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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Analisis faktor-faktor yang mempengaruhi perilaku kader terhadap penemuan suspek TB paru di Puskesmas Panombeian Panei Kabupaten Simalungun tahun 2020 Patrice Armando Sipayung; Asriwati Asriwati; Tengku Moriza
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.232

Abstract

Introduction: According Global TB Report in 2018, there were 842,000 new cases of pulmonary TB (319/100,000 people) and 116,000 fatalities from pulmonary TB (44/100,000 people), including those who were HIV-positive. Objective: The stuay aimed to determine the most important characteristics that will affect the detection of TB suspects at Panombeian Panei Health Centre in 2020, including age, education, occupation, knowledge, attitudes, distance, family support, counseling, and cadre compensation. Method: This stuay was analytic study. The sample was 132 health centre cadres from population of 196 by using proportional and random sampling methods. Univariate, bivariate with chi-square test, and multivariate with logistic regression test were utilized in the data analysis. The Result: The p-value of age (0.059 OR 1.426), occupation (0.008 OR 0.055), knowledge (0.026 OR 2.899), attitude (0.821 OR 1.756), distance (0.041 OR 2.593), family support (0.038 OR 2.617), counseling (0.620 OR 1.297), compensation (0.004 OR 6,475). Conclusion: The findings showed that identification of TB suspects was influenced by employment, knowledge, distance, family support, and compensation but not by age, education, attitude, or counseling. It is advised that the local government improve the dedication to collaboration with connected parties such health agencies, sub-districts, business sector, non-governmental organizations, health and religious groups.
Kejadian stunting pada balita usia 12-59 bulan di Desa Serule Kecamatan Bintang Kabupaten Aceh Tengah Neni Ekowati Januariana; Tuty Hertati Purba; Agnes Sry Vera Nababan; Simah Bengi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.233

Abstract

Stunting is a condition of toddlers with less length or height compared to age as measured by length or height that is more than <-2 SD of child growth, according to the World Health Organization (WHO). This study aimed to determine the factors affecting stunting in children aged 12-59 months in Serule Village, Bintang District, Central Aceh Regency. This is analytic observational research with a cross-sectional approach. The statistical test used the chi-square test. The population was 48 toddlers, all sampled by total sampling technique. I indicated a relationship between maternal knowledge and the occurrence of stunting in toddlers with a p-value = .002. There was a relationship between infectious diseases and the occurrence of stunting toddlers with a p-value = .001. There was a relationship between sanitation and the occurrence of stunting toddlers with p = .004. There was a relationship between LBW and the occurrence of stunting toddlers with a p-value = 0.000. There is a relationship between exclusive breastfeeding and stunting in toddlers with p = 0.000. There was a relationship between food intake and the occurrence of stunting in toddlers with p = .001. Conclusion of this study It is expected that mothers of toddlers pay more attention to their health, maintain environmental hygiene, fulfill their food intake, and only give breast milk when they are 0-6 months old.
Uji aktivitas antibakteri formulasi sediaan sabun padat transparan ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap bakteri Cutibacterium acnes Siti Aisyah Jamil; Yayuk Putri Rahayu; Minda Sari Lubis; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.234

Abstract

Acne is a skin disease that begins with an increase in sebum production which is exacerbated by an attack by the Cutibacterium acnes bacteria. Currently, there are many anti-acne preparations, one of which is in the form of soap, but only a few contain natural herbs. One plant that has an active substance or agent that has the potential to prevent and treat acne leaves belimbing wuluh (Averrhoa bililmbi L.) with its antibacterial properties. Besides having the potential to prevent and treat acne, this plant is also very easy to find in Indonesia. This research was conducted to see whether starfruit leaf extract could be formulated as soap preparation and whether it had antibacterial properties against Cutibacterium acnes. The research method for fresh starfruit leaves was made into Simplicia and extracted using 96% ethanol, phytochemical screening was carried out on fresh starfruit leaves and extracts. Transparent solid soap formulation with belimbing wuluh leaf extract with concentrations of 2.5%, 5%, and 7.5%. Evaluation preparations included physical quality tests, pH tests, foam height and stability tests, skin moisture tests, irritation tests, Panelist preference tests, and antibacterial activity against Cutibacterium acnes. The results and conclusions show that fresh starfruit leaves and extracts contain compounds belonging to class alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Belimbing wuluh leaf extract can be formulated into transparent solid soap preparation, has a distinctive aroma extract, is homogeneous, pH 9-11, with spreadability 26-29mm. Antibacterial activity included the insensitive category at all concentrations. The panelist's preferred formula was preparation with a concentration of 2.5%
Sediaan krim ekstrak jeruk nipis (Citrus aurantifolia S.) Sebagai Obat luka sayat pada mencit jantan (Mus musculus) Madani Sirait; Gabena Indrayani Dalimunthe; Minda Sari Lubis; D. Elysa Putri Mambang
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.235

