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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Uji aktivitas antioksidan dan evaluasi fisik sediaan emulgel kombinasi ektraks daun kelor dan ekstrak daun karamunting Adhi Gunawan; Annisa Fatmawati; Wahyu Yuliana Solikhah; Nafa Meilingga Putri; Baiq Husnul Hotimah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.283

Abstract

Antioxidants can be used as skin care cosmetics by preventing the formation of new free radicals, neutralizing and avoiding chain reactions, thereby slowing down premature aging caused by damage skin. Emulgel is a topical preparation that has several advantages, including thixotropic, non-greasy, easy to spread, easy to clean, mild, easy to rinse, longer shelf life, transparent, and comfortable to use. The aim of this study was to form a combination of Moringa leaf (Moringa oleifera Lam) extract and Karamunting leaf extract into an emulsion dosage form and determine the antioxidant activity using the DPPH method. The emulgel base formulation uses Carbopol as a gelling agent and a combination of Moringa and Karamunting leaf (Melastoma malabathricum L.) extracts with various concentrations (25% : 75%, 50% : 50%, 75% : 25%). The results showed that the emulgel preparation combined with Karamunting leaf extract and Moringa leaf extract met all the physical test standards for the preparation, and the results of the antioxidant activity test showed that formula I had the highest antioxidant activity, with IC50 value is 40.07 ppm, which means it is a very strong antioxidant.
Uji aktivitas antibakteri ekstrak etanol asam sunti terhadap bakteri Streptococcus mutans Novika Utami; Haris Munandar Nasution; Rafita Yuniari; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.286

Abstract

Asam sunti is belimbing wuluh, which is processed into a special food additive from Aceh Province because it becomes dregs and interferes. Belimbing is processed into asam sunti for seasoning or additional dishes. Belimbing contains active compounds such as alkaloids, triterpenoids, saponins, tannins, and flavonoids. Because Belimbing has an antibacterial pharmacological effect, it has been shown to fight bacteria that cause dental caries. The main cause of dental caries is the activity of Streptococcus mutans bacteria. The researcher took the research problem regarding the test of the inhibitory power of asam sunti extract. They know the antibacterial activity of 96% ethanol extract. The method used in this study was an experimental method with independent variables, namely asam sunti simplicia and asam sunti concentration. The main variables were the secondary characteristics and the metabolite content of the asam sunti ethanol extract. The tests included inhibiting asam sunti's ethanol extract against bacteria. The results of plant identification showed that the antibacterial inhibition zone of the ethanol extract of asam sunti belimbing wuluh ethanol extract with a concentration of 20% (18.54) mm, 40% (20.79) mm, and concentration of 60% (21.48) mm including Thus is known that the concentration of ethanol extract of asam sunti Belimbing wuluh on 20%-60% is an effective concentration to inhibit Streptococcus mutans bacteria The concentration of the ethanol extract has very strong antibacterial powder, causing a large inhibition zone.
Tingkat kepuasan pelayanan pasien BPJS kesehatan terhadap pelayanan obat di apotek X Kota Sibolga Salmah Handayani Lubis; Fenny Hasanah; Eva Sartika Dasopang; Lathifur Rasyidah Tanjung
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.292

Abstract

Health-related issues are one of the most pressing needs of society. Indonesia has government-run health insurance that is directly under its control. When patients obtain services that are considered appropriate or above expectations, patient satisfaction is achieved. This research uses a survey research approach and is descriptive. Surveys distributed to respondents were used to collect data. Eighty respondents who met the inclusion requirements were sampled. The data used is primary data, information obtained directly from respondents, with data collection methods such as providing questionnaires, which are filled in by the respondents themselves and sent back to the researcher. The findings of the study, which were based on SPSS patient characteristics analysis, showed that females accounted for the most significant percentage of respondents (43), followed by the 46-55 years age group (32.5%) and housewives (27.5%), (n=26; 32.5%) had the highest hypertension diagnosis on SPSS analysis, while (n=18; 69%) had the highest drug name of amlodipine. The results, according to the Servqual model, showed that the guarantee dimension had the largest average of 98%(Assurance), while the responsiveness dimension had the lowest average of 92% (waiting time).
Aktivitas Analgesik dan Antiinflamasi Nanoemulsi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) secara In Vivo Recky Patala; Viani Anggi; Isna Paula; Nur Sakina
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.295

