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Current Biomedicine
Published by Institut Pertanian Bogor
ISSN : 29628490     EISSN : 29854784     DOI : https://doi.org/10.29244/currbiomed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary
Aim. Current Biomedicine aims to publish scientific article in the biomedical fields. Scope. Current Biomedicine will publish widely relevant topic in the field of biology (life science), directly or indirectly, support the improvement of human health. These fields include, but are not limited to: anatomy, physiology, histology, embryology, genetics, pharmacology, toxicology, pharmacy, parasitology, pathology, microbiology, clinics, radiology and imaging, surgery, experimental surgery, reproduction, ethnomedicine, phytopharmaceuticals, biotechnology, biomedical engineering, bioinformatics, public health, epidemiology, legislation and bioethics, and one health.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol. 1 No. 2 (2023): July" : 8 Documents clear
Effect of the partial solar eclipse on the behavior and activity of rats Tarigan, Ronald; Achmadi, Pudji; Bustamam, Isdoni; Santoso, Koekoeh
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.62-69

Abstract

Circadian rhythm is the adaptation response of animals against light alteration that affects various behavioral and physiological responses. Bright light is a danger signal for nocturnal animals because it exposes them more to predators. This research aimed to study the changes in the behavior of rats during the partial solar eclipse (PSE) period. The PSE period occurred across Bogor, Indonesia, on 9 March 2016. The PSE started at 06.19 AM, peaked at 07.21 AM, and ended at 08.30 AM. The light level decreased since the early solar eclipse, then dropped significantly at the peak period. The activities of six mature male Sprague Dawley rats were measured using Opto-Varimex-5 Auto Track System during the PSE period. The measurements were repeated one day after the PSE period as the non-PSE period. There were significant differences (P<0.05) in stereotypic time, burst of stereotypic movement, and horizontal count in the early, peak, and end periods of the PSE period compared with the values at the same time of the non-PSE period. The activities of rats changed during the PSE period. Rats did not rest as in their normal nocturnal behavior during darkness but were more active and stressed because of the rapid change in light level during the PSE period.
Penyembuhan luka sayatan menggunakan krim ekstrak teripang laut dan kunyit Alpayet, Rahmat; Mustika, Aulia Andi; Rahma, Anisa; Andriyanto; Sutardi, Lina Noviyanti
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.54-61

Abstract

Background: Skin is the outermost layer that covers and protects the body and is vulnerable to trauma, such as wounds. Turmeric and sea cucumbers are known to have properties in wound healing. Objective: This study aims to determine the effectiveness of a mixture of sea cucumber and turmeric extracts in the form of a cream to heal incision wounds in rats. Methods: Twenty-five male white rats, Sprague Dawley strain, and body weights of 250–300 g were anesthetized, and their skins were slashed. The rats were divided into five groups, namely negative control (wounds without treatment), positive controls (wounds treated with Bioplacenton® topically), and three treatment groups (wounds treated with sea cucumber and turmeric extract cream with concentrations of 0.5%, 1%, and 2% topically). Wound healing parameters were observed daily, namely accelerated wound closure and inflammation reduction. Data were analysed descriptively and tested using the non-parametric Kruskal-Wallis’s test. Results: The results showed that the wounds closed completely in all treated groups. Healing time in the group receiving treatment (positive control and concentration treatment of 0.5%, 1%, and 2% were 8.3 ± 1.5 days, 10.3 ± 0.6 days, 9.3 ± 0 .6 days, and 8.3 ± 1.5 days, respectively) faster than the healing time of the group that did not receive treatment (negative control was 12.6 ± 0.6 days). Conclusion: This study showed that sea cucumber and turmeric extract cream has the potential and is effective for wound healing and can be used as an alternative for wound treatment.
Uji sitotoksik ekstrak cabai merah keriting (Capsicum annuum) pada sel WiDr secara in vitro Fadholly, Amaq; Sudjarwo, Sri Agus; Rantam, Fedik Abdul; Mustika, Aulia Andi; Andriyanto, Andriyanto; Pristihadi, Diah Nugrahani; Sutardi, Lina Noviyanti
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.70-75

Abstract

Latar belakang: Kanker masih menjadi salah satu penyebab kematian di dunia. Salah satu alternatif metode untuk mengobati kanker adalah dengan obat herbal yang mempunyai khasiat sebagai antikanker. Tujuan: Penelitian ini bertujuan untuk manganalisis efek sitotoksik esktrak Capsium annuum pada sel WiDr. Metode: Kemampuan sitotoksik ekstrak Capsium annuum diuji secara in vitro pada sel WiDr menggunakan metode MTT tetrazolium reduction assay. Hasil: Hasil uji MTT menunjukkan bahwa ekstrak Capsicum annuum menghambat proliferasi sel WiDr seiring dengan peningkatan konsentrasi (400, 800, dan 1600 ppm), dengan persentase penghambatan sel tertinggi diperoleh pada konsentrasi 800 ppm dari setiap kelompok terapi 24, 48, dan 72 jam. Nilai inhibitory concentration 50 (IC50) terendah dihasilkan oleh kelompok waktu terapi 48 jam, yaitu 651,18 ppm. Simpulan: Nilai IC50 ekstrak Capsicum annuum untuk sel WiDr memiliki nilai yang tinggi yang menunjukkan belum efektif sebagai obat antikanker. Penelitian lebih lanjut dibutuhkan untuk mendapatkan dosis terbaik agar dapat menghambat pertumbuhan sel WiDr secara maksimal.
Perkembangan terkini penyakit strangles yang disebabkan oleh bakteri Streptococcus equi subspecies equi di Indonesia Rotinsulu, Dordia Anindita
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.76-85

