cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Mohammad Rizki Fadhil Pratama
Contact Email
mohammadrizkifadhilpratama@umpr.ac.id
Phone
+6287815093560
Journal Mail Official
bjop@umpr.ac.id
Editorial Address
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
Location
Kota palangkaraya,
Kalimantan tengah
INDONESIA
Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
 26   27   28   29   30 
Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats Prajawanti, Kadeq Novita; Negara, Yohanes Ardian Kapri; Arianing, Intan Febiola; Junitasari, Fitri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6871

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin production or action, often leading to pancreatic β-cell dysfunction and apoptosis. Pro-inflammatory cytokines, notably Tumor Necrosis Factor-alpha (TNF-α), play a critical role in the pathogenesis of type 2 diabetes (T2D). While Tagetes erecta (marigold) has demonstrated potential in lowering blood glucose in hyperglycemic conditions, its anti-inflammatory effects in diabetic models remain underexplored. This study aimed to evaluate the antidiabetic and TNF-α lowering effects of T. erecta extract in alloxan-induced diabetic rats. Twenty-five male Wistar rats were divided into a normal control group (n=5) and a diabetic group (n=20) induced by alloxan (blood glucose ≥126 mg/dL). Diabetic rats were then randomized into four treatment subgroups (n=5 each): untreated diabetic control, and diabetic groups treated with T. erecta extract at doses of 25 mg/kg BW, 50 mg/kg BW, or 75 mg/kg BW (administered intraperitoneally). Statistical analysis revealed that T. erecta extract significantly reduced blood glucose levels in alloxan-induced diabetic rats (p <0.05). Furthermore, the highest dose of T. erecta extract (75 mg/kg BW) effectively attenuated elevated TNF-α levels, demonstrating a significant anti-inflammatory effect. In conclusion, this study provides compelling evidence that T. erecta extract exhibits both antidiabetic and anti-inflammatory properties by significantly lowering blood glucose and TNF-α levels in alloxan-induced diabetic rats, particularly at the 75 mg/kg BW dose.
Stability of Hand Body Gel Formulated with Avocado (Persea americana), Stingless Bee Honey, and Bee Pollen Fauziyah, Nur; Kustiawan, Paula Mariana
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6919

Abstract

The development of hand body care products in gel form, incorporating natural ingredients, remains an underexplored area, particularly concerning the combination of avocado (Persea americana) extract, Stingless bee (Trigona sp.) honey, and pollen in cosmetic formulations. Gel formulations are favored for their superior skin moisturizing properties and enhanced dermal absorption compared to lotions. This study aimed to evaluate the stability and moisturizing efficacy of novel hand body gel formulations containing varying ratios of P. americana extract combined with Trigona bee pollen and honey. Employing an experimental quantitative design, three distinct gel formulations were prepared with different concentrations of P. americana extract with Trigona bee pollen and honey. The stability of these formulations as skin moisturizers was assessed through a comprehensive evaluation encompassing organoleptic properties, homogeneity, potential for irritation, pH, spreadability, viscosity, and moisture content analysis using skin analysis instrumentation. The results indicated that the gel formulation designated F1, containing 2.5% P. americana extract and 7.5% honey combined with bee pollen, exhibited the highest skin moisture content, suggesting its potential as an effective moisturizing hand body gel.
Purple Yam (Dioscorea alata) Extract Increasing Dopamine Levels and Improving the Brain's Microscopic Features in Parkinson's Model Mice Yuliani, Sapto; Utami, Dwi; Nurani, Laela Hayu; Ramadhan, Muhammad Marwan; Ainiyah, Nadia Putri; Bachri, Mochammad Saiful; Widyaningsih, Wahyu; Amukti, Danang Prasetyaning
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.7267

Abstract

Parkinson's disease (PD) is a severe neurodegenerative disorder, that causes progressive motor issues from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNpc). Purple yam (Dioscorea alata), rich in anthocyanins, shows promise as a natural antioxidant and neuroprotectant. This study investigated the antiparkinsonian effects of D. alata extract on dopamine levels and brain microscopic features in a haloperidol-induced PD mouse model. Thirty-five male mice were randomly allocated into seven groups: normal (CMC-Na and aqua pro injection), haloperidol-induced negative control (CMC-Na), positive control (levodopa 39 mg/kgBW), curcumin (200 mg/kgBW), and D. alata extract-treated groups (100, 200, and 400 mg/kgBW). Treatments were administered daily for seven days. On day 8, all groups, except the normal control, received an intraperitoneal injection of haloperidol (2 mg/kgBW) to induce Parkinsonism. Three hours post-haloperidol injection, dopamine levels were measured from orbital vein blood. Subsequently, brains were harvested for histological examination of the SNpc using Toluidine blue staining. Data were statistically analyzed using one-way ANOVA followed by LSD post-hoc tests. The 400 mg/kgBW dose of D. alata extracts significantly increased dopamine levels (p<0.05) compared to the negative control group. Microscopic analysis of the SNpc in mice treated with 400 mg/kgBW extract revealed preserved, dark, and solid neuronal morphology, with significantly higher scoring results (p<0.05) when compared to the levodopa-treated group. These findings suggest that D. alata extract, particularly at a dose of 400 mg/kgBW, exhibits potential antiparkinsonian activity by elevating dopamine levels and mitigating dopaminergic neuronal damage in a haloperidol-induced PD mouse model.
Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats Kasmadi, Fathnur Sani; Rahman, Ave Olivia; Rahman, Havizur; Yuliawati, Yuliawati; Samudra, Agung Giri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.7525

