 20 (2.27%), Etoricoxib 14 (1.59%) and Ketoprofen 1 (0.11%).
Uji aktivitas diuretik ekstrak etanol daun sirih merah (Piper crocatum Ruiz & Pav) terhadap tikus putih jantan (Rattus novergicus) Muhammad Yunus; Jefri Naldi; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.195

Abstract

Background: According to the World Health Organization (WHO), the prevalence of hypertension in the world reached over 1.13 billion people in 2015, implying that one out of every three persons was diagnosed with hypertension. Flavonoids found in red betel leaves (Piper crocatum Ruiz & Pav) serve as antifungals, diuretics, antihistamines, antihypertensives, insecticides, bactericidal, antiviral, and enzyme inhibitors. The study aimed to find the best dose of red betel leaves extract as a diuretic in male white rats. The study was experimental laboratory. Alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids are among the phytochemicals tested. A total of 25 male white rats were separated into five groups. Red betel leaves extract was administered to groups 1, 2, and 3 at dosages of 250mg/kg, 350 mg/kg, and 650mg/kg, respectively. Group 4 received a 0.5% Na CMC suspension as a negative control, while Group 5 received a furosemide suspension as a positive control. The average urine volume at 1-6 hours and the buildup of urine were used to calculate the rat urine volume. The results showed the accumulation of urine volume for 6 hours. The treatment group of red betel leaf ethanol extract at a dose of 250mg/kgBW obtained 0.57mL, a dose of 350mg/kgBW obtained 2.38mL, and a dose of 650mg/kgBW obtained 4.29mL, negative control (CMC 0.5%) obtained 0.2mL, positive control obtained 27.52mL. The study concluded that red betel leaves extract has diuretic action and that the ethanol extract of red betel leaves at a dosage of 650 mg/kgBW is the most effective dose.
Kualitas Daging Domba Berdasarkan Keragaman, Jumlah Dan Cemaran Bakteri Di Pasar Tradisional Desa Klambir V Kecamatan Hamparan Perak Kabupaten Deli Serdang Alfath Rusdhi; Tengku Gilang Pradana; Muhammad Sadiqulamin
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.196

Abstract

Meat is an essential food ingredient in meeting nutritional needs. The purpose of this research is to detect the total plate count and bacterial contamination in lamb meat. The research method used in this study is descriptive because it describes the characteristics of a population or a phenomenon that is being studied in a trial and error manner. From the observation data, 6 samples of lamb meat obtained from the traditional market in Kampung Lalang were analyzed using descriptive methods, which revealed the presence of Escherichia coli and Salmonella sp bacteria. The highest TPC analysis value was found in vendor 2 and vendor 3, sample 2, with a count of 6.55x106 cfu/g and 7.15x106 cfu/g, respectively, while the lowest contamination was found in vendor 1, sample 2, with a count of 4.57x105 cfu/g. These values are in accordance with the permissible limits of Escherichia coli (1 x 101 colonies/gram) and Salmonella sp (negative/25 grams) as set by the Indonesian National Standards (SNI). The results of the study indicate that 6 samples of lamb meat were not contaminated with Escherichia coli and Salmonella sp bacteria, demonstrating that the lamb meat sold in the traditional market of Klambir V Village complies with the Indonesian National Standards (SNI) and is suitable for consumption.
Analisis senyawa acetaminophen dalam sampel biologis dengan berbagai macam metode Lina Nurfadhila; Marsah Rahmawati; Nur Komala fitri; Salsabila Granadha Nibullah; Welly Windari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.197

Abstract

Acetaminophen or Paracetamol is a compound that has pharmacological effects as an analgesic and antipyretic. The purpose of this journal review is to identify and understand the various methods that can be used to analyze biological samples of patients when taking paracetamol through their biological samples. The initial process for carrying out the analysis is to carry out sample preparation, samples are prepared by various suitable methods such as liquid-liquid extraction methods, solid phase extraction (SPE) and protein precipitation methods, then samples will be analyzed using appropriate methods. instruments such as GC-MS, LLE, LC-MS, HPLC-MS, or UHPLC-MS. Of the several instruments used the HPLC-MS method is the most effective method for analyzing biological samples, because HPLC-MS is considered fast, selective and sensitive and has the lowest LLOQ quantification value or lower limit.

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