cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Sumardi
Contact Email
sekretariatjisk@gmail.com
Phone
+6285297402947
Journal Mail Official
sekretariatjisk@gmail.com
Editorial Address
Jl. Melati II No. 3 Medan City TK I Regional Government Complex
Location
Unknown,
Unknown
INDONESIA
Jurnal Indah Sains dan Klinis
Published by Yayasan Penelitian dan Inovasi Sumatera
ISSN : -     EISSN : 27471942     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing
The Jurnal Indah Sains dan Klinis (JISK) is a journal about health which contains scientific and clinical issues published by the Yayasan Penelitian dan Inovasi Sumatera (YPIS) which includes studies on Pharmacy, Medicine, Nursing, Midwifery, Chemistry, Biology, Microbiology, Tissue Culture and others. other. disciplines related to health. The beginning of JISK was published at the end of December 2020, published by the Sekolah Tinggi Kesehatan Indah Medan. Since 2022, the publication of Volume 3 Number 2 has been carried out by the Yayasan Penelitian dan Inovasi Sumatera (YPIS),
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 90 Documents
 5   6   7   8   9 
Assessing Drug-Likeness The Natural Compounds of Polar Extract Curcuma xanthorrhiza Rhizome via Lipinski's Rules with SWISSADME Web Tool Sumardi, Sumardi; Suprianto, Suprianto
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.03

Abstract

Curcuma xanthorrhiza, commonly known as Javanese turmeric, is widely recognized for its medicinal properties, with its polar extract containing various bioactive compounds. This study aims to assess the drug-likeness of natural compounds found in the polar extract of Curcuma xanthorrhiza rhizome using Lipinski's Rule of Five, analyzed through the SWISSADME web tool. The compounds alpha pinene, alpha thujene, beta pinene, and zingiberene were evaluated for their physicochemical properties, including molecular weight, hydrogen bond donors and acceptors, lipophilicity, and solubility. The analysis confirms that these compounds meet the criteria for oral drug-likeness. Additionally, specific parameters such as fractionCsp3, iLOGP, and MLOGP were found to significantly influence the permeability of these compounds, further supporting their potential as orally administered therapeutics. The findings underscore the utility of SWISSADME in preclinical screening of natural products, offering a valuable approach to identify promising candidates for drug development. This study highlights the potential of Curcuma xanthorrhiza polar extract as a source of drug-like compounds, paving the way for further pharmacological and clinical investigations.
ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi, Sumardi; Suprianto, Suprianto; Siregar, Suci Rahmadani; Zai, Arifin Putra; Tambubolon, Regina Elianda; Mairani, Fridelly
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
Dampak Pewarna Ekstrak Etanol Buah Naga Merah (Hylicerius polyhizus) terhadap Lip Balm Minyak Bunga Kenanga (Cananga oil) Meilani, Debi; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.02

Abstract

Background: Red dragon fruit holds promise as a natural dye alternative due to its anthocyanin content. Objective: This study aimed to evaluate the potential of ethanol extract from red dragon fruit as a dye in Lip Balm formulations and investigate how varying the concentration of this extract affects the formula. Method: The study involved extracting the dye from red dragon fruit and incorporating it into a Lip Balm preparation using natural fruit-based dyes. Results: The findings indicated that the red dragon fruit extract yielded favorable results after undergoing various tests, including organoleptic evaluation, homogeneity, melting point, irritation, and user preference. Conclusion: The extract of red dragon fruit can be utilized as a dye in Lip Balm formulations. The resulting colors range from pink to dark red, with higher concentrations of the extract producing more intense colors in the final Lip Balm product containing ylang-ylang flower oil (Cananga oil)
Potensi Antihiperglikemia Kombinasi Ekstrak Daun Salam dan Ikan Gabus Razoki, Razoki; Simanjuntak, Nerly Juli Pranita
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.04

