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Herlinda Mawardika
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INDONESIA
Jurnal Pharma Bhakta
Published by Institut Ilmu Kesehatan Bhakti Wiyata Kediri
ISSN : -     EISSN : 27971163     DOI : 10.56710
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal ini mempublikasikan hasil penelitian pada fokus dan bidang : 1. Biologi Farmasi 2. Farmasi Komunitas 3. Teknologi Farmasi 4. Kimia Farmasi 5. Farmakologi dan Farmasi Klinik
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 77 Documents
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OVERVIEW OF PHYTOCHEMICAL COMPOUNDS AND PHARMACOLOGICAL ACTIVITIES OF Borassus flabellifer Linn. AS A REGIONAL EMBLEM PLANT OF SOUTH SULAWESI Agus, Wahyuni
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Borassus flabellifer Linn. (palmyra palm) is a member of the Arecaceae family with important ecological, economic, and pharmacological roles, and serves as the floral emblem of South Sulawesi, Indonesia. Traditionally, almost all parts of the plant have been used for food, beverages, and handicrafts. Objective: This review summarizes its phytochemical constituents and pharmacological activities. Methods: Relevant articles were collected from Scopus, ScienceDirect, PubMed, and Google Scholar. Publications from 2005 to 2025 were screened using the keywords Borassus flabellifer, palmyra palm, phytochemistry, and pharmacological activity. Based on inclusion and exclusion criteria, 19 articles were analyzed. Result: Findings indicate that plant parts contain bioactive compounds such as flavonoids, phenols, alkaloids, saponins, tannins, terpenoids, and steroidal saponins including flabelliferins and borassosides. These metabolites are linked to antioxidant, anti-inflammatory, cytotoxic, antidiabetic, antibacterial, antifungal, and diuretic effects, through mechanisms such as free radical scavenging, suppression of inflammation, induction of apoptosis, inhibition of carbohydrate-digesting enzymes, and regulation of renal electrolyte excretion. Conclusion: Overall, Borassus flabellifer shows strong potential as a source of phytopharmaceuticals and natural drug candidates. Beyond pharmacological value, its ecological resilience, cultural significance, and economic importance support its designation as the floral emblem of South Sulawesi. Further preclinical and clinical studies are needed to validate therapeutic efficacy and safety.
Efektivitas dan Keamanan Ceftaroline VS Ceftriaxone dalam Terapi Community-Acquired Pneumonia: Bukti dari Satu Dekade Penelitian Riandika, Andi Ameilia Sari
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Background: Community acquired pneumonia (CAP) remains a leading cause of morbidity and mortality among hospitalized adults. Appropriate selection of empirical antibiotics is crucial to prevent treatment failure and limit antimicrobial resistance. Ceftriaxone has long been the standard empirical therapy for moderate to severe CAP in many clinical guidelines. However, ceftaroline fosamil, a newer generation cephalosporin with activity against Streptococcus pneumoniae (including penicillin resistant strains), has emerged as a potential alternative. Objective: This review aims to evaluate randomized controlled trial (RCT) evidence published between 2015 and 2025 comparing the efficacy and safety of ceftaroline versus ceftriaxone in the treatment of CAP among hospitalized. Methods: A literature search was conducted in PubMed, ScienceDirect, and Scopus for RCTs published between 2015 and 2025 based on the checklist prism. Results: Evidence from RCTs (2015–2025) supports ceftaroline as an effective alternative to ceftriaxone for the management of CAP in hospitalized adults. Several pooled analyses suggest superiority of ceftaroline in terms of clinical cure, while no significant differences were observed in mortality outcomes. The safety profiles of both agents were generally comparable. Conclusion: This review supports ceftaroline as an effective empirical alternative to ceftriaxone for moderate to severe CAP, with evidence indicating potential advantages in clinical cure rates.
