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OVERVIEW OF PHYTOCHEMICAL COMPOUNDS AND PHARMACOLOGICAL ACTIVITIES OF Borassus flabellifer Linn. AS A REGIONAL EMBLEM PLANT OF SOUTH SULAWESI Wahyuni Agus
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i2.150

Background: Borassus flabellifer Linn. (palmyra palm) is a member of the Arecaceae family with important ecological, economic, and pharmacological roles, and serves as the floral emblem of South Sulawesi, Indonesia. Traditionally, almost all parts of the plant have been used for food, beverages, and handicrafts. Objective: This review summarizes its phytochemical constituents and pharmacological activities. Methods: Relevant articles were collected from Scopus, ScienceDirect, PubMed, and Google Scholar. Publications from 2005 to 2025 were screened using the keywords Borassus flabellifer, palmyra palm, phytochemistry, and pharmacological activity. Based on inclusion and exclusion criteria, 19 articles were analyzed. Result: Findings indicate that plant parts contain bioactive compounds such as flavonoids, phenols, alkaloids, saponins, tannins, terpenoids, and steroidal saponins including flabelliferins and borassosides. These metabolites are linked to antioxidant, anti-inflammatory, cytotoxic, antidiabetic, antibacterial, antifungal, and diuretic effects, through mechanisms such as free radical scavenging, suppression of inflammation, induction of apoptosis, inhibition of carbohydrate-digesting enzymes, and regulation of renal electrolyte excretion. Conclusion: Overall, Borassus flabellifer shows strong potential as a source of phytopharmaceuticals and natural drug candidates. Beyond pharmacological value, its ecological resilience, cultural significance, and economic importance support its designation as the floral emblem of South Sulawesi. Further preclinical and clinical studies are needed to validate therapeutic efficacy and safety.

Efektivitas dan Keamanan Ceftaroline VS Ceftriaxone dalam Terapi Community-Acquired Pneumonia: Bukti dari Satu Dekade Penelitian Andi Ameilia Sari Riandika
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i2.151

Background: Community acquired pneumonia (CAP) remains a leading cause of morbidity and mortality among hospitalized adults. Appropriate selection of empirical antibiotics is crucial to prevent treatment failure and limit antimicrobial resistance. Ceftriaxone has long been the standard empirical therapy for moderate to severe CAP in many clinical guidelines. However, ceftaroline fosamil, a newer generation cephalosporin with activity against Streptococcus pneumoniae (including penicillin resistant strains), has emerged as a potential alternative. Objective: This review aims to evaluate randomized controlled trial (RCT) evidence published between 2015 and 2025 comparing the efficacy and safety of ceftaroline versus ceftriaxone in the treatment of CAP among hospitalized. Methods: A literature search was conducted in PubMed, ScienceDirect, and Scopus for RCTs published between 2015 and 2025 based on the checklist prism. Results: Evidence from RCTs (2015–2025) supports ceftaroline as an effective alternative to ceftriaxone for the management of CAP in hospitalized adults. Several pooled analyses suggest superiority of ceftaroline in terms of clinical cure, while no significant differences were observed in mortality outcomes. The safety profiles of both agents were generally comparable. Conclusion: This review supports ceftaroline as an effective empirical alternative to ceftriaxone for moderate to severe CAP, with evidence indicating potential advantages in clinical cure rates.

LITERATUR REVIEW : PERAN APOTEKER DALAM PENCEGAHAN MEDICATION ERROR PADA PASIEN PEDIATRIK Rieka Nurul Dwi Anggraeni
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i2.154

Background: Medication errors (MEs) in pediatric patients are a serious patient safety concern. MEs in children often occur due to insufficient understanding of pediatric dosing and non-compliance with standard operating procedures (SOPs) by healthcare professionals. Objective: This article aims to review the role of pharmacists in preventing MEs in pediatric patients through an analysis of recent literature. Methods: The article was prepared as a literature review using sources from online databases (ScienceDirect, PubMed, Google Scholar) published between 2020 and 2025. Inclusion criteria included full-text availability, relevance to the topic, and focus on the pediatric context. Results: Several studies show that pharmacist interventions, such as prescription review, education, audit, medication reconciliation, and participation in ward rounds, can reduce the incidence of MEs by 64–73%. Studies in Indonesia revealed that 92% of pediatric prescriptions did not include body weight and only 16% contained complete information, indicating a high potential for dosing errors. Pharmacist-led education for healthcare providers and parents/caregivers plays an important role in improving understanding and preventing medication administration errors at home. Conclusion: Pharmacists play a crucial role in preventing pediatric MEs through clinical and educational interventions. Active pharmacist involvement in multidisciplinary teams is strongly recommended to improve pediatric patient safety.

