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CERATA
Published by Universitas Muhammadiyah Klaten
ISSN : 20891458     EISSN : 26851229     DOI : https://doi.org/10.61902/cerata
Core Subject : Health,
Medicine & Pharmacology
Its Journal covers a lot of common problems or issues related to the Pharmaceutical sciences, including Pharmacetics, Biopharmacy, Drug Delivery Systems, Pharmaceutical Physics, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Biotechnology and Microbiology, Pharmacology and Toxicology, Pharmacokinetics, Clinical and Community Pharmacy, Pharmaceutical Regulation and Marketing, Herbal Medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 118 Documents
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Optimasi Formula Sirup Ekstrak Etanol Daun Sukun (Artocarpus altilis) Dengan Pemanis Sorbitol dan Co – Solvent Propilen Glikol Nurul Hidayati; Ivan Nuryanto; Saifudin Zukhri
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i2.80

Abstract

Breadfruit leaves (Artocarpus altilis) are effective in reducing high blood sugar levels. One of the uses of breadfruit is by making it into syrup. The manufacture of breadfruit leaf ethanol extract is expected to improve the bitter taste of breadfruit leaves. This study aims to determine the effect of variations of sorbitol and propylene glycol and to obtain the optimum value of sorbitol and propylene glycol on the physical properties and hedonic value of syrup preparations. Breadfruit leaveswas extracted by multilevel maceration with 70% ethanol. Thick breadfruit leaf extract made syrup preparations in 5 runs with variations of sorbitol: propylene glycol, namely Run 1 (20%: 25%), Run 2 (35%: 10%), Run 3 (31.25%: 13.75% ), Run 4 (27.5%: 17.5%) and Run 5 (23.75%: 21.25%). The syrups were tested for their physical properties including organoleptic, viscosity, pH and hedonic tests. The test results are optimized with Simplex Lattice Design. The optimum formula of the predicted results is verified by analysis of one sample t-test with a 95% confidence level.The results showed an increase in sorbitol and propylene glycol increased the pH and hedonic values but did not affect the viscosity value of syrup preparations. Sorbitol concentration of 30,0005% and propylene glycol 14.9995% produced syrup with pH and hedonic value optimum differed insignificantly with p-values> 0.05.
Skrining Fitokimia Dari Infusa Dan Ekstrak Etanol 70% Daun Cincau Hijau(Cyclea barbata Miers) Siti Nur Oktavia; Endang Wahyuningsih; Sholikhah Deti Andasari; Normaidah
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.84

Abstract

Green grass jelly leaf (Cyclea barbata Miers) is a plant that has many benefits with the content of green grass jelly leaves (Cyclea barbata Miers) which are carbohydrates, fats, proteins and other compounds such as polyphenols, flavonoids and minerals such as calcium, phosphorus, vitamin A, and vitamin B. This study aims to determine the comparison of the results of the phytochemical screening of infusion and green grass jelly leaf extract (Cyclea barbata Miers). This research is a type of experimental research conducted at the Laboratory of Pharmaceutical Analysis STIKES Muhammadiyah Klaten. The research stages included sample preparation, extraction process, and phytochemical screening. The data analysis of this research is in the form of qualitative, the data is presented in tabular form and then the results are described. The results of phytochemical screening on green grass jelly leaves showed that the maceration and infusion processes of green grass jelly leaves contain flavonoids, alkaloids, saponins, and tannins. The difference is in the color change that occurs from the results of determining the flavonoid compounds, the results show that the color of the maceration extract is brownish yellow, while the color in the infusion is yellow. The conclusion of this study shows that green grass jelly leaf extract contains flavonoids, alkaloids, saponins, and tannins.
FORMULASI SABUN MANDI CAIR EKSTRAK KULIT JERUK MANIS VARIETAS SIAM (Citrus sinensis L.) DENGAN VARIASI KONSENTRASI SURFAKTAN SODIUM LAURIL SULFAT Handayani, Sri; hidayati, Nurul; aprilianti, Rian
CERATA Jurnal Ilmu Farmasi Vol 9 No 2 (2018): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v9i2.86

Abstract

Citrus sinensis L. skin is a high-value waste because it contains vitamin C. The Citrus sinensis L. skin of siam varieties is formulated into liquid soap using sodium lauryl sulfate which acts as a surfactant and as a good foaming agent. The aims of this study are to determine the effect of variations in the concentration of sodium lauryl sulfate surfactant on the quality control test for liquid bath soap. The type of research used is experimental research. This research uses the extract of conjoined sweet orange peel obtained by maceration for 6 days using 70% ethanol solvent and maceration repeated for 4 days so that the extract obtained is more. Liquid soap is made in 3 formulas with varying concentrations of sodium lauryl sulfate. Formula I uses a concentration of 8%, formula II 17% and formula III 26%. The quality control test of the preparation includes organoleptic, pH, specific gravity, viscosity and high foam. The data obtained were statistically analyzed with one-way analysis of variance (ANOVA) with a confidence level of 95%. The results showed that variations in the concentration of sodium lauryl sulfate could affect the quality control test for liquid bath soap. The three formulas of liquid bathing soap extract of sweet orange peel that meet the standard are 2nd formulas, namely black, distinctive odor of orange peel, thick consistency with pH 6, having specific gravity between 1.039-1.095 g / ml, having a viscosity of between 1.10- 7.90 cps and foam height 0.80-2.00 cm.
Uji Efektivitas Ekstrak Etanol Daun Cincau Hijau (Cyclea barbata Miers) Terhadap Bakteri Staphylococcus aureus Muchson Arrosyid; Sutaryono; Resia Muliana
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i2.87

