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INDONESIA
Jurnal Indah Sains dan Klinis
Published by Yayasan Penelitian dan Inovasi Sumatera
ISSN : -     EISSN : 27471942     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing
The Jurnal Indah Sains dan Klinis (JISK) is a journal about health which contains scientific and clinical issues published by the Yayasan Penelitian dan Inovasi Sumatera (YPIS) which includes studies on Pharmacy, Medicine, Nursing, Midwifery, Chemistry, Biology, Microbiology, Tissue Culture and others. other. disciplines related to health. The beginning of JISK was published at the end of December 2020, published by the Sekolah Tinggi Kesehatan Indah Medan. Since 2022, the publication of Volume 3 Number 2 has been carried out by the Yayasan Penelitian dan Inovasi Sumatera (YPIS),
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 95 Documents
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Efektivitas Antimikroba Kombinasi Ekstrak Etanol Rimpang Kunyit (Curcuma longa L.) dan Hidroksiapatit dalam Menghambat Pertumbuhan Streptococcus sobrinus Ritonga, Ahmad Hafizullah; Purba, Kristin Eliana; Aritonang, Barita; Herlina, Herlina; Harefa, Karnirius
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.01

Abstract

Latar Belakang: Karies gigi merupakan salah satu masalah kesehatan mulut dengan prevalensi tertinggi di seluruh dunia, yang memengaruhi baik anak-anak maupun orang dewasa. Streptococcus sobrinus berperan penting dalam perkembangan karies dengan memfermentasi karbohidrat dan menghasilkan asam yang menyebabkan demineralisasi enamel. Penggunaan antimikroba kimiawi konvensional dapat menimbulkan efek samping, termasuk gangguan mikroflora oral dan berkembangnya resistensi bakteri. Oleh karena itu, diperlukan alternatif antimikroba alami. Tujuan: Penelitian ini bertujuan untuk mengevaluasi efektivitas antimikroba dari kombinasi ekstrak etanol rimpang kunyit (Curcuma longa L.) dan hidroksiapatit terhadap Streptococcus sobrinus. Metode: Penelitian eksperimental ini menilai berbagai rasio ekstrak etanol kunyit dan hidroksiapatit terhadap pertumbuhan Streptococcus sobrinus menggunakan metode zona hambat. Skrining fitokimia juga dilakukan untuk mengidentifikasi senyawa bioaktif dalam ekstrak kunyit. Hasil: Analisis fitokimia menunjukkan adanya alkaloid, flavonoid, tanin, dan saponin. Pengujian antibakteri menunjukkan zona hambat sebesar 10,6 mm untuk ekstrak kunyit, 7,7 mm untuk hidroksiapatit, dan 10,7 mm untuk kombinasi dengan rasio 3:1. Kesimpulan: Ekstrak etanol rimpang kunyit yang dikombinasikan dengan hidroksiapatit menunjukkan aktivitas penghambatan terhadap Streptococcus sobrinus, sehingga berpotensi sebagai antimikroba alami untuk pencegahan karies gigi.
Aktivitas Antiinflamasi Ekstrak Metanol Herba Puguntano (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi λ-Karagenan Asfianti, Vivi; Sagala, Vanny Yosepha; Febriady, Andy; Suprianto; Syarifuddin, Shofian
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.02

Abstract

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemical exposure, or microbial agents. When excessive, this response may worsen tissue damage and require treatment. Interest in medicinal plants as alternative anti-inflammatory agents remains high because conventional nonsteroidal anti-inflammatory drugs, although effective, may cause adverse effects. Puguntano herb (Picria fel-terrae Lour.) contains flavonoids, saponins, tannins, glycosides, and steroids or triterpenoids that may contribute to anti-inflammatory activity. Objective: This study aimed to evaluate the anti-inflammatory effect of the methanolic extract of puguntano herb in male white rats with λ-carrageenan-induced paw edema and to identify the most effective tested dose. Methods: An experimental design was used in twenty-five healthy male rats divided into five groups. The negative control received 0.5% Na-CMC, the positive control received sodium diclofenac 2.25 mg/kg body weight, and the treatment groups received extract doses of 50, 100, and 200 mg/kg body weight. Acute inflammation was induced by intraplantar injection of 1% λ-carrageenan. Paw volume was measured with a digital plethysmometer for 360 minutes. Percentage of inflammation and percentage of inhibition were analyzed using one-way ANOVA followed by Tukey’s test. Results: The methanolic extract showed anti-inflammatory activity at all tested doses. A dose-dependent pattern was observed, with greater edema suppression at higher doses. The 200 mg/kg body weight dose produced the strongest effect and showed activity comparable to sodium diclofenac. Conclusion: The methanolic extract of puguntano herb demonstrated anti-inflammatory potential in this model, with the 200 mg/kg body weight dose as the most effective treatment for further preclinical study
Potensi Antipiretik Ekstrak Metanol Herba Pugun Tanoh (Picria fel-terrae Lour.) pada Tikus Putih Jantan yang Diinduksi 2,4-Dinitrofenol Romansa Sianipar; Asfianti, Vivi; Debi Meylani
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.04