Abstract

Pain and Inflammation are our body's average protective measures. The presence of an inflammatory process is characterised by typical features, namely the appearance of redness, swelling in the area of inflammation, heat, and the onset of pain. One of the traditional plants widely obtained in Indonesia is Curcuma longa L. Curcuma longa L. contains flavonoid and curcumin compounds known to have analgesic and anti-inflammatory effects. The ethanol extract of Curcuma longa L. rhizome is formulated in nanoemulsion dosage form to reduce toxicity, improve drug distribution efficiency, and increase the bioavailability of drugs with low absorption. This study aims to determine the effect of the administration of nanoemulsion of ethanol extract of Curcuma longa L. at doses of 20 and 25 mg/kg bw on analgesic and anti-inflammatory activities carried out on male white rats of Wistar strain induced by 1% acetic acid and 1% carrageenan. Rats were divided into five groups (n=5), namely standard control (nanoemulsion without extract), positive control (mefenamic acid nanoemulsion for analgesic test and diclofenac sodium nanoemulsion for anti-inflammatory test), negative control (1% acetic acid nanoemulsion and 1% carrageenan nanoemulsion), P1 (extract nanoemulsion dose of 20 mg/kg bw), and P2 (extract nanoemulsion dose of 25 mg/kg bw). Furthermore, the number of writhing was measured from 5 to 60 minutes, and the leg volume changed from 1 to 6 hours. The results showed a decrease in the number of writhes with an increase in % Protection and significant inhibition of inflammation (p<0.05) in both doses of 20 mg/kg bw and 25 mg/kg bw with a per cent protection of 35.21% and a decrease in oedema volume by 64.79%. Nanoemulsion of Curcuma longa L. extract at doses of 20 and 25 mg/kg bw has activity as an analgesic and anti-inflammatory induced by 1% acetic acid and 1% carrageenan
Identifikasi DNA babi sebagai metode validasi untuk autentikasi halal menggunakan polymerase chain reaction Mariyani Mariyani; Ni nyoman Yuvita Yani; Ikhsan Hi. Amir Sene
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.296

Abstract

To protect consumers from fake halal labelling on food products, cosmetics and medicines, a method is needed to guarantee a product's Halal. Pork is one type that is often used to mix with beef because the two types of meat have physical similarities if not carefully considered. DNA-based analysis, often used for halal authentication, is the real-time PCR method, so this study aims to prove that conventional PCR methods can detect DNA at the same concentration. This study uses two parameters: the specificity test carried out using pig DNA samples and cow and chicken DNA as a comparison. The second parameter is the detection limit test on absolute DNA carried out at 4 concentrations, namely 50, 5, 0.5 and 0.05 ng/µL, while the relative detection limit test (pork-cow mixture) with variations in pork concentration, namely 100%, 5%, 3%, 1%, and 0.5%. The analysis showed that the primers were specific to pig DNA with an absolute detection limit of 0.05 ng/µL and a relative detection limit of 0.5%. This PCR method meets the validation requirements for identifying target species so that it can be used for halal authentication of various products.
Pembuatan mikrokristalin selulosa dari ubi jalar (Ipomoea batatas (L.) Lamk.) dengan Avicel PH 102 sebagai pembanding dan evaluasi mutu fisik Shinta Mida Ariani Harahap; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.297