Abstract

Indonesia is a country that is rich in plant diversity. One of them is lime, which is used as a traditional wound medicine. Lime contains essential oil compounds, flavonoids, saponins, tannins, alkaloids, citric acid, amino acids, vitamin B1, and vitamin C. Based on previous research, flavonoids, tannins, and saponins can heal wounds. Making simplicia using an oven at 50oC  and characterizing simplicia Extraction using the maceration method with 96% ethanol is then concentrated using a rotary evaporator. Orientation on the preparation of the cream was carried out until a good cream texture was found, and a cream preparation test was carried out to comply with the requirements in the literature. The test animals used were 24 male mice, which were divided into six treatment groups. The first group was treated with betadine, the second group was treated with cream without extract, the third group was treated with 2 grams of extract cream, the fourth group was treated with 3 grams of extract cream, the fifth group was treated with 4 grams of extract cream, and the sixth group was untreated. Each group was given a 10-mm wound. Based on the treatment carried out for 14 days, the best formulation was a 4-gram lime extract cream, and the wound healed on day 9, which was the same as the comparison used, namely betadine.
Uji Toksisitas Akut ekstrak Etanol Bunga Turi Putih (Sesbania grandiflora (L.) Pers.) Terhadap Parameter SGOT dan SGPT pada Organ Hati Tikus Putih Jantan (Rattus norvegicus) Galur Wistar Fikih Putri Ayu Nabila; Jamilatur Rohmah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.244

Abstract

Turi plants contain phenolic compounds, tannins, flavonoids, alkaloids, and glycosides. In addition, Turi plants also contain potentially toxic compounds such as pyrrolizidine compounds. This study aimed to determine the acute toxicity of ethanol extract of white turi flowers on toxic symptoms, macroscopic observation of liver organs, and measurement of SGOT and SGPT levels. This type of research is a laboratory experimental study using the Post Test Only Control Group Design research design. Rats were divided into four groups: standard control, 10,000, 15,000, and 20,000 mg/kgBB, then observed for toxic symptoms, liver macroscopic, and SGOT-SGPT levels. Phytochemical test results showed that turi flowers contain alkaloid, saponin, tannin, steroid, and triterpenoid compounds. Macroscopic observation of the liver showed normal condition. The results of the One-way ANOVA test on SGOT and SGPT levels showed significant differences in each group. Based on the results of the study, it can be concluded that there is toxicity of ethanol extract of white turi flower to rats seen from toxic symptoms that appear but have not caused death in rats. Besides that, white turi flower extract can affect increasing SGPT and SGPT levels
Pengaruh Pelaksanaan Pemberian Makanan Tambahan Penyuluhan (PMT-P) Terhadap Pola Makan Dan Status Gizi Pada Balita (12-59 Bulan) Di Bakaran Batu Sartika Simanjuntak; Haripin Togap Sinaga
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.252

