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Journal of Pharmaceutical and Sciences.

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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 616 Documents

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Review Artikel: Docking Molekuler Obat Anti Diabetes Melitus Issabella Elsiana; Kholifatul Ulum; Klaritya Anisya Kurnia; Shafa Qotrunnada Widyatamaka; Shipa Paujiah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Diabetes mellitus is a disease caused by damage to the pancreas organ such as insulin secretion abnormalities, insulin resistance, and insufficient production of the hormone insulin which can cause an increase in blood glucose levels. To overcome this, people with diabetes mellitus need antidiabetic drugs. In general, these drugs work by controlling sugar levels in the body. Although there are various therapeutic options for treating diabetes mellitus, there are often side effects that can be detrimental. Therefore there is a need for effective treatment, and the use of natural products is recommended as an alternative treatment method. This study aims to find natural product compounds that have medicinal potential as an alternative treatment for diabetes mellitus. The method used in this review is by searching published scientific literature in the form of PubMed, Elsevier journals, NCBI, and Google Scholar by differentiating the exclusions that have been set. The results of this review show positive results where there are various natural compound compounds that have potential as antidiabetic drugs. However, this is still limited to molecular docking, so further studies are needed.

Review Artikel: Pemanfaatan Kimia Komputasi Dengan Berbagai Metode Dalam Menentukan Desain Senyawa Baru Lina Nurfadhila; Diah Muldianah; Diany Aprillia Nurdimayanthi; Dinda Shafira Rahmawati; Hajar Hartati; Hana Fadhilah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Research in the pharmaceutical field is helped by the development of technology and science, one of which is in the field of medicinal chemistry related to drug discovery and treatment development design. Computation is one of the techniques in drug development with molecular docking and Quantitative Structure Activity (HKSA) methods which include synthesis, purification, design, identification and activity testing of a compound. The method used is to conduct studies from various sources with a total of 29 journals found on various official websites and which are used as the main journal as many as 10 journals with various computational techniques, namely molecular docking, PM3 semiempirical, AM1 semiempirical, in silico and HKSA. The potential of compounds from various literatures results in several medicinal purposes, namely as anticancer, antimalarial, antibacterial, anti-HIV and covid prevention. The potential of these compounds is obtained from different chemical compounds. The compounds used in this journal include compounds derived from 1,3-dibenzolythiourea, quinine compounds, fluoroquinolone parent compounds, chalcone-derived compounds, kuwanon compounds and their derivatives, leonurin compounds and their derivatives, compounds derived from N-(Benzoil)-N'-phenylthiourea, Beta asaron-derived compounds, meisiindigo-derived compounds and quercetin compounds.

Review : Potensi Yoghurt Sinbiotik Kombinasi Rempah Sebagai Suplementasi Probiotik Dan Antioksidan Berbasis Nutrasetikal Bahan Alam Dari Lontar Usadha Taru Pramana Sebagai Kearifan Pengobatan Lokal Bali Ameilia Ameilia; I Gede Bayu Somantara; Aliya Nur Hasanah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Along with the development of COVID-19 cases, health maintenance efforts to maintain and increase endurance are significant. Healthy living efforts that need to be implemented are by regulating the intake of nutritional supplementation of both macronutrients and micronutrients. One type of nutraceutical food with complex nutrients that has the potential to be used as a nutraceutical for supplementation efforts is yogurt. Traditionally, yogurt is also mentioned in the Balinese medical wisdom, namely, Usadha. In Usadha, yogurt combines ingredients found in Lontar Usadha Taru Pramana (Usadha, which contains various medicinal plants). The method used to compile this article is a systematic review literature study. Relevant information was collected from Google Scholar, Science Direct, ProQuest, Pubmed, and EBSCO. Scopus, Sinta, or Garuda-indexed articles published in the last five years were selected. Based on the literature search, it is known that the addition of each turmeric, ginger, secang, and cinnamon extract to yogurt can improve the physicochemical quality and nutritional content of the yogurt, especially antioxidants, thus contributing to health maintenance and being able to maintain the probiotic stability of yogurt. The combination of spiced yogurt with ginger, turmeric, secang wood, and cinnamon rhizomes can be used as probiotic-antioxidant supplementation to support a healthy lifestyle related to maintaining the immune system.

