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Journal of Pharmaceutical and Sciences.

jps
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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 555 Documents

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Formulasi dan Uji Stabilitas Emulgel Ekstrak Etanol Bunga Telang (Clitoria ternatea L) Sebagai Lotion Annisa Fatmawati; Geby Ariskha; Anggraini Putri Rusdiana Dewi; Ika Ristia Rahman; Tri Yanuarto
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cosmetic preparations derived from natural ingredients have the potential to become self-sufficient active raw materials with antioxidant activity. Natural ingredients provide a source of antioxidants, which can capture free radicals and prevent premature aging. Butterfly pea flower extract (Clitorea ternatea L) has antioxidant, antibacterial, and anti-fungal activity. Making Emulgel preparations with the active ingredient of butterfly pea flower extract aims to increase the comfort and effectiveness of topical use as a cosmetic. Butterfly pea flower extraction was carried out by soaking the butterfly pea powder using 70% ethanol (1:5). Determination of total flavonoid content using AlCl3 and potassium acetate reagents with the Visible Spectrophotometry method. Emulgel extract of butterfly pea flower was prepared by varying the concentration of the extract (0.5%, 1.0%, and 2.0% w/w) and then mixed in an emulgel base using ultra turrax for 10 minutes. Furthermore, the Emulgel was tested to evaluate its physical properties and storage stability at room temperature on day 0 and day 28. Evaluation includes organoleptic observations and pH. The total content of total flavonoids in the ethanol extract of butterfly pea flowers was 5.74 ± 0.32 mgEQ. Formula III (2% EEBT) is the best formula based on organoleptic, pH, adhesion, spreadability, and room temperature stability tests

Angka Lempeng Total Dan Cemaran Bakteri Pada Daging Domba di pasar Tradisional Kampung Lalang Erika Triayu; Kurniawan Sinaga; Alfath Rusdhi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Meat is an important food ingredient in meeting nutritional needs. The purpose of this study was to detect total plate count and bacterial contamination in lamb meat. The research method used in this research is descriptive method, because this research describes the characteristics of a population or a phenomenon that is the object of research that is experimental. Observational data were analyzed using a descriptive method of 6 samples of lamb meat obtained from the traditional market in Kampung Lalang and found Escherichia coli and Salmonella sp. The highest TPC analysis values were found in traders 2 and 3 samples 2, namely 6.45x106 cfu/g and 7.05x106 cfu/g and the lowest amount of contamination was found in traders 1 sample 2, namely 4.5x105 cfu/g. In accordance with the limit for Escherichia coli 1x 101 colonies/gram and the limit for Salmonella sp negative/25 gram. The results showed that 95% of the lamb meat samples were contaminated with Escherichia coli and Salmonella sp. This shows that the lamb meat sold in Kampung Lalalang traditional markets does not meet the Indonesian National Standard (SNI) or is unfit for consumption.

Hubungan Pola Makan Dan Status Gizi Terhadap Kejadian Hipertensi Pada Lansia Di Puskesmas Sultan Daulat Kota Subulussalam Tuty Hertati Purba; Mariyanaq Mariyanaq; Athira Demitri Athira Demitri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background: Hypertension is a chronic disorder in which blood pressure in the blood vessels rises. Hypertension is characterized as having a systolic pressure of more than 140 mmHg and a diastolic pressure greater than 90 mmHg. The study aimed to assess the impact of food and nutritional status on the prevalence of hypertension in the elderly at Sultan Daulat Health Centre in Subulussalam City. The study was an analytic observational design with a case control. All older adults at the Sultan Daulat Health Centre in Subulussalam City who were hypertensive or not were included in the research. The case sample consisted of 22 hypertensive respondents, while the control sample consisted of 22 non-hypertensive respondents. The chi-square statistical test was used to assess data bivariately The results showed that there was a relationship between diet with a p-value of 0.004 <05 and OR 7.600 (95% CI) 1.732 – 33.347, fat intake with a p-value of 0.001 <05 and OR 13.571 (95% CI) 2.991 – 61.586, sodium intake with a p-value 0.000<05 and OR 12.000 (95% CI) 2.862 – 50.306 and nutritional status with a p-value of 0.002<05 and OR 9.643 (95% CI) 2.362 – 39.365 with the incidence of hypertension in the elderly at the Sultan Daulat Health Centre, Subulussalam. This study's recommendations were intended to regulate a balanced diet, minimize consumption of foods high in fat and sodium, and eat foods high in fiber to control excess body weight.

