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Mohammad Rizki Fadhil Pratama
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Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Antihypertension Profile During Pregnancy at a Private Hospital in Surabaya Wiputri, Oktaviany Irma; Rahma, Iftakhur; Samlan, Karima
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7938

Abstract

Hypertension during pregnancy, a significant obstetric complication, can lead to severe consequences such as preeclampsia. This study aimed to determine the pattern of antihypertensive medication use, including drug type, route of administration, dosage, and frequency, as well as investigate the relationship between clinical data, including blood pressure and proteinuria, and the use of single or combination antihypertensive therapy in pregnant women with hypertension. A retrospective observational study was conducted on 108 pregnant women with hypertension admitted to the inpatient unit of a private hospital in Surabaya, Indonesia. Data on patient demographics, comorbidities, antihypertensive medications, blood pressure, and proteinuria levels were collected and analyzed. The majority (79.65%) of patients were aged between 20 and 35 years. Common comorbidities included obesity (62.50%), pre-existing hypertension (18.75%), and a history of preeclampsia in previous pregnancies (6.25%). Nifedipine (73.26%) was the most frequently used single antihypertensive medication, followed by methyldopa (23.26%). Combination therapy, primarily nifedipine and methyldopa (92.31%), was commonly employed. Most patients (97.35%) achieved blood pressure control, and 47.79% showed improvement in proteinuria levels. Nifedipine and the combination of nifedipine and methyldopa were the most frequently used antihypertensive medications in this cohort. Most patients achieved blood pressure control, indicating effective management of hypertension during pregnancy. Further studies are warranted to investigate the long-term outcomes and optimize antihypertensive therapy strategies in this population.
Chemical Compound Profile of Bajakah Kalalawit (Uncaria gambir Roxb) Stem Extract Using Liquid Chromatography High-Resolution Mass Spectrometry Fawaid, Ainun; Mahfudh, Nurkhasanah
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7942

Abstract

Uncaria gambir Roxb., commonly known as Bajakah Kalalawit, is a plant endemic to Kalimantan, Indonesia, with potential medicinal properties. While previous studies have investigated the phytochemical composition of U. gambir leaves, limited information exists regarding the constituents of its stem extract. This study aimed to comprehensively characterize the chemical composition of U. gambir stem extract using Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS). Ethanol (96%) was employed as the solvent for maceration extraction (1 : 5, plant material : solvent ratio) for three days. Subsequently, the dried extract was subjected to LC-HRMS analysis. Compounds with an Area Under the Curve (AUC) value greater than or equal to 1% were considered as major constituents. The results revealed the presence of 18 distinct chemical compounds in the U. gambir stem extract, providing valuable insights into its phytochemical profile and laying the foundation for further investigations into its potential pharmacological activities.
Analysis of Amino Acid Profiles in Bone, Oil, and Muscle Tissue and Wound Healing Activity of Pangasius hypophthalmus Oil in Rattus norvegicus Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Hanif, Novriyandi; Roosita, Katrin; Darusman, Huda Shalahudin; Aprilyana, Lia
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8182

Abstract

Patin (Pangasius hypophthalmus), a commercially important freshwater fish, is a rich source of protein containing both essential and non-essential amino acids, crucial for various biological functions. This study aimed to determine the amino acid composition of muscle tissue, oil, and bones of P. hypophthalmus and evaluate the wound healing potential of its oil extract in Rattus norvegicus. High-Performance Liquid Chromatography was employed to quantify the levels of essential and non-essential amino acids in each tissue. Results revealed that P. hypophthalmus oil exhibited the highest total amino acid content, particularly rich in histidine, arginine, and lysine. The wound healing activity of P. hypophthalmus oil extract was assessed in a rodent model, demonstrating a significant reduction in wound area (0.62-0.84 mm) and an impressive wound healing percentage (79-84.45%). These findings suggest that different parts of P. hypophthalmus possess valuable nutritional and therapeutic properties. Notably, the high amino acid content of P. hypophthalmus oil, particularly essential amino acids, highlights its potential as a promising source for developing pharmaceutical products, including amino acid supplements, wound healing agents, and formulations for metabolic support. Further research is warranted to fully explore the therapeutic potential of P. hypophthalmus oil and its bioactive components.
The Strategic Role of the Indonesian FDA in Empowering Micro, Small, and Medium Enterprises in the Drug and Food Sectors: A Review Kashuri, Mohamad; Ikrar, Taruna
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8432