Abstract

Background: Pugun tanoh herb (Picria fel-terrae Lour.) is a medicinal plant belonging to the family Scrophulariaceae and has traditionally been used to treat malaria, promote diuresis, relieve colic, reduce fever, and manage skin diseases. Objective: This study aimed to evaluate the antipyretic activity of the methanol extract of Pugun tanoh herb in male white rats (Rattus norvegicus) induced with 2,4-dinitrophenol and to determine the most effective dose. Methods: This experimental study used a digital thermometer to measure changes in the body temperature of rats. The extract was administered at doses of 50, 100, and 200 mg/kg body weight, with Na-CMC as the negative control and paracetamol at 20 mg/kg body weight as the positive control. Results: The results showed that the methanol extract of Pugun tanoh herb exhibited antipyretic activity. Doses of 50, 100, and 200 mg/kg body weight reduced the body temperature of rats, with mean temperatures of 37.416 °C, 36.776 °C, and 36.388 °C, respectively. Conclusion: The dose of 200 mg/kg body weight demonstrated the strongest antipyretic effect. This activity is presumed to be associated with the flavonoid content of Pugun tanoh herb.
Uji Aktivitas Antioksidan Ekstrak n-Heksan, Etil Asetat dan Metanol Herba Puguntano (Picria fel-terrae Lour.) dengan Metode DPPH Ushbah Safira; Asfianti, Vivi; Samran
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.05

Abstract

Background: Antioxidants are compounds that play a role in inhibiting or reducing oxidative damage caused by free radicals. Objective: This study aimed to evaluate the characteristics of simplicia, phytochemical constituents, reflux extraction process, and antioxidant activity of puguntano herb extract using the DPPH method with UV-Vis spectrophotometry. Methods: Simplicia characterization included macroscopic examination, moisture content, water-soluble extractive value, ethanol-soluble extractive value, and total ash content. Phytochemical screening was performed using thin-layer chromatography to detect alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Puguntano herb was extracted by reflux using n-hexane, ethyl acetate, and methanol as solvents, followed by concentration with a rotary evaporator to obtain thick extracts. Antioxidant activity was assessed using the DPPH method after 60 minutes of incubation at a wavelength of 516 nm. Results: The simplicia characterization showed a moisture content of 7.23%, water-soluble extractive value of 38.6%, ethanol-soluble extractive value of 5%, and total ash content of 10.71%. Phytochemical screening revealed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. Conclusion: The IC50 values of the n-hexane, ethyl acetate, methanol extracts, and quercetin were 216.8478, 30.6781, 21.3478, and 4.973 µg/mL, respectively
Aktivitas Kombinasi Ekstrak Daun Sirsak (Annona muricata Linn) dan Kulit Buah Naga (Hylocereus polyrhizus) pada Staphylococcus aureus dan Escherichia coli Suprianto; Sri Zuwinda Zusya Pane; Sumardi
Jurnal Indah Sains dan Klinis Vol 7 No 1 (2026): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v7i1.03

Abstract

Background: Bacterial infections caused by Staphylococcus aureus and Escherichia coli remain clinically relevant due to their ability to cause skin and gastrointestinal infections. The growing concern over antimicrobial resistance has increased interest in plant-derived antibacterial agents. Soursop leaves (Annona muricata L.) and red dragon fruit peel (Hylocereus polyrhizus) contain secondary metabolites that may contribute to bacterial growth inhibition. Objective: This study aimed to evaluate the antibacterial activity of combined ethanolic extracts of A. muricata leaves and H. polyrhizus peel against S. aureus and E. coli, and to determine the most effective extract ratio based on inhibition zone diameter. Methods: This laboratory experimental study used the disc diffusion method on Nutrient Agar medium. The plant materials were extracted by maceration using 70% ethanol. Five extract ratios were tested, namely 0.05:2.95, 0.10:2.90, 0.15:2.85, 0.20:2.80, and 0.25:2.75. Amoxicillin was used as the positive control, while distilled water served as the negative control. Inhibition zones were measured after 24 hours of incubation at 37°C. Results: The extract combinations showed weak antibacterial activity against S. aureus, with mean inhibition zones ranging from 1.08 to 3.18 mm. Against E. coli, four ratios showed weak activity, while the 0.25:2.75 ratio produced moderate inhibition with the highest mean zone of 5.18 mm. The positive control produced a strong inhibition zone of 13.13 mm, whereas the negative control showed no inhibition. Conclusion: The combination of A. muricata leaf and H. polyrhizus peel extracts demonstrated limited antibacterial activity and did not indicate a strong synergistic effect. The 0.25:2.75 ratio showed the best activity against E. coli and may be considered for further optimization using higher concentrations and more specific antibacterial assays.

Page 10 of 10 | Total Record : 95

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