Abstract

Infection is a disease caused by bacteria. For Example of bacteria that can cause infection is bacteria Staphylococcus aureus. The development of traditional medicines derived from nature received the attention of people and the government. Green cincau leaves (Cyclea barbata Miers) is one of plants containing compound as antibacterial. The purpose of this study was to determine the effectiveness of the ethanol extract of green cincau leaves (Cyclea barbata Miers) and to determine the value of Minimum Inhibitory Concentration (MIC) on the growth of Staphylococcus aureus bacter. This research is a type of experimental research. Green cincau leaves (Cyclea barbata Miers) were extracted using maceration method with 96% ethanol obtained by rendering of 4.32% b/b. Microbiology tests use the paper disc diffusion method. Green cincau leaf extract (Cyclea barbata Miers) was made into 3 concentrations namely 25%, 50%, 75% and negative controls using aquadestilata. The results of the research on ethanol extract of green cincau leaves (Cyclea barbata Miers) effectively inhibited the growth of Staphylococcus aureus bacteria. The 50% concentration has an average of 13.20 mm. The concentration of 75% has an average of 15.99 mm. Statistical results show differences in all concentrations with negative aquadestilata controls.
Formulasi Tablet Kunyah Asetosal Dengan Variasi Konsentrasi PVP Sebagai Bahan Pengikat Nurul Hidayati; Ninda Meilany; Sholikhah Deti Andasari
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.89

Abstract

Acetosal which at low doses can be efficacius as an antiplatelet. Acetosal chewable tablet thereby increasing compliance in taking the drug. The aim of this study was to know the effect of polivini pirolidone (PVP) concentration to physical properties and to find out the concentration of PVP which produces the best physical properties. Acetosal chewable tablet is made by direct compression method into 3 formulas with variations concentrations of PVP binder, the first (FI) is using PVP 1%, the second (FII) PVP 3%, the thirth (FIII) PVP 5%. The tablet evaluation included weight uniformity, hardness, friability, disintegration time, liking and responsiveness. The homogeneous analysis used the one-way ANOVA method and the post hoc LSD test, then if the data were not homogeneous, the Kruskall-Wallis test and the Mann-Whitney test. The results showed that the variation in the concentration of PVP as a binder had an effect on the physical properties of acetosal chewable tablets, namely the increase in PVP could increase the brittleness of the tablets, reduce the hardness and disintegration time of the tablets. The PVP 3% concentration in formula II produced the best physical properties of acetosal chewable tablets, namely fulfilling the requirements for weight uniformity, hardness 4,549 ± 0,306 kg, friability 0,183 ± 0,076 %, disintegration time 14,20 ± 0,255 minutes and can be accepted by consumers in the preference and taste response test.
PEMERIKSAAN BAKTERIOLOGI ES BATU BALOK DI KOTA KLATEN agustina, Anita; Al'Azzah, Zuhdiyyah Habibullah
CERATA Jurnal Ilmu Farmasi Vol 9 No 2 (2018): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v9i2.90

Abstract

Ice cubes beams is that cooled water then molded into beams large extremely known to the public and is considered safe to eat. Storage of ice cubes beams that only in put it on the roadside with closed using plastic or sacks and plastic sheeting allow the presence of bacterial contamination. The purpose of this research is analyzing and knows the value of the ALT and MPN Coliform on ice cubes beams that sold in the city of Klaten. The research is observational. A sample of ice cubes beam used is 3 samples to be taken from the seller in in Klaten north, in Klaten central and southern district Klaten. Samples of ice cubes beam were tested ALT and MPN Coliform to determine the value of bacterial contamination. The result of the research using ALT method, shows 2 samples to meet the standard of contamination of samples A and B, while for sample C exceeds the standard of contamination determined by BPOM RI No. HK.00.06.1.52.4011 that is 1x104 UK / ml. For the results of the research using MPN Coliform method, showed that the three samples exceeded the standard of the contamination that has been determined by BPOM RI No. HK.00.06.1.52.4011 ie <3 cells/ ml. The conclusion of this research is that all three samples ice cubes beams unfit for consumed.
Kesesuaian Pelayanan Informasi Obat (PIO) di Apotek Kecamatan Tulung Kabupaten Klaten Rahmi Nurhaini; Fany Munasari; Ratna Agustiningrum
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.94