Abstract

Background: Flavonoids, as secondary metabolites found in bay leaves, exhibit antioxidant properties that help prevent damage to pancreatic β cells by neutralizing free radicals responsible for cell injury. Protein from snakehead fish plays a role in regulating blood sugar levels by inhibiting the α-glucosidase enzyme. Objective: This study aimed to assess the potential of combining the two extracts to lower blood sugar levels in mice. Method: Six groups were used in the study, each receiving a 250 mg/kg BW dose and 40% glucose inducer: Aquades (A), ethanol extract of bay leaves (EEDS), snakehead fish extract (EIG), and combinations of ethanol extracts of bay leaves and snakehead fish (EEDS-IG) in ratios of 1:1, 2:1, and 3:1 (w/w). Results: The study revealed that EEDS and EIG reduced blood sugar levels by 12.14%, 66.9%, 55.0%, 69.3%, 69.7%, and 69.3% at the 120th minute, respectively, for each group. Conclusion: The combination of EEDS and EIG has the potential to reduce blood sugar levels, particularly at a 2:1 ratio
Analisis Parasetamol Tablet dengan Metode Fourier Transform Infra Red (FTIR) Saragih, Safitri; Suprianto, Suprianto; Samran, Samran
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.05

Abstract

Background: Paracetamol, a widely used analgesic and antipyretic medication, is commonly prescribed in government healthcare facilities. The FTIR method provides rapid measurements by analyzing spectral graphs that reveal the functional groups within the tested compounds. According to the Indonesian Pharmacopoeia, VI Edition 2020, paracetamol content in tablet formulations must range between 90.0% and 110.0%. Objective: This study aimed to evaluate the paracetamol content in tablet preparations and assess their compliance with the 2020 Indonesian Pharmacopoeia standards and the packaging labels. Method: The research was conducted experimentally using FTIR spectroscopy. A solvent mixture of ethanol and distilled water (1:1) was employed, with analyses performed over the wavelength range of 4000–400 cm⁻¹. Results: The paracetamol content was found to be highest in tablet B (100.33 ± 1.003%), followed by tablet A (100.29 ± 1.002%), tablet D (100.24 ± 1.002%), and tablet E (100.14 ± 1.001%), with the lowest levels observed in tablet C (99.69 ± 0.996%). Method validation indicated an RSD value of 0.056%, confirming that the procedure was accurate and reliable. Conclusion: The findings demonstrate that the FTIR method is suitable for the quantitative analysis of paracetamol in tablet formulations. Moreover, the results meet the standards outlined in the 2020 VI Edition of the Indonesian Pharmacopoeia.
Avocado Seed Ethanol Extract's Ability to Reduce Hyperuricemia in Mice Sylvia Winata; Rena Meutia; Astriani Natalia; Asyrun Alkhairi Lubis
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.01

Abstract

Background: Hyperuricemia causes uric acid buildup in the blood, often in older people due to how the body processes purines. Studies show avocado seeds (Persea americana Mill.) may reduce blood uric acid through their flavonoid content, which fights off oxygen molecules and reduces inflammation, stopping a process called xanthine oxidation. Objective: This study aims to assess the effectiveness of avocado seed extract in lowering uric acid levels in male mice. Method: Mice were induced with potassium bromate, and the mice were divided into six groups of five individuals each. The groups included a negative control (Na CMC 0.5%), a positive control (allopurinol 10 mg/kg BW), treatment 1 (avocado seed extract 120 mg/kg BW), treatment 2 (avocado seed extract 150 mg/kg BW), treatment 3 (avocado seed extract 180 mg/kg BW), and a normal group (not treated). Checked uric acid levels for seven days. Then, used a statistical test and a BNT test with the LSD method to examine the results. Results: The findings showed that avocado seed extract given at a dose of 120-180 mg/kg body weight can reduce uric acid levels in mice. Conclusion: The best dose, 150 mg/kg BW, reduced hyperuricemia levels by 37.3%, with a significance value of 0.118
Identifikasi Cemaran Mikroba pada Kosmetik Sediaan Lip Tint dan Lip Cream  dengan Metode Angka Lempeng Total (ALT) Melia Sari; Leny; Ahmad Faisal Nasution; Ema Erliza
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.03

