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INDONESIA
Jurnal Indah Sains dan Klinis
Published by Yayasan Penelitian dan Inovasi Sumatera
ISSN : -     EISSN : 27471942     DOI : -
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing
The Jurnal Indah Sains dan Klinis (JISK) is a journal about health which contains scientific and clinical issues published by the Yayasan Penelitian dan Inovasi Sumatera (YPIS) which includes studies on Pharmacy, Medicine, Nursing, Midwifery, Chemistry, Biology, Microbiology, Tissue Culture and others. other. disciplines related to health. The beginning of JISK was published at the end of December 2020, published by the Sekolah Tinggi Kesehatan Indah Medan. Since 2022, the publication of Volume 3 Number 2 has been carried out by the Yayasan Penelitian dan Inovasi Sumatera (YPIS),
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 90 Documents
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Pengembangan Cleansing Oil Berbasis Minyak Biji Alpukat (Persea americana Mill.) dengan Variasi Konsentrasi Surfaktan sebagai Pembersih Make-Up Tahan Air Adek Chan; Ervina Syahfitri Lubis; Hendri Faisal; Osy Devitania
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.01

Abstract

Background: Avocado seeds contain 15–25% oil and are rich in bioactive compounds such as alkaloids, flavonoids, tannins, saponins, and terpenoids, making them a potential natural ingredient for skincare formulations. Objective: This study aimed to develop a cleansing oil using avocado seed oil with varying surfactant concentrations to evaluate its effectiveness in removing waterproof makeup. Method: The oil was extracted from avocado seeds using the Soxhlet method with n-hexane, yielding 20% oil. Cleansing oil formulations were prepared using surfactant concentrations of 4%, 6%, and 8%, and tested for organoleptic characteristics, homogeneity, pH, irritation, viscosity, stability, user preference, and cleansing performance. Result: All formulations showed safe pH levels (6.4–7.0), no skin irritation, good physical stability, and were well accepted by users. The formulation with 8% surfactant demonstrated the best cleansing ability. Conclusion: Avocado seed oil is suitable for use in cleansing oil formulations, particularly when combined with higher surfactant concentrations, offering an effective and natural solution for removing waterproof makeup
Gambaran Penggunaan Obat Antibiotik dan Analgetik pada Resep Pasien Poli Gigi di RSUD Muyang Kute Razoki, Razoki; Elvi Sasmi; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.02

Abstract

Background: Dental and oral diseases often lead to infections and pain, thus requiring treatment with antibiotics and analgesics. These conditions, if not treated properly, can significantly impact patients' quality of life and may result in further complications. Objective: This study aims to provide an overview of the use of antibiotics and analgesics in prescriptions for dental clinic patients at RSUD Muyang Kute. Method: A descriptive retrospective study was conducted on 80 prescriptions from patients at the Dental Clinic in September 2024. The sampling technique used was random sampling. Results: The majority of patients were female (60%) and within the age range of 26–45 years (37.5%). The most frequently prescribed antibiotic was amoxicillin (92.5%), followed by a combination of amoxicillin and metronidazole (3.75%), lincomycin (2.5%), and cefadroxil (1.25%). The most commonly used analgesic was a combination of paracetamol and dexamethasone (97.5%), followed by mefenamic acid and dexamethasone (2.5%). Conclusion: Amoxicillin and the combination of paracetamol-dexamethasone were the preferred drugs due to their high effectiveness, safety, and relatively affordable cost.
Profil Pelayanan Resep dengan Obat Glibenklamid di Apotek Wilayah Nagan Raya Razoki, Razoki; Friska Rezki Hasibuan
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.04

