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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Uji Aktivitas Ekstrak Etanol Daun Labu Siam (Sechium edule Jacq. Swartz) sebagai Antibakteri Mycobakterium smegmatis Christel Sambou; Douglas N. Pareta; Sarah Sambow; Wilmar Maarisit; Jabes Kanter; Jeane Mongi; Hanna M. Rumagit; Selvana Tulandi; Joke L. Tombuku; Reky R. Palandi; Nerni O. Potalangi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.217

Abstract

The membrane structure of Mycobacterium smegmatis is similar to that of Mycobacterium tuberculosis, allowing TB testing to be performed on Mycobacterium smegmatis without directly testing on Mycobacterium tuberculosis. Antibacterial testing uses the paper disc method with several treatments, namely extract concentrations of 1 µg/disc, 2 µg/disc, and 4 µg/disc, as well as positive control streptomycin 2 µg/disc and negative control 70% ethanol. The research results obtained at Extract Concentrations of 1, 2, and 4 µg/disc have moderate antibacterial activity seen from the inhibitory zone diameter, namely 8.73 mm, 9.17 mm, and 9.73 mm, and the positive control is strong because it has a zone diameter of 13.27 and the negative control does not give a zone. The conclusion is that the extract of siam pumpkin leaves has moderate antibacterial activity.
Formulasi sediaan pasta gigi ekstrak etanol buah takokak (Solanum torvum Sw.) dan tulang ikan tuna sirip kuning (Thunnus albacares) terhadap bakteri Streptococcus viridans dan bakteri Escherichia coli Hendri Faisal; Hanafis Sastra; Muhammad Andry; Melia Sari; Adek Chan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.218

Abstract

Takokak (Solanum torvum Sw.) is a traditional plant used as vegetables, fruits, ornamental plants and medicinal purposes. Takokak fruit contains secondary metabolites of alkaloids, flavonoids, saponins, tannins and steroids. Tuna fish bones are one of the biggest wastes from the tuna processing industry. Tuna fish bones contain minerals that are quite high compared to other parts of the body because the main elements of fish bones are calcium, phosphorus and carbonate. This study aims to make toothpaste preparations of ethanol extract of large chili fruit and yellowfin tuna bones and to determine the inhibition zone against Streptococcus viridans and Escherichia coli bacteria. This type of research is done experimentally. This type of research includes the manufacture of toothpaste preparations with concentrations of F1 (10%), F2 (15%), F3 (20%). Preparation evaluation included organoleptic test, homogeneity test, spreadability test, foam formation test, pH test, viscosity test, extrudability test and activity test for Streptococcus viridans and Escherichia coli bacteria. The results of the research were carried out to evaluate the physical preparations of toothpaste with ethanol extract of large chili fruit and yellow fin tuna bones, each toothpaste formulation met the organoleptic requirements, homogeneity, spreadability, foam formation, pH, viscosity and extrudability. Toothpaste preparations of ethanol extract of takokak fruit and yellow tuna bones have antibacterial effectiveness on Streptococcus viridans F1 (9.85 ± 0.32), F2 (11.85 ± 0.45), F3 (13.05 ± 0.34) and Escherichia coli F1 (3.15 ± 0.73), F2 (3.75±0.40), F3 (4.5±0.25). One way Anova data analysis showed a sig value of 0.00 <0.05 meaning that each concentration was significantly different, so that the results of the bacterial inhibition zone affected each concentration of toothpaste preparations.The conclusion of this study is that the ethanol extract of large chili fruit and yellow fin tuna bones can be formulated as a toothpaste preparation and effectively inhibits the growth of Streptococcus viridans and Escherichia coli bacteria in the weak, medium and strong categories.
Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus) Lilik Septiana; Rida Evalina Tarigan; Muhammad Andry; Vannissa Andriani Irawan; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.220

Abstract

Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.
Penetapan kadar flavonoid total ekstrak etanol, fraksi etil asetat dan n-heksan pada daun kakao (Theobroma cacao L.) dengan metode spektrofotometri uv-vis Zikra Maqfirah; Muhammad Amin Nasution; M. Pandapotan Nasution; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.43

