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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Formulasi dan evaluasi sediaan hand cream ekstrak etanol brokoli (Brassica oleracea L.) Silvy Aldila; Veronica Bellacaesa; Tunik Saptawati; Rissa Maharani Dewi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.198

Abstract

Broccoli (Brassica oleracea L.) extract contains flavonoid compounds and vitamin C. Vitamin C has a protective role against free radicals, brightens skin tone, and enhances sensitivity to keep skin moist. The content of broccoli is very suitable for preparation in hand cream preparations with moisturizing function for dry skin, especially hand skin, because hand skin only has endocrine sweat glands, so it is easy to water. to handle. evaporation (transepidermal water loss) occurs. In this study, three formulations of hand cream were made with three concentration variants of broccoli extract, namely F1 (2g), F2 (3g) and F3 (4g). In addition, tests for the physical properties of the composition include sensory testing, homogeneity, pH, dispersion, adhesion and viscosity. The results showed that the formulas F1, F2 and F3 met the requirements of testing the mechanical and physical parameters of the preparation. The conclusion of this study was that the hand cream composition produced had an average pH value of 6, a dispersion of 5 cm, a adhesion of 3 s and a viscosity of 32000 cPs and was concluded to meet the requirements for physical characteristics.
Tata cara sertifikasi pemenuhan aspek cara pembuatan obat tradisional yang baik (CPOTB) bertahap dalam rangka kemudahan bagi usaha mikro kecil (UMK) di Bandung Jawa Barat Ivanna Fauziyah Kusnadi; Patihul
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.202

Abstract

Traditional medicine products continue to grow rapidly, both produced by UMOT, UKOT, IOT, IEBA, and the pharmaceutical industry. With the development of the use of traditional medicine, UMK such as UKOT and UMOT are becoming more formed. However, the high number of UMK present was not followed by the fulfillment of provisions related to the inspection of the facilities carried out. Based on the BBPOM Annual Report in Bandung, inspection of UMOT/UKOT facilities was carried out on 21 facilities and 33.33% did not meet the requirements (TMK). One of the results of inspection of facilities that did not meet these requirements was because they did not meet CPOTB aspects, both sanitation hygiene and documentation (42.86%). This can be caused by the lack of awareness of business actors regarding the basics in making a traditional medicinal product starting from the establishment of the facility and also the ignorance of business actors regarding the legal basis that must be adhered to. This article aims to explain the procedure for certifying the fulfillment of CPOTB aspects in order to make it easier for UMK to register their places with Balai POM.
Regulasi pengawasan iklan obat tradisional yang berlaku di Indonesia Taqiyyah Qothrunnadaa; Ade Zuhrotun
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.203

Abstract

The economic growth of the pharmaceutical industry is in line with the growing growth of the Indonesian herbal or traditional medicine industry. People's interest in buying a product is influenced by several factors. One of them is the way the product is promoted, such as advertising. The increasing circulation of traditional medicines has led to an increase in the use of excessive advertising or unscrupulous producers who do not meet the requirements, so a system is needed that can protect the public and ensure that the advertisements promoted are in accordance with applicable regulations. Therefore, a search of primary and secondary literature related to regulations regarding Advertising was carried out. The regulation governing advertising, especially for Traditional Medicines, is Keputusan Menteri Kesehatan No. 386/MENKES/SK/IV/1994 mengenai Pedoman Periklanan: Obat Bebas, Obat Tradisional, Alat Kesehatan, Kosmetika, Perbekalan Kesehatan Rumah Tangga dan Makanan-Minuman.
Analisis cemaran bakteri Staphylococcus aureus pada daging ayam krispy pinggir jalan dan fast food di daerah Teladan kota Medan Adelia Ramadani; Yayuk Putri Rahayu; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.205

Abstract

Chicken meat is a highly nutritious food containing protein, fat, minerals and other substances. Chicken meat is easily contaminated with the pathogen Staphylococcus aureus which can cause Staph Food Poisoning (SFP) or food poisoning due to contamination from unhygienic traders, processing, and the environment. The purpose of this study was to identify the presence of S. aureus pathogenic bacteria in roadside crispy fried chicken meat and well-known fast food brands in the Teladan area of Medan city and to analyze the contamination value of S. aureus bacteria whether it meets the Indonesian National Standard (SNI) < 1X102 CFU/ml. The research method was to determine the presence of S. aureus in the sample using Baird Parker Agar Base (BPA) and Egg Yolk media. Specific identification using Gram stain test, coagulase test, and catalase test. Calculation of contamination value of S. aureus with Total Plate Count (TPC). The results on roadside crispy fried chicken were positive for the presence of S. aureus with a contamination value exceeding the threshold above 1X102 CFU/ml so it did not meet SNI standards. Fast food crispy fried chicken meat is known to be negative in the absence of S. aureus pathogenic bacteria so that it meets SNI standards.
Analisis Cemaran Bakteri Coliform pada Saus Jajanan di Sekitar Sekolah Menengah Kejuruan di Kota Medan Lisda Mayanti; Yayuk Putri Rahayu; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.206

