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Herlinda Mawardika
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Institut Ilmu Kesehatan Bhakti Wiyata Kediri Jl KH Wahid Hasyim No. 65, Kediri, Jawa Timur Telp. (0354)773299
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Jurnal Pharma Bhakta
Published by Institut Ilmu Kesehatan Bhakti Wiyata Kediri
ISSN : -     EISSN : 27971163     DOI : 10.56710
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal ini mempublikasikan hasil penelitian pada fokus dan bidang : 1. Biologi Farmasi 2. Farmasi Komunitas 3. Teknologi Farmasi 4. Kimia Farmasi 5. Farmakologi dan Farmasi Klinik
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 74 Documents
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THE MINIMALIST ANALYSIS OF THE COST OF USING CEFIXIME AND METRONIDAZOLE ANTIBIOTICS IN BPJS CLASS III PATIENTS WITH CHILD ACUTE DIARRHEA IN THE INPATIENT CARE INSTALLATION OF RSM AHMAD DAHLAN, KEDIRI CITY (JANUARY – JUNE PERIOD) IN 2023 Sugeng Walujo, Djembor; Ayu Sagita, Fivo
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.126

Abstract

Diarrhea is a disease caused by bacterial infection characterized by nausea, vomiting, abdominal pain, headache, fever, chills, and discomfort. The choice of antibiotics for the treatment of diarrhea is based on the severity, location of the infection, and type of infecting microorganism. The purpose of the study was to determine the minimum cost of antibiotic use in BPJS class III patients with acute diarrhea in the inpatient installation of RSM Ahmad Dahlan Kediri City from January to June 2023. This study was an observational analytic study with a cross-sectional research design through a retrospective approach. Then the data were analyzed using SPSS, using the Mann Whitney test analysis method. The results showed that metronidazole antibiotics were more cost minimization than cefixime antibiotics with an average of Rp3,663,288 and Rp4,295,103, respectively. Based on the results of the statistical test, the p value was 0.294> 0.05, so it can be interpreted that the amount of direct medical costs between patients using cefixime antibiotic therapy and metronidazole antibiotics did not differ significantly.
CASE STUDY OF THE USE OF WOUND CARE MEDICATION IN DIABETES MELLITUS PATIENTS WITH COMPLICATIONS Anikasari, Erni; Emelia Cantessa, Imelda
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.127

Abstract

Hiperglikemia merupakan karakteristik penyakit Diabetes Mellitus yang disebabkan karena adanya gangguan insulin yaitu karena sekresi nya maupun sensitivitas insulin. Diabetes Mellitus kronik menjadi penyebab ganguan kardiovakusler, sehingga pengunaan terapi obat beragam. Penelitian ini bertujuan untuk mengetahui pola penggunaan obat rawat lukan pada pasien DM dengan komplikasi. Metode penelitian yang digunakan adalah observasional deskriptif dengan pengumpulan data dari rekam medis pasien DM yang mengalami komplikasi. Data yang dianalisis meliputi jenis obat yang paling sering diresepkan, frekuensi penggunaan, serta kepatuhan pasien. Hasil penelitian menunjukkan bahwa Terapi obat yang digunakan meliputi cairan infus NaCl, injeksi levofloxacin, injeksi ranitidin, injeksi ondancetron, injeksi santagesik, injeksi ceftriaxon, injeksi dopamine, meylon, serta obat oral seperti paracetamol tablet, metformin tablet, dan azithromycin tablet untuk mengatasi nyeri dan infeksi, serta terapi rawat luka dengan cairan NaCl dan salep gentamicin. Kesimpulan dari penelitian ini adalah penggunaan obat rawat luka pada pasien Diabetes Mellitus adalah cairan NaCl dan Genatamisin.
POLA PENGOBATAN PASIEN DISPEPSIA (ICD 10 : K-30) RAWAT JALAN DI RSUD X Sari Poespita Dewi Wahyuni, Kumala; Admaja, Wika; Ayu Kusumaratni, Dyah; Farida, Umul; Khusnul Khulukia, Widya
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.128

