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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Kepatuhan Minum Obat pada Pasien Diabetes Melitus Tipe 2: Profil HbA1c dan Lipid di Klinik Aulia Jombang 2020 Ronald Pratama A.; Cahya Yudha Laksmana Putra; Retno Budiarti; Oki Nugraha Putra; Angelica Kresnamurti; Sulistiawati Sulistiawati
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.230

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by high blood sugar levels due to insulin secretion or work defects. Poor treatment adherence leads to uncontrolled glycemic levels and complications. Therefore, ensuring patient adherence to therapy and reducing HbA1c and lipid profiles is essential. This research employs an observational, cross-sectional design, using non-probability purposive sampling to select 55 respondents via the Slovin formula. The study examines medication adherence as the independent variable, Hba1c levels, and lipid profile as the dependent variables. Data analysis involves SPSS, utilizing univariate and bivariate methods for ordinal and nominal scales. MMAS-8 questionnaire assesses the knowledge, while data comes from questionnaires and medical records of type 2 DM patients at Aulia Jombang Clinic. Study findings showed notable adherence to treatment, with 38 respondents (60.9%) complying and 17 (30.1%) not. Chi-square tests yielded significance, p values: HbA1c 0.012, LDL 0.035, total cholesterol 0.008, triacylglycerides 0.011, and HDL 0.002, based on MMAS-8 questionnaire data. In conclusion, the results indicate statistical significance (p-value < 0,05), so there is a positive correlation coefficient, indicating that higher levels of treatment adherence are associated with more optimal HbA1c control and lipid profiles.
Efektivitas antibakteri ekstrak etanol daun bisbul (Diospyros discolor Willd) terhadap bakteri Propionibacterium acnes Nanda Nadia; D. Elysa Putri Mambang; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.240

Abstract

The bisbul plant (Dyospiros discolor Willd) is a plant whose fruit is often consumed by the public. Bisbul leaves are known to have antibacterial and antifungal activity. The purpose of this study was to determine whether the ethanol extract of bisbul leaves (Diospyros discolor Willd) has antibacterial effectiveness against Propionibacterium acnes bacteria. This research was conducted using experimental methods which included sample collection, macroscopic examination, microscopic examination, simplex preparation, characteristic examination, phytochemical screening, preparation of ethanol extract, and testing of antibacterial effectiveness against Propionibacterium acnes bacteria using the agar diffusion method. The results of the macroscopic examination conducted on the bisbul leaf simplex were brownish-green leaves, flat edges, 5 cm long leaves, 4 cm wide leaves, had a distinctive odor and a slightly bitter taste. The simplex characteristic results obtained water content of 4%, water-soluble essence content of 21%, 23% ethanol-soluble extract content, 4.8% total ash content and 0.3% acid-insoluble ash content. Phytochemical screening of simplex powder and ethanol extract of bisbul leaves showed the presence of alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The results of the antibacterial effectiveness test of the ethanol extract of bisbul leaves showed that the diameter of the inhibition zone was larger at a concentration of 80%, namely 15.98 mm, compared to concentrations of 70% and 60%, namely 15.43 mm and 14.18 mm. From the results of the study it can be concluded that the ethanol extract of bisbul leaves can provide antibacterial effectiveness against Propionibacterium acnes bacteria.
Skrining fitokimia dan uji aktivitas antibakteri ekstrak etanol daun kayu Jawa ((Lannea coromandelica) (Houtt) Merr terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermidis Munaziatul Jannah; Haris Munandar Nasution; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.241

Abstract

Jawa wood (Lannea coromandelica) (Houtt.) Merr. is a tropical plant that has potential as a medicinal plant. Almost all parts of this plant can be used in traditional medicine. This wild plant can be found easily in various locations such as home gardens, roadsides and community gardens. This study aims to evaluate the potential antibacterial activity of ethanol extract from the leaves of Kayu Jawa (Lannea coromandelica) (Houtt.) Merr. Against the growth of Propionibacterium acnes and Staphylococcus epidermidis bacteria. This research used experimental methods involving sample collection, macroscopic examination, microscopic examination, simplicia making, characteristic examination, Phytochemical Screening, and Antibacterial Activity Test using ethanol extract from Kayu Jawa ((Lannea coromandelica) (Houtt) Merr) against the bacteria Propionibacterium acnes and Staphylococcus epidermidis, using the agar diffusion method. Macroscopic examination results show that the leaves of Kayu Jawa have a tapered shape with a total of 7-11 strands. The flowers produced are single and yellowish-green in color, while the fruit has seeds of a certain length. Microscopic examination reveals the upper epidermis, palisade fragments, coral flowers, and wooden vessels with thickened spirals and stairs. The characteristics of simplicia show a water content of 4%, soluble essence content in water 21%, soluble essence content in ethanol 23%, total ash content of 4.8%, and insoluble ash content of 0.4% acid. The results of phytochemical screening on simplicia powder and ethanol extract of Kayu Jawa leaves showed contents such as alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The antibacterial activity test showed that Jawa wood showed potential as an antibacterial agent, with different inhibitory abilities depending on the concentration used. At a concentration of 20%, an inhibition zone of 6.85 mm was observed against Propionibacterium acnes and 5.75 mm against Staphylococcus epidermidis. Meanwhile, at a concentration of 80%, the area of inhibition increased to 14.15 mm against Propionibacterium acnes and 11.75 mm against Staphylococcus epidermidis.
Pengaruh Ekstrak etil Asetat dari Daun Sisik Naga (Pyrrosia piloselloides (L) Presl) terhadap Staphylococcus aureus Arfiandi Arfiandi; Neri Fadjria; Dewi Nofita; Putri Nandinanti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.255