Deteksi Bakteri Patogen Pada Daging Ayam Di Pasar Tradisional Hamparan Perak Nuraini Sihotang; Kurniawan Sinaga; Alfath Rusdhi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Chicken meat is a source of animal protein for humans. The aim of this study was to detect pathogenic bacteria in chicken meat sold at the Silver Plain traditional market. The method used in this study is descriptive because research that describes the characteristics of a population or a phenomenon that is the object of research is trial and error. From the observational data analyzed descriptively as many as 10 samples from 10 traders obtained from the silver overlay market found the presence of Salmonella sp and Escherichia coli bacteria. The results showed that the highest number of colonies was found in trader 10, namely 3.8x106 cfu/g and the lowest in trader 5, namely 3.9x104 cfu/g, this was not in accordance with the maximum limit of microbial contamination in foodstuffs (fresh chicken meat) according to the National Standard. Indonesia (SNI) 7388:2009 namely TPC 1 x 106 colonies/gram. The results also showed that 70% of the chicken meat samples were contaminated with Salmonella sp bacteria, and 60% of the samples were contaminated with Escherichia coli bacteria. This shows that the quality of chicken meat sold in the Silver Plain traditional market does not meet the Indonesian National Standard (SNI) 7388:2009 Escherichia coli 1 x 101 colonies/gram, and Salmonella sp negative/25gram

Faktor Yang Mempengaruhi Penggunaan Obat Kategori Over The Counter Pada Mahasiswa UNSIKA Mally Ghinan Sholih; Indah Laily Hilmi; Rahmi Indian
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Survey conducted by the Statistics Indonesia in 2020 regarding self-medication, it was recorded that 88,28% people of West Java carried out self-medication, one of which was with over the counter drugs. The high use of this Over The Counter (OTC) category of drugs increases the possibility of abuse in terms of use. The purpose of this study is to identify the factors that influence the use of drugs in the OTC category and to test it againts Singaperbangsa Karawang University (UNSIKA) students. This research was conducted from January to March 2022 using a descriptive analytic design with a cross sectional approach. The instrument used is a questionnaire. The sampling technique used is the accidental sampling method with a sample consisting of 392 UNSIKA students who entered the inclusion criteria. The results of the univariate analysis shows that the majority of respondents have good knowledge, are influenced by product effectiveness and efficiency, have adequate information availability, believe in manufacturers, are influenced by usage preferences, and use drugs well. The results of the bivariate analysis using the Chi square method indicates that there is a relationship between knowledge, trust in manufacturers, and usage preferences for the use of drugs in the OTC category with a significance value of 0.001 (p <0.05) and there is no relationship between product effectiveness and efficiency and the availability of information on the use of drugs in the over the counter category with a significance value of 0.911 and 0.973, respectively (p > 0.05).

Sintesis Senyawa Asetil Vanilat melalui Vanilin dan Peranannya Sebagai Komponen Senyawa Analgesik Salman Salman; Elvira Julia Ariyanto; Shafira Intan Anggraini; Siti Nafisa; Welly Windari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

People in Indonesia are inseparable from pain such as pain. This pain disease is treated with analgesic drugs such as aspirin. Where in aspirin, the salicylate group is most widely used as an analgesic. Aspirin differs from other salicylic acid derivatives in that it has an acetyl group. It is this acetyl group that can inactivate cyclooxygenase, so this drug is called an NSAID. In the synthesis of acetyl vanillate from aspirin via vanillin, the aim is to obtain the synthesis of acetyl vanillic compounds. Vanillin oxidation was carried out using Tollens reagent (AgNO3). The results of the FTIR spectrum showed that there were differences in acetyl vanillic and vanillic acid compounds. Synthesis of acetyl vanillic is carried out by oxidizing vanillin to produce vanillic acid which is then carried out by acetylation of vanillic acid to form acetyl vanillic compounds. The resulting compounds were characterized using the FTIR spectrum and compared to their identification using HNMR. Identification using FTIR is better than HNMR because the carboxylic acid group appears compared to HNMR. HNMR is covered with a large peak of carboxylic groups in the proton environment.