Abstract

Indonesia is a developing country that has complex problems, especially regarding nutrition. Based on SSGI results (2021), Deli Serdang Regency has (underweight) 11.30% and 9.5% (wasted). The consequences of malnutrition have an impact on the growth and development of children under five, causing malnutrition and stunting. Therefore, the government's efforts to overcome nutritional problems by issuing Law No. 36 of 2009 concerning Health articles 170 and 171. Prevention efforts are carried out through growth monitoring at posyandu while toddlers who have nutritional problems are followed up with a supplementary feeding program (PMT). This study aims to assess the effect of PMT Extension on eating patterns and nutritional status before giving additional food as reference material for information regarding PMT Extension which is popular with toddlers at the Community Health Center and Village in Bakaran Batu. The method used in this research is primary data collected directly by researchers and secondary data to complete research needs obtained from Posyandu in Bakaran Batu Dusun 4 and 5. This type of research is Quasi Experimental with a one group pre and post test design. The population in the study were all toddlers who attended Posyandu Wijaya Kesuma Dusun 4 and 5 with a sample of 30 people
Fermentasi kombucha bunga telang (Clitoria ternatea L) sebagai produk bioteknologi sederhana dalam memberikan reaksi farmakodinamik mencit (Mus musculus L) yang terpapar asap rokok dan morfometri ovarium Dwiyarina Margarisa; Firman Rezaldi; Isti Dwi Pruschia; Muhammad Andry; M. Fariz Fadillah; Mutia Muhardiyanti; Hendra Jaya; Leni Halimatusyadiah; Muhammad Amin Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.254

Abstract

One of the fertility indicators in women is the optimal functioning of the ovaries. Exposure to cigarette smoke affects the decline in ovarian function in quality and quantity. The main components contained in cigarette smoke include tar, nicotine, carbon monoxide, inorganic gases, heavy metals, nitrosamines, carbonyls, formaldehyde, and polynuclear aromatic hydrocarbons. The main components contained in cigarette smoke positively influence female reproductive hormone levels and even reduce fertility. One of the efforts to prevent free radicals from cigarette smoke and have the potential as a natural antioxidant is consuming butterfly pea flower kombucha. The butterfly pea flower kombucha from previous studies contains phytochemicals that can inhibit free radicals. This study aimed to study the effect of butterfly pea flower kombucha on the ovary morphometry of female mice exposed to cigarette smoke. The design of this study was Completely Randomized Design (CRD). The test animals used were female mice aged 10 to 12 weeks weighing 20 to 20 g in a total of 24 mice. The butterfly pea flower kombucha given was ten mL/L, 20 mL/L, 30 mL/L, and 40 mL/L. Cigarette smoke exposure to mice was carried out on days 1-20 as much as one stick and treated with butterfly pea flower kombucha on days 21-40. Mating of female mice was carried out on the 40th day. Observations of ovarian morphometry such as length, width, weight, and number of corpus luteum were carried out on the 18th day of gestation. ANOVA and DMRT with a confidence level of 1% is the data analysis performed. The conclusion of this study was that butterfly pea flower kombucha had a good effect on improving fertility levels, which could be observed with test parameters such as length, width, weight, and number of corpus luteum and administration of kombucha with a concentration of 40 mL/L was the best treatment.
Penetapan Kadar Kafein Dari Ekstrak Daun Kopi Robusta (Coffea canephora Pierre ex A. Froehner) Dan Daun Kopi Arabika (Coffea arabica L.) Dengan Metode Kromatografi Cair Kinerja Tinggi. Tri Damaiyanti; Muhammad Amin Nasution; Haris Munandar Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.257

