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INDONESIA
Jurnal Tumbuhan Obat Indonesia
Published by Universitas Tidar
ISSN : 1979897X     EISSN : 23548797     DOI : https://doi.org/10.31002/jtoi
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health
Jurnal Tumbuhan Obat Indonesia is published periodically twice a year. Result or review written by researcher from university or research Institute. Journal TOI has had an ISSN print version since 2008 and has an online Volume 6 number 1 year 2013.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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Kajian Empiris dan Etnofarmasi Tumbuhan Hutan Berkhasiat Obat Asal Desa Adat Tenganan Pegringsingan Karangasem Bali sebagai Antinyeri dan Antiinflamasi : Empirical and Ethnopharmacology Studies of Forest Plants with Medicinal Efficacy from the Traditional Village of Tenganan Pegringsingan Karangasem Bali as Pain Relief and Anti-Inflammation Nita, Ni Luh Kade Arman Anita Dewi; Gusti Ayu Putri Cantika Dewi; Megawati , Fitria; Megawati , Putu Era Sandhi Kusuma Yuda; Megawati , Erna Cahyaningsih
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.873

Abstract

Etnofarmasi adalah multidisiplin ilmu yang menghubungkan ilmu kefarmasian dengan adat budaya masyarakat yang terdiri dari obat dan cara menggunakan bahan alam untuk pengobatan berdasarkan ciri khas komunitas etnik suatu daerah di Desa Adat Tenganan Pegringsingan Karangasem pada pengobatan nyeri dan inflamasi. Tujuan penelitian ini adalah mengetahui pemanfaatan tanaman obat beserta bagian tanaman, cara pengolahan, cara penggunaannya yang digunakan dalam pengobatan nyeri dan inflamasi serta mengetahui indeks kegunaan (use value) dan fidelity level (FL) tanaman hasil studi etnofarmasi dan mengetahui potensi tanaman lain yang ada di Hutan Desa Adat Tenganan Pegringsingan Karangasem. Penelitian ini dilakukan dengan metode survei/observational dan pemilihan responden secara snowball sampling, yaitu mencari responden yang dianggap memiliki pengetahuan mengenai pengobatan tradisional. Penelitian kualitatif digunakan dengan metode wawancara dan penyajian data dan untuk kuantitatif dengan indeks kegunaan. Pada penelitian ini menggunakan variabel mandiri, yaitu studi etnofarmasi sebagai pengobatan nyeri dan inflamasi di Hutan Desa Adat Tenganan Pegringsingan Karangasem. Proses pengumpulan data dilakukan dengan pengamatan langsung, yaitu mengamati, mendengar, mencatat dan mempelajari dari narasumber. Perhitungan hasil dilakukan dengan rumus Use value (UV) dan Fidelity Level (FL). Berdasarkan hasil wawancara yang telah dilakukan dengan kedua narasumber yang telah memenuhi kriteria inklusi didapatkan hasil wawancara 12 jenis tanaman obat yang digunakan oleh narasumber sebagai pengobatan nyeri dan inflamasi. Terdapat 26 jenis tanaman obat yang berasal dari hutan desa adat yang tidak digunakan oleh narasumber dalam pengobatan namun tanaman tersebut memiliki khasiat dalam pengobatan nyeri dan inflamasi. Tanaman tersebut berasal dari Hutan Desa Adat Tenganan Pegringsingan Karangasem serta berasal dari sekitar lingkungan pekarangan dari narasumber.
Morphology Profile, Anatomy and Phytochemistry of Beluntas Leaves (Pluchea indica): Profil Morfologi dan Anatomi dari Daun Beluntas (Pluchea Indica) serta Perbedaan Profil Kandungan Kimia dari Daun Beluntas pada Kondisi Geografis yang Berbeda Wijaya, Sumi; Kurnia Setiawan, Henry
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.885