Abstract

Background: Community pharmacies have shifted from focusing only on products to providing care centered on patients. Pharmacists now have the role of gathering patient information, giving proper counseling, and ensuring medicine labels are clear and correct. This is crucial for chronic diseases like type 2 diabetes mellitus, where drugs such as glibenclamide must be used properly to avoid risks. Objective: This study aimed to describe how pharmacies in Nagan Raya provide prescription services for glibenclamide, especially in terms of patient data collection, counseling, and labeling. Methods: A descriptive study was done using the simulated patient method. A total of 90 pharmacies were randomly chosen. The researcher acted as a patient’s family member and presented a prescription for glibenclamide. Observations were recorded right after each visit using a structured and validated checklist. Results: Of the 90 pharmacies visited, 85 (94.4%) dispensed the medicine. However, only 18.8% asked for the patient's address, and fewer than 10% asked about other key information like user identity or medication history. No pharmacy asked about symptoms, allergies, or comorbidities. For counseling, 64.7% mentioned how often to take the drug, 15.3% explained timing, and just 1.2% discussed side effects. Labels were provided in 65.9% of cases, but some were incomplete or used wrongly. Conclusion: The quality of prescription services for glibenclamide in Nagan Raya is still lacking. Important steps like patient assessment and counseling are often missed. Better training and stronger supervision are needed to improve pharmacy services and ensure patient safety
Profil Pelayanan Resep dengan Obat Glibenklamid di RSUD Muyang kute Bener Meriah Masriani; Razoki, Razoki; Astriani Natalia Br Ginting
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.03

Abstract

Background: Optimal pharmaceutical services are essential in chronic disease management, particularly in diabetes mellitus, where glibenclamide is frequently prescribed. Inadequate dispensing practices and lack of patient information can compromise treatment outcomes. Objective: This study aimed to evaluate the profile of prescription services involving glibenclamide at RSUD Muyang Kute Bener Meriah, focusing on drug availability, patient information gathering, medication counseling, and labeling practices. Methods: A descriptive observational design was applied using the simulated patient method. Researchers visited the pharmacy unit with a standardized prescription scenario involving glibenclamide. Data were collected using an observation checklist immediately after each interaction. Results:The majority of pharmacy staff did not actively collect essential patient information. Counseling was limited to usage instructions, with no mention of adverse effects or drug interactions. Labels were incomplete, often missing key components such as patient name, drug name, or preparation date. However, the availability of glibenclamide remained consistent during the observation period. Conclusion: Prescription services for glibenclamide at RSUD Muyang Kute are still below optimal standards. Improvements in patient assessment, communication, and labeling practices are necessary to enhance medication safety and treatment effectiveness
Validasi Metode Penetapan Kadar Monosodium Glutamat pada Mie Ayam dengan Spektrofotometri UV–Vis Setelah Derivatisasi Ninhidrin Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya; Cyndi Veronica; Sumardi; Debi Meilani
Jurnal Indah Sains dan Klinis Vol 6 No 2 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i2.05

Abstract

Pendahuluan: Mie Ayam merupakan aneka olahan mie yang dijajakan, disajikan dan dinikmati dengan cita rasa yang sangat lezat; dijajakan dari mulai gerobak jalan, di pinggir jalan maupun tempat lesehan. Mie Ayam diolah dengan penambahan berbagai bahan tambahan pangan agar diperoleh makanan yang dapat membangkitkan selera konsumen. Mie Ayam yang disajikan harus diproses dengan benar sehingga konsumen aman setelah konsumsi makanan tersebut. Monosodium glutamate (MSG) merupakan bahan tambahan pangan yang biasa ditambahkan pada makanan untuk meningkatkan cita rasa makanan, terutama rasa lezat makanan. MSG ditambahkan pada produk pangan tidak lebih dari 10g/kg Bahan Pangan agar konsumen terjamin kesehatannya. MSG dapat diderivatisasi dengan ninhidrin sehingga penetapan kadar dapat dilakukan dengan spektrofotometri visibel. Tujuan: Menentukan kadar MSG pada Mie Ayam secara spektrofotometri UV. Metode: Penetapan kadar MSG dilakukan secara spektrofotometri UV setelah dilakukan derivatisasi dengan Ninhidrin. Hasil: Kadar MSG pada Mie diperoleh pada rentang 1,9441- 2,4726 g/kg bahan pangan dan di bawah batas maksimum 10 g /kg bahan pangan menurut EPSA. Kesimpulan: Kadar MSG pada Mie Ayam pada rentang tertentu dan masih di bawah batas maksimum.
Formulasi Sediaan Lulur Body Scrub Ekstrak Etanol Umbi Lobak Putih (Raphanus sativus L.)DARI EKSTRAK ETANOL UMBI LOBAK PUTIH (Raphanus sativus L.) Limbong, Yulia
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.01