Uji Kualitatif Dan Penetapan Kadar Flavonoid Total Ekstrak Etanol Herba Pegagan (Centella asiatica) Dengan Variasi Konsentrasi Pelarut Wahyu Yuliana Solikah; Annisa Fatmawati; Adhi Gunawan; Astri Yeni Defri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Gotu Kola (Centella asiatica) has been known as a medicinal plant that has pharmacological activity in various diseases. One of the many bioactive compounds found is flavonoids. This study aims to determine the effect of concentration on total levels of flavonoids in the ethanol extract of Centella asiatica herb (EEHP). The method of measuring total flavonoid content was UV-Visible spectrophotometry with a maximum lambda of 412 nm and using quercetin as a reference standard. The results of total flavonoid levels in EEHP 50%, EEHP 70%, EEHP 80%, and EEHP 96% were 5.58 mgQE/g; 5.24 mgQE/g; 6.67 mgQE/g; 11.92 mgQE/g. The ANNOVA test showed a significant difference in the results of 96% EEHP flavonoid levels with a sig value of 0.001 (<0.5). Trigger concentration is proven to affect the levels of flavonoids contained in the extract. The highest levels of flavonoids were obtained at 96% EEHP, which is 11.92 mgQE/g.

Pengaruh Kandungan Obat Demam Sirup Terhadap Kasus Gagal Ginjal Akut Pada Anak Salman Salman; Shiyami Aulia Nur Darmawan; Nina Elyyana; Syifa Khairunnisa; Anggi Ayu Pratama; Tiara Nurayuni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Kidney failure is a condition when the kidneys cannot function properly to filter or remove waste from the body. This study aimed to determine the solvents in syrup fever drugs, namely ethylene glycol and diethylene glycol, which are suspected of causing acute kidney failure in children. The method is to collect journals from various databases such as Google Scholar, PubMed, NCBI, and others. The results of ethylene glycol (EG) and diethylene glycol (DEG) in fever syrup can affect damage the kidneys if their administration exceeds the threshold. The formation of oxalic acid metabolites from ethylene glycol can precipitate into calcium oxalate monohydrate crystals in the tubules’ lumen, which triggers kidney stones and acute kidney injury. In Diethylene Glycol, the formation of metabolites of 2-hydroxyethoxyacetic acid (HEAA) has. Toxic effects resulting from the buildup of HEAAs cause acidosis and kidney organ failure.

Review Pengembangan Formulasi Sediaan Nano Minyak Atsiri Terhadap Aktivitas Farmakologi Aliya Azkia Zahra; Ike Susanti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Essential oils are liquids from the extraction process of plants or parts of aromatic plants which generally contain volatile terpenoids. This oil is characterized by distinctive odor from each plant that causes by differences in its constituent compounds. Essential oils have many pharmacological activities such as antioxidant, antibacterial etc. The development of many nano formulations has been developed, including essential oils. Nanoemulsion, nanogel, and nanoemulgel are forms of nano formulations that are applied in the manufacture of pharmaceutical preparations containing essential oils. Therefore, the purpose of this review is to present the results of the latest research on essential oil formulations using nanotechnology that have been widely developed and their effect on pharmacological activity. The articles used in this review were published from 2013-2023 which are indexed by Scopus. The formulation of essential oil preparations in nano form enhances the pharmacological effects of essential oils including increasing the effects of antioxidants, antibacterial, antifungal, antiproliferative, antiviral and reducing toxicity which can be useful as a reference for nano preparation formulations for essential oils.