Review Article : Implikasi Suplemen Asam Folat Prenatal terhadap Risiko Autism Spectrum Disorder (ASD) pada Keturunannya Diah Muldianah; Indah Laily Hilmi; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Folic acid plays an important role for the health of mothers and babies, especially in the growth and development of the fetus. Based on several previous studies, it was found that prenatal folic acid deficiency or excess can increase the risk of Autism Spectrum Disease (ASD) in infants. This raises concerns about the adverse effects of prenatal folic acid supplements including an increased risk of ASD. Therefore, this literature review article was created to further explore the implications or involvement of maternal folic acid supplementation on the risk of ASD in their offspring. The Google Scholar, Pubmed, and Connected Papers electronic databases were used to find literature that met the criteria. The results of this review found a potential beneficial effect of prenatal folic acid supplementation on the risk of developing ASD, although conflicting results have been reported. In summary, this literature review article demonstrates that prenatal folic acid supplementation can significantly reduce the risk of ASD in offspring compared to women without prenatal folic acid supplementation.

Metode Analisis Cemaran Mikroba pada Makanan : Review Artikel Aditia Putra Tama; Vina Luthfiana Hasna; Khamairah Azzahrawaani Hermawan; Marsah Rahmawati Utami; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Food is one of the important things in the sustainability of human life. The main function of food for humans is to meet the nutritional needs of the body, where these nutrients must be met according to gender, age, daily physical activity, and body weight. As the main and basic function of food itself, in order to be a good source of nutrients and energy, of course, the food must be ensured to be safe, clean, does not contain harmful food-enhancing ingredients, and is free from sources of disease. The source of this disease can arise from food that has been contaminated, one of which is food contaminated with microbial contamination. This article aims to inform the analysis of microbial contamination methods in various foods. The method used in writing this article review is to search for several references in the form of scientific journals or scientific articles from research with the keyword microbial contamination analysis.

Pengaruh fermentasi tepung kulit kopi Oleh Aspergillus oryzae dengan penambahan dua variasi konsentrasi urea dan amonium sulfat terhadap penurunan serat kasar salman salman; Kurniawan Sinaga; Meutia Indriana; Yessi Febriani; Zulfikar Zulfikar
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

The high yield of coffee causes an increase in the amount of coffee husk waste produced, so innovations are needed to process coffee waste so that it can be helpful and not wasted. The study aimed to reduce crude fiber in fermented coffee husks using Aspergillus oryzae to become animal feed. The research was conducted using experimental and descriptive methods: coffee husk flour (Coffea sp.), Aspergillus oryzae, urea, ammonium sulfate, and minerals. Coffee husk flour was fermented in dry media and wet media at room temperature for 24 hours, 48 hours, and 72 hours. After fermentation, test the analysis of the decrease in the amount of crude fiber in the sample using the Wendee method test. The results showed that the fermentation of coffee husk flour (Coffea sp.) using Aspergillus oryzae with the addition of urea, ammonium sulfate, and minerals could reduce the amount of crude fiber. The difference in fermentation media showed that fermentation in wet media gave better crude fiber reduction results than fermentation in dry media. The crude fiber yield of dry media sample N1 is 0.25 grams (25%), and sample N2 is 0.22 grams (22%), while the crude fiber yield of wet media sample N1 is 0.13 grams (13%) and sample N2 is 0.11 grams (11%). Fermentation with Aspergillus oryzae produces ligninase, an enzyme that breaks down lignin which can degrade lignin into simpler compounds.

Formulasi Sediaan Ekstrak Etanol Kulit Buah Alpukat (Persea Americana Mill.) Sebagai Krim Alas Bedak Hamdhani Hamdhani; Muharni Saputri; Sudewi Sudewi; Linda Margata
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Avocado (Persea americana Mill.) is a plant that is widely grown in Indonesia. Peel avocado is known to contain secondary metabolites such as flavonoids which are useful as antioxidants. This study aims to determine the peel of avocado (Persea americana Mill.) in the form of ethanol extract can be formulated into a foundation cream preparation which at a certain concentration has antioxidant activity. Method; The study was conducted using an experimental method, using peel avocado test material (Persea americana Mill.) processed by maceration using 96% ethanol extract formulated into a foundation cream preparation in a concentration of 1.5%; 2%; 2.5%; and blank. Examination of the physical quality of the preparation includes homogeneity test, pH test, viscosity test, stability test, irritation test, moisture test and antioxidant activity test. Result; The results showed that the yield of peel avocado (Persea americana Mill.) was 12.99%. All formulations met the requirements of the gel evaluation test with a pH range of 6.0-6.5. After doing the cycling test, it was 5.9-6.2. The viscosity results are 15,250-20,050 mPa.S. All formulations are homogeneous and stable. Formulation 3 has an IC50 value of (54.74µg/mL) in the "strong" antioxidant category and has a % recovery value of 67.23%.