Abstract

Background: Repeated use of these products can lead to microbial contamination, making lip tint and lip cream susceptible to microbial contamination. Objective: To find contamination and identify the types of microbes contained in lip color cosmetics and lip creams. Methods: The methods used for bacterial contamination analysis include the Total Plate Count (TPC) test, bacterial identification on selective agar media, and Gram staining. Results: The Total Plate Count (TPC) results for lip tint samples after 1 month of use were 1.50 x 102 colonies/ml, 2 months 5.00 x 102 colonies/ml, and 3 months 5.50 x 102 colonies/ml. For lip cream samples after 1 month of use, the counts were 1.50 x 102 colonies/ml, 2 months 2.50 x 102 colonies/ml, and 3 months 15.00 x 102 colonies/ml. Pathogenic microbes detected in lip tint samples used for 1-3 months included S. aureus and C. albicans, while lip cream samples used for 1-3 months contained S. aureus, P. aeruginosa, C. albicans, and E. coli. All products that have been sampled for testing are within acceptable limits for Total Plate Count (TPC) according to BPOM Regulation Number 16 of 2024. Conclusion: All tested lip tint and lip cream samples met the required standards
Korelasi Konsumsi Sidaguri dengan Kadar Asan Urat Darah Suprianto, Suprianto; Adek Chan; Joko Wibowo; Samran; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.02

Abstract

Background: Hyperuricemia as an indicator of increased blood uric acid. The prevalence rate in Indonesia is not recorded with certainty. However, the prevalence of gout reached 655,745 people out of 238,452,952 people in Indonesia, ranking first in Southeast Asia. Sidaguri flavonoids have inhibitory power against Xanthine Oxidase so that they can reduce uric acid. Objective: The study was aimed at detecting the effect and correlation of Sidaguri capsule consumption (Sida rhombifolia L) on reducing uric acid in patients. Method: The study was conducted Pretest and Posttest on 22 patients with hyperuricemia with the Easy Touch GCU Instrument. Results: The results showed that the average uric acid level before the intervention was 8.37 mg/dL and after the intervention was 6.57 mg/dL. Conclusion: Sidaguri capsules have an effect on reducing uric acid levels in patients
Tinjauan Literatur: Mekanisme Antibakteri Ekstrak Kulit Jeruk Purut (Citrus hystrix DC.) Indah Pratiwi; Diding Pradita; Indah Pertiwi; Yulia Safitri Limbong
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.04

Abstract

Latar Belakang: Infeksi bakteri patogen masih menjadi salah satu tantangan utama dalam dunia kesehatan, apalagi dengan meningkatnya kasus resistensi antibiotik yang membuat pengobatan infeksi semakin sulit. Kondisi ini mendorong para peneliti untuk mencari alternatif lain yang lebih aman, mudah diakses, dan tetap efektif. Salah satu sumber yang kini banyak dilirik adalah tanaman obat, termasuk kulit jeruk purut (Citrus hystrix DC.), yang secara tradisional dikenal memiliki banyak manfaat kesehatan. Tujuan: Artikel ini bertujuan untuk meninjau berbagai literatur terkait potensi antibakteri dari ekstrak kulit jeruk purut, termasuk senyawa aktif yang dikandungnya, cara kerjanya terhadap bakteri, serta faktor-faktor yang memengaruhi efektivitasnya. Metode: Proses tinjauan dilakukan dengan mengumpulkan berbagai publikasi ilmiah yang diterbitkan dalam kurun waktu 2010 hingga 2024, menggunakan database seperti Google Scholar, PubMed, dan ScienceDirect. Literatur dipilih berdasarkan relevansi dengan topik, kualitas publikasi, serta ketersediaan informasi terkait senyawa aktif, aktivitas antibakteri, dan mekanisme kerjanya. Fokus pencarian difokuskan pada kata kunci seperti Citrus hystrix, antibacterial mechanism, phytochemicals, dan natural antimicrobial agents. Hasil: Berbagai sumber yang ditinjau, ditemukan bahwa kulit jeruk purut kaya akan senyawa bioaktif seperti flavonoid (naringin, hesperidin, narirutin), minyak atsiri (limonene, citronellal, dan β-pinene), tanin, dan saponin. Senyawa-senyawa ini menunjukkan aktivitas antibakteri terhadap berbagai jenis bakteri Gram-positif dan Gram-negatif. Cara kerjanya antara lain dengan merusak dinding dan membran sel bakteri, mengganggu sintesis protein dan DNA, serta menghambat kerja enzim yang penting bagi kelangsungan hidup sel bakteri. Aktivitas antibakteri ini juga sangat dipengaruhi oleh metode ekstraksi, jenis pelarut, dan konsentrasi ekstrak yang digunakan. Kesimpulan: Tinjauan ini menunjukkan bahwa ekstrak kulit jeruk purut punya potensi besar untuk dikembangkan sebagai agen antibakteri alami. Selain relatif aman dan mudah diperoleh, ekstrak ini juga menunjukkan mekanisme kerja yang beragam sehingga berpeluang untuk melawan bakteri yang sudah kebal terhadap antibiotik tertentu. Namun, diperlukan penelitian lanjutan yang lebih mendalam, terutama untuk memastikan konsistensi senyawa aktifnya, uji keamanan, dan efektivitasnya dalam skala klinis. Dengan pendekatan ilmiah yang tepat, kulit jeruk purut bisa menjadi salah satu solusi alami untuk menghadapi krisis resistensi antibiotik yang sedang kita hadapi saat ini.
Penapisan Virtual terhadap Empat Belas Senyawa Aktif dalam Ekstrak Polar Rimpang Curcuma Menghambat Aktivitas Thioesterase Polyketide Synthase 13 dari MTb: Studi Moleculer Docking Sumardi; Sumardi, Sumardi
Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i1.05