LITERATUR REVIEW : PERAN APOTEKER DALAM PENCEGAHAN MEDICATION ERROR PADA PASIEN PEDIATRIK Anggraeni, Rieka Nurul Dwi
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Background: Medication errors (MEs) in pediatric patients are a serious patient safety concern. MEs in children often occur due to insufficient understanding of pediatric dosing and non-compliance with standard operating procedures (SOPs) by healthcare professionals. Objective: This article aims to review the role of pharmacists in preventing MEs in pediatric patients through an analysis of recent literature. Methods: The article was prepared as a literature review using sources from online databases (ScienceDirect, PubMed, Google Scholar) published between 2020 and 2025. Inclusion criteria included full-text availability, relevance to the topic, and focus on the pediatric context. Results: Several studies show that pharmacist interventions, such as prescription review, education, audit, medication reconciliation, and participation in ward rounds, can reduce the incidence of MEs by 64–73%. Studies in Indonesia revealed that 92% of pediatric prescriptions did not include body weight and only 16% contained complete information, indicating a high potential for dosing errors. Pharmacist-led education for healthcare providers and parents/caregivers plays an important role in improving understanding and preventing medication administration errors at home. Conclusion: Pharmacists play a crucial role in preventing pediatric MEs through clinical and educational interventions. Active pharmacist involvement in multidisciplinary teams is strongly recommended to improve pediatric patient safety.
ANALGESIC POTENTIAL OF ETHANOL EXTRACT OF KETAPANG LEAVES (Terminalia catappa L.) ON MICE USING THE HOTPLATE METHOD Hesturini, Rosa Juwita; Anjani, Ade Giriayu; Briandini Dwi Astuti; Afdyta Doria Bilhis
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Background: Pain is a sensory experience from tissue damage that can occur over a certain duration. Pain management is generally carried out by administering analgesic drugs. Ketapang leaves have potential as a natural analgesic alternative. Objective: To evaluate the analgesic activity of ketapang leaf extract in male white mice. Methods: A total of 15 mice were divided into five groups: 0.5% Na CMC as a negative group, a positive control Asetil salisilat acid 500 mg/KgBW, and three treatment groups given sampel at doses of 300 mg/KgBW, 400 mg/KgBW, and 500 mg/KgBW. The analgesic test was conducted using the hot plate methog, and the mice's response to heat stimulus was observed for 60 minutes after oral suspension administration. Results: Extract at various doses significantly increased the latency period of the mice compared to the negative control group. The highest latency period was shown by the 500 mg/KgBW dose, which was 9.39 seconds. This suspected activity is due to the content of flavonoid, alkaloid, saponin, and steroid compounds, which may blockade of the cyclooxygenase pathway. Conclusion: The extract of ketapang leaves possesses analgesic percentages of 33%, 36%, and 55%, respectively. The most effective dose was 500 mg/KgBW, with an analgesic percentage of 55%.
STUDI IN SILICO NANOPARTIKEL PERAK BUNGA TELANG SEBAGAI ANTIBAKTERI Septian Dwi Mulyana; Nur An Nitta Rizki Fanani; Thiya Rahma Karina; Khoirun Niswatunnisa Niswatunnisa; Nadine Detta Rezza Nevanda; Septiara Dwi Ariyanti
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Latar belakang: Antibakteri adalah senyawa dengan kemampuan memperlambat dan menginaktivasi bakteri patogen yang menjadi sumber dari infeksi. Jenis bakteri yang sering ditemukan yaitu Staphylococcus aureus, Salmonella spp., Klebsiella spp., Escherichia coli dan Streptococcus pyogenes yang dapat menimbulkan gejala seperti peradangan hingga pembentukan abses. Nanopartikel perak (AgNP) merupakan partikel logam dengan ukuran 1–100 nm yang dikenal memiliki potensi antibakteri tinggi. Nanopartikel perak memerlukan reduktor untuk membantu terjadinya interaksi kimia (sintesis), sehingga dapat menjadi AgNP. Dalam proses pembentukan AgNP, diperlukan adanya agen pereduksi yang berperan untuk membantu terjadinya interaksi kimia (sintesis), sehingga ion perak (Ag⁺) dapat berubah menjadi nanopartikel perak (AgNP). Clitoria ternatea atau bunga telang digunakan sebagai bahan aktif dalam sintesis nanopartikel perak berbasis green synthesis yang ramah lingkungan, di mana senyawa flavonoid berperan sebagai agen reduktor dan penstabil. Tujuan: Untuk mengetahui potensi nanopartikel perak bunga telang sebagai agen antibakteri melalui pendekatan studi in silico. Metode: Dalam pengembangan senyawa antibakteri untuk mengidentifikasi kemungkinan interaksi molekuler keterikatan senyawa pada protein target. Hasil: Hasil docking menunjukkan bahwa senyawa Quercetin memiliki nilai binding affinity sebesar -5,96 kkal/mol pada reseptor 6J90, mengindikasikan afinitas ikatan lebih tinggi dibanding ligan alaminya (2,71 kkal/mol). Simpulan: Berdasarkan hasil yang didapatkan bahwa senyawa Quercetin dari nanopartikel perak bunga telang memiliki potensi yang baik untuk dikembangkan sebagai kandidat antibakteri efektif.
