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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Uji aktivitas antibakteri kombinasi ekstrak kulit dan biji Pepaya (Carica papaya L.) terhadap bakteri Staphylococcus aureus dan Escherichia coli Indra Ginting; Singgar Ni Rudang; Muhammad Andry; Mayang Sari; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.262

Abstract

Background;; Infectious diseases suffered by many people include Enterobacter infection from E.coli and skin infections due to S. aureus. One of the plants that have antibacterial properties is papaya like seeds and skin. Objekctives; The purpose of this study was to determine the activity of papaya skin and Seed (Carica papaya L.) extracts against S. aureus and E.coli. Method; The study used experimental method. The extraction used was maceration with ethanol 80%, 60% solvent. 40% and 20%. Antibacterial Activity Test using disc diffusion method and phytochemical screening test on papaya skin extract (Carica papaya L). Result; The results of screening tests on papaya skin extract (Carica papaya L) were positive for alkaloids, saponins, tannins, flavonoids and steroids. The results obtained at 60% ethanol showed that the combined extract of papaya skin and seeds (Carica papaya L) on S. aureus with concentrations (20:80) - (80:20) was 11.9 mm - 15.6 mm. In E. coli with a concentration (20:80) - (80:20) of 9.7 mm - 14.9 mm. Conclusion; The conclusions from the results of research on the combination of papaya skin and papaya seeds (Carica papaya L) of various concentrations inhibited S.aureus bacteria more than E.coli bacteria.
Penentuan Kadar Fenolik Total, Profil Metabolit Sekunder dari Ekstrak Daun Manggis dan Pemanfaatan Potensinya dalam Sediaan Teh Herbal sebagai Antikanker Muhammad Andry; Hanafis Sastra Winata
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.265

Abstract

Background; Mangosteen leaves (Garcinia mangostana L.) have secondary metabolites, namely phenolics, flavonoids, tannins, saponins, and triterpenoids. Phenolics are one of the largest groups of compounds found in mangosteen leaves which have several pharmacological and therapeutic functions, one of which is anti-cancer. Objectives; To determine the total phenol content and profile of secondary metabolites and the type of phenolic extract of mangosteen leaves. Method; Using UV-Vis spectrophotometer Folin-Ciocalteu method with the gallic acid standard. Profile of secondary metabolites and phenolic types using LCMS. Results; Based on the research that has been done, the total phenolic content is obtained where the highest concentration is in the ethanol extract 96% (290.90 mg GAE/g extract or 29.08%), then ethyl acetate extract (161.07 mg GAE/g extract or 16, 10%). Identification of LCMS, detected 15 compounds, including 6 phenolic compounds. Phenolic compounds found were gallic acid, amarogentin, oleuropein glucoside, mandelic acid, vanillic acid, and gentisic acid.. Conclusion; Phenolic compounds can act as antioxidants by protecting body cells from damage caused by free radicals such as degenerative diseases, one of which is cancer due to free radical induction.
Aktivitas Gel Ekstrak Daun Mengkudu (Morinda citrifolia) Terhadap Pertumbuhan Bakteri Penyebab Jerawat Staphylococcus epidermidis Claudya Claudya; Rena Meutia; Yolanda Eliza Putri Lubis
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.276

Abstract

Noni (Morinda citrifolia L.) is a plant that contains several chemistry compounds including flavanoids, saponins, tannin, Polyphenols and terpenoids as an antibacterial. The purpose of this study was to determine the ethanolic extract of noni (Morinda citrifolia L.) can be formulated into antibacterial gel preparations and inhibit the growth of Staphylococcus epidermidis bacteria and to determine the concentration of ethanolic extract of noni (Morinda citrifolia L.) can inhibit growth of Staphylococcus epidermidis bacteria. This research was conducted experimentally with evaluation of gel preparations and testing of antibacterial activity against concentration of 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml, positive control, and negative control. The research results on the evaluation gel preparation with concentration of 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml meet the gel preparation requirements as well as antibacterial acitivity tests, namely Staphylococcus epidermidis with a concentration of 10 mg/ml inhibiton zone 8 mm (weak), 15 mg/ml inhibiton zone 10,9 mm (medium), 20 mg/ml inhibition zone 16,75 (strong), 25 mg/ml inhibiton zone 12,1 mm (medium), and 30 mg/ ml inhibition zone 13,4 mm (medium). Conclusion : it was concluded that for a concentration of 20mg/ml with the highest diameter of the inhibition zone against Staphylococcus epidermidis bacteria
Uji Kualitas Kimia Kefir Dari Imbangan Susu Kambing Dan Susu Sapi Dengan Lama Fermentasi Yang Berbeda Alfath Rusdhi; Purwo Siswoyo; Tiara Adelia
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.284

