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Rizal Irfandi
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Jl. Bumi 18 Blok A 15 No. 1 Bumi Permata Hijau, Makassar, Sulawesi Selatan, Indonesia
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INDONESIA
Hayyan Journal
Published by Education and Talent Development Center Indonesia
ISSN : -     EISSN : 30466679     DOI : https://doi.org/10.51574/hayyan.v1i1.1130
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Medicine & Pharmacology
Focus and Scope This journal publishes articles related to chemistry. The scope of this journal includes: Inorganic Chemistry Organic Chemistry Physical Chemistries Chemical Instruments Analytical Chemistries Materials Chemicals Industrial chemistry Biochemistry Applied Science Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 101 Documents
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Progress in Electrochemical MIP Sensors for Detection of Bisphenol A: A Mini review Andi Eka Kartika; Andi Bulqiah Nur Bunyamin
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5151

Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical widely used in the production of polycarbonate plastics and epoxy resins, raising concerns regarding its migration into food, beverages, and the environment. This mini-review summarizes recent advances in molecularly imprinted polymer (MIP)-based electrochemical sensors for BPA detection, with emphasis on recent developments in sensor fabrication, nanomaterial modification, and analytical performance. The review discusses MIP synthesis strategies, sensor platforms, nanomaterial modifications, and analytical performance. Recent studies have demonstrated that MIP-based electrochemical sensors can achieve highly sensitive BPA detection with limits of detection ranging from 0.03 pM to 52 nM, wide linear ranges, and successful application in real samples such as drinking water, milk, and packaged beverages. The incorporation of nanomaterials, including graphene, carbon nanotubes, and gold nanoparticles, has significantly improved electron transfer, sensitivity, and selectivity. Despite these advances, challenges related to long-term stability, reproducibility, template removal efficiency, and matrix interference remain. Overall, MIP-based electrochemical sensors represent a promising platform for rapid, selective, and cost-effective BPA monitoring in environmental and food safety applications.
Effect of Liquid and Solid Salting Methods on the Organoleptic Characteristics of Traditional Salted Eggs Elfira Jumrah
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5156

Abstract

This study aimed to evaluate the effect of solid and liquid salting methods on the organoleptic characteristics of traditional salted eggs. The research employed an experimental method using different salt concentrations in both salting media. The solid salting method utilized mixtures of salt and ash at ratios of 1:3, 1:4, and 1:5, while the liquid salting method used salt-water ratios of 1:0.5, 1:0.4, and 1:0.3 supplemented with garlic and chili peppers as natural flavoring agents. Duck eggs were cured for 7 days at room temperature and subsequently boiled before organoleptic evaluation. Sensory analysis was conducted based on color, aroma, taste, texture, and overall acceptance. The results showed that both salting methods significantly affected the sensory quality of salted eggs. In the solid salting treatment, the 1:3 salt-to-ash ratio produced the best characteristics, including bright orange yolk color, firm texture, balanced salty taste, and desirable aroma. Meanwhile, in the liquid salting treatment, the 1:0.5 salt-to-water ratio was the most preferred by panelists due to its attractive orange yolk color, balanced saltiness, soft texture, and pleasant spicy aroma derived from garlic and chili peppers. Higher salt concentrations promoted better osmotic dehydration, protein denaturation, and yolk texture formation, resulting in improved organoleptic quality. In conclusion, both solid and liquid salting methods effectively produced salted eggs with acceptable sensory properties; however, salt concentration and salting media played important roles in determining product quality. Optimization of salting conditions is therefore essential for producing traditional salted eggs with superior organoleptic characteristics and higher consumer acceptance.
Integrative Mapping of Phytochemistry, Pharmacology, Green Extraction, and Bioeconomics Peperomia pellucida (L.) Kunth: Systematic Literature Review Subakir Salnus; Ayu Sri Wiyanti; Hardianti Rahman; Yusran Katarina; Wisye Riska Leleallo Sura'; Andi Bau Andriwati
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5183