Abstract

Pendahuluan: Data rekamedik pasien dispepsia rawat jalan di RSUD X pada tahun 2021 menunjukkan bahwa gejala yang paling umum adalah mual, nyeri, dan muntah. Untuk mengurangi atau menghilangkan gejala yang timbul, pasien diberikan terapi farmakologis dan non farmakologis. Tujuan : untuk mengetahui pola pengobatan pada pasien dispepsia rawat jalan di RSUD X tahun 2021. Metode : menggunakaan metode deskriptif observasional dengan pendekatan retrospektif. Populasi sebanyak 423 pasien. Tehnik sampling yang digunakan adalah teknik puposive sampling dengan besar sampel 81 pasien. Hasil : Dari 81 pasien dispepsia rawat jalan di RSUD X pada tahun 2021, sebagian besar adalah perempuan, yaitu 55 orang (67,9%), dan hampir setengahnya adalah dari kelompok usia 41 hingga 60 tahun, yaitu 30 orang (37,0%). Hampir semua responden mengalami dispepsia dengan keluhan tunggal, yaitu 74 orang (90,1%). Sebagian besar pasien menerima obat tunggal sebanyak 44 orang (54,3%) dengan peresepan golongan PPI, yaitu Lansoprazole sebanyak 20 orang (24,7%) dan obat golongan Blocker H2, yaitu Ranitidine sebanyak 24 orang (29,6%). Sedangkan pola peresepan kombinasi yang paling banyak adalah Lansoprazole 30 mg dan Sucralfat sirup, yaitu sebanyak 17 orang (21,0%).
LITERATURE REVIEW ANALISIS KADAR KAFEIN DALAM KOPI BUBUK (Coffea canephora P.) DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Werdiningsih, Wiwik; Prodyanatasari, Arshy
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.132

Abstract

Kopi merupakan salah satu minuman yang berasal dari seduhan biji kopi yang sudah diproses menjadi bubuk. Kopi memiliki kandungan kafein yang bermanfaat secara klinis, namun ada efek samping yang ditimbulkan jika mengkonsumsi kafein berlebihan, yaitu gugup, gelisah, tremor, insomnia, hipertensi, mual, dan kejang. Tujuan penelitian ini adalah untuk menganalisis jurnal yang membahas tentang kandungan kadar kafein dalam kopi bubuk di Kota Palu dan Kota Bengkulu menggunakan metode spektrofotometri UV-VIS. Metode yang digunakan adalah systematic literatur review (SLR). Sampel penelitian diambil dengan teknik purposive sampling sejumlah 2 jurnal. Data dianalisis dengan mencari kesamaan (compare), ketidaksamaan (contrast), memberikan pandangan (criticize), menggabungkan (synthesize), meringkas (summarize) yang disajikan dalam bentuk deskriptif. Hasil penelitian didapatkan kadar kafein dalam kopi bubuk di Kota Palu terendah adalah 0,83% dan tertinggi adalah 2,63%. Kadar kafein dalam kopi bubuk di Kota Bengkulu terendah adalah 0,14% dan tertinggi adalah 2,03%. Terdapat 2 sampel kopi bubuk di Kota Palu dan 2 sampel kopi bubuk di Kota Bengkulu yang meniliki kadar kafein tidak sesuai dengan syarat SNI 01-3542-2004. Hal ini dikarenakan perbedaan lokasi tumbuh tanaman kopi yang berbeda-beda tempat sehingga mempengaruhi nilai kadar kafeinnya yang terkandung di dalam kopi.
REVIEW ARTIKEL : PERBANDINGAN JENIS BAHAN PENGIKAT PADA FORMULASI TABLET KUNYAH Putri Diar Faizah, Nadya; Fila Ila El Kodar, Indah; Rahmati, Dewi; Mellyana, Hanifah; Idawati Sofia, Armelia; Regita Faradila, Arina; Rindianti, Nolia; Ratnasari , Desi
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.135

Abstract

Latar belakang: Tablet merupakan bentuk sediaan padat yang mengandung bahan aktif serta bahan lain. Tablet dapat hadir dalam bentuk yang tidak dilapisi atau dilapisi. Tablet yang tidak dilapisi mencakup tablet yang bisa dikunyah, tablet yang menghasilkan gelembung, tablet hisap, tablet yang mudah larut, dan tablet yang ditempatkan di bawah lidah. Tablet kunyah diproduksi melalui proses pemadatan, biasanya memanfaatkan manitol, sorbitol, sukrosa, dan dekstrosa sebagai bahan pengisi dan pengikat, serta mengandung zat pewarna dan perasa untuk meningkatkan tampilan dan cita rasa. Tujuan: berfungsi untuk meningkatkan pemahaman yang lebih baik mengenai bahan pengisi yang baik pada tablet kunyah sehingga dapat menghasilkan produk obat yang baik. Metode: literatur review article. Kesimpulan: Berdasarkan data yang telah dikumpulkan terkait dengan bahan pengikat sediaan tablet kunyah dapat disimpulkan bahwa setiap bahan pengikat memiliki keunggulan tersendiri dan pemilihan bahan harus disesuaikan dengan karakteristik bahan aktif yang digunakan, serta kriteria fisik seperti kekerasan, kerapuhan, dan waktu hancur.
DETERMINASI PENETAPAN KADAR TANIN EKSTRAK ETANOL DAUN JATI (Tectona grandis L.f) SECARA SPEKTROFOTOMETRI UV-VIS Basuki, Dewy Resty; Pri Hardini; Abdul Aziz, Muhammad
JURNAL PHARMA BHAKTA Vol 5 No 1 (2025): Mei 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/jpb.v5i1.136