FORMULASI DAN UJI AKTIVITAS GEL ANTI ACNE BERBASIS EKSTRAK DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP BAKTERI Cutibacterium acnes Muhammad Fadhil Kamil; Fitriyanti Fitriyanti; Wahyudin Bin Jamaludin
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Acne is an inflammatory condition of the pilosebaceous unit involving infection by Cutibacterium acnes. Ramania leaves (Bouea macrophylla) contain flavonoids, saponins, and tannins with known antibacterial properties. Objective: This study aimed to formulate a methanolic extract gel of Ramania leaves and evaluate its physical and organoleptic qualities as well as its antibacterial activity against C. acnes. Method: The extract was obtained via maceration and formulated in a carbopol-based gel with concentrations of 5%, 7.5%, 10%, 15%, and 20%. Physical evaluations included organoleptic testing, homogeneity, pH, viscosity, adhesiveness, and spreadability. Antibacterial activity was tested using the well diffusion method. Results: showed all gel formulas met standard physical and organoleptic criteria. The 5% extract gel demonstrated the largest inhibition zone against C. acnes (22.8 mm ± 2.06). Concentrations above 10% showed decreased effectiveness, likely due to saturation or physical instability. Conclusion: The 5% Ramania leaf extract gel is the most effective and stable formulation for topical anti-acne application
The FORMULATION, CHARACTERIZATION, AND ANTIOXIDANT ACTIVITY OF TRANSPARENT SOAP CONTAINING MUNG BEAN SEEDS AND SPROUTS (Vigna radiata L.) Lia Agustina; Tria Kartika Rahayu; David Raditya Soehartono; Ninis Yuliati
JURNAL PHARMA BHAKTA Vol 6 No 1 (2026): Mei (2026)
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Transparent solid soap is an innovative cosmetic product designed to improve aesthetic value and consumer acceptance. The incorporation of natural antioxidants has attracted growing interest due to their protective effects against free radicals. Mung bean (Vigna radiata L.), particularly its seeds and sprouts, exhibits antioxidant activity associated with flavonoid compounds, yet its application in transparent soap formulations remains limited. Objective: This study aimed to evaluate the physical quality and antioxidant activity of transparent soap formulations containing mung bean (Vigna radiata L.) seeds and sprouts. Method: Mung bean seeds and sprouts were dried, pulverized into powder, and subjected to phytochemical screening for flavonoid. Each powder was incorporated into transparent solid soap formulations. Antioxidant activity was evaluated in vitro using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. Commercial soap with known antioxidant activity was used as a positive control, while soap base without mung bean powder served as a negative control. Physical quality evaluation included organoleptic, pH, wetting test, skin irritation test, and stability assay. Conclusion: The incorporation of mung bean seed and sprout powders influenced the physical characteristics of transparent soap and provided antioxidant activity. Transparent soap containing mung bean sprouts exhibited stronger antioxidant activity, indicated by a lower IC₅₀ value, compared to soap containing mung bean seeds, suggesting that mung bean sprouts are a more effective natural antioxidant source.

Page 8 of 8 | Total Record : 77

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