Abstract

The primary focus of this study revolves around the microbiological assessment of the effectiveness of ethyl acetate extract derived from Dragon's Scales Leaf (Pyrrosia piloselloides (L)) against Staphylococcus aureus. The employed method entailed the use of the diffusion technique with paper discs. The ethyl acetate extract of Dragon's Scales Leaf was formulated in three distinct concentrations, namely 40%, 60%, and 80%. In addition, Gentamicin at a 1% concentration served as the positive control. The measurements yielded inhibitory zone diameters of 14.05 mm, 15.49 mm, 14.90 mm, and 14.81 mm for the ethyl acetate extract and Gentamicin, respectively. This investigation's observed inhibitory zone diameters fall within the 'weak' category, with the highest extract concentration displaying a strength equivalent to Gentamicin as the positive control. In light of these findings, it can be concluded that the ethyl acetate extract of Dragon's Scales Leaf (Pyrrosia piloselloides (L)) can impede the growth of Staphylococcus aureus bacteria.
Uji sitotoksisitas ekstrak etanol daun sirih cina (Peperomia pellucida [L.] Kunth) dengan metode brine Shrimp lethality test Fadhlah Al-Uyun Nasution; Ridwanto Ridwanto; Zulmai Rani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.260

Abstract

The degree of harm a drug inflicts on cells, for instance, cancer cells, is known as its cytotoxicity. Cytotoxic substances can stop cancer cell proliferation, making anticancer medications possible. Plant extracts or active chemicals derived from plants can be used as herbal plants' anticancer agents. Among these is Chinese betel, a plant with numerous health benefits despite being frequently regarded as a weed. This study looked at the LC50 value using the BSLT method to identify the type of secondary metabolite chemicals and the cytotoxicity of Chinese betel leaf ethanol extract. This study looks at the number of Artemia salina deaths to characterise, screen for phytochemicals, and determine the cytotoxicity of Chinese betel leaves using the BSLT method- leaf larvae with LC50 values expressed. In the phytochemical screening test, Chinese betel leaves exhibited positive results for saponin, flavonoid, alkaloid, tannins, and steroids. The findings of the cytotoxicity test utilising probit analysis demonstrated that the ethanol extract of Chinese betel leaves is poisonous and may have anticancer properties, with an LC50 value of 335.7376 µg/mL.
Uji antibakteri gel hand sanitizer ekstrak daun bawang (Allium fistulosum) tehadap bakteri Staphylococcus aureus Nurasni Nurasni; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.263

Abstract

The ability to inhibit bacterial growth from hand sanitizer gel is quite good. Leeks (Allium fistulosum) contain allicin which can function as an inhibitor of the growth of Staphylococcus aureus bacteria. This research aimed to eamine the antibacterial activity of Staphylococcus aureus from Hand Sanitizer gel containing leek extract. The procedure includes making simplicia, characterization, and making extracts through maceration with concentrations of 20%, 30%, and 40%, then carrying out an antibacterial test using the agar diffusion method. The test results showed that the bacterial inhibition zone at concentrations of 20%, 30%, and 40% respectively was 3.5 mm; 5.0mm; and 5.9 mm in the medium category. This research concludes that the formulation with the best concentration is the formulation with a concentration of leek extract as large as the inhibition zone for Staphylococcus aureus bacteria in the medium category.
Analisis kadar natrium benzoat pada kecap pedas yang beredar di pasaran dengan metode kromatografi lapis tipis (KLT) dan spektrofotometri Uv-Vis Tamara Army; Ainil Fithri Pulungan; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.266