Abstract

Coffee is a plant that contains caffeine and can be processed into a delicious drink. Currently, it has achieved very high popularity throughout the world, ranking second after water and tea in the list of most preferred drinks. Coffee drinks are popular with various groups, from teenagers to adults, and in Indonesia, coffee is even the most giant drink consumed, only behind water in consumption levels. On average, people consume coffee around 3-4 times a day, reflecting how popular this drink is among the Indonesian population. Coffee has relatively high levels of caffeine, and continued excessive consumption can increase the risk of developing several types of diseases, such as hypertension, heart disease, and stroke. According to the Food and Drug Monitoring Agency (BPOM), the maximum limit for caffeine consumption in food and drinks is 150 mg per day and 50 mg per serving. Excessive and continuous coffee consumption can increase the risk of developing certain diseases such as hypertension, heart disease and stroke. This research aimed to determine the secondary metabolite content of robusta coffee leaves and arabica coffee leaves and to determine the caffeine content in robusta coffee leaves and arabica coffee leaves using high-performance liquid chromatography. The stages of this research include processing plant material, characterisation, making ethanol extract, phytochemical screening, and determining caffeine content in robusta coffee leaf extract and Arabica coffee leaves using high-performance liquid chromatography. Extracts from Robusta coffee leaves and Arabica coffee leaves are made using the maceration method using 96% ethanol. The resulting extract was then concentrated using a rotary evaporator, and qualitative testing of caffeine was carried out using the Parry method. Caffeine levels were determined using high-performance liquid chromatography, using the regression equation y = ax+b, where y is the area, a= 49.668, and b= - 16.536. The caffeine content in Robusta coffee leaf extract was measured at around 51.42916 mg/g, while Arabica coffee leaf extract had a caffeine content of around 29.97927 mg/g.
Uji Aktivitas Antibakteri Fraksi N-Heksan Kulit Bawang Merah (Allium cepa L.) Terhadap Bakteri Streptococcus mutans Ika Yeni Siahaan; Haris Munandar Nasution; Muhammad Amin Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.258

Abstract

Caries, or cavities, is a disease caused by damage to the enamel layer caused by the activity of bacteria in the mouth, one of which is the Streptococcus mutans bacterium. One of the plants that is useful as an antibacterial is the red onion (Allium cepa L.). The objective of this research was to determine the content of secondary metabolites in shallot skin and the antibacterial activity of the n-hexane and ethyl acetate fractions of shallot skin against Streptococcus mutansbacteria. An antibacterial activity test was carried out using the Kirby-Bauer diffusion method using paper discs. Empty Kirby-Baurer disks were dipped for 15 minutes into each solution of the n-hexane fraction and ethyl acetate fraction of shallot skin in various concentrations of 10%, 30%, 50%, and 70%. The positive controls used were amoxicillin disks, and the negative controls used DMSO. The content of secondary metabolites in the ethyl acetate fraction of shallot skins, which are semi-polar, is alkaloids, flavanoids, and tannins. Meanwhile, the n-hexane fraction of shallot skin contains nonpolar compounds, namely saponins and steroids or triterpenoids. The antibacterial test results of the ethyl acetate fraction of shallot skin obtained the diameter of inhibition at a concentration of 10% (7.33 ± 1.52), a concentration of 30% (9.67 ± 1.52), a concentration of 50% (13.33 ± 1, 52), and a 70% concentration (15.67 ± 1.52). While the n-hexane fraction of shallot skin obtained the diameter of the inhibition zone at a concentration of 10% (1.00 ± 1.00), a concentration of 30% (8.67 ± 1.52), a concentration of 50% (9.67 ± 1.52), and a 70% concentration (11.33 ± 1.52). The n-hexane fraction and the ethyl acetate fraction of shallot skin (Allium cepa L.) had antibacterial activity against Streptococcus mutans, with the best inhibition being the ethyl acetate fraction at a concentration of 70% classified as intermediate.
Deteksi Bakteri Proteolitik Dari Ileum Gallus Gallus Sebagai Kandidat Agen Probiotik Pakan Fermentasi Unggas Tengku Gilang Pradana; Alfath Rusdhi; Indah Pratiwi Purba
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.261

Abstract

The ileum is part of the small intestine that functions as the absorption of food and for the growth and development of bacteria to degrade feed, such as lactic acid bacteria. The purpose of this study was to explore and detect proteolytic bacteria from the ileum of Gallus gallus as a candidate probiotic agent. The research method is a selection of proteolytic bacteria, catalase, and motility. The results showed that the average proteolytic index in isolates GP sp. 4, GP sp.3, and GP sp. 1 were 1.533, 1.531, and 1.500. Nine isolates were gram-positive and one gram-negative (GP sp. 3). The ten isolates could hydrolyze hydrogen peroxide, as indicated by the formation of air bubbles. The motility test showed that eight isolates were motile and the other two isolates were non-motile (GP sp.8 and GP sp.10). The ten proteolytic bacterial isolates obtained did not have the potential to be used as probiotic agents for fermented poultry feed because low proteolytic index value.

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