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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 235 Documents

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Cytotoxic Effect of Ethanolic Extract of Sarang Semut (Myrmecodia pendens) on HeLa Cervix Cancer Cell Line In Vitro Experimental Study Fatmawati, Dina; Puspitasari, Prista Karina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Sarang semut (Myrmecodia pendens) is a traditional plant that has been known to contain anti cancer components. Flavonoids and tannins were contained in sarang semut plant which are believed has cytotoxic effect against cancer cell line. This study aims at cytotoxic effect ethanolic extract of sarang semut at various concentrations on HeLa cervical cancer cell line.Design and Method: The method was quasi experimental with post test only non equivalent control group design. HeLa cell was divided into two groups. The first group as positive control with doxorubicin, second group as treatment with ethanolic extract of sarang semut at various concentrations. Ethanolic extract of sarang semut concentrations used were 3,91 Î¼g/ml; 7,81 Î¼g/ml; 15,63 Î¼g/ml; 31,25 Î¼g/ml; 62,50 Î¼g/ml; 125 Î¼g/ml; 250 Î¼g/ml; 500 Î¼g/ml; 1000 Î¼g/ml. Cytotoxic effect was evaluated by direct counting method with tryphan blue dye then using probit regression analysis to find IC50 value.Result: Inhibitory concentration 50 (IC50) value ethanol extract of sarang semut was 33,28 Î¼g/ml. Ethanol extract of sarang semut had a cytotoxicity effect categorized as the moderately active (20 Ã¬g/ml< IC50< 100Ã¬g/ ml). Inhibitory concentration 50 (IC50) value doxorubicin was 5,56 Î¼g/ml. Cytotoxicity effect of doxorubisin higher than cytotoxicity effect of ethanolic extract of sarang semut.Conclusion: Ethanolic extract of sarang semut (Myrmecodia pendens) had a cytotoxic effect categorized as the moderately active on HeLa cell (Sains Medika, 3(2):112-120).

The Correlation between the Dimention of Trust among the Member of the Group and the Effectiveness of PBL Tutorial Group Istadi, Yani
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: The tutorial plays a central role in problem-based learning (PBL). The effective implementation of small group tutorials is one of the key contributors to the students success in examinations. This study aimed to identify factors perceived as the predictors for effectiveness of PBL group tutorial.Design and method: The subjects of the study were all of the students (year of 2008) of the Medical College of Sultan Agung Islamic University taking the Tropical Disease Module. The adapted version of the scales adopted in this study included the scale developed by Van den Bossche et al for assessing team (group) effectiveness, trust dimension and learning behavior, a scale developed by Dolmans & Ginns (2005) for assessing tutorâ€™s performance, a 5 points likert scale was used to asses the student opinions. Quantitative approach with correlation and multiple regression analysis was applied.Result: Of 238 students included in the study 84 (37.3%) were male and 139 (62.3%) were female. There was a significantly positive correlation between the trust dimension related to the interpersonal relationship among the members of tutorial group with the effectiveness of tutorial group ( r = 0.631, p< 0.01). There was a medium correlation among cohesion, group potency and psychological (r= 0,700, p < 0.05 there was correlation among the variables of (r = 0,557, p < 0,001), group potency (r = 0,517, p < 0,001), and psychological assurance (r = 0,437, p < 0.001). These three variables contributed to the group effectiveness as much as 48.4% with a F value of 87.857. The component of independence was not found to be the predictive factors for group effectiveness. The correlations among the variables of cohesion, group potency and psychological assurance resulted in contingency coeficien of 0.700 with p<0.05.Conclusion: The higher trust related to the interpersonal relationship among the member of groups, the more effective the group will be. Cohesion, group potency and psychological assurance were found to be the predictive factors for group effectiveness (Sains Medika, 3(1):16-23).