ANALGESIC POTENTIAL OF ETHANOL EXTRACT OF KETAPANG LEAVES (Terminalia catappa L.) ON MICE USING THE HOTPLATE METHOD Rosa Juwita Hesturini; Ade Giriayu Anjani; Briandini Dwi Astuti; Afdyta Doria Bilhis
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i2.157

Background: Pain is a sensory experience from tissue damage that can occur over a certain duration. Pain management is generally carried out by administering analgesic drugs. Ketapang leaves have potential as a natural analgesic alternative. Objective: To evaluate the analgesic activity of ketapang leaf extract in male white mice. Methods: A total of 15 mice were divided into five groups: 0.5% Na CMC as a negative group, a positive control Asetil salisilat acid 500 mg/KgBW, and three treatment groups given sampel at doses of 300 mg/KgBW, 400 mg/KgBW, and 500 mg/KgBW. The analgesic test was conducted using the hot plate methog, and the mice's response to heat stimulus was observed for 60 minutes after oral suspension administration. Results: Extract at various doses significantly increased the latency period of the mice compared to the negative control group. The highest latency period was shown by the 500 mg/KgBW dose, which was 9.39 seconds. This suspected activity is due to the content of flavonoid, alkaloid, saponin, and steroid compounds, which may blockade of the cyclooxygenase pathway. Conclusion: The extract of ketapang leaves possesses analgesic percentages of 33%, 36%, and 55%, respectively. The most effective dose was 500 mg/KgBW, with an analgesic percentage of 55%.

STUDI IN SILICO NANOPARTIKEL PERAK BUNGA TELANG SEBAGAI ANTIBAKTERI Septian Dwi Mulyana; Nur An Nitta Rizki Fanani; Thiya Rahma Karina; Khoirun Niswatunnisa Niswatunnisa; Nadine Detta Rezza Nevanda; Septiara Dwi Ariyanti
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.153

Background: Antibacterials are compounds with the ability to slow down and inactivate pathogenic bacteria that can cause inflammation and abscess formation. Silver nanoparticles (AgNP) are metal particles measuring 1–100 nm that are known to have high antibacterial potential. In the formation process, a reducing agent is required to facilitate chemical interactions. Butterfly pea flower (Clitoria ternatea) is used as the active ingredient in the synthesis of silver nanoparticles based on green synthesis, where flavonoid compounds act as reducing agents. Objective: To determine the potential of butterfly pea flower quercetin as an antibacterial agent through in silico studies. Methods: The study was conducted in silico with protein 6J90 as the receptor and quercetin as the test ligand, with preparation through geometry optimization and molecular docking validation. Drug-likeness, pharmacokinetic, toxicity, and ligand– receptor interactions were analyzed using Lipinski’s rule of five, PreADMET, Toxtree, AutoDock Tools, and Discovery Studio. Results: The study showed that the test compound met drug-likeness criteria, had a good pharmacokinetic profile, and was not carcinogenic with a safe exposure limit of ≤0.15 µg/day, with a binding affinity value of −5.96 kcal/mol that was more stable than the natural ligand. Conclusion: In silico studies show that quercetin from butterfly pea flower silver nanoparticles has potential as an antibacterial agent, with a binding affinity value of −5.96 kcal/mol to the 6J90 protein, which is more stable than natural ligands.