Abstract

This review examines the evolving role of the Indonesian Food and Drug Authority (BPOM) in empowering Small and Medium Enterprises (SMEs) within the pharmaceutical and food sectors. While significant strides have been made in recent years, challenges remain. These include discrepancies between regulatory objectives and the practical capabilities of SMEs, particularly in navigating complex regulatory frameworks. While digitalization initiatives and technical assistance programs have shown promise, their impact is often hindered by resource limitations and resistance to change among stakeholders. This review underscores the critical need for a balanced approach that effectively integrates regulatory oversight with targeted support for SME growth. Fostering an ecosystem that encourages innovation and ensures regulatory compliance necessitates a multi-stakeholder approach, demanding more sustainable and effective coordination among government agencies, industry associations, and academic institutions. The success of BPOM's empowerment efforts hinges on adopting flexible, technology-driven, and results-oriented strategies. Future endeavors should prioritize long-term evaluations of existing programs, develop robust metrics to assess their effectiveness and explore innovative approaches to address the evolving regulatory landscape in the digital era.
The Effect of Directly Observed Treatment Strategy on Cost Utility of Pulmonary Tuberculosis Patients at Banten Regional Public Hospital Udin, Baha; Yusransyah, Yusransyah; Saepudin, Saepudin
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8601

Abstract

Pulmonary tuberculosis (TB) is one of the communicable diseases with high prevalence in some provinces in Indonesia, including the Province of Banten. Considering its high prevalence and the high cost of treatment resulting from multiple treatment components, research on the analysis of treatment costs of TB is very important. This study aimed to determine the effect of implementing the directly observed treatment (DOT) strategy on the cost-utility of pulmonary TB patients. The study was conducted at Banten Regional General Hospital using the perspective of the health provider and patients by involving 24 TB patients. Treatment cost was calculated by including direct medical costs, direct non-medical costs, and indirect costs, and then categorized into initial and final cost-utility. The average cost-effectiveness ratio (ACER) was then calculated by setting the patient's quality of life as the clinical outcome in this study. This study found that the average value of the average cost-utility ratio (ACUR) for the initial cost-utility and the final cost-utility were IDR 2,682,343.53 and IDR 2,402,153.15, respectively, and the difference was statistically significant (p=0.006). It indicates that the DOT strategy can potentially improve the utility costs of the treatment of TB patients at Banten Regional Hospital.
Evaluation of Aqueous Extract from Cosmos caudatus Leaves in Alloxan-Induced Diabetic Rats Rosdah, Ayeshah Augusta; Natasha, Amanda; Tamzil, Nia Savitri; Subandrate, Subandrate
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8652

Abstract

Kenikir (Cosmos caudatus), often consumed as a vegetable in Southeast Asia, possesses therapeutic benefits for several diseases, including diabetes mellitus. However, there has been limited investigation of the aqueous extract of C. caudatus for this disease model. This study aimed to examine the glucose-lowering effect of C. caudatus aqueous extract in an alloxan-induced diabetes model in rats. Ultrasound-assisted extraction was performed to obtain an aqueous extract of C. caudatus leaves. Qualitative phytochemical screening was carried out to identify the presence of bioactive compounds. Male Wistar rats were allocated to the following experimental groups: non-diabetic, diabetic without treatment, and diabetic treated with glibenclamide or aqueous C. caudatus extract at concentrations of 25%, 50%, or 100%. Diabetes was induced by intraperitoneal injection of 150 mg/kg alloxan. Random blood glucose and body weight were monitored before (Day 0) and after treatment (Days 3 and 7). There was a trend of weight loss in diabetic rats compared to non-diabetic rats, though the difference was not statistically significant. After 7 days of treatment, there was a comparable decrease in the blood glucose of diabetic rats treated with 50% or 100% of aqueous C. caudatus extract and those treated with glibenclamide. Qualitative phytochemical screening indicated the presence of steroid, saponin, phenol, and flavonoid compounds. The total phenolic content was 38.48 mg GAE/g and IC50 DPPH antioxidant activity was 375.64 ppm. This study demonstrated that an aqueous extract of C. caudatus exhibits a blood glucose-lowering effect in an alloxan-induced diabetic rat model.
Could Nigella sativa Extract be a Promising Anticancer Agent? Shabana, Mennatallah; Amer, Ahmed Abd El-Moniem
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8995

Abstract

Nigella sativa, commonly known as black seed, has a long history of traditional use in folk medicine. Recent scientific investigations have highlighted its significant therapeutic potential, particularly in cancer treatment. Thymoquinone, the primary bioactive compound in N. sativa, has demonstrated promising anticancer properties in numerous preclinical studies. This review comprehensively examines the current understanding of N. sativa's anticancer potential, focusing on the pharmacological actions of thymoquinone. We analyzed high-quality research articles from various databases to assess the efficacy of N. sativa and its constituents in cancer treatment. Furthermore, we explored the potential of N. sativa as an adjunct therapy within existing cancer treatment guidelines. Finally, we discuss the safety profile of N. sativa and propose future research directions to fully realize its therapeutic potential in cancer management.
Natural Self-Foaming Clay Soap with Etlingera elatior Fruit Extract for Skincare Aspadiah, Vica; Zubaydah, Wa Ode Sitti; Indalifiany, Astrid; Sahidin, Sahidin; Fristiohady, Adryan; Malaka, Muhammad Hajrul; Muliadi, Rahmat; Parrung, Arsyani
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.5800