Abstract

Latar Belakang: Lulur body scrub merupakan seBackground: A body scrub is a cosmetic preparation used to help remove dead skin cells and improve skin appearance. One natural ingredient that can be used in a body scrub formulation is white radish (Raphanus sativus L.). White radish contains flavonoids and saponins, which act as antioxidants and have potential as skin lightening agents. Objective: This study aimed to formulate and evaluate a body scrub preparation using ethanol extract of white radish tubers at varying concentrations of 2%, 4%, and 6%. Method: This research was conducted experimentally. Tests included organoleptic evaluation, homogeneity, pH, irritation, spreadability, viscosity, emulsion type, stability, and effectiveness in moisturizing, smoothing, and wrinkle reduction using a skin analyzer. Result: The results showed that the body scrub preparation was semi-solid, brownish-white in color, had a distinctive aroma, and was homogeneous. The emulsion type was o/w, with a pH ranging from 6.1 to 6.5, and did not cause skin irritation. Stability tests demonstrated good product stability, and effectiveness tests demonstrated a significant increase in skin moisture, smoothness, and wrinkle reduction (p ≤ 0.05), especially with the 6% concentration. Conclusion: The conclusion of this stuLatar Belakang: Lulur tubuh adalah sediaan kosmetik yang digunakan untuk membantu mengangkat sel kulit mati dan memperbaiki penampilan kulit. Salah satu bahan alami yang dapat digunakan dalam formulasi lulur tubuh adalah lobak putih (Raphanus sativus L.). Lobak putih mengandung flavonoid dan saponin, yang bertindak sebagai antioksidan dan berpotensi sebagai agen pencerah kulit. Tujuan: Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi sediaan lulur tubuh menggunakan ekstrak etanol umbi lobak putih pada berbagai konsentrasi 2%, 4%, dan 6%. Metode: Penelitian ini dilakukan secara eksperimental. Pengujian meliputi evaluasi organoleptik, homogenitas, pH, iritasi, daya sebar, viskositas, tipe emulsi, stabilitas, dan efektivitas dalam melembapkan, menghaluskan, dan mengurangi kerutan menggunakan skin analyzer. Hasil: Hasil menunjukkan bahwa sediaan lulur tubuh berupa semi-padat, berwarna putih kecokelatan, memiliki aroma yang khas, dan homogen. Tipe emulsi adalah o/w, dengan pH berkisar antara 6,1 hingga 6,5, dan tidak menyebabkan iritasi kulit. Uji stabilitas menunjukkan stabilitas produk yang baik, dan uji efektivitas menunjukkan peningkatan yang signifikan pada kelembapan kulit, kehalusan, dan pengurangan kerutan (p ≤ 0,05), terutama pada konsentrasi 6%. Kesimpulan: Kesimpulan dari penelitian ini adalah ekstrak umbi lobak putih (Raphanus sativus L.) dapat diformulasikan menjadi lulur tubuh yang aman dan efektif yang mencerahkan kulit dan mengangkat sel kulit mati. Kirim masukan Panel samping Histori Tersimpandy is that white radish (Raphanus sativus L.) tuber extract can be formulated into a safe and effective body scrub that brightens skin and removes dead skin cells.diaan kosmetik yang digunakan untuk membantu pengangkatan sel kulit mati dan memperbaiki tampilan kulit. Salah satu bahan alami yang dapat digunakan dalam formulasi lulur adalah umbi lobak putih (Raphanus sativus L.). Umbi lobak putih mengandung senyawa flavonoid dan saponin yang berperan sebagai antioksidan dan berpotensi sebagai agen pencerah kulit. Tujuan: Penelitian ini bertujuan untuk merumuskan dan mengevaluasi sediaan lulur body scrub menggunakan ekstrak etanol umbi lobak putih dengan variasi konsentrasi 2%, 4%, dan 6%. Metode: Penelitian ini merupakan secara eksperimental. Pengujian meliputi secara organoleptik, homogenitas, uji pH, iritasi, daya sebar, viskositas, tipe emulsi, stabilitas, dan efektivitas kelembaban, kehalusan, serta pengurangan kerutan menggunakan alat skin analyzer. Hasil: penelitian ini menunjukkan bahwa sediaan lulur body scrub memiliki semi padat, warna putih kecoklatan, aroma khas, dan homogen. Tipe emulsi minyak/air, pH berkisar 6,1-6,5, serta tidak menyebabkan iritasi pada kulit. Uji stabilitas menunjukkan kestabilan sediaan yang baik dan uji efektivitas menunjukkan adanya peningkatan kelembaban, kehalusan, dan pengurangan kerutan pada kulit secara signifikan (p ≤ 0,05) terutama pada formula dengan konsentrasi 6%. Kesimpulan: dari penelitian ini menunjukkan ekstrak umbi lobak putih (Raphanus sativus L.) dapat diformulasikan menjadi lulur body scrub yang aman, efektif sebagai mencerahkan kulit dan mengangkat sel kulit mati.
Skrining Fitokimia, Profil Kromatografi Lapis Tipis dan Karakterisasi FTIR Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) Adinda Seftia; Suprianto; Effendy De Lux Putra; Samran; Siti Nurbaya
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.02