FORMULASI DAN UJI AKTIVITAS GEL ANTI ACNE BERBASIS EKSTRAK DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP BAKTERI Cutibacterium acnes Muhammad Fadhil Kamil; Fitriyanti Fitriyanti; Wahyudin Bin Jamaludin
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.155

Background: Acne is an inflammatory condition of the pilosebaceous unit involving infection by Cutibacterium acnes. Ramania leaves (Bouea macrophylla) contain flavonoids, saponins, and tannins with known antibacterial properties. Objective: This study aimed to formulate a methanolic extract gel of Ramania leaves and evaluate its physical and organoleptic qualities as well as its antibacterial activity against C. acnes. Method: The extract was obtained via maceration and formulated in a carbopol-based gel with concentrations of 5%, 7.5%, 10%, 15%, and 20%. Physical evaluations included organoleptic testing, homogeneity, pH, viscosity, adhesiveness, and spreadability. Antibacterial activity was tested using the well diffusion method. Results: showed all gel formulas met standard physical and organoleptic criteria. The 5% extract gel demonstrated the largest inhibition zone against C. acnes (22.8 mm ± 2.06). Concentrations above 10% showed decreased effectiveness, likely due to saturation or physical instability. Conclusion: The 5% Ramania leaf extract gel is the most effective and stable formulation for topical anti-acne application

The FORMULATION, CHARACTERIZATION, AND ANTIOXIDANT ACTIVITY OF TRANSPARENT SOAP CONTAINING MUNG BEAN SEEDS AND SPROUTS (Vigna radiata L.) Lia Agustina; Tria Kartika Rahayu; David Raditya Soehartono; Ninis Yuliati; Chin Siang Kue
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.167

Background: Transparent solid soap is an innovative cosmetic product designed to improve aesthetic value and consumer acceptance. The incorporation of natural antioxidants has attracted growing interest due to their protective effects against free radicals. Mung bean (Vigna radiata L.), particularly its seeds and sprouts, exhibits antioxidant activity associated with flavonoid compounds, yet its application in transparent soap formulations remains limited. Objective: This study aimed to evaluate the physical quality and antioxidant activity of transparent soap formulations containing mung bean (Vigna radiata L.) seeds and sprouts. Method: Mung bean seeds and sprouts were dried, pulverized into powder, and subjected to phytochemical screening for flavonoid. Each powder was incorporated into transparent solid soap formulations. Antioxidant activity was evaluated in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. Commercial soap with known antioxidant activity was used as a positive control, while soap base without mung bean powder served as a negative control. Physical quality evaluation included organoleptic, pH, wetting test, skin irritation test, and stability assay. Conclusion: The incorporation of mung bean seed and sprout powders influenced the physical characteristics of transparent soap and provided antioxidant activity. Transparent soap containing mung bean sprouts exhibited stronger antioxidant activity, indicated by a lower IC₅₀ value, compared to soap containing mung bean seeds, suggesting that mung bean sprouts are a more effective natural antioxidant source.

ANALYSIS OF DRUG PLANNING USING THE CONSUMPTION METHOD IN THE PHARMACY INSTALLATION OF FATIMAH ISLAMIC HOSPITAL, CILACAP muhammad yogie prastowo; Yuniariana Pertiwi; IKRIMATUL CHOIRIYAH
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.168

Background: This study highlights the importance of effective drug management to ensure the availability of safe, high-quality medicines. Ineffective inventory planning may lead to shortages or excess stock, both of which can cause harm. Objective: This study aims to analyze drug planning using the consumption method to improve stock management efficiency. Methods: Data were collected through surveys and analysis of hospital drug consumption patterns. This study emphasizes the integration of pharmaceutical services with drug logistics management as a strategy to enhance the overall quality of health services. Results: Of the 100 drug samples analyzed, 83 required procurement, while 17 did not due to adequate availability. The most frequently consumed drug was acetylcysteine cap 200 mg, with a total usage of 20,607 tablets. Conclusions: Fatimah Islamic Hospital in Cilacap applies the consumption method by considering previous usage data, remaining stock, safety stock, and lead time.