Abstract

Etlingera elatior (Wualae), a plant recognized for its flavonoid-derived antioxidant properties, presents a potential source for cosmeceutical applications. This study investigated the formulation and evaluation of a Self-Foaming Clay Soap (SFCS) incorporating an ethanol extract of E. elatior fruit. The SFCS base, comprising surfactant as a cleansing and foaming agent combined with bentonite clay for enhanced serviceability and oil adsorption, was formulated with varying concentrations of bentonite (0%, 5%, 10%, 15%, and 20% w/w), designated as FI to FV, respectively, alongside other necessary excipients. The resulting SFCS preparations underwent rigorous physical and chemical stability assessments following accelerated storage conditions (freeze-thaw cycles). Evaluated parameters included organoleptic properties, foam stability and height, viscosity, dispersibility, homogeneity, and pH. The evaluation revealed that Formulation II (FII), containing 5% w/w bentonite, exhibited the most favorable stability profile and met the established criteria for SFCS semisolid preparations. Specifically, FII demonstrated a foam stabilization rate of 84.61% and a foam height of 2.6 cm after freeze-thaw cycling, a viscosity of 10,000 cPs, a spreadability diameter of 4.1 cm, a homogeneous texture devoid of coarse particles, and a skin-compatible pH of 5. These findings suggest that an SFCS formulation incorporating a 5% w/w concentration of bentonite and E. elatior fruit extract holds promising potential as a stable and efficacious skincare preparation.
Combined Effects of Curcuma xanthorrhiza Rhizome and Persea americana Leaves Extracts on Streptozotocin-Induced Diabetes in Rats Thong, Vertirico; Ahnafani, Miyada Nur; Lestari, Helda Dwi; Ahnafani, Mayada Nur; Kurniawati, Darini
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.5837

Abstract

Indonesia's rich biodiversity encompasses numerous plants with ethnomedicinal applications, including avocado (Persea americana) leaves and temulawak (Curcuma xanthorrhiza) rhizomes, traditionally used for managing diabetes mellitus. This study investigated the antidiabetic activity of a combination of C. xanthorrhiza rhizomes and P. americana leaves in streptozotocin (STZ)-induced diabetic rats. Extracts were obtained via 72-hour maceration using 96% ethanol, followed by phytochemical screening and a 3-day toxicity assessment in rats at doses of 50, 150, and 200 mg/kg BW. Diabetic rats, induced with a single intraperitoneal injection of 20 mg/kg STZ, were treated for 14 days with three different combination formulas of C. xanthorrhiza rhizome and P. americana leaf extracts: Formula 1 (0.6 g : 0.4 g), Formula 2 (0.4 g : 0.6 g), and Formula 3 (0.4 g : 0.4 g). Metformin (500 mg/kg/day) served as the positive control, and 0.5% CMC-Na was the negative control. Phytochemical analysis revealed the presence of various bioactive compounds in both extracts. No significant toxicity was observed in rats across the tested doses. The Mann-Whitney test indicated a significant difference in blood glucose levels in diabetic rats after 14 days of treatment (p=0.037). Notably, all combination formulas exhibited antidiabetic activity. Specifically, Formula 1 demonstrated comparable antidiabetic efficacy to metformin (500 mg/kg). These findings suggest that combining C. xanthorrhiza and P. americana extracts possesses significant antidiabetic potential.
Effect of Quercetin and Zinc Oxide Concentrations on pH and In Vitro Activity of Sunscreen Lipstick Wisudyaningsih, Budipratiwi; Barikah, Kuni Zu'aimah; Kamelia, Ilfi Nur
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6797

Abstract

Quercetin, a naturally occurring flavonoid, exhibits significant antioxidant properties, making it a promising candidate for photoprotective applications. Concurrently, zinc oxide is a well-established physical blocker of ultraviolet A (UV-A) radiation. This study aimed to optimize the synergistic combination of quercetin (as an anti-UV-B agent) and zinc oxide (as an anti-UV-A agent) within a sunscreen lipstick formulation to enhance broad-spectrum photoprotection. A factorial design, implemented using Design Expert 13.0 software, was employed for the optimization. The independent variables were the concentrations of quercetin and zinc oxide, while the dependent responses included pH, Sun Protection Factor (SPF), percentage of Erythema Transmission (%TE), and percentage of Pigmentation Transmission (%TP). Statistical analysis evaluated the individual and interactive effects of the components on these responses. Both quercetin and zinc oxide individually demonstrated a positive influence on increasing the pH and SPF values of the formulations, while concurrently reducing both %TE and %TP values. Notably, a significant synergistic interaction between quercetin and zinc oxide was observed, further influencing the SPF, %TE, and %TP values. The optimized formula, derived from the overlay contour plot generated by the factorial design, comprised 2.5% quercetin and 15% zinc oxide. This optimal combination yielded a pH of 5.027, an SPF of 22.713, a %TE of 0.012, and a %TP of 0.004. The optimized combination of quercetin and zinc oxide in a sunscreen lipstick formulation effectively provided desirable pH values and substantial in vitro sunscreen efficacy. These findings suggest that this novel formulation holds significant potential as a broad-spectrum photoprotective cosmetic product.

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