Abstract

Latar Belakang : Salah satu tanaman yang banyak dimanfaatkan sebagai bahan obat yaitu tanaman jati (Tectona grandis L.f) dan banyak ditemukan di Indonesia. Komoditas tanaman jati digunakan untuk berbagai hal mulai dari bahan baku furniture, meubel sampai bahan obat. Tanaman jati merupakan tergolong dalam famili Lamiaceae yang memiliki karakterisitik daun yang spesifik dengan adanya pigmen warna antosianin yang memiliki antioksidan tinggi. Daun jati merupakan tanaman empiris yang digunakan sebagai obat antara lain, obat jantung, penurun kadar kolesterol, anemia, kegemukan, hipertensi, diabetes, luka dan obat radang pada tenggorokan maupun sendi, tidak hanya untuk pengobatan penyakit, namun juga bisa digunakan sebagai pewarna alami. Uji pendahuluan ekstrak dan infusa daun jati menunjukan adanya senyawa metabolit sekunder meliputi alkaloid, flavanoid, tanin, dan saponin. Infusa dari daun jati hanya mengandung terpenoid.. Tujuan Penelitian : Penelitian ini bertujuan untuk menetapkan kadar tanin dalam ekstrak etanol daun jati pada berbagai konsentrasi dengan metode spektrofotometri UV-Vis. Metode Penelitian : Sampel uji penelitian ini adalah daun tanaman jati yang diekstraksi dengan pelarut etanol, kemudian dilakukan skrining fitokimia. Pengujian kadar tanin dilakukan pada beragam konsentrasi seperti 2, 4, 6, 8, dan 10 ppm diukur menggunakan spektrofotometri UV-Vis pada panjang gelombang maksimal. 738 nm. Hasil : Hasil uji skirining fitokimia menunjukan positif adanya senyawa alkaloid, flavonoid, saponin dan tanin. Hasil penetapan kadar tanin didapatkan kadar sebesar 9,191% den gan persamaan garis lurus y = 0,0917 x + 0,0041. Kesimpulan : Kadar senyawa tanin sebesar 9,191%.
CASE REPORT : JUVENILE IDIOPATHIC ARTHRITIS Dharmayati, Evy; Tamara, Aulia
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Juvenile rheumatoid arthritis, now more commonly known as juvenile idiopathic arthritis (JIA), is a chronic form of arthritis that occurs in children under 16 years of age. It is characterized by persistent inflammation in one or more joints for at least six weeks without an identifiable cause. Objective: Evaluate the clinical condition of a patient with polyarticular JIA who has received methotrexate therapy, and to assess the effectiveness of intra-articular triamcinolone acetonide as an adjunct treatment. Methods: This study based on a case illustration of a 4-year-old boy diagnosed with polyarticular JIA. Data were obtained through medical history, physical examination, methotrexate treatment records, and planned intra-articular injection procedures. A literature review was also conducted to evaluate the effectiveness of triamcinolone acetonide as adjunct therapy in polyarthritis. Results: The 4-year-old patient, weighing 18 kg and measuring 109 cm in height, had experienced symptoms for the past two years. Despite methotrexate therapy—gradually increased from 10 mg/m² to 15 mg/m² per week since December 2020—he continued to present with swelling in the hands and feet, stiffness in both knees and elbows, and pain that limited joint extension. Literature indicates that intra-articular triamcinolone acetonide demonstrates approximately 70% effectiveness in managing symptoms in patients with polyarticular JIA. Conclusions: JIA is a chronic inflammatory disease that requires comprehensive management. In this case, methotrexate alone did not fully alleviate symptoms, making additional therapy necessary. Intra-articular triamcinolone acetonide is effective and may serve as a viable option to improve joint function and reduce inflammation in polyarticular JIA.
HUBUNGAN KUALITAS PELAYANAN KEFARMASIAN TERHADAP KEPUASAN PASIEN DI PUSKESMAS NGANTRU KABUPATEN TULUNGAGUNG TAHUN 2025 Sugeng Walujo, Djembor
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: High-quality, optimal health services are essential for community well-being. Pharmaceutical service standards guide pharmacy staff in delivering these services, minimizing the risk of medication errors. Objective: A 2025 study aimed to explore the correlation between the quality of pharmaceutical services and patient satisfaction at the Ngantru Regency Tulungagung Public Health Center. Methods: The study employed an analytical observational method with a cross-sectional design. Ninety-seven patients from the health center, meeting specific inclusion and exclusion criteria, were selected using purposive sampling. Data were collected via questionnaires, with the quality of pharmaceutical