Formulasi sediaan garam mandi dengan penambahan pewarna alami kopigmentasi kesumba keling (Bixa orellana L.) dan angkak merah Salman Salman; Agustina Magdalena; Sudewi Sudewi; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Annato seeds and red yeast rice contain carotenoids and anthocyanins as natural dyes so that they can replace synthetic dyes. This study aims to determine the copigmentation of annatto seeds and red yeast rice in the form of ethanol extract which can be formulated as a natural dye into salt bath preparations. Methods; Annatto seeds and red yeast rice were macerated using 96% ethanol. Making formulations in concentrations of 3%, 6% and 9%. Then the preparation evaluation test was carried out which included the pH test, water content test, dissolution time test, moisture test and irritation test. Result; The yield of annatto seeds and red yeast rice was 8.65% and 11.19%, respectively. The preparation of copigmented bath salts of annatto seeds ethanol extract with red yeast rice is a preparation that has a pH range of 7.4-7.5, with a dissolving time of under 5 minutes. The preparation of copigmented bath salts with the ethanol extract of annatto seeds and red yeast rice with a concentration of 6% (F2) is a preparation containing a water content of 13.5% and a humidity of 58.8% including the "moist" category. the results of testing on volunteers showed that salt bath from copigmentation of annatto seeds and red yeast rice did not cause irritation

Formulasi Dan Uji Efektivitas Sediaan Salep Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S.Moore) Terhadap Penyembuhan Luka Bakar Pada Marmut Jantan (Cavia porcellus) Muharni Saputri; Yessi Febriani; Olyvia putri Olyvia putri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Scar tissue formation due to infectious burns causes delayed maturation of the epidermis. Sintrong contains flavonoids, alkaloids, glycosides, saponins, tannins, and steroids which have anti-inflammatory and antioxidant functions and can protect the body from the harmful effects of free radicals. Preparations with good titration and long exposure times are needed to treat burn problems. This study aims to determine the process of making sintrong leaf ointment (Crassocephalum crepidiodes (Benth.) S.Moore) and the effect of treating burns from sintrong leaf extract in an ointment preparation that has been tested on male guinea pigs (Cavia porcellus). Methods; In this study, test methods were used by means of simplicia preparation, characterization, test phytochemical screening, extraction, formulation and adjustment of ointment preparations to concentrations of 0.5%, 1% and 1.5%, as well as evaluation of ointment tests which included stability tests, sensory tests, homogeneity tests,adhesion, spreadability, pH test, irritation test and efficacy test of ointment preparations. The results obtained from the characteristic examination indicate that the simplicia of the sintrong leaf has fulfilled the requirements of the characteristic test for simplicia. Result; The results of the phytochemical test showed that the positive sintrong leaves contained alkaloids, flavonoids, glycosides, saponins, tannins and triterpenes or steroids. The results of the evaluation of the ethanol extract of sintrong leaf ointment for stable results. The best formulation is formula 3 with a concentration of 1.5% with a wound healing diameter of 0.13 cm on the 21st day

Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Sintrong (Crassocephalum crepidioides (Benth.) S. Moore) Terhadap Tikus Putih Jantan Yang Diinduksi Aloksan Muharni Saputri; Debi Sanura Boru perangin angin; Salmah Handayani Lubis
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Diabetes is a disease that occurs over a long period of time caused by the pancreas not being able to produce insulin optimally or the body not using insulin effectively. The administration of antidiabetic drugs in the form of insulin and oral is the treatment for diabetes. However, because the price is expensive for the middle to lower class, the treatment of sintrong leaf medicinal plants (Crasocephalum crepidioides (Benth.) S. Moore m mm) was developed. The purpose of this study was to determine the effectiveness of ethanol extract of sintrong leaves as an antidiabetic and able to reduce blood sugar levels (BSL) from fasting male white rats induced by alloxan. Methods; The stages of this study include plant identification, preparation of dry powder simplisia, characterization of simplisia, screening of secondary metabolite compounds (phytochemistry), extraction of dry simplisia powder of sintrong leaves, and testing of antidiabetic activity using 25 rats divided into 5 groups, the negative control group (CMC-Na), the positive control group (metformin), the test group of ethanol extract of sintrong leaves at a dose of 75 mg / kgbw, 150 mg / kgbw, and 300 mg / kgbw. As a test group, the administration of extracts to rats was given orally and then the BSL was measured. Blood sugar was determined at the beginning of fasting, day 3, 6, 9, 12, 15. Blood sugar of each group was statistically analyzed by one-way ANOVA method. Results; Based on the test results from each test group, the ethanol extract of sintrong leaves showed that the ethanol extract of sintrong leaves as antidiabetic activity that can reduce fasting BSL in male rats with an effective dose of 150 mg/kgbb with BSL obtained 89.40 mg/dL on day 15

Page 5 of 62 | Total Record : 616

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Home Page

OAI Link

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Journal Mail Official admin@journal-jps.com

Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Contact Name
Salman

Contact Email
salman.kimia@gmail.com

Phone
+6285277011177

Journal Mail Official
admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
Kota medan,

Sumatera utara

INDONESIA