Efek Antidiabetes Fraksi N-Heksana, Etil Asetat, Dan Air Dari Bunga Telang (Clitoria Ternatea L.) Pada Tikus Jantan yang Diinduksi Streptozotocin-Nikotinamid sunarti sunarti; Peppy Octavini
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels. Increased blood glucose levels are caused by impaired insulin secretion, insulin sensitivity, or both. The therapeutic target of the treatment of diabetes mellitus is controlled blood glucose levels, so that the treatment is carried out continuously and for a long time. The side effects of synthetic drugs in diabetes mellitus cause impaired kidney function, and also hypoglycemia. One alternative therapy that has fewer side effects and is safe is treatment with natural herbs. Clitoria Ternatea L. contains polar compounds such as anthocyanin flavonoids, which have antidiabetic activity. Fractionation is necessary to be able to separate compounds based on the level of polarity. This study aims to determine whether there is a hypoglycemic effect on the n-hexane, ethyl acetate, and aqueous fractions of the ethanol extract of butterfly pea flower in test animals induced by streptozotocin-nicotinamide. Wistar strain male rats were used. 30 rats were divided into 6 treatment groups consisting of normal, positive, and negative groups; the n-hexane fraction test preparation group; ethyl acetate fraction; and the water fraction group. The GOD-PAP method was used to measure blood glucose samples. The obtained blood glucose data were analyzed using the one-way ANOVA test. This study showed that the entire treatment group of the n-hexane fraction, ethyl acetate fraction, and water fraction at a dose of 400mg/KgBW had antidiabetic activity in Streptozotocin-Nicotinamide-induced test animals with an average glucose level in the n-hexane fraction of 113.89 mg/dL, the fraction ethyl acetate of 109.72 mg/dL, and the water fraction of 135.41 mg/dL. Based on the analysis of the post-hoc LSD test on day 14, the n-hexane fraction group and the ethyl acetate group at a dose of 400 mg/KgBW did not have a significant difference with the positive control. Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels. Increased blood glucose levels are caused by impaired insulin secretion, insulin sensitivity, or both. The therapeutic target of the treatment of diabetes mellitus is controlled blood glucose levels, so that the treatment is carried out continuously and for a long time. The side effects of synthetic drugs in diabetes mellitus cause impaired kidney function, and also hypoglycemia. One alternative therapy that has fewer side effects and is safe is treatment with natural herbs. Clitoria Ternatea L. contains polar compounds such as anthocyanin flavonoids, which have antidiabetic activity. Fractionation is necessary to be able to separate compounds based on the level of polarity. This study aims to determine whether there is a hypoglycemic effect on the n-hexane, ethyl acetate, and aqueous fractions of the ethanol extract of butterfly pea flower in test animals induced by streptozotocin-nicotinamide. Wistar strain male rats were used. 30 rats were divided into 6 treatment groups consisting of normal, positive, and negative groups; the n-hexane fraction test preparation group; ethyl acetate fraction; and the water fraction group. The GOD-PAP method was used to measure blood glucose samples. The obtained blood glucose data were analyzed using the one-way ANOVA test. This study showed that the entire treatment group of the n-hexane fraction, ethyl acetate fraction, and water fraction at a dose of 400mg/KgBW had antidiabetic activity in Streptozotocin-Nicotinamide-induced test animals with an average glucose level in the n-hexane fraction of 113.89 mg/dL, the fraction ethyl acetate of 109.72 mg/dL, and the water fraction of 135.41 mg/dL. Based on the analysis of the post-hoc LSD test on day 14, the n-hexane fraction group and the ethyl acetate group at a dose of 400 mg/KgBW did not have a significant difference with the positive control.

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Home Page

OAI Link

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Contact Name Salman

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Phone +6285277011177

Journal Mail Official admin@journal-jps.com

Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Contact Name
Salman

Contact Email
salman.kimia@gmail.com

Phone
+6285277011177

Journal Mail Official
admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
Kota medan,

Sumatera utara

INDONESIA