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Herlinda Mawardika
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INDONESIA
Jurnal Pharma Bhakta
Published by Institut Ilmu Kesehatan Bhakti Wiyata Kediri
ISSN : -     EISSN : 27971163     DOI : 10.56710
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal ini mempublikasikan hasil penelitian pada fokus dan bidang : 1. Biologi Farmasi 2. Farmasi Komunitas 3. Teknologi Farmasi 4. Kimia Farmasi 5. Farmakologi dan Farmasi Klinik
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 74 Documents
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OVERVIEW OF PHYTOCHEMICAL COMPOUNDS AND PHARMACOLOGICAL ACTIVITIES OF Borassus flabellifer Linn. AS A REGIONAL EMBLEM PLANT OF SOUTH SULAWESI Agus, Wahyuni
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Borassus flabellifer Linn. (palmyra palm) is a member of the Arecaceae family with important ecological, economic, and pharmacological roles, and serves as the floral emblem of South Sulawesi, Indonesia. Traditionally, almost all parts of the plant have been used for food, beverages, and handicrafts. Objective: This review summarizes its phytochemical constituents and pharmacological activities. Methods: Relevant articles were collected from Scopus, ScienceDirect, PubMed, and Google Scholar. Publications from 2005 to 2025 were screened using the keywords Borassus flabellifer, palmyra palm, phytochemistry, and pharmacological activity. Based on inclusion and exclusion criteria, 19 articles were analyzed. Result: Findings indicate that plant parts contain bioactive compounds such as flavonoids, phenols, alkaloids, saponins, tannins, terpenoids, and steroidal saponins including flabelliferins and borassosides. These metabolites are linked to antioxidant, anti-inflammatory, cytotoxic, antidiabetic, antibacterial, antifungal, and diuretic effects, through mechanisms such as free radical scavenging, suppression of inflammation, induction of apoptosis, inhibition of carbohydrate-digesting enzymes, and regulation of renal electrolyte excretion. Conclusion: Overall, Borassus flabellifer shows strong potential as a source of phytopharmaceuticals and natural drug candidates. Beyond pharmacological value, its ecological resilience, cultural significance, and economic importance support its designation as the floral emblem of South Sulawesi. Further preclinical and clinical studies are needed to validate therapeutic efficacy and safety.
Efektivitas dan Keamanan Ceftaroline VS Ceftriaxone dalam Terapi Community-Acquired Pneumonia: Bukti dari Satu Dekade Penelitian Riandika, Andi Ameilia Sari
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Community acquired pneumonia (CAP) remains a leading cause of morbidity and mortality among hospitalized adults. Appropriate selection of empirical antibiotics is crucial to prevent treatment failure and limit antimicrobial resistance. Ceftriaxone has long been the standard empirical therapy for moderate to severe CAP in many clinical guidelines. However, ceftaroline fosamil, a newer generation cephalosporin with activity against Streptococcus pneumoniae (including penicillin resistant strains), has emerged as a potential alternative. Objective: This review aims to evaluate randomized controlled trial (RCT) evidence published between 2015 and 2025 comparing the efficacy and safety of ceftaroline versus ceftriaxone in the treatment of CAP among hospitalized. Methods: A literature search was conducted in PubMed, ScienceDirect, and Scopus for RCTs published between 2015 and 2025 based on the checklist prism. Results: Evidence from RCTs (2015–2025) supports ceftaroline as an effective alternative to ceftriaxone for the management of CAP in hospitalized adults. Several pooled analyses suggest superiority of ceftaroline in terms of clinical cure, while no significant differences were observed in mortality outcomes. The safety profiles of both agents were generally comparable. Conclusion: This review supports ceftaroline as an effective empirical alternative to ceftriaxone for moderate to severe CAP, with evidence indicating potential advantages in clinical cure rates.
LITERATUR REVIEW : PERAN APOTEKER DALAM PENCEGAHAN MEDICATION ERROR PADA PASIEN PEDIATRIK Anggraeni, Rieka Nurul Dwi
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Medication errors (MEs) in pediatric patients are a serious patient safety concern. MEs in children often occur due to insufficient understanding of pediatric dosing and non-compliance with standard operating procedures (SOPs) by healthcare professionals. Objective: This article aims to review the role of pharmacists in preventing MEs in pediatric patients through an analysis of recent literature. Methods: The article was prepared as a literature review using sources from online databases (ScienceDirect, PubMed, Google Scholar) published between 2020 and 2025. Inclusion criteria included full-text availability, relevance to the topic, and focus on the pediatric context. Results: Several studies show that pharmacist interventions, such as prescription review, education, audit, medication reconciliation, and participation in ward rounds, can reduce the incidence of MEs by 64–73%. Studies in Indonesia revealed that 92% of pediatric prescriptions did not include body weight and only 16% contained complete information, indicating a high potential for dosing errors. Pharmacist-led education for healthcare providers and parents/caregivers plays an important role in improving understanding and preventing medication administration errors at home. Conclusion: Pharmacists play a crucial role in preventing pediatric MEs through clinical and educational interventions. Active pharmacist involvement in multidisciplinary teams is strongly recommended to improve pediatric patient safety.
ANALGESIC POTENTIAL OF ETHANOL EXTRACT OF KETAPANG LEAVES (Terminalia catappa L.) ON MICE USING THE HOTPLATE METHOD Hesturini, Rosa Juwita; Anjani, Ade Giriayu; Briandini Dwi Astuti; Afdyta Doria Bilhis
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Pain is a sensory experience from tissue damage that can occur over a certain duration. Pain management is generally carried out by administering analgesic drugs. Ketapang leaves have potential as a natural analgesic alternative. Objective: To evaluate the analgesic activity of ketapang leaf extract in male white mice. Methods: A total of 15 mice were divided into five groups: 0.5% Na CMC as a negative group, a positive control Asetil salisilat acid 500 mg/KgBW, and three treatment groups given sampel at doses of 300 mg/KgBW, 400 mg/KgBW, and 500 mg/KgBW. The analgesic test was conducted using the hot plate methog, and the mice's response to heat stimulus was observed for 60 minutes after oral suspension administration. Results: Extract at various doses significantly increased the latency period of the mice compared to the negative control group. The highest latency period was shown by the 500 mg/KgBW dose, which was 9.39 seconds. This suspected activity is due to the content of flavonoid, alkaloid, saponin, and steroid compounds, which may blockade of the cyclooxygenase pathway. Conclusion: The extract of ketapang leaves possesses analgesic percentages of 33%, 36%, and 55%, respectively. The most effective dose was 500 mg/KgBW, with an analgesic percentage of 55%.

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