Abstract

The research aims to study the quality of kefir chemistry from the balance of goat's milk and cow's milk with different fermentation periods. Research uses experimental methods with a complete random design of factorial patterns. The first factor is the type of milk (cow milk 100%, goat milk 50% + milk cow 50%, and goat milk 100%), the second factor is long permentation (24, 36 and 48 hours). The results showed the type of milk, the length of the permentation and the interaction of real effect on protein levels, fats, alcohol, total dissolved solids and total lactic acid. Kefir quality is a balanced high protein, low in fat and alcohol found in goat's milk kefir with fermentation for 60 hours, where the amount of protein is 4.16%, fat 4.27%, and alcohol 0.59%, Total dissolved solids 5.5667% and Total lactic acid is 0.7871%.
Penetapan Kadar Betametason Valerat Pada Sediaan Krim betametasone 0,1 % Secara Kromatografi Cair Kinerja Tinggi Indriati Indriati; Ferdinan Jalung; Herviza Wulandary Pane
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.287

Abstract

Background; Medicine is used as a support in the world of health. Medicine is a material intended for use in establishing diagnoses, preventing, reducing, eliminating, curing diseases or symptoms of diseases, injuries or bodily and spiritual disorders in humans or animals, beautifying the body or parts of the human body. Objective; To validate the method of determining the level of Betamethasone Valerate using HPLC with stationary phase C18 and mobile phase methanol: water that meets the requirements of the method validation test including precision, accuracy, selectivity, linearity and sensitivity. Methods; This research is a type of Quasy Experimental research with a Pretest Posttest Nonequivalent Control Group design, namely in this design the experimental group and control group are not randomly selected, in other words this design is carried out before and after treatment. Results; The determination of levels is carried out after the method to be used has been proven valid after going through the validation test processes. The determination of levels was carried out on the five face cream samples as much as 3 totolan in each sample. The results of the level determination test showed that the five samples did not contain betamethasone valerate and triamcinolone acetonide. Conclusion; The KLT-densitometry method used to quantify the content of topical corticosteroids in Betamethasone 0.1% cream tested has met the validation parameters of ICH and AOAC includes accuracy, precision, specificity, linearity, LOD, LOQ.
Analisis kadar natrium benzoat pada tauco yang dipasarkan dipajak kota Kisaran dengan metode spektrofometri ultraviolet Nur’aini Dalimunthe; Yulia Kusumanti; Farida Umamy
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.288

Abstract

Background; One of the preservatives that is permitted for use in food is sodium benzoate.Sodium benzoate is a salt or ester of benzoic acid (C6H5COOH) that is produced commercially through chemical synthesis. Sodium benzoate is also known as sodium benzoate or sodium benzoate. This preservative is a salt of sodium benzoic acid, a polyunsaturated fat that is approved for use by the United States Food and Drug Administration (FDA) and has been used by food and beverage manufacturers for more than 80 years to prevent microbial growth.Sodium benzoate has the molecular formula C7H5NaO2 and molecular weight Appears as odorless or almost odorless white crystalline granules or powder, soluble in 2.8 parts water and 90 parts ethanol (95%). Objective; This research aims to determine the extent of benzoate found in Tauco which is marketed in the Kisaran City Market. Method; The analysis was carried out using a qualitative method with the aim of determining the Tauco benzoate content using the FeCl3 test, esterification test and sublimation test, quantitative methods using UV-Vis spectrophotometry and to determine the sodium benzoate content according to established standards. Absorbance was measured by UV-Vis spectrophotometry at a maximum wavelength of 225 nm. Result;The results showed that the sodium benzoate content was Ten Tauco samples are A= 125.8555 mg/kg, B= 71.1929 mg/kg, C= 98.9557 mg/kg, D= 174.3942 mg/kg and E = 78.9945 mg/kg.. meet The standard requirement for the maximum use limit is 450 mg/kg. Conclusion; The conclusion of this research is that the sodium benzoate content meets the requirements and does not exceed the maximum threshold set by BPOM No. 36 of 2021, namely 450 mg/kg Tauco.
Uji Aktivitas Antipiretik Ekstrak Daun Bidara (Ziziphus Spina Christi L) Terhadap Mencit Jantan (Mus Musculus) Ferdinan Jalung; Mila Febrina Rindayani; Meity Christiani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.289

Abstract

Background; Indonesia has thousands of types of plants spread across various regions. The existing biodiversity can be used as raw material for modern and traditional medicines. Indonesian people have long known and used traditional medicine to treat various diseases. The increasingly expensive price of modern medicine on the market is one reason to explore the use of traditional medicine again. Many types of medicinal plants in Indonesia have been used as raw materials for medicine, some of these plant species have even been clinically tested for their phytochemical content, efficacy and safety of use. Objectives; To find out that bidara leaf extract (Ziziphus spina-christi L.) has antipyretic activity. Method; This type of research is experimental research.Extraction is carried out to filter out polar compounds so 60% ethanol liquid is used. Results; From the results of research that has been carried out, it was found that the average difference in temperature reduction between time and fever temperature was from 30 minutes to 120 minutes. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200mg/30 g BW of mice, NaCMC and Paracetamol at 30 minutes respectively were 0.27, 0.37, 0.44, 0 .04 and 0.8oC. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200 mg/30 g BW of mice, NaCMC and Paracetamol at 60 minutes respectively were 0.6, 0.67, 0.94, 0.07 and 1.47oC. For doses of 100 mg/30 g, 150 mg/30 g BW of mice, 200 mg/30 g BW of mice, NaCMC and Paracetamol at 90 minutes respectively were 1.04, 1, 1.24, 0, 07 and 2.1oC. Conclusion; Bidara leaf extract (Ziziphus spina-christi L.) has antipyretic activity in mice. Bidara leaf extract (Ziziphus spina-christi L.) which has antipyretic activity is at a dose of 100 mg, 150 mg and 200 mg/30 grams of body weight for mice.
Uji Aktivitas Antioksidan Ekstrak Bunga Telang (Clitoria ternatea L.) Dengan Metode DPPH (2,2 DIiphenyl 1-1 Pickrylhydrzyl) Yulia Kusumanti; Eldesi Medisa Ilmawati; Usti Fina Hasanah Hasibuan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.290