Abstract

Sodium benzoate is one of the preservatives allowed in food and beverages. The objective of this research was to determine the level of sodium benzoate found in spicy soy sauce. Qualitative tests are first carried out on samples with the Thin Layer Chromatography (KLT) method, and quantitative tests are carried out using the spectrophotometry Uv-Vis method to determine the preservative level of sodium benzoate. Qualitative tests on KLT plates were carried out by optimising eluents (N-Butanol: Ethyl Acetate: Ammonia, Methanol: Ethyl Acetate: Ammonia, and Isopropanol: Ammonia), where the results of the three eluents showed that the Isopropanol: Ammonia eluents had Rf values from three samples that were close to each other with the comparison Rf values. The results of quantitative analysis on spectrophotometry Uv-Vis showed the total levels of Spicy Soy Sauce A 264.16±12.3206 mcg/g, Spicy Soy Sauce B 317.8±21.8643 mcg/g and Spicy Soy Sauce C 110.2±23.5356 mcg/g. Based on these results, it can be concluded that sodium benzoate levels in samples A, B, and C meet the requirements of the maximum usage limit standard, which is not more than 600 mg/kg.  
Kualitas Rendang Daging Kambing dengan Penambahan Irisan Bawang Batak (Allium chinense G. Don) Ditinjau dari Kadar Protein dan Kadar Lemak Nur Asmaq; Kabul Warsito
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.267

Abstract

This research aims to determine the quality of lamb rendang by adding sliced Batak onions (Allium chinense G. Don) to make it. The materials used in this research were lamb, Batak onions, chilies, shallots, garlic, galangal, ginger, turmeric, lemongrass, turmeric leaves, bay leaves, lime leaves, coconut, and salt. The method used in this research was an experimental method with a completely randomized non-factorial design with four treatments and four replications. The parameters tested were the lamb rendang's protein and fat content. The treatments in this study were P0 (control/rendang without adding Batak onions), P1 (addition of 5% Batak onion slices/meat weight); P2 (accumulation of 10% Batak onion slices/weight of meat), P3 (collection of 15% Batak onion slices/weight of heart). This study showed that the addition of sliced Batak onions in making rendang had a significant effect (P<0.01) on lamb rendang's protein and fat content. The protein content in the P3 treatment showed a value of 29.51%, while the fat content in P3 was 15.38%.
Skrining Fitokimia, Formulasi, dan Karakteristik Fisik Sediaan Soothing Gel Daging Daun Lidah Buaya (Aloe vera (L.) Burm.f.) Rosalinda Mahdalena Sinaga; Minda Sari Lubis; Gabena Indrayani Dalimunthe; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.274

Abstract

The content of aloe vera (Aloe vera (L.) Burm.f.) can make the skin not dry quickly and feel moisturised. Soothing gel is a preparation that works effectively to restore skin moisture, provide comfort and a cooling effect on red and irritated skin so that the skin condition returns to normal and prevents skin dryness. The study aimed to determine the various secondary metabolites in aloe vera leaf flesh, to determine differences in concentrations of aloe vera leaf flesh in soothing gel preparations on the physical characteristics of the practices and to determine material changes before and after stability tests were carried out using the cycling test method. The research method was used experimental, with the independent variables varying the aloe vera leaf flesh concentration 0% (blank), 1%, 2%, and 3%, and the dependent variable secondary metabolites and physical characteristics. The sample preparation method is wet sorting, and other methods used are phytochemical screening, viscometry, and cycling tests. The results of the phytochemical screening showed that aloe vera leaf flesh contains secondary metabolites of flavonoids, glycosides, tannins, saponins, and steroids. The results of the soothing gel formulation with variations in the aloe vera leaf flesh concentration of 0%, 1%, 2%, and 3% showed differences in colour, distinctive aroma, consistency, spreadability, adhesion, pH, and viscosity that met the requirements. The stability test results using the cycling test method showed physical changes in consistency, spreadability, adhesion, pH, and viscosity. However, these changes still met the requirements for good gel preparation according to SNI 16-4399-1996.
Analisis resiko kesehatan lingkungan pencemaran timbal (Pb) pada hasil laut yang beredar di pasar Sambu Medan Tina Meirindany; Khodijah Tussolihin Dalimunthe
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.279

Abstract

Plumbum (Pb) is a heavy metal that damages and pollutes the environment. The presence of these heavy metal damages and pollutes the environment. The presence of these heavy metals changes marine biota's life and threatens human health through contaminated food chains. The results of measuring lead (Pb) levels in anchovies and squid circulating in the Sambu Market in Medan exceed the 2009 SNI threshold. This study aims to estimate the exposure to lead (Pb) of those who eat anchovies and squid in the Sambu Market with Desktop Risk Analysis of Environmental Health. The research results show that the risk magnitude (RQ) of exposure to Plumbum (Pb) in people who consume anchovies and squid is RQ>1. Based on risk management, the safe consumption rate is at least 0.06 grams per day for adults with a body mass of 55 kg. Risk management is also carried out by managing sources of reciprocal pollutants (Pb) by controlling the amount of industrial waste that may be discharged into waters, which requires direct supervision from the local Environmental Service.

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