Abstract

Drug Information Services (PIO) at this time is not just delivering drugs but drugs must be clearly informed to patients so that patients are not mistaken in using the drugs received. A service is considered good if it is in accordance with established standards. This study aims to determine the suitability of information services carried out by Pharmacists in Apotek Kecamatan Tulung Kabupaten Klaten. This research is descriptive in nature using total sampling. The sample in this study were 3 Pharmacists. The results showed that the suitability of drug information service (PIO) in Apotek Kecamatan Tulung Kabupaten Klaten was the most frequently performed namely explaining the time of use of the drug 100% always done and explaining the amount of drug taken at the time drinking in patient 100% always done while explaining the side effects medication from drugs given to patients 100% rerely done.
Hubungan Kepatuhan Minum Obat terhadap Keberhasilan Terapi pada Pasien Hipertensi di Puskesmas Prambanan Sleman Bulan Januari – Februari 2020 Hesti Sumiasih; Trilestari; Widyaningrum Utami
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.95

Abstract

Hypertension or high blood pressure can be interpreted as an increase in systolic and diastolic blood pressure of more than 140 mmHg. Hypertension is often referred to as the silent disease. One of the determining factors for the success of therapy in hypertensive patients is adherence to taking antihypertensive drugs. The purpose of this study was to determine the relationship between medication adherence to the success of therapy in hypertensive patients at Prambanan Public Health Center, Sleman. This research is a non-experimental research with analytical survey method and cross sectional design. The study was conducted on 100 respondents who met the inclusion and exclusion criteria. The research was conducted from January to February 2020. The research instrument used was the MMAS-8 questionnaire which had been tested for validity and reliability. The relationship between the level of adherence and the success of therapy was analyzed using the Chi-Square test. Patient adherence rate was 32% high, 44% moderate, and 24% low. Patients who achieved therapeutic success were 57% and did not achieve therapeutic success as much as 43%. Based on the results of statistical analysis using the Chi-Square test, the results showed P = 0.037. This shows that there is a significant relationship between medication adherence to the success of therapy in hypertensive patients at Prambanan Public Health Center, Sleman.
Uji Toksisitas Ekstrak Etanol Batang Petai Cina (Leucaena leucochepala) Terhadap Cacing Gelang Ayam (Ascaridia galli) Febriana Rahmadani; Siwi Hastuti
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.97

Abstract

Leucaena stem ( Leucaena leucochapala ) was a plant that has been widely known and used as a medicinal treatment. This plant contains tanins, saponins and flavonoids. Was to know the toxicity for ethanol extract of (Leucaena leucochepala) towards (Ascaridia galli) with in vitro method. In this study there were 10 serial dilutions of the dose, the highest dose was 5000 µg/ml of ethanol extract of Leucaena leucochepala plus 0,3 ml of DMSO and dilution with NaCl 0,9. Used 150 tail worm’s added 15 tails to control. The result is observed by 24 hours. Data have been obtained by calculating amount of died worm’s 24 hours after treatment. Through the data, LC50 value was analyzed by probit analysis. This experimental’s result was a significant correlation betweenconcentrations of petai cina extract and worm’s death. The results of the probit analysis showed LC50 price of ethanol extract of Leucaena leucochepala was 5751,451 µg/ml. It means that the petai cina stem has toxic potential because it LC50 is < 1000 µg/ml. Extract of ethanol stems petai cina producted showed that the test toxicity acutely one plants with the in vitro declared toxic. And the price LC50 that established is 5751,451 µg/ml declared toxic.
Gambaran Pengobatan Diare Akut Anak di Puskesmas Jiwan Madiun Reni Ariastuti; Dunung Kusumawati
CERATA Jurnal Ilmu Farmasi Vol 11 No 1 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i1.110

Abstract

Diarrhea is a digestive tract disease with a consistency of loose stools and an increased frequency. The morbidity and mortality rates for children diarrhea in Indonesia still tend to be high. This study aims to determine the description of pharmacological therapy in the treatment of outpatients with acute diarrhea in Jiwan Public Health Center, Madiun by referring to the management of diarrhea therapy from the Ministry of Health. This research was conducted in a descriptive observational manner with retrospective data collection on outpatients with acute diarrhea at the Jiwan Public Health Center, Madiun in the Januri-June 2019 period. Sampling used a purposive sampling technique that met the inclusion criteria. The type of data used in this study is secondary data taken from patient medical records. Data analysis of the results of the study was carried out descriptively to determine the demographic distribution and treatment of patients with acute diarrhea in children at the Jiwan Public Health Center, Madiun. Most of the treatments had met the management of diarrhea. The percentage of drug use included using ORS as much as 29%, antidiarrheal attalpulgite and kaolin pectin by 26%, zinc 25%, anti-vomiting used by domperidone 7% and metochlopramide 4%, cotrimoxazole antibiotics 49% of the total cases 100% (75 cases). Evaluation of the dose of co-trimoxazole and zinc, there were 10% and 75% incorrect doses.

Page 2 of 12 | Total Record : 118

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