Abstract

Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf extract nanoparticle gel. Previous research from our group highlighted the significant wound-healing potential of a conventional R. pinnata gel. This present study aimed to evaluate the wound-healing efficacy of a novel R. pinnata nanoparticle gel in male Wistar rats, specifically investigating the impact of nanotechnology application. Nanoparticles were successfully formulated via the ionic gelation method, utilizing 0.250 g of R. pinnata extract, 0.1% chitosan, 0.2% sodium tripolyphosphate, and 0.5% Tween 80. Characterization revealed an average nanoparticle size of 165.70±42.76 nm with a zeta potential of 22.0±1.83 mV. The wound-healing efficacy was assessed across five treatment groups: a positive control (Bioplasenton®), a plain gel base (Formula 0), and nanoparticle gels at 0.5% (Formula I), 1% (Formula II), and 1.5% (Formula III) extract concentrations. Statistical analysis using one-way ANOVA (p <0.05) demonstrated a significant difference in incision wound healing across the groups. Formula III, containing 1.5% R. pinnata nanoparticle extract, exhibited the most superior wound-healing effect, achieving 100% inhibition by day 14, elevated hydroxyproline levels (59 µg/mL), and histologically confirmed excellent skin tissue repair. Formulas II and I followed in efficacy. These compelling findings underscore the significant potential of utilizing nanotechnology in the development of topical preparations for accelerated and effective wound healing.
Piper cubeba L. f. Nanoemulsion: Formulation and Effect on Antioxidant Activity in Rat's Hippocampus and Prefrontal Cortex Dwita, Lusi Putri; Iwo, Maria Immaculata; Mauludin, Rachmat; Elfahmi, Elfahmi
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.8720

Abstract

The previous study showed that Piper cubeba extract increased brain antioxidant capacity, alleviating cognitive impairment in rats. However, brain-targeted drug delivery is often limited by the blood-brain barrier. One of the approaches to overcome this obstacle is nanocarrier. This study aimed to formulate a nanoemulsion (NE) of P. cubeba extract and determine the antioxidant activity in the brain. The research begins with the determination of excipients and the formula of NE. The formula was then tested for globule size, polydispersity index, thermodynamic stability, zeta potential, pH, and viscosity. The globule's shape was determined using transmission electron microscopy (TEM). The antioxidant activity was tested by catalase and lipid peroxidase activity in the brain after giving NE orally for seven days. Formulations of NE resulted in nano-size globules and were stable thermodynamically. The NE formula significantly increased catalase and inhibited lipid peroxidase activities in the Rat's hippocampus and prefrontal cortex. This study resulted in a stable formula and low-cost production of P. cubeba extract NE, which is active as the brain's antioxidant and is feasible to develop as a neuroprotective agent for various neurodegenerative diseases.
Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.) Setiawan, Abdul Aziz; Yuniarto, Ari; Taptajani, Emir Rizky
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.9059

Abstract

Free radicals contribute to various diseases by inducing oxidative stress. Single black garlic (Allium sativum L.) is recognized for its phenolic compounds, which possess radical-scavenging properties. This study aimed to develop and evaluate instant granules containing black A. sativum extract for their antioxidant activity and physicochemical characteristics. An instant granule formulation was developed using a 70% ethanol extract of a single black A. sativum, with three distinct formulas containing 5%, 7.5%, and 10% extract (Formulas 1, 2, and 3, respectively). The granules were subjected to comprehensive physical quality assessments, including organoleptic properties, moisture content, angle of repose, flow rate, dissolution time, and tapped density. Antioxidant activity was quantified using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, reporting IC50 values. All instant granule formulations successfully met the established physical quality requirements across all evaluated parameters. Furthermore, the antioxidant activity demonstrated a concentration-dependent effect, with IC50 values of 119.576 ppm for Formula 1, 82.000 ppm for Formula 2, and 59.962 ppm for Formula 3. This study confirms that instant granules formulated with a single black A. sativum extract exhibit significant antioxidant potential and possess desirable physical characteristics, indicating their promise as a natural antioxidant supplement.
Molecular Docking Study of Illicium verum Hook f. as Elastase and Collagenase Inhibitor in Anti-aging Mechanism Rahman, Ave; Widiandani, Tri; Widyowati, Retno
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.9574