services as the independent variable and patient satisfaction as the dependent variable. Chi-square tests were used for data analysis. Result: The results indicated that 80.4% of respondents rated the pharmaceutical services as very good, while 19.6% rated them as good. Additionally, 69.1% of respondents reported being very satisfied with the services, and 30.9% reported being satisfied. The chi-square test revealed a statistically significant relationship (p < 0.05) between the quality of pharmaceutical services and patient satisfaction at the Ngantru Health Center. Conclusions: The results of this study can be described that maximum efforts in pharmaceutical services at Ngantru Health Center provide support for community satisfaction in health services. This effort is to provide assurance that pharmaceutical services are carried out optimally so that patients get the best service in the health sector.
TINJAUAN OBAT ANTIKEJANG DALAM PENATALAKSANAAN KEJANG DEMAM: ASPEK FARMAKOLOGIS, STRUKTUR KIMIA DAN PENDEKATAN KLINIS Hasdin, Fauziah
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Febrile seizures are the most common neurological disorder in children aged 6 months to 6 years. Although generally benign, complex febrile seizures are associated with increased risk of epilepsy. Objective: This review analyzes anticonvulsant drugs used in febrile seizure management, emphasizing the correlation between chemical structure, pharmacokinetics, and clinical efficacy, while assessing the potential of emerging agents. Method: A narrative review was conducted using literature published between 2010 and 2025, retrieved from PubMed, ScienceDirect, and Google Scholar, with keywords related to anticonvulsants and febrile seizures.Result: Benzodiazepines demonstrate rapid onset and effectiveness in acute management due to their lipophilic structure. Prophylactic agents such as phenobarbital and valproate are effective but linked to long-term adverse effects. Newer agents like levetiracetam and lacosamide offer favorable pharmacokinetics, low toxicity, and selective non-GABAergic mechanisms. Conclusions: Anticonvulsant selection should be guided by chemical structure and pharmacokinetic profile. Benzodiazepines remain first-line treatment, while levetiracetam and lacosamide are promising options for complex cases. Further research is needed to strengthen clinical evidence in pediatric populations.
PENGARUH PERBEDAAN BASIS CMC-NA DAN PGA PADA PASTA GIGI EKSTRAK DAUN BIDURI (Calotropis gigantea L.) TERHADAP MUTU FISIK DAN AKTIVITAS ANTIBAKTERI Streptococcus mutans Tri Prasongko, Erfan; Eka Rahmawati, Azhariana; Resvaty, Ananda Intan Dwi
JURNAL PHARMA BHAKTA Vol 5 No 2 (2025): November 2025
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Background: Toothpaste is a semi-solid preparation used to clean teeth and maintain oral health. Innovations in utilizing natural ingredients, such as Biduri leaf extract (Calotropis gigantea L.), in toothpaste formulation are based on its content of active compounds like flavonoids, tannins, and saponins, which have potential antibacterial properties and thus are beneficial for maintaining dental cleanliness and health. Objective: This study aims to determine the effect of different bases, CMC-Na and PGA, in Biduri leaf extract (Calotropis gigantea L.) toothpaste on its physical quality and antibacterial activity against Streptococcus mutans. Methods:Toothpaste was formulated into two preparations: Formulation 1 (3% CMC-Na base) and Formulation 2 (20% PGA base). Physical quality evaluations included organoleptic testing, pH, homogeneity, and foam height, while stability testing was conducted using the cycling test method. The data were analyzed using Independent T-Test and Paired T-Test. Results: There were significant differences in the physical quality of Biduri leaf extract toothpaste between the CMC-Na and PGA bases in terms of pH and foam height (p<0.05), but no differences in organoleptic properties and homogeneity. In the stability test, both bases were unstable in terms of pH and foam height. Antibacterial activity testing against Streptococcus mutans showed no significant difference between the two bases (p>0.05). Conclusion: The difference between CMC-Na and PGA bases in Biduri leaf extract (Calotropis gigantea L.) toothpaste affects its physical quality and stability, but does not influence its antibacterial activity against Streptococcus mutans.

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