Abstract

The sauce is a type of food additive prepared from the main ingredients of chilies and tomatoes, served as a complement to food and often served in snack foods. Nowadays, sauces are in great demand by all groups, but many traders need to pay more attention to their wares, both in terms of presentation and how to process them, for example diluting sauces with unclean water so they are contaminated with pathogenic microbes. One form of biological contamination that can occur in the sauce is the presence of coliform bacteria. This group of coliform bacteria includes Escherichia coli (E. coli), Gram-negative bacteria that are rod-like and do not form spores. Normally, E. coli is part of the normal intestinal flora, but it can cause illnesses such as diarrhea when opportunistic. The purpose of this study was to test the level of bacterial contamination as measured by the Total Plate Count (ALT), as well as to determine the presence of coliform bacteria and identify E. coli bacteria in the sauces used in various types of snacks around SMKs in the city of Medan. Methods The research approach involves the use of two methods, namely the Total Plate Number (ALT) and the Most Probable Number (MPN). Based on the determination of the value of ALT < 1 x104 coli/g and MPN < 100/g. The results of the study from 5 samples of various snack sauces around one of Medan City Vocational Schools were not suitable for consumption because they did not meet SNI No.7388:2009 with the amount of microbial contamination in chili sauce that is above 1x10⁴ colonies/g and exceeding the maximum MPN coliform limit in chili sauce, i.e., above 100 colonies/g.
Efetivitas tablet Fe dalam meningkatkan kadar hemoglobin ibu hamil Mila Syari; Rahmi Fitria; Elvina Sari Sinaga; Harahap Harahap; Yuka Oktafirnanda
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.208

Abstract

Introduction: Iron deficiency is when a person has a low number of red blood cells (erythrocytes) in the blood, causing anaemia. Anaemia occurs due to a lack of haemoglobin, which means a lack of oxygen supply throughout the body. Lack of oxygen can cause the body to become weak, lethargic, and lacking energy. In pregnancy, anaemia can occur because the increase in plasma volume is greater than the increase in haemoglobin levels. Purpose: This study aims to determine the effectiveness of Fe tablets in increasing Hb levels in pregnant women at the Amaliun Health Center. Methods: This study used an analytical, quantitative method with a pre-experimental design using a one-group pre-test and post-test design. Data was collected using a questionnaire and data analysis using the T-Dependent test. The research sample consisted of 38 pregnant women. Results: The results showed that the average difference in Hb levels before and after being given Fe tablets was 1.5 gr% ± 0.57 gr%. The statistical test results showed a value of p = 0.00, which means that Fe tablets have an effect on increasing haemoglobin levels in pregnant women. Conclusion: This study concluded that Fe tablets had a significant effect with p=0.00. Therefore it is expected that the puskesmas will provide counselling and health counselling to prevent anaemia during pregnancy.
Uji aktivitas antihiperurisemia ekstrak daun kopasanda (Chromolaena Odorata (L.) R.M.King & H.Rob terhadap mencit putih jantan (Mus Musculus L.) yang diinduksi kalium oxonat Asyrun Alkhairi Lubis; Muhammad Yunus; Jefri Naldi; Muhammad Andry; Pricella Ginting; Fira Safitri; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.209

Abstract

Background: Kopasanda leaves (Chromolaena Odorata (L.) R.M.King & H.Rob have been known as medicinal plants and spread in North America, Asia, West Africa and Australia have antibacterial and antioxidant properties, because the active compounds contained in Kopasanda leaves include: alkaloids, flavonoids, steroids, quinone saponins, and tannins. Purpose; This study was to determine the activity of ethanol extract of kopasanda leaves (Chormolaena Odorata (L.) in reducing uric acid levels and to test antihyperuricemia levels and phytochemical screening. Method; This study used a laboratory experimental research design, to extract the chemical content in kopasanda leaves using maceration method using 70% ethanol. This research includes sampling, simplisia making, extract making, phytokimi screening, suspension making, test animal preparation and antihyperuricemia testing. The research data were analyzed using the crucible wallis test statistical test. Result; The study showed a decrease in uric acid levels in the EEDK group 20 mg / BB = 0.86%, EEDK 40 mg / BB = 1.18% and EEDK 80 mg / BB = 2.3%. The results of Wallis' crucial statistical test on day 9 showed a significant difference with a p-value of 0.000. The results of further difference tests showed a significant difference in each treatment. Conclusion: in this study is the ethanol extract of kopasanda leaves (Chromolaena Odorata (L), R.M.King &; H. Rob) the most effective is 80 mg / BB, this is evidenced by the results of one way anova statistical test with a p-value of 0.000 (<0.05).
Uji Aktivitas Produk Sediaan lipgloss dari buah kesumba keling (Bixa orellana L) sebagai pewarna alami Christica Ilsanna Surbakti; Artha Yuliana Sianipar; Cut Masyitah Thaib
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.214