Abstract

Skin aging, a natural physiological process intensified by external factors that augment the activity of aging-related enzymes such as elastase and collagenase, leads to the degradation of collagen solubility and the disruption of elastin fiber cross-linking. This study aimed to investigate the potential of secondary metabolites from Illicium verum fruit as inhibitors of both elastase and collagenase through an in silico molecular docking approach. The methodology involved ligand and protein preparation, validation of the docking protocol, the molecular docking simulation itself, and subsequent visualization of amino acid residue interactions. The protein targets utilized were elastase (PDB ID: 1Y93) and collagenase (PDB ID: 2D1N). The docking results identified gingerol as exhibiting the highest binding affinity for elastase (-7.99 kcal/mol), followed by carvacrol (-6.79 kcal/mol) and ferulic acid (-6.24 kcal/mol). Similarly, for collagenase, gingerol displayed the strongest interaction (-8.47 kcal/mol), followed by carvacrol (-6.30 kcal/mol) and α-pinene (-6.24 kcal/mol). Notably, gingerol and carvacrol also demonstrated favorable amino acid similarity scores and promising interactions within the active sites of both elastase and collagenase. In conclusion, this molecular docking study suggests that the secondary metabolites of I. verum fruit possess potential anti-aging activity by inhibiting elastase and collagenase enzymes.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 8 No. 1 February 2025 Borneo J Pharm, Chief Editor of
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.9637

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published at February 2025. This edition contains ten articles: Pharmaceutical Regulations, Pharmacology-Toxicology, Clinical-Community Pharmacy, Pharmacognosy-Phytochemistry, Analytical Pharmacy-Medicinal Chemistry, and Natural Product Development, and. This edition includes writings from three countries: Egypt, Indonesia, and Libya. The authors come from several institutions, including Indonesian Food and Drug Authority, Universitas Lambung Mangkurat, Universitas Borneo Lestari, Institut Teknologi Bandung Universitas Muhammadiyah Surabaya, Universitas Mahasaraswati Denpasar, Universitas Muhammadiyah Palangkaraya, Universitas Islam Indonesia, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang, University of Tripoli, Egypt-Japan University of Science and Technology, El Ezaby Pharmacy, Universitas Ahmad Dahlan, IPB University, and Universitas Sriwijaya. Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors, could re-participate for the publication in the next edition on May 2025. Wassalamu’alaikum Wr. Wb.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 8 No. 2 May 2025 Borneo J Pharm, Chief Editor of
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.10305

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm) has been published in May 2025. This edition contains ten articles: Pharmacology-Toxicology, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, and Natural Product Development. This edition includes writings from two countries: Indonesia and Thailand. The authors come from several institutions, including Universitas Sari Mulia, Universitas Borneo Lestari, Universitas Ahmad Dahlan, Sekolah Tinggi Ilmu Kesehatan Samarinda, Universitas Alma Ata, Universitas Jambi, Universitas Bengkulu, Universitas Muhammadiyah Prof Dr Hamka, Institut Teknologi Bandung, Universitas Halu Oleo, Thammasat University, Universitas Jember, Universitas Airlangga, Universitas Anwar Medika, Universitas Muhammadiyah Kalimantan Timur, and Universitas Muhammadiyah A.R. Fachruddin. Editorial boards are fully aware that there is still room for improvement in this edition; hence, with all humility, we are willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors, reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate in the publication in the next edition in August 2025. Wassalamu’alaikum Wr. Wb.
Cost Analysis of Inpatient Stroke Treatment at PKU Muhammadiyah Yogyakarta Hospital Based on INA-CBG's Tariff in 2023 Hadning, Ingenida; Oktaviani, Aulia
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.7261

Abstract

Stroke incidence in Yogyakarta Province is among the highest in Indonesia, frequently necessitating prolonged patient care and rehabilitation. The recent adjustment of INA-CBG's tariffs, as stipulated in Regulation of the Minister of Health of the Republic of Indonesia Number 3 of 2023, has increased reimbursement rates for inpatient hemorrhagic stroke (Classes 1, 2, and 3) and ischemic stroke (Class 1). Despite these revisions, many hospitals report disparities between operational costs and the INA-CBG's reimbursement rates. This study represents the first dedicated evaluation of INA-CBG's tariffs, specifically concerning the 2023 ministerial regulation, for inpatient stroke management. We aimed to ascertain the financial discrepancies between the average actual costs of inpatient stroke treatment and the updated INA-CBG's tariffs at PKU Muhammadiyah Yogyakarta Hospital. Employing an observational design with a cross-sectional approach, we retrospectively collected data from inpatient stroke patients treated between January and September 2023. Data analysis involved descriptive statistics and a one-sample t-test. The findings reveal that, for most cases, the average actual costs incurred by the hospital were significantly lower than the corresponding INA-CBG's tariffs, indicating a consistent profit margin for the institution.

Page 28 of 30 | Total Record : 300

 26   27   28   29   30 

Filter by Year

2018 2025


Reset
Filter By Issues
All Issue Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy Vol. 4 No. 2 (2021): Borneo Journal of Pharmacy Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy Vol. 3 No. Special-1 (2020): Borneo Journal of Pharmacy: COVID-19 Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy Vol. 3 No. 1 (2020): Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy More Issue