Probiotics Effect on Interleukin-4 (IL-4) and Imunoglobulin E (IgE) Levels on Asthmatic Patients Pujiati, Pujiati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Probiotics may play a role in immune system maturation and may reduce the risk of allergies and asthma in childhood. However, the therapeutic benefits of probiotics in asthma depend on various factors such as strain of probiotics and dosing regimen. Objectives: The aims of this study was to evaluate the effect of probiotic (LactoBÃ‚Â®) on Immunoglobulin E (IgE) and Interleukin (IL-4) serum level in childhood Asthma. Methods: Forty children aged 1-5 years with asthma were recruited into a randomized controlled trial. The children were assigned into a probiotic (Lactobacillus acidophilus, Bifidobacterium longun, Streptococcus; Lacto BÃ‚Â®) or an equivalent volume of placebo, twice daily orally for 8 weeks. The IgE and IL-4 serum level were determined by ELISA. The differences between groups were analyzed by t-test dependent with confidence interval of 95%. Results: In intervention group, mean of IgE serum levels after the probiotics treatment was significantly lower compared to that of before the treatment (148.18 pg/mg; 283.20 pg/mg; respectively). Mean of IL-4 serum levels after the treatment was significantly lower compared with that of before the treatment (111.03 pg/mg; 142.08 pg/mg respectively). In control group, there were no significant differences between IgE serum levels mean before the administration of placebo and after the intervention (292.39 pg/ml; 286.94 pg/ml respectively). There were no significant differences between IL-4 serum levels mean before and after the treatment (136.76 pg/ml; 139.56 pg/ml).Conclusion: there was an effect of probiotics supplementation on IgE and IL-4 serum levels in childhood asthma.

Effect of Strenuous Physical Activity on Cortisol and Leukocyte in Mice Mushidah, Mushidah; Nasihun, Taufiqurrahman; Hussaana, Atina
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Strenuous physical activities cause an increase in free radicals, physical stress, psychological stress and decreased immunity. Psychological stress affects the hypothalamic-pituitary-adrenal (HPA) axis leading to increased levels of cortisol and blood cell apoptosis. However, the studies on the effect of strenuous physical activities on cortisol levels and leukocyte count showed inconsistent findings. Objectives: To examine the effect of strenuous exercise on cortisol levels and leukocytes count.Methods: In this study with post test only control group design, 15 male BALB/c mice were randomly assinged to the following 3 groups: control (non-exercised) group (G-0), once strenouse physical activity (G-1), 3 times strenuous physical activity (G-2). Cortisol levels were evaluated by ELISA.White blood count was determined. Data were analyzed by one way ANOVA test followed by Post Hoc and Pearson, with a confidence level of 95%.Results: The mean cortisol level in group G-0, G-1, G-2 were 11.86 Â± 2.10Î¼g/dL, 32.00 Â± 0.86Î¼g/dL, 44.58 Â± 1.74Î¼g/dL respectively. The number of leukocytes in G-0, G-1, G-2 were 6180Â±540.37/mm3, 4650Â±217.94/mm3, 4180Â±130.38/mm3 respectively. One way ANOVA showed a significant difference between groups (p <0.001). Post Hoc Test showed that the levels cortisol in G-1 and G-2 were significantly higher than thatof G-0 (p <0.001). The number of leukocyte in G-1 and G-2 was lower than that of G-0 (p <0.001). There was a significant negative correlation between cortisol levels and the number of leukocytes (r = -20.14, p <0.001).Conclusions: Strenuous physical activity increasescortisol levels and decrease the number of leukocytes in BALB /c mice.

The Role of Antioxidant to Prevent Free Radicals in The Body Zulaikhah, Siti Thomas
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

AbstractAntioxidants are compounds that can counteract or reduce the negative impact oxidants in the body. Antioxidants work by donating an electron to compounds that are oxidant so that the oxidant compound activity can be inhibited. Antioxidants are classified into two, namely antioxidant enzymes and non-enzyme. Antioxidant enzymes as enzyme superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), a non-enzyme antioxidant found in many vegetables and fruits, which include reduced glutathione (GSH), vitamin C, E, Î²- carotene, flavonoids, isoflavones, flavones, antosionin, catechins, and isokatekin, and lipoic acid. Low antioxidant enzymes can be used as a marker of high levels of free radicals in the body. Following review aims to provide an overview of the role of antioxidants in preventing the formation of free radicals in the body.