Abstract

Cocoa (Theobroma cacao L.)  is a plant that is cultivated on plantations in Indonesia. One part of the cacao plant that has the potential to be developed as a traditional medicine is the cacao leaf because it contains secondary metabolites of flavonoids. Flavonoids have many properties, including acting as antioxidants, protecting cell structures, anti-inflammatories, preventing osteophoresis, and antibiotics. The purpose of this study is to determine the content of secondary metabolites and total flavonoid levels in ethanol extract, ethyl acetate fraction and n-hexane in cocoa leaves. In this study, the initial steps taken are sample collection, sample processing into simplicia, simplicia characterization test then preparation of cocoa leaf ethanol extract by maceration method using 70% ethanol solvent, followed by partitioning process with liquid-liquid extraction method to obtain ethyl acetate fraction and n-hexane and phytochemical screening is carried out. Determination of total flavonoid levels using the UV-vis spectrophotometric method at a wavelength of 437 nm with quercetin as a comparison.The results of this study showed that a cocoa leaf ethanol extract contains alkaloid compounds, flavonoids, tannins, saponins, steroids and glycosides, the ethyl acetate fraction contains alkaloid compounds, flavonoids, tannins, steroids and glycosides, while the n-hexan fraction contains alkaloid compounds, flavonoids and steroids. Total flavonoid levels in cocoa leaves from an ethanol extract amounted to 39.1422±0.0540 mg QE/g, ethyl acetate fraction 45.274±0.0629 mg QE/g and n-hexane fraction 21.4812±0.7048 mg QE/g. The highest flavonoid levels are obtained in the ethyl acetate fraction.
Pola terapi pengobatan glaukoma di RSUD Hasri Ainun Habibie Kabupaten Gorontalo Dizky Ramadani Putri Papeo; Ahmad Rifly Suleman; Kadaria Toana; Chinta Suryaningrum; Intan Nusi; Erika Dami; Fhigra Marfiah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.191

Abstract

Background: Glaucoma is an eye condition that damages the optic nerve, causing loss of vision and even blindness. Damage to the optic nerve is often associated with high intraocular pressure (IOP), but in some cases, glaucoma can occur with normal IOP levels. There are several types of glaucoma, one of which is primary angle closure glaucoma. Angle-closure glaucoma can cause sudden and severe symptoms such as eye pain, headache, nausea, and blurred vision. Objective: This study aims to determine the pattern of glaucoma treatment therapy in one of the hospitals in Gorontalo District. Methods: Using patient medical record data, the SOAP method, and several literature studies. Results: Obtained some medical record data. From medical records, it found that the most widely used drugs to reduce intraocular pressure were tim ophthal eye drops 0.25% and glauceta 250 mg oral drug. Timolol maleate is the most commonly used beta adreno-receptor blocker, especially in the treatment of glaucoma. Glauceta 250 is a drug that contains Acetazolamide indicated to reduce the fluid that accumulates in the eyeball and reduce eyeball tension. Conclusion: From the results of the study, it can conclude that the treatment pattern of most glaucoma patients used the 0.25% tim ophthal drug with the results of 5 times the ophthal 0.25% team administration and the administration of 3 eye drops, namely HPMC + dextran 70 + glycerin, Potassium iodide + sodium iodide dan HPMC + dextran.
Penetapan Kadar Kafein Ekstrak Daun Teh Hijau Dan Putih Camellia Sinensis (L.) Dengan Kromatografi Cair Kinerja Tinggi Selfia Lestary; Muhammad Amin Nasution; Ridwanto Ridwanto; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.199

Abstract

Tea, a widely popular and frequently consumed beverage, is integral to daily routines. Despite the potential long-term risks associated with excessive caffeine consumption, such as hypertension, heart disease, and stroke, caffeine is a prominent choice among a diverse spectrum of individuals in society. The objective of this research endeavour is to discern the caffeine content present in extracts derived from green and white tea leaves by applying the high-performance liquid chromatography (HPLC) method. The research procedure encompasses a series of stages, encompassing the preparation of botanical materials, extraction employing ethanol solvent, characteristic analysis, phytochemical screening, and quantification of caffeine levels within the green and white tea leaf extracts utilising the HPLC technique. The extraction process of green and white tea leaves entails maceration utilising 96% ethanol, followed by concentration via a rotary evaporator. The determination of caffeine concentrations is executed using the high-performance liquid chromatography method. A phytochemical screening analysis of ethanol extracts derived from green and white tea leaves unveiled a myriad of chemical compound classes, including alkaloids, flavonoids, saponins, tannins, and steroids. The quantification of caffeine content within the samples is ascertained by calculating the area under the curve (AUC) on the chromatograms of green and white tea extracts. The quantification results for caffeine content in the green tea extract reveal a value approximately equivalent to 98.4278069571 mg/g. The white tea extract demonstrates a content value of approximately 136.131488681 mg/g.
Uji aktivitas antioksidan ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan metode DPPH Selfiani Selfiani; M. Pandapotan Nasution; Anny Sartika. D; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.200