Abstract

Beluntas (Pluchea indica), is one of species in Asteraceae family, traditionally used to increase appetite, to treat indigestion, rheumatism and body odor problems. This study aims to provide morphological and anatomical profiles of Beluntas leaves which are often used in medicine, to determine the chemical content of Beluntas leaves using phytochemical screening tests and thin layer chromatografic profiles, and also to determine flavonoids, polyphenols and alkaloids contents. The observation results showed Beluntas leaves are an oval leaf shape with pinnate leaf reinforcement. Anatomical observation of the leaves, found that the leaf type is equifacial with collateral vascular bundles, the presence of non glandulair multicellular trichomes with constricted in the cross wall, papillae and glandular Compositae trichomes. Tube method results and thin layer chromatography profiles showed Beluntas leaves contained polyphenols, saponins, alkaloids, flavonoids, steroids and essential oils. The chromatogram profile with infrared spectrophotometry shows the wave numbers in the fingerprint region 1515 – 1516, 1259 – 1260, 1159 – 1162, 1112 – 1115, 1046 – 1048, 811 – 812, 505 – 506 and 452 – 454 cm-1. The total amounts of polyphenols, flavonoid and alkaloid contained in Beluntas leaves were 3.1 - 7.7% w/w, 0.5 - 1.2% w/w and 0.03 – 0.08% w/w, respectively.
Optimasi Formula Nanohydrogel Icariin Sebagai Afrodisiak.: Optimization of Icariin Nanohydrogel Formula as an Aphrodisiac Tajudin, Tatang; Indratmoko , Septiana; Prawatya, Adecya Nur
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.998

Abstract

Decreased sexual desire is a type of sexual dysfunction that is common in men. Sexual dysfunction can be controlled by using herbs that have activity as aphrodisiacs. Many herbs are efficacious as aphrodisiacs, one of which is the icariin compound from the epimedium plant. However, the use of oral drugs must go through absorption and distribution processes to cause pharmacological effects, besides that the first pass effect that occurs in the liver reduces the bioavailability of the drug. This study aims to optimize the icariin nanohydrogel formula for use as a topical aphrodisiac, preparation characteristics, and the effect of nanohydrogel on the diffusion of icariin compounds. Formula optimization was carried out using the Simplex Latice Design (SLD) method with variations of carbopol, HPMC and TEA. Quantitative data analysis of aphrodisiac activity was analyzed by One Sample T-Test. The optimal formulation is obtained at a ratio of 1.415 (carbopol) : 2.168 (HPMC) : 1.208 (TEA), resulting in a clear, cucumber fish oil-scented preparation that is stable, with a viscosity of 19753.3 cps and an adhesive force of 0.387 seconds, pH 6.1, as well as a spreading power with a diameter of 5.56 cm. The hedonic test conducted on 4 formulas with the addition of fragrance shows that formula 3 is preferred by the respondents, followed by formula 4, formula 2, and formula 1. The cumulative amount of the penetrated preparation is 0,174 µg/cm2 at 10 minutes, 0,283 µg/cm2 at 15 minutes, 0,398 µg/cm2 at 30 minutes, 0,498 µg/cm2 at 60 minutes, and 0,603 µg/cm2 at 120 minutes.
Medicinal Plants used for Antihypercholesterolemia in Ethnic Groups of Celebes Island, Indonesia: Pemanfaatan Tumbuhan Obat sebagai Antihiperkolesterolemia di Berbagai Etnis di Pulau Sulawesi, Indonesia Rahmawati, Nuning; Haryanti, Sari; Yanti Marfuatush Sholikhah, Ika; Subositi, Dyah; Widodo, Harto; Mujahid, Rohmat; Widiyastuti, Yuli
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 2 (2023): December 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i2.1025

Abstract

This study aimed to identify the utilization of medicinal plants used by selected traditional healers who met inclusion criteria to treat high cholesterol levels in ethnic groups of Celebes Island, Indonesia. Data collection was carried out through interviews, observation, and sample collection. This study revealed 67 concoction information and identified the use of 48 plant species distributed in 32 families among 39 healers in 20 ethnic groups in Celebes Island. Peperomia pellucida (L.) Kunth (UV=0.21), lamiaceae (15.63%), and leaves (57.35%) were determined as the most prominent species, family, and plant part used. The most widely prescribed rule of use is internal administration (94.03%) with a frequency of 3x1 per day (44.78%) for a week to a month (56.72%). However, conservation efforts need to be initiated immediately since more than 50% of healers made no cultivation efforts
Peningkatan Aktivitas Afrodisiak Mikroemulsi Icariin, Ekstrak Purwaceng dan Ekstrak Pasak Bumi: Enhancement of Aphrodisiac Activity of Icariin, Purwaceng Extract, and Pasak Bumi Extract Microemulsion Ajeng Puspo Aji; Rochany Septianingsih; Septiana Indratmoko; Y, Asep Nurrahman; Lisa Indriana
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.984