The Correlation between Duration of Employment, Body Posture and Smoking Habit on Low Back Pain Incidence An Analytic Observational Study Among Taxi Driver in Semarang Municipality Firmanita, Syifa Dian; Rosdiana, Ika; Indrayani, Ulfah Dian
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Low back pain ((LBP) ranks as number two of neurological diseaseÃ¢â‚¬â„¢s highest prevalence after cephalgia and migraine in Indonesia. Objective: This study aim to determine the relationship between duration of employment, body posture and smoking habit on the incidence of low back pain on taxi driver. Method: This research is an observational analytic cross sectional design. Seventyfour taxi drivers in Semarang municipality was screened with BeckÃ¢â‚¬â„¢s Depression Inventory Scale to meet the inclusion and exclusion criteria. Respondents were then given Risk Factor of LBP questionnaire. Data were analyzed with a bivariate correlation test contingency coefficient to see the relationship between duration of employment, body posture, smoking habit and low back pain.Result: the taxi driver with duration of employment >10 years were moderate smokers and having astenis body posture. The analysis of correlation coefficients contingency test showed a significance relationship between duration of employment (p = 0,000), body posture (p = 0,000), and moderate smokers (p=0.010) with the incidence of LBP. Conclusion: the taxi driver with duration of employment >10 years with astenis body posture, and moderate smokers were posstively correlated with LBP.

HIGH DOSE VITAMIN C ADMINISTRATION EFFECT IN LEYDIG CELLS, SERTOLI CELLS NUMBER, AND SPERM QUALITY ON MALE WISTAR RATS Dwi Juniatiningrum, Ratna; Nasihun, Taufiqurrachman; Isradji, Israhnanto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2018): June 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction:Â Most infertile male areÂ associatedÂ with poor spermatogenesis due toÂ oxidative stress, and can be preventedÂ withÂ vitamin C.Â However,Â excessiveÂ amount of high dose of vitaminÂ CÂ canÂ hinderedÂ and lower the sperm quality.Â Objective: To prove that high dose vitamin C is capable to decrease the number of leydig cells, sertoli cells, and sperm qualityÂ on male wistar rats.Methods:Â This research was using experimental methodÂ with PostÂ Test Only Controlled Group Design.Â Of 24Â male Wistar rats,Â divided randomly to 4 groups.Â Normal groups (NorÂ -G),Â only given 2 ml/day distilled water;Â vitamin CÂ groupÂ (VC18-G,Â VC36-G,Â andÂ VC72-G)Â givenÂ 18 mg/day, 36 mg/day and 72 mg/dayÂ vitamin C respectively, dissolved in 2 ml of distilledÂ water.Â Sperm,Â the number of Leydig cellsÂ andÂ Sertoli cells wereÂ takenÂ from theÂ epididymis andÂ left right testicleÂ on dayÂ 21.Â Sperm analysis using WHO standard, while the number of Leydig cells and Sertoli cells with HE staining.Results:Â Mann Whitney analysis indicated that the number of sperm inÂ VC36-GÂ andÂ VC72-G are lower compared to thatÂ of Nor-GÂ andÂ VC18-G groups,Â p <0.05.Â Post-Hoc LSDÂ analysis showed that theÂ lowest number of LeydigÂ andÂ Sertoli Cell,Â and the weakest spermÂ motility and morphologyÂ inÂ VC36-GÂ andÂ VC72-GÂ groups, compared to that ofÂ Nor-GÂ andÂ VC18-GÂ groups,Â p <0.05Â .Conclusion: Vitamin C 36Â and 72 mg/dayÂ were capable of reducingÂ LeydigÂ andÂ Sertoli cellsÂ number, andÂ worsen spermÂ quality,Â characterized by decreased in sperm concentration, motility and morphologyÂ inÂ WistarÂ male-Â rats.