Abstract

The general of kesumba keling fruit is one of the potential plants as natural dyes.Moreover,kesumba keling fruit also useful for diuretic,antipiretic,and neutralizing toxins in the body.One of the plants that can be made in lip coloring is kesumba keling fruit one of the most used cosmetic product is lipgloss..lipgloss in using be easy to apply and give a shiny impression.The purpose of this research is to know if kesumba keling fruit skin extract can be used as natural dye substitute for synthetic dyes on lipid dye preparations.On day 1 to 30 color prepararion on change.Lipgloss with consentration of kesumba keling 10% light yellow,12% giving dark yellow,14% consentration giving a reddish yellow color.Lipgloss preparation is the distinctive smell of kesumba keling fruit extract that is most preffered by panelist with concentration of 12%,because the preparation of lipgloss from kesumba keling fruit extract doesn’t cause irritation.Conclusions : Point out the difference between icreasing concentration of the kesumba celing fruit extract to used in formula then the more consentrated color of the lipgloss produced increased.Lipgloss with 10% concentration are light yellow,lipgloss preparation with 12% concentrated are dark yellow,lipgloss preparation with 14% conceration are reddish yellow and on days1 to 30 preparation on change.
Evaluasi Pengujian mutu biji pepaya (Carica papaya L.) yang di ekstraksi secara maserasi dengan pelarut etanol 70% Christica Ilsanna Surbakti; Modesta Tarigan; Grace Anastasia Ginting
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.215

Abstract

Background : In papaya seed (Carica papaya L.) the bitter taste is caused by carpain alkaloid content. Carpain is an alkaloids free class of alkaloids. This carpain alkaloid can lower blood pressure, kill amoeba, bladder stones, urinary tract, and worms. But often found traditional medicine that does not produce the expected effect, generally due to not meet the quality standard or it could be due to misinformation and mistaken assumption against traditional medicine. In terms of side effects it is recognized that traditional medicine has relatively small side effects compared to modern medicine. Therefore, researchers are interested to make a quality and efficacious extract, thus the herbal products can be maintained quality, quality and efficacy that can cure various diseases. Objectives : To find out the percentage of yield of extract after maceration of papaya seed extraction, secondary metabolite identification and characterization of papaya seed by using 70% ethanol solvent. Method : The samples used in this research are Bangkok papaya fruit seeds from Jl. Student, Ex. Marindal, Kec. Patumbak, Kab. Deli Serdang, North Sumatra. Sampling is done purposively without comparing with the same sample from other regions. This research uses experimental laboratory experimental design consist of several stages including: sample collection, making simplicia, making of extract, identification of secondary metabolite compound, and quality test of papaya seed extract (Carica papaya L.) by maceration method. Results : In result of rendement have obtained extract of ethanol thick with percentage of rendement extract equal to 15,672% from 500 gram simplicia papaya seeds. In phytochemical screening test, the compounds contained in the extract of ethanol papaya seeds seeds are alkaloids, flavonoids, saponins, steroids / triterpenoids, and tannins and on the characterization test of papaya seed extract obtained water content of 1.15%, water soluble juice content of 46.35 %, ethanol soluble content of 18.61%, total ash content of 7.25% and 0.92% acid soluble ash content that meets the extract requirements set by MMI. Conclusion : It is known that the yield after the paperasi seed extraction is done, the secondary metabolite results show negative results only on the cyanogenic glycoside test, and the characterization test has met the requirements set by MMI.
Analisis kadar vitamin C pada buah naga putih (Hylocereus undatus) dan buah naga merah (hylocereus polyrhizus) dengan perbandingan metode spektrofotometri uv dan titrasi iodimetri Claudy Friesta Melanie; Gabena Indrayani Dalimunthe; Ridwanto; Fathur Rahman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.216

Abstract

Dragon fruit is natural source of antioxidants. We can consume not only dragon fruit flesh, but the skin is also very beneficial for health, in reality it is only considered as waste that has not been used properly. This study aims to analyze the levels of vitamin C in white dragon fruit and red dragon fruit with a comparison of uv spectrophotometry and iodimetric titration methods. The stages of the research included extracting from dragon fruit, screening phytochemicals, testing levels of vitamin C using iodimetric titration, testing levels of vitamins using UV spectrophotometry. The results showed that red dragon fruit contains alkaloids, flavonoids, saponins, tannins, triterpenoids and glycosides, while white dragon fruit contains alkaloids, flavonoids, saponins and steroids. Determination of vitamin C levels by iodimetric titration method on red dragon fruit skin was 9.240 ± 3.029 mg, on red dragon fruit flesh was 11.587 ± 1.893 mg and vitamin C levels on white dragon fruit skin was 9.827 ± 3.933 mg, on white dragon fruit flesh was 13.347 ± 3.143 mg in 100 gram sample. While the spectrophotometric method obtained vitamin C levels in white dragon fruit flesh, namely 332.93 mg/100g, in red dragon fruit flesh, 24.99 mg/100g, while red dragon fruit skin, which was 16.59 mg/100g, in white dragon fruit skin, namely 10.47 mg/100g.

Page 16 of 62 | Total Record : 616

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