Abstract

Microcrystalline cellulose is an excipient used in the manufacture of directly felt tablets, namely as a filler, binder, and crushing agent and can be isolated from fibrous plants. One of the abundant fibrous plants in Indonesia is sweet potato (Ipomoea batatas L.). The main chemical composition of sweet potatoes includes carbohydrates, namely dietary fibre (hemicellulose, cellulose), starch, and several types of sugar. The objective of this research was to make microcrystalline cellulose from sweet potato (Ipomoea batatas L.) and see the comparison of physical quality evaluation of microcrystalline cellulose results from sweet potato (Ipomoea batatas L.) with Avicel PH 102. This research used the hydrolysis method of HCl 2.5 N acid by heating at a temperature of 105ºC for 10-15 minutes with the ratio of alpha-cellulose and acid used is (1: 20). Then, evaluated the physical quality of microcrystalline cellulose from sweet potatoes by organoleptic tests, identification, pH determination, solubility of substances in water and drying loss. The results of this research show that sweet potato cellulose can be used as microcrystalline cellulose, namely with the results of a physical quality evaluation that meets the requirements when compared to Avicel PH 102; each includes organoleptic where both are in powder form, do not have the same smell and taste, but there are differences in colour where Avicel PH 102 is white. In contrast, microcrystalline sweet potato cellulose is yellowish-white. On identification, both produce violet blue; pH 5.2 and pH 6.5; solubility of substances in water 0.2% and 0.1%; drying shrinkage of 0.71% and 2.53%; And in the starch test, both did not produce a violet-blue solution.
Pembuatan mikrokristalin selulosa dari wortel (Daucus carota L.) dengan avicel PH 102 sebagai pembanding dan evaluasi mutu fisik Chairina Milda; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.298

Abstract

Carrots (Daucus carota L.) are vegetable types of annuals because they only produce once and then die. Carrot tubers are reddish-yellow due to the high content of carotene. Microcrystalline cellulose is one of the excipients (additives) in tablet preparations, namely as a filler, which is considered a binding agent because it can increase the compactness ability of tablets from compression mixtures. Microcrystalline cellulose comes from natural resources containing lignocellulose fibers such as wood and non-wood. One of the abundant fibrous plants in Indonesia is carrots (Daucus carota L.). The main chemical composition of carrots includes carbohydrates, namely dietary fiber (hemicellulose, cellulose), starch, and several types of sugar. This research aimed to determine whether carrot cellulose (Daucus carota L.) can be made into microcrystalline cellulose and compare the physical quality of carrot cellulose microcrystalline results with Avicel PH 102. Microcrystalline cellulose is made by a delignification process using 15% NaOH, followed by a bleaching process using 3.5% NaOCl, and then continued with a hydrolysis process with HCl 2.5N. Then, microcrystalline cellulose is carried out a physical quality evaluation, which includes organoleptic, identification, pH, solubility of substances in water, shrinkage of dryers, and starch. The results of the research showed that carrots can be made into microcrystalline cellulose, namely with the results of physical quality evaluation compared to Avicel PH 102, organoleptic powder, odorless, tasteless, and yellowish white (microcrystalline cellulose) and white (Avicel PH 102); identification, each of which produces a blue-violet color; pH 5.67 and 6.5; the solubility of substances in water is 0.1% each; drying shrinkage 4.70% and 2.53%; and starch, respectively not formed violet blue solution.
Skrining fitokimia dan isolasi senyawa flavonoid dari ekstrak etanol kulit buah menteng (Baccaurea racemosa (Reinw.) Müll.Arg) Muhammad Ari Mukhtizar; Haris Munandar Nasution; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.299

Abstract

The menteng plant, which belongs to the Euphorbiaceae family, is a subtropical plant worldwide. Flavonoids are one of the groups of phenolic compounds found in plant tissues that can act as antioxidants. This research aimed to determine the class of chemical compounds found in the Menteng fruit peel and determine the characteristics of fruit peel flavonoids by UV Spectrophotometry and IR Spectrophotometry. %. Phytochemical screening showed positive for alkaloids, flavonoids, and steroids/triterpenoids, while tannins, saponins, and glycosides were negative from 400 grams of simplisia produced 39.1 grams of viscous extract. Characterization of crystal isolates of UV spectrophotometry showed a wavelength of 280 nm, inferred to be a flavanoid. The results of IR spectrophotometry show the O-H, C-H aliphatic, C=C aromatic, C=O, C-H, and C-O groups.
Efektivitas penyembuhan luka bakar menggunakan salep ekstrak etanol daun ciplukan (Physalis angulata L.) pada kelinci Cindy Marlina Tambunan; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.300