THERAPEUTIC SAFETY AND RATIONALITY IN CLINICAL PHARMACY: THE ROLE OF PRECLINICAL STUDIES AND THE ZEBRAFISH MODEL IN SUPPORTING CLINICAL DECISION-MAKING: KEAMANAN DAN RASIONALITAS TERAPI DALAM FARMASI KLINIK: KONTRIBUSI STUDI PREKLINIK DAN MODEL ZEBRAFISH TERHADAP PENGAMBILAN KEPUTUSAN KLINIS Fauziah Hasdin; Wahyuni Agus
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.169

Background: Clinical pharmacy practice requires the implementation of safe and rational therapies to optimize clinical outcomes and minimize the risk of adverse drug reactions. Limited availability of early clinical data, particularly for newly developed drugs and the increasing use of natural products, poses challenges in therapeutic decision-making. Under these conditions, preclinical studies serve as an essential source of early evidence for evaluating compound safety prior to human use. Objective: This review aims to examine the role of preclinical studies using the zebrafish (Danio rerio) model in supporting clinical decision-making in clinical pharmacy practice. Methods: This article was conducted using a narrative review approach of national and international scientific literature addressing therapeutic safety, clinical pharmacy, preclinical studies, and the application of the zebrafish model. Result: The literature indicates that zebrafish offer significant advantages as an efficient, sensitive, and translationally relevant preclinical model for toxicity testing and drug safety assessment, including natural product–based compounds. Integration of preclinical data with clinical considerations contributes to improved accuracy of therapeutic decisions and strengthens the role of clinical pharmacists in ensuring patient safety. Conclusions: Zebrafish-based preclinical studies represent a significant supportive component in evidence-based clinical pharmacy practice.

GAMBARAN TINGKAT PENGETAHUAN PASIEN RAWAT JALAN UMUM TENTANG PENGGUNAAN AMOKSISILIN DI PUSKESMAS DONO KABUPATEN TULUNGAGUNG Djembor Sugeng Walujo; Indah Sri Hartini; Yogi Bhakti Marhenta; Wika Atmaja; Krisogonus Ephrino Seran; Hariyani Hariyani; Fitria Wahyuning Wulan; Aditha Nur Azizah
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v6i1.170

Background: Irrational use of antibiotics, including amoxicillin, contributes to the increase in bacterial resistance and the risk of adverse drug reactions. Adequate patient knowledge is a key factor in promoting appropriate antibiotic use. Objective: To describe the level of knowledge among general outpatients regarding the use of amoxicillin at Dono Public Health Center, Tulungagung Regency. Methods: This study used a descriptive quantitative design with sampling involving 85 respondents who had previously received an amoxicillin prescription. Data were collected using a structured questionnaire consisting of 12 items covering nine knowledge parameters: drug classification, administration rules, dosage, adherence to schedule, appropriate indications, duration of use, legal access, side effects, and common misconceptions. Results: The results showed that 52.94% of respondents had a moderate level of knowledge, 36.47% had a good level of knowledge, and 10.59% had a poor level of knowledge. The highest knowledge score was found in the classification parameter (98.82%), while the lowest scores were in side effects (48.24%) and common misconceptions (49.41%). Conclusion: Patients generally demonstrated adequate knowledge of the basic aspects of amoxicillin use; however, gaps remain in understanding the risks of resistance, side effects, and appropriate indications. Strengthening education and implementing continuous interventions are essential to encourage rational antibiotic use.

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Reviewer

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Contact Name
Herlinda Mawardika

Contact Email
herlinda.mawardika@iik.ac.id

Phone
+6287852768636

Journal Mail Official
pharmabhakta@iik.ac.id

Editorial Address
Institut Ilmu Kesehatan Bhakti Wiyata Kediri Jl KH Wahid Hasyim No. 65, Kediri, Jawa Timur Telp. (0354)773299

Location
Kota kediri,

Jawa timur

INDONESIA

Abstract

Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Herlinda Mawardika

Contact Email herlinda.mawardika@iik.ac.id

Phone +6287852768636

Journal Mail Official pharmabhakta@iik.ac.id

Editorial Address Institut Ilmu Kesehatan Bhakti Wiyata Kediri Jl KH Wahid Hasyim No. 65, Kediri, Jawa Timur Telp. (0354)773299

Location Kota kediri, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Herlinda Mawardika

Contact Email
herlinda.mawardika@iik.ac.id

Phone
+6287852768636

Journal Mail Official
pharmabhakta@iik.ac.id

Editorial Address
Institut Ilmu Kesehatan Bhakti Wiyata Kediri Jl KH Wahid Hasyim No. 65, Kediri, Jawa Timur Telp. (0354)773299

Location
Kota kediri,

Jawa timur

INDONESIA