Abstract

Background: Rambutan (Nephelium lappaceum L.) leaves have potential as a source of bioactive secondary metabolites, yet baseline data on their preliminary chemical profile and functional-group features are still limited. Objective: This study aimed to (i) screen the phytochemical constituents of rambutan leaf ethanol extract, (ii) verify major metabolite classes using thin-layer chromatography (TLC), and (iii) characterize dominant functional groups by Fourier Transform Infrared (FTIR) spectroscopy. Method: Dried rambutan leaves collected from Langkat Regency and Binjai City were extracted by maceration with 96% ethanol (1:10; 3×24 h), followed by remaceration (1×24 h). The filtrate was concentrated at 58 °C. Qualitative tests were conducted for alkaloids, flavonoids, tannins, saponins, and steroids. TLC analysis employed silica gel 60 F254 plates with class-specific mobile phases, while FTIR spectra were recorded in the range of 4000–600 cm⁻¹. Results: The extract yield was 25.7%. Phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, saponins, and steroids, with TLC Rf values of 0.70 and 0.46 (alkaloids), 0.80 (flavonoids), 0.70 (tannins), and 0.50 (steroids). FTIR bands at 3365 cm⁻¹ (O–H), 3010 cm⁻¹ (aromatic C–H), 1629 cm⁻¹ (C=C), and 1048 cm⁻¹ (C–O) indicated oxygenated secondary metabolites, particularly phenolic-related compounds. Conclusion: The integrated phytochemical screening, TLC, and FTIR approach provides a concise chemical baseline for rambutan leaf ethanol extract, supporting its potential use in further standardization and marker-based studies.
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Kumis Kucing (Orthosiphon aristatus) dan Daun Mangga Madu (Mangifera indica L.) terhadap Propionibacterium acnes Agus Kristina; Suprianto; Debi Meilani; Andy Febriadi; Shofian Syarifuddin
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.03