Abstract

Pendahuluan: Tuberkulosis (TB) yang disebabkan oleh Mycobacterium tuberculosis (Mtb) masih menjadi masalah kesehatan global dengan angka kejadian dan resistensi obat yang tinggi. Salah satu target molekuler yang menjanjikan dalam pengembangan obat anti-TB adalah enzim Polyketide Synthase 13 Thioesterase (Pks13-TE), yang berperan penting dalam biosintesis asam mikolat, komponen utama dinding sel Mtb. Aktivitas enzim ini berkontribusi terhadap virulensi dan kelangsungan hidup Mtb, sehingga penghambatannya dipandang sebagai strategi terapeutik yang potensial. Tujuan: Penelitian ini bertujuan untuk mengeksplorasi potensi senyawa polar alami dalam temu lawak (Curcuma xanthorrhiza) sebagai inhibitor Pks13-TE melalui pendekatan in silico berbasis simulasi Molecular Docking. Metode: Sebanyak empat belas senyawa dari ekstrak polar Temu Lawak dianalisis interaksinya terhadap situs aktif Pks13-TE menggunakan perangkat lunak AutoDock Tools dan PyMOL. Parameter yang diamati meliputi energi ikatan (binding affinity), jenis ikatan hidrogen dan hidrofobik, serta keterlibatan residu katalitik dalam kompleks protein-ligan. Hasil: Hasil simulasi menunjukkan bahwa tiga senyawa α-pinene, α-thujene, dan Desmethoxycurcumine memiliki afinitas pengikatan yang paling kuat dibanding senyawa lain. Ketiganya berinteraksi stabil dengan residu-residu penting dalam domain thioesterase, menunjukkan potensi sebagai inhibitor kompetitif. Kesimpulan: Temuan ini mendukung pemanfaatan senyawa alam dari Temu Lawak sebagai kandidat awal dalam skrining obat TB berbasis target molekuler. Studi lanjutan in vitro dan in vivo diperlukan untuk mengkonfirmasi aktivitas biologis dan toksisitas dari senyawa terpilih.

Page 8 of 9 | Total Record : 90

 5   6   7   8   9 

Filter by Year

2020 2025


Reset
Filter By Issues
All Issue Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis Vol 6 No 1 (2025): Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis Vol 3 No 3 (2022): Jurnal Indah Sains dan Klinis Vol 3 No 2 (2022): Jurnal Indah Sains dan Klinis Vol 3 No 1 (2022): Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis Vol 2 No 2 (2021): Jurnal Indah Sains dan Klinis Vol 2 No 1 (2021): Jurnal Indah Sains dan Klinis Vol 1 No 1 (2020): Jurnal Indah Sains dan Klinis More Issue