Abstract

Background: The current state of Indonesian society in general is concerning. People want to use motorized vehicles to travel instead of walking or cycling. All this leads to an increase in the amount of unfastened radicals inside the body. Antioxidants are needed to overcome the risks of unfastened radicals. Indonesia is very rich in herbal sources consisting of numerous flora, one of which is the telang flower (clitoria ternatea l.) which is thought to have antioxidants. Activity: To determine the antioxidant activity of telang flower (Clitoria ternatea L.) by dpph (2,2-Diphenyl 1-1 Picrylhydrazyl). Method: Antioxidant activity test can be done by using several kinds of methods, namely dpph, abts, etc..Results: Classification of secondary metabolite compounds found in flower telang (Clitoria ternatea L.) includes alkaloids, flavonoids, quinones, saponins, tannins, and steroids with the technique used with the DPPH test. The results of the test sample for the extract of telang flower (Clitoria ternatea L.) have an IC50 of 356.65 ppm and are classified as very weak. The ic50 value assessment of the ethanol extract of telang flower (Clitoria ternatea L.) with methanol as solvent has a value of 95.Conclusion: Assessment of antioxidant activity can be assessed from IC50. The IC50 assessment of the flower telang (Clitoria ternatea L.) has obtained different results, namely the weak and strong IC50. This can be influenced by the maximum wavelength used, as well as the storage temperature of the extract of a plant. In addition, a good solvent, namely methanol, is needed in measuring the IC50 of telang flower (Clitoria ternatea L.) using DPPH.
Profil penyimpanan dan pemeriksaan mutu obat di Puskesmas Mutiara Kisaran Mila Febrina Rindayani; Nur’aini Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.291

Abstract

Background: Storage of Pharmaceutical Supplies is a regulatory activity for Pharmaceutical Supplies that are received so that they are safe (not lost), protected from physical and chemical damage, and the established requirements maintain their quality. Pharmaceutical preparations are drugs, medicinal materials, traditional medicines, and cosmetics. Objective: To determine the storage and quality inspection of medications at the Mutiara Health Center in Kisaran. Method: This type of research is descriptive observation research. Results: Mutiara Health Center has a separate drug warehouse from the service building. The space inside the drug storage is arranged according to the U flow so that it makes it easier for officers to move. The warehouse clerk's desk is placed near the warehouse exit. It is integrated with the medicine storage room because it is not partitioned, there is no particular workspace for the warehouse, and it has sufficient ventilation. Conclusion: The drug storage system at the Mutiara Health Center in Kisaran warehouse in 2019 is in the excellent category with a percentage value of 85% consisting of 80% spatial arrangement, 80% method of drug storage, 90% stock card recording, and 90% quality observation
Profil Obat Antihipertensi Pada Pasien Hipertensi Dengan Penyakit Ginjal Kronis Oki Nugraha Putra; Fitri Kamilia Krismianti; Ikadona Logos Kaukaba
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.227

Abstract

Hypertension is one of the cardiovascular complications of chronic kidney disease (CKD). Control of blood pressure can prevent the progression of CKD and reduce the risk of cardiovascular complications. Antihypertensive drugs are required to control blood pressure. This study aimed to describe the profile of antihypertensive drug use in hypertensive patients with CKD. It was a retrospective study using medical records of hypertensive patients with CKD at Syarifah Ambami Rato Ebu Hospital, Bangkalan, from January 2019 to August 2021. This study was conducted between November 2021 and February 2022. The profile of antihypertensive drug use is shown descriptively. Forty-two hypertensive patients with CKD who met the inclusion criteria were included in this study, with more than 90% including end-stage kidney disease. Anemia is the most common complication in hypertensive patients with CKD. Loop diuretics (furosemide) and calcium channel blockers (nicardipine, amlodipine) are the most widely used antihypertensive drugs, with percentages of 28%, 25%, and 19%, respectively. The most commonly used antihypertensive combinations were furosemide + nicardipine by 46% and the combination of furosemide + candesartan + nifedipine by 43%. This study concludes that loop diuretics and calcium channel blockers are the most widely used antihypertensive drugs in hypertensive patients with CKD.

Page 20 of 66 | Total Record : 654

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