Abstract

Background: Horses have played an essential role in human life for thousands of years, including for transportation, sports, consumption, and recreation. Because of the benefits of horses and their importance to humans, the effects of horse diseases can also affect humans. One of the most frequently diagnosed infectious diseases in horses worldwide is strangles caused by the beta-hemolytic bacterium Streptococcus equi subspecies equi. Objective: This review aims to collect the latest information on strangles, including the epidemiology, diagnosis, prevention, and treatment of strangles globally and specifically in Indonesia. Results: Strangles cases have been reported sporadically in Indonesia. Laboratory diagnosis of strangles can be performed through bacteriological culture, PCR and serological tests. Streptococcus equi subspecies equi is susceptible to penicillins. Conclusion: Control of strangles can be conducted by applying biosecurity and vaccination. However, currently, there is no commercially available strangles vaccine in Indonesia.
Total plate count dalam isi telur ayam ras di pasar tradisional Kecamatan Waru, Kabupaten Sidoarjo Budiarto, Budiarto; Kirana, Sabila Citra; Lestari, Tita Damayanti; Budiarto; Puspitasari, Yulianna; Mutamsari Witaningrum, Adiana; Permatasari, Dian Ayu
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.86-94

Abstract

Background: Microbial contamination in consumed chicken eggs can endanger human health. Bacteria can grow and develop in food so that it can reduce the food quality. Determination of food quality can be done by various methods, one of which is Total Plate Count (TPC). Objective: The aim of this study was to determine the level of bacterial contamination in chicken eggs sold at traditional markets in Waru District, Sidoarjo Regency. Methods: Thirty samples were collected from two traditional markets, Waru Market and Wadung Asri Market. This study used the pour plate method of TPC test. Egg contents were diluted and then inoculated in Nutrient Agar. The media inoculated with the sample suspension was incubated at 37°C for 24 hours. The growing bacterial colonies were counted and analyzed using the Standard Plate Count. This study's data are presented descriptively and compared with the Indonesian National Standard (SNI) 7388-2009 maximum requirement of contaminant bacteria in chicken eggs is 1×105 CFU/mL. Results: The results showed that the averages TPC in two traditional markets were 2.1×104 CFU/mL in Waru Market and 3.4×103 CFU/mL in Wadung Asri Market. The average TPC still meets the maximum limit of microbial contamination listed in SNI 7388-2009. Conclusion: The average values of TPC in both markets are not the same, but the qualities of chicken eggs sold in Waru Market and Wadung Asri Market are good and suitable for consumption.
Immunostimulatory activity of avocado oil in mice (Mus musculus) Jusuf, Elena Adjani; Mustika, Aulia Andi; Andriyanto, Andriyanto
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.95-102

Abstract

Avocado fruit contains bioactive compounds that have the potential to act as an immunomodulator. This study aims to identify the ability of avocado oil as an immunomodulator based on the macrophage phagocytic activity and index of mice injected with nonpathogenic Staphylococcus aureus and to determine the most effective dose as an immunomodulator. This study used 30 male Deutschland Denken Yoken (DDY) mice, which were divided into five groups: placebo as negative control (mineral water), positive control (commercial immunomodulator containing Echinacea purpurea extract), and avocado oil 1 g/kg BW, 3 g/kg BW, and 5 g/kg BW. The treatment was carried out orally once a day for 14 days. Mice were induced by nonpathogenic Staphylococcus aureus on day 15 intraperitoneally, and after one hour, mice were euthanized to collect the peritoneal fluid. Peritoneal fluid smear preparations were made before active macrophages and phagocytosed Staphylococcus aureus were observed under a microscope. Phagocytic activity and phagocytic index were calculated. Avocado oil 5 g/kg BW showed the highest phagocytic activity and phagocytic index results with values of 71.00% ± 5.40% and 2.79 ± 0.14, respectively. Avocado oil enhances non-specific immune responses through macrophagephagocytic activity and index, demonstrating its immunostimulatory potential.
Front Matter Vol 1 No 2 Biomedicine, Current
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.i-iv

Abstract

https://doi.org/10.29244/currbiomed.1.2.i-iv
Back Matter Vol 1 No 2 Biomedicine, Current
Current Biomedicine Vol. 1 No. 2 (2023): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.1.2.v-xi

Abstract

https://doi.org/10.29244/currbiomed.1.2.v-xi

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