Abstract

This study aims to integrate scientific evidence on phytochemistry, pharmacology, green extraction, and bioeconomics of Peperomia pellucida (L.). Kunth through the Systematic Literature Review approach. The research was conducted by searching the Scopus database for articles using keywords related to Peperomia pellucida, phytochemicals, pharmacology, extraction, toxicology, antioxidants, antibacterial activity, and antidiabetic activity. Of the initial 89 articles, the selection process across identification, screening, eligibility, and inclusion yielded 34 articles for narrative analysis. The study found that P. pellucida contains various bioactive compounds, including flavonoids, alkaloids, tannins, saponins, phenols, terpenoids, steroids, lignans, phenylpropanoids, essential oils, dillapiole, quercetin, apigenin, stigmasterol, and fucosterol. The compound exhibits antioxidant, anti-inflammatory, antidiabetic, antibacterial, antihypertensive, anticancer, gastroprotective, neuroprotective, antiarthritis, antimalarial, and wound-healing activities. Extraction techniques such as maceration, solvent fractionation, MAE, IL-MAE, NADES, fermentation, drying, and gamma irradiation have been shown to affect compound content, biological activity, safety, and extract quality. This study concludes that P. pellucida has the potential to be developed as an ingredient in herbs, functional foods, phytopharmaceuticals, cosmetics, topical products, bioaccharicides, and bioeconomic commodities, but still requires standardization, safety validation, and further research.
Integration of Digital Health, Telemedicine, and Healthcare Service Management: Implications for Quality of Care and Health System Sustainability – A Scoping Review Jeki Purnomo; Nurfalia Harfah; Irfan Kurniawan
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5212

Abstract

Background: Digital health and telemedicine have evolved into structural components of modern healthcare systems, fundamentally transforming how access, service delivery, and care coordination are organized. While their adoption accelerated during the COVID-19 pandemic, their broader implications for healthcare service management, quality of care, and system sustainability remain variably understood. Aim: This scoping review aims to synthesize current evidence on the integration of digital health, telemedicine, and healthcare service management, with a focus on their impact on quality of care and health system sustainability. Methods: A scoping review design was applied following PRISMA-oriented principles. Literature published between 2020 and 2026 was identified from major scientific databases, including PubMed, Scopus, and ScienceDirect. Studies were included if they examined digital health or telemedicine interventions and reported outcomes related to healthcare access, service quality, patient experience, efficiency, or sustainability. Evidence was synthesized across four domains: digital health ecosystem, access to care, service quality, and efficiency–sustainability. Results: The findings indicate that digital health and telemedicine expand healthcare access by reducing geographical and temporal barriers, improve service quality through enhanced coordination and communication, and increase operational efficiency by optimizing resource utilization and reducing unnecessary hospital visits. In addition, digital health contributes to system sustainability by enabling flexible, adaptive service delivery models and improving system resilience. However, these benefits are conditional on factors such as infrastructure readiness, interoperability, governance frameworks, and digital equity. Conclusion: Digital health and telemedicine should be conceptualized as healthcare service-management infrastructure rather than standalone technologies. Their impact on quality and sustainability depends on effective integration with clinical workflows, organizational processes, and policy frameworks. Future health systems must focus on governance, equity, and continuous performance evaluation to realize the full potential of digital transformation.
The Role of Psychosocial and Cultural Factors in Adolescent Reproductive Health Literacy in Sinjai Regency Andi Nurzakiah Amin; Ismi Sultan
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5221

Abstract

Adolescent reproductive health literacy in Indonesia remains a critical issue, particularly in rural areas such as Sinjai Regency, South Sulawesi. Despite national programs like Pusat Informasi dan Konseling Remaja (PIK-R), gaps persist in integrating psychosocial and cultural dimensions into health education. This study aims to analyze the role of psychosocial and cultural factors in shaping adolescent reproductive health literacy, using an interdisciplinary approach that combines public health, psychology, and socio-cultural analysis. A qualitative descriptive design with a case study approach was employed between September and December 2025. Data were collected from 60 respondents (40 adolescents, 10 parents, and 10 health workers) through semi-structured interviews, focus group discussions (FGDs), and direct observation at schools and Posyandu remaja. Thematic analysis was used to identify recurring patterns, supported by triangulation to ensure validity. The findings reveal three dominant themes: psychosocial readiness, socio-cultural norms, and community-based interventions. Psychosocial factors such as confidence, emotional openness, and peer influence determined adolescents’ willingness to engage in reproductive health education. Socio-cultural norms, including religious values and family expectations, acted as both enablers and constraints, while community leaders served as cultural gatekeepers. Community-based interventions, particularly those involving peers, families, and respected leaders, were found to legitimize and sustain adolescent participation. In conclusion, adolescent reproductive health literacy in Sinjai is shaped by the interaction of psychosocial readiness and socio-cultural acceptance, legitimized through community-based interventions. Effective strategies must therefore integrate psychosocial empowerment, cultural sensitivity, and community participation to enhance knowledge, reduce stigma, and ensure sustainability in health promotion efforts.
The Role of High-Performance Liquid Chromatography for Compound Analysis Nita Magfirah Ilyas
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5235