Abstract

Background: Acne is strongly linked to the overgrowth of Propionibacterium acnes. Because long-term use of conventional antibacterials may contribute to resistance and irritation, plant-derived extracts are being explored as alternative or complementary options. Kumis Kucing (Orthosiphon aristatus) and Mangga Madu (Mangifera indica L.) leaves are known to contain secondary metabolites that may help suppress bacterial growth. Objective: This study aimed to evaluate the antibacterial effect of combined ethanol extracts of O. aristatus and M. indica leaves against C. acnes and to determine which formulation ratio produced the best inhibition. Method: Each plant material was extracted separately using ethanol, then blended into five different combination formulas (F1–F5). Antibacterial activity was assessed in vitro using the disc diffusion technique with a standardized inoculum (0.5 McFarland). The diameter of the clear zone around each disc was measured and used to categorize antibacterial strength. Results: Qualitative phytochemical screening confirmed that both extracts contained key metabolite groups, including alkaloids, tannins/phenolics, flavonoids, and saponins. The negative control showed no clear zone, while clindamycin (positive control) produced a strong inhibition zone of 19.2 mm. All combined formulas inhibited C. acnes, with inhibition zones between 8.6 mm and 11.5 mm. Formula 3 generated the widest zone (11.5 mm; strong category), whereas Formula 2 showed the smallest inhibition (8.6 mm; weak category). Conclusion: The ethanol extracts of O. aristatus and M. indica leaves, when combined, were able to inhibit C. acnes. The level of inhibition varied with the mixing ratio, and Formula 3 demonstrated the most promising antibacterial activity among the tested formulations
Penetapan Kadar Total Fenol dan Total Flavonoid pada Lotion Berbahan Ekstrak Daun Sisrsak (Annona muricata) dan Kulit Buah Naga Merah (Hylocereus polyrhizus) Menggunakan Spektrofotometri UV–VIS Siregar, Suci Rahmadani; Suprianto; Chandra Pranata; Marbun, Intan Coni Caroline
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.04

Abstract

Background: Phenolic and flavonoid compounds from soursop (Annona muricata) leaves and red dragon fruit (Hylocereus polyrhizus) peel have potential applications in lotion formulations; therefore, their quantification is important for quality evaluation. Objective: To determine total phenolic content (TPC) and total flavonoid content (TFC) in lotion formulations containing combined plant extracts and to assess the analytical method performance. Method; Four formulations were prepared: F0 (without extract), F1 (0.5% + 0.5%), F2 (1.0% + 1.0%), and F3 (1.5% + 1.5%). TPC was measured using the Folin–Ciocalteu method (mg GAE/g) and TFC using the AlCl₃ colorimetric method (mg QE/g). Method validation included repeatability (%RSD, n = 6) and spike-recovery accuracy at 80–120%. Results: The method showed good precision (%RSD 1.08% for TPC and 1.21% for TFC) and acceptable accuracy with recoveries of 98–102%. F0 showed non-detectable values, while increasing extract concentration resulted in higher TPC (3.82 ± 0.14 to 9.71 ± 0.33 mg GAE/g) and TFC (0.86 ± 0.05 to 2.35 ± 0.10 mg QE/g). Differences among formulations were statistically significant (p < 0.05). Conclusion: The UV–Vis method is suitable for determining TPC and TFC in lotion matrices, and higher levels of combined extracts significantly increase both parameters, supporting their use for quality standardization of herbal lotions.
Formulasi Sediaan Lotion Antioksidan Ekstrak Daun Sirsak (Annona muricata L.) dan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) sebagai Pelembab Sumardi; Suprianto; Azzahra, Innayah; Lisa Syafrida
Jurnal Indah Sains dan Klinis Vol 6 No 3 (2025): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v6i3.05

Abstract

Background: A lotion made from ethanol extracts of Sirsak (Annona muricata) leaves and Naga Merah fruit (Hylocereus polyrhizus) peels is a potential antioxidant moisturizer, but its quality, safety, and hydration effect need confirmation. Objective: To formulate five oil-in-water lotions with different extract ratios (total extract 3% w/w) and evaluate physical quality, preliminary safety, and moisturizing performance. Method: The formulations were tested for organoleptic properties, homogeneity, pH, and spreadability. A simple irritation test and a three-day forearm hydration assessment using a skin analyzer were conducted in 25 panelists, followed by one-way analysis of variance. Results: All formulations had pH 6.67–6.96, with minor inhomogeneity observed in one formulation. Acceptable spreadability was achieved by three formulations under specific loads. No irritation occurred. All formulations increased hydration, with significant differences between them (p < 0.001); the two best-performing formulations produced the highest and most stable moisture over three days. Conclusion: The combined-extract oil-in-water lotion at 3% w/w is feasible and preliminarily safe, and the two top formulations are recommended for further development

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