The Relationship between Total Blood Cholesterol Level and VO2 max in 6-Minute Walk Test An Analitical Observational Study in Students of Medical Faculty UNISSULA aged 19 to 21 years Innash, Rahmaan; Rosdiana, Ika
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2013): January-June 2013
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

The increase in total cholesterol level is a risk factor for coronary heart diseases leading to decrease in fitness. VO2 max is the biggest advocate for heart and lung fitness. There have been few studies conducted on relationship between total cholesterol level and VO2 max. The purpose of the study was to determine the relationship between total colesterol level and VO2 max through the 6-minute walk test. In this Analytical observational study with the population of medical faculty students of 2009, 2010, 2011 included 51 persons aged 19-21 years. Total cholesterol level was measured by specthrophotometer from blood. VO2 max analyzed by the 6-minute walk test. The study resulted in mean VO2 max of 24.48 ml/kg/min, mean of total blood cholesterol of 164.16 mg/dl. Pearson correlation test showed there was a significant correlation between total blood cholesterol level and VO2 max (p < 0.05), with negative correlation r = -0.281. An increase in the blood levels of total cholesterol will decrease physical fitness (VO2 max).

TOPICAL ADMINISTRATION OF ALOE VERA EXTRACT GEL INCREASED THE NUMBER OF MACROPHAGES AND EPITHELIALIZATION IN UVB-INDUCED SUNBURN Tadihoedojo, Ersje Retnowati; Dharmana, Edi; Chodidjah, Chodidjah
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

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INTRODUCTION: The UVB exposure may cause sunburn (second degree burn). Aloe vera (AV) is widely used in wound healing, including sunburn.OBJECTIVE: To evaluate the effect of topical Aloe vera extract gel on the number of macrophages and epithelialization in UVB induced sunburn.METHODS: This posttest only-control group design used twenty female BALB/c mice with UVB-induced sunburn randomly divided into 4 groups. Control groups (Cntrl-G) were given a base gel. Group AV-25, AV-50, and AV-75 were topically treated with Aloe vera gel at the concentration of 25%, 50% and 75% respectively for 5 days. On day 5, after terminated, the samples of skin tissue were prepared for histological study using hematoxlyin eosin (HE) staining. Data were analyzed using one way ANOVA, Post-hoc LSD and Pearson correlation.RESULTS: ANOVA analysis showed that the number of macrophages and epithelialization among groups was a significantly difference (p <0.05). Post hoc analysis demonstrated that the mean number of macrophage in AV-75 (6.50), AV-50 (5.13), and AV-25 (3.93) were significantly higher compared to that of Cntrl-G (2.93). The mean of epithelialization AV-75% (25.35), AV-50 (18.15), and AV-25 (15.38), were significantly (p <0.05) higher compared to that of Cntrl-G (9.30). The Pearson correlation test indicated that there is a strong positive correlation (0.88) between the number of macrophages and epithelialization (p <0.05).CONCLUSION: The topical administration of Aloe vera gel extract for five days increased the number of macrophages and epithelialization in sunburned UVB induced sun burn.

Pengaruh Konsentrasi Ekstrak Etanolik Daun Teh Hijau (Camellia sinesis L.) dalam Sediaan Krim terhadap Sifat Fisik dan Aktivitas Antibakteri Widyaningrum, Naniek; Murrukmihadi, Mimiek; Ekawati, Syarifatun Karunia
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Green tea, is one of the herbs that have been proven to be effective as an anti-acne, among others.Green tea leaves contain 30-40% polyphenols known as catechins most of which are antimicrobial. For ease of use, the ethanolic leaf extract of green tea is made in cream. This study aimed to determine the effect of variations in the concentration of ethanolic extract of green tea leaves in cream on the physical properties and antibacterial activity of acne bacteria in particular.Design and Method: In this study, green tea leaf extract condensed obtained by maceration using 50% ethanol solution. Cream formula that is made in five concentration ethanolic extract of green tea leaves 1%, 3%, 5%, 7%, and 9% use a modified formula antiacne cream. Cream tested physical properties include homogenity, percent separation, dispersive power and adhesion. During the antibacterial activity was also tested. The data obtained were analyzed statistically using the non-parametric Kruskal-Wallis test followed by Mann Whitney test with a level of 95%.Results: The preparation cream ethanolic leaf green tea extract at various concentrations have good homogenity and not separate, the greater concentration of cream ethanolic extract of green tea leaves get smaller power and energy dispersive adhesion, whereas the inhibitory against Staphylococcus aureus bacteria is getting biger. Conclusion: Cream ethanolic extract of green tea leaves that are comparable with the positive control (Ristra acne creaming) the physical properties and the antibacterial activity at a concentration of 7% (Sains Medika, 4(2):147-156).

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