Abstract

Erectile dysfunction (ED) refers to medical issues concerning men's sexual health. Purwaceng, pasak bumi, and epimedium plants contain aphrodisiac compounds that can boost stamina, libido (sexual desire), and male fertility. The formula for microemulsions is 80: PEG 400: oil shavings in a ratio of 73.6711: 12.5705: 13.7584, with icariin, purwaceng, and pasak bumi added. The microemulsion system was created because it contained a large number of active ingredients. The stability of a microemulsion is further influenced by surfactants (tween 80) and cosurfactants (PEG 400) as emulsifiers, as well as the oil used as a solvent for the active component (bottled oil). The goal of this study was to create a microemulsion that would mix icariin, pasak bumi, and purwaceng substances to improve solubility and synergize pharmacological effects. The formulation is optimized using Simplex Lattice Design (SLD) to produce the optimal formula. The microemulsion formulations of icariin, pasak bumi extract, and purwaceng extract produce optimal microemulsions and enter into good microemulsion susceptibility. They can also increase the aphrodisiac effectiveness when compared to the administration of the single active substance icariin, pasak bumi extract, and purwaceng extract. As a result, this product exhibits microemulsion capabilities, allowing it to minimize dose while increasing effect.
Uji Toksisitas Akut Ekstrak Etanol Daun Alpukat (Persea americana Mill.) dan Pengaruhnya Terhadap Hepar Mencit BALB/c: Acute Toxicity Testing of The Ethanol Extract of Persea americana Mill. and Its Influence on The Hepars of BALB/c Mice Ririn, Ririn Lispita Wulandari; Pamungki, Wicaksaning Dyah; Ningsih, Fitri Mustiko
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1150

Abstract

Avocado leaf ethanol extract as a traditional medicine has been proven to have various pharmacological activities, but the safety of its use is not yet known. This study aims to determine the range of LD50 values, toxic symptoms, changes in body weight, and SGPT SGOT levels of Balb/c mice. The research was carried out experimentally using a fixed dose toxicity test method with a randomized matched pre and post-test control group design. EEDA is made by 70% ethanol maceration. The acute toxicity test consists of 2 stages: preliminary and main tests. Preliminary tests were carried out with a dose of extract 300 mg/kg BW once administered. After 24 hours of observation, there were no toxic symptoms, the test dose was increased to 2000 mg/kg BW. The main test was carried out using 10 test animals which were divided into 2 groups, each given a dose of extract 2000 mg/kg BW once and CMC Na 1% (negative control). Observation of toxic symptoms and death was carried out for 14 days. The LD50 value is determined from the results of toxic symptoms and death of test animals. Toxic symptoms were analyzed descriptively, and changes in body weight and SGOT SGPT levels were analyzed statistically (95% confidence level). The research results show that avocado leaf ethanol extract has an LD50 value range of >2000 mg/kg BW. The test dose of 2000 mg/kg BW did not cause toxic symptoms and death. SGOT and SGPT levels were still within normal limits, however, changes in SGPT levels were significantly different from controls. Thus, an extract dose of 2000 mg/kg BW has an acute toxic effect on the liver of mice.
Increasing Artemisinin Content on Artemisia Plants Through Endophytic Bacteria Inoculation as An Effort to Support the Availability of Malaria Drugs : Peningkatan Kandungan Artemisinin pada Tanaman Artemisia Melalui Inokulasi Bakteri Endofit Sebagai Upaya Mendukung Ketersediaan Obat Malaria Yuliani, Farida; Nureida, Fadila Rona; Fairuzia, Fazat; Rosidah, Eva Hana; Nugroho, Agung Wahyu; Amiroh, Afifatul
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1155

Abstract

In 2020, malaria cases worldwide increased from 219 million cases to 241 million cases with 627 thousand deaths. This creates problems in terms of the availability of malaria drugs. In addition, resistance to Plasmodium sp. against the commonly used malaria drug chloroquine is another problem. Therefore, in the treatment of malaria, combination-based treatment with artemisinin is highly recommended. However, there are obstacles in the production of artemisinin because its content in plants is relatively low. Therefore, this research aims to increase artemisinin content using endophytic bacteria. The method used is a factorial design with 2 factors, namely Accessions (Green & Purple) and endophytic bacteria concentration (0%, 1%, and 2%). Endophytic bacteria isolated from artemisinin plants were first cultured in a nutrient-rich medium to increase their population. Then, they were inoculated by spraying them twice a week for two months with each accession in each treatment combination. The results showed that inoculation with endophytic bacteria had the best concentration in increasing artemisinin content, namely 1% in green and purple Artemisia accessions. Artemisinin inoculation of 1% was able to increase artemisinin by 27.85% compared to control plants in green Artemisia and purple Artemisia accessions with an increase of 32.89% compared to control plants. The best concentration of endophytic bacteria in increasing artemisinin content is 1%.
In Silico Study of Acetogenin Compounds from Soursop (Annona muricata) Leaves as Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: Studi In Silico Senyawa Acetogenin dari Daun Sirsak (Annona muricata) Sebagai Inhibitor Sodium-Glucose Cotransporter-2 (SGLT2) Tedjo, Aryo
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1156