Abstract

Antioxidant compounds are substances that can absorb or neutralize free molecules so they can prevent degenerative diseases such as heart disease and cancer. Antioxidants are able to donate electrons to stop free radical chain reactions that can damage the body. Jasmine flower leaves contain bioactive substances such as flavonoids, alkaloids, and tannins which are potential ingredients as natural antioxidants. One method to measure or determine free radical scavenging antioxidants is the DPPH (1,1-Diphenyl-2-Picrylhidrazyl) method. This study aims to determine the antioxidant activity of the ethanol extract of jasmine leaves based on the IC value50. The methods used in this study included examination of simplicia characteristics, phytochemical screening and antioxidant activity tests using the DPPH method (1,1-Diphenyl-2-picrylhidrazyl) using a UV-Vis spectrophotometer. The results of this study revealed that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) showed that the extract contained chemical compounds of alkaloids, flavonoids, saponins, tannins, and steroids. In addition, this study also revealed that the ethanol extract of jasmine leaves has antioxidant activity with an IC value50 namely 56.05 µg/mL and for vitamin C the IC value was obtained50 3.70 µg/mL. This shows that the ethanol extract of jasmine leaves positively contains secondary metabolites and has the potential as an antioxidant with a strong classification compared to vitamin C, which is an antioxidant with a very strong classification.
Penetapan kadar flavonoid total ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan spektrofotometri Uv-Vis Hastri Kholifah; M. Pandapotan Nasution; Anny Sartika Daulay; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.201

Abstract

Traditional medicine uses plants with a natural ingredient content as its raw material. The bioactive compounds found in plants are secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, steroids, and saponins. One of the plants containing secondary metabolite compounds is jasmine. This study aims to determine the chemical compounds contained in the ethanol extract and the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. The stages of this research included processing plant simplicia, making ethanol extract, examining characteristics, screening phytochemicals, and determining the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. Extract jasmine flower leaves by maceration method using 96% ethanol solvent; the extract obtained was concentrated using a rotary evaporator; then the total flavonoid content was determined using the UV-Vis spectrophotometry method. The research shows that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) contains several secondary metabolite compounds, such as flavonoids, glycosides, alkaloids, saponins, steroids, and tannins. A number of steps were taken to find out how many flavonoids were in the ethanol extract as a whole. These included finding the maximum wavelength of quercetin, the operational time, making a quercetin calibration curve, and using UV-Vis spectrophotometry to determine how many flavonoids were in the extract. The analysis results reveal that the total flavonoid content in the ethanol extract of jasmine flower leaves is approximately 40.10911 ± 0.5878 mg QE/g.
Analisis aktivitas antioksidan ekstrak etanol daun jeruk kuok (Citrus nobilis L.) dengan metode DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Nurul Hasanah; Rafita Yuniart; Haris Munandar Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.204

Abstract

When the body is excessively exposed to free radicals, the need for antioxidants increases as the body lacks sufficient protection. Some secondary metabolites in plants that can act as antioxidants include flavonoids, alkaloids, and tannins. This research aims to identify secondary metabolite compounds present in the raw material and extract of Citrus nobilis L. (kuok orange) leaves and evaluate antioxidant activity by determining IC50 values. This study employs several methods, including analyzing crude characteristics, phytochemical screening, and antioxidant activity testing using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method with spectrophotometry UV-Visible. The characterization results of the natural material indicate a water content of 6.66%, a water-soluble compound content of 19.64%, an ethanol-soluble compound content of 24.67%, a total ash content of 4.44%, and an acid-insoluble ash content of 0.66%. These findings align with values documented in the existing literature on MMI. Phytochemical screening results reveal that the crude material and ethanol extract of Citrus nobilis L. (kuok orange) leaves contain various chemical compounds, including alkaloids, flavonoids, saponins, tannins, glycosides, and steroids. The IC50 value for the ethanol extract of Citrus nobilis L. leaves is approximately 40.4587 g/mL, categorizing it as very strong. This indicates that the ethanol extract of Kuok orange leaves possesses secondary metabolite compounds with a highly potent antioxidant capability.  
Skrining fitokimia, formulasi dan uji mutu fisik nanoserum ekstrak bonggol nanas (Ananas comosus (L.) Merr) Rahma Maulidia Fitri; Minda Sari Lubis; Gabena Indrayani Dalimunthe; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.207

Abstract

Nanoserum is a slightly viscous transparent or semi-transparent preparation whose particle size is smaller than conventional serum. The purpose of this study was to find out that pineapple hump extract contains secondary metabolites, has physical quality and has a good level of stability in the form of nanoserum. The method used in this research is experimental, the sample used is pineapple hump. The data collected is in the form of quantitative and qualitative. The results showed that pineapple hump extract contains secondary metabolites of alkaloids, flavonoids, tannins, saponins, steroids, glycosides. Organoleptic test all formulas have a clear and transparent color. In the particle size and polydispersibility index tests (F0), (F1), (F2), (F3), all formulas showing particle size and polydispersibility index met the requirements of <1000 nm and polydispersibility index <0.5. Percent transmittance test (F0), (F1), (F2), (F3), all formulas have clear and transparent visual appearance according to the requirements of 90%-100%. There was no change in the stability level of nanoserum in the organoleptic test, the particle size test and the polydispersibility index (F0), (F1), (F2), (F3). There is a change in particle size and polydispersibility index afterCyling test, however, it is still categorized as good because it is in the range of quality requirements, namely <1000 nm and the polydispersibility index <0.5.

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