Abstract

Indonesian people have long used plants as medicine and for health maintenance, which is inherited from generation to generation. One plant that can be used in traditional medicine is the ciplukan plant (Physalis angulata L.), which is a small plant that can grow anywhere. It turns out not only has a unique taste but is also beneficial for health; ciplukan can be used to treat flu and sore throat, whooping cough, bronchitis, mumps, ulcers, and also Ayan or epilepsy. Empirically, the use of ciplukan plants functions as a cure for smallpox, which has been used by the community by bathing. Smallpox is shaped like a blistered burn and will be shaped like an ulcer. So, researchers are interested in developing in the form of ointment because it is more effective to use and can be taken anywhere. This research was conducted to determine that ethanol extract of ciplukan leaves can be formulated on the basis of absorbent ointment and to determine the healing effect of burns in rabbits from the preparation of ethanol extract ointment of ciplukan leaves (Physalis angulata L.). Ciplukan leaf extract is made from simplicial ciplukan leaves by maceration method and then tested for the effectiveness of healing burns on rabbits using ointment. The ointment is made in 4 formulations, namely F0, F1 (10%), F2 (15%), and F3 (20%) using white Vaseline as the ointment base. Evaluation of ointment preparations includes physical stability (shape, smell and colour, homogeneity, pH, dispersion, adhesion and viscosity. All formulas of ointment preparations are good in storage. In ointment preparations in the homogeneity test, all formulas are homogeneous. In pH inspection, dispersion, adhesion and viscosity all meet requirements according to predetermined or established standards. Ciplukan leaf extract can be formulated into an ointment dosage form. Ointment preparations with a high concentration are most effective in healing burns in rabbits.
Penetapan kadar fenolik total ekstrak etanol, fraksi etil asetat dan n-heksan daun kopi robusta (Coffea canephora Pierre ex A. Froehner) dengan metode spektrofotometri Uv-Vis Yulia Nanda Putri; Muhammad Amin Nasution; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.301

Abstract

Phenolic compounds have various biological effects, such as antioxidant activity, can reduce the risk of cancer, coronary heart disease, stroke and other neurodegenerative diseases. Robusta coffee leaves (Coffea canephora Pierre ex A. Froehner) have activity as antioxidants because they contain abundant phenolic compounds. This study aims to determine the ratio of total phenolic levels between ethanol extract, ethyl acetate fraction and n-hexane fraction from robusta coffee leaves. In this study, the first step taken was a characterization test on simplicial powder and robusta coffee leaves macerated with 70% ethanol solvent. The maserat obtained is further fractionated with n-hexane and ethyl acetate. Followed by phytochemical screening on coffee leaf samples. Furthermore, the extract, n-hexane fraction and ethyl acetate determined total phenolic levels using visible spectrophotometry at a wavelength of 749 nm. Determination of total phenolic levels using the Folin-Ciocalteu method with gallic acid standards. Total phenolic levels are expressed in mg gallic acid equivalent (GAE) per gram of simplicial. The results showed that 70% ethanol extract of robusta coffee leaves had a total phenolic content of 25.9438± 0.0889 mg GAE/g. From the fractionation results show that the ethyl acetate fraction of robusta coffee leaves has a greater total phenolic content compared to the n-hexan fraction of 28.048 ± 0.3692 mg GAE / g and followed by the n-hexane fraction of 15.5231 ± 0.7213mg GAE / g. This is because the fractionation method can increase the desired compound content by removing or separating unwanted compounds, thus making the compound results in the use of fractions purer.

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