Abstract

Acetogenin derived from soursop (Annona muricata) leaves are known to have antidiabetic and anticancer activities. Nevertheless, there has been no study related to the compounds found in A. muricata leaves, such as acetogenin, as SGLT2 inhibitors. This research aims to investigate the activity of acetogenin compounds as SGLT2 inhibitors while maintaining low selectivity against SGLT1 using molecular docking methods using Molegro Virtual Docker (MVD). Based on the Rerank score, five acetogenin compounds, namely muricin H, annonacin A, annopentocin B, murihexocin C, and corossolone, are predicted to be SGLT2 inhibitors with better selectivity compared to empagliflozin. Among these five compounds, muricin H and corossolone exhibit the most similarity in interaction with amino acid residues in the SGLT2 A-chain compared to empagliflozin. In silico ADMET analysis results indicate that both compounds have absorption, distribution, and metabolism capabilities, similar to empagliflozin. However, it should be noted that both compounds are more toxic, with muricin H predicted to have hepatotoxic properties.
Potensi Tanaman Ganjan (Artemisia vulgaris) dalam Penyembuhan Luka Sayat pada Tikus (Sprague Dawley): The Potential of Ganjan (Artemisia vulgaris) in Wound Healing in Rats (Sprague Dawley) Istiqomah, Indriana Noor; Mashuri; Abdillah, Achlish; Azizah, Laili Nur
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1159

Abstract

Recent studies have focused on exploring natural remedies to accelerate wound healing. One such herbal plant is the Ganjan plant (Artemisia vulgaris), which contains essential oils, coumarins, flavonoids, triterpenoids, and phenolic acids, which make it a good candidate for natural remedies. This study analyzed the wound-healing potential of the Ganjan plant using a true experimental research design on 16 male Sprague Dawley rats. The rats were divided into four groups and subjected to different treatments, including a negative control group without treatment (K1), a 10% Ganjan herbal extract ointment group (K2), a 30% Ganjan herbal extract ointment group (K3), and a positive control group with 10% betadine ointment (K4). The ointments were applied once daily for 21 days or until the wounds healed, and wound area measurements were taken every three days. The results showed that the 10% and 30% Ganjan ointments effectively reduced the wound area, and there was no difference in wound contraction between 10% and 30% Ganjan ointment and 10% Betadine. The study concludes that Ganjan plant extract ointment is an effective natural remedy for wound healing and that the best results are seen in the 30% Ganjan extract ointment group.
Antifungal Activity the Active Fraction of Orange Jasmine (Murraya paniculata (Linn) Jack) Leaves and Stem Bark Against Malassezia furfur: Aktivitas Antifungi Fraksi Aktif Daun dan Kulit Batang Kemuning (Murraya paniculata (Linn) Jack) terhadap Malassezia furfur Mulangsri, Dewi Andini Kunti; Rosella, Sevitia; Isna Azmut Baroroh
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 1 (2024): July 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i1.1186

Abstract

Leaves and stem bark of orange jasmine have bioactive compounds such as phenol and flavonoids, which these compounds could be extracted by organic solvent and have antifungal activity against Malassezia furfur which cause excema, dandruff and tinea versicolor in humans. Fractionation of the extract would obtain a specific compound based on the polarity of the solvent. This research aims to know the active fraction of leaves and stem bark of orange jasmine which had antifungal activity against Malassezia furfur.  The simplicia powder of leaves and stem bark orange jasmine was macerated with 96% ethanol solvent and then fractionated as gradually with n-hexane, ethyl acetate, and water solvent. The antifungal activity of ethanol extract and fractions was tested against Malassezia furfur with 80; 90; 100% concentration by disk diffusion method at 37˚C for 48 hours of incubation. The data of antifungal activity was analyzed by two-way ANOVA. The result of this research showed antifungal activity from active fraction as water fraction of leaves and stem bark of orange jasmine against Malassezia furfur. The diameter of inhibition zones for the active fraction of leaves and stem bark of orange jasmine such as 8.6 – 14 mm and 12.3 – 15.8 mm respectively.

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