Abstract

High Performance Liquid Chromatography (HPLC) is one of the analytical methods widely used for the separation, identification, and quantification of compounds in various types of samples. This literature review aims to examine the role of HPLC in the analysis of active compounds, contaminants, residues, and chemical components in the fields of pharmacy, food, cosmetics, and natural materials. The method used is a literature study reviewing nine scientific articles discussing the principles, method development, validation, and application of HPLC on various sample matrices. The review results show that HPLC has advantages in terms of sensitivity, selectivity, accuracy, and the ability to separate compounds in complex matrices. Some applications found include the analysis of hydroquinone in cosmetics, determination of niacinamide in chicken meat, β-carotene in carrots, tetracycline residues in tilapia fish, differentiation of bovine and porcine gelatin, and quantification of curcumin and piperine in microparticle formulations. Based on the study results, HPLC has been proven to be an important and reliable analytical method, especially when accompanied by appropriate chromatographic condition optimization and method validation.
Phytochemical Fingerprinting, Green Extraction, and Nanobiotechnology of Jahe Emprit (Zingiber officinale var. amarum): A Mini Review Subakir Salnus
Hayyan Journal Vol. 3 No. 1 (2026): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i1.5258

Abstract

Jahe emprit (Zingiber officinale var. amarum) has attracted growing scientific attention because its gingerols, shogaols, zingerone, essential oils, and related metabolites support functional food and phytopharmaceutical development. This review synthesizes recent evidence on phytochemical fingerprinting, green extraction, nanobiotechnological delivery, bioactivities, and translational barriers of jahe emprit and closely related ginger materials. Literature was selected through systematic query expansion, screening, citation chaining, and relevance ranking of studies published mainly between 2017 and 2026. The reviewed studies show that chromatographic, spectroscopic, metabolomic, and chemometric approaches can improve authentication and quality marker identification, especially for 6-gingerol, 6-shogaol, zingerone, alpha-zingiberene, and location-sensitive essential oil profiles. Green extraction methods, particularly supercritical CO2 extraction, microwave-assisted extraction, ultrasound-assisted extraction, and enzyme-assisted extraction, improve yield, selectivity, and bioactive preservation compared with conventional methods. Nanocarriers such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, and plant-derived exosome-like nanoparticles enhance solubility, stability, bioavailability, and targeted delivery in preclinical models. Nevertheless, clinical translation remains constrained by inconsistent quality standards, limited pharmacokinetic data, scale-up uncertainty, regulatory ambiguity, and insufficient long-term safety evidence. Standardized quality markers, reproducible extraction protocols, validated nanoformulations, and rigorous clinical trials are needed to convert jahe emprit from promising bioresource into scalable therapeutic products.
Synthesis Methods of Nanocellulose from Various Biomass Sources: A Review Muhammad Nur Alam
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5261

Abstract

Nanocellulose has become a strategic renewable nanomaterial because it combines high specific surface area, tunable surface chemistry, biodegradability, and strong reinforcement ability. This review analyzes synthesis methods of nanocellulose from various biomass sources, particularly agricultural residues, non-wood plants, forestry biomass, and agro-industrial waste. The review focuses on chemical, mechanical, enzymatic, and hybrid extraction strategies, including acid hydrolysis, alkaline and bleaching pretreatment, high-pressure homogenization, ultrasonication, TEMPO-mediated oxidation, deep eutectic solvent pretreatment, ionic liquid-assisted extraction, and bacterial biosynthesis. The synthesis shows that acid hydrolysis remains effective for producing highly crystalline cellulose nanocrystals, while mechanical and enzymatic routes are more relevant for cellulose nanofibrils. Green solvent-assisted and mechano-enzymatic approaches provide better prospects for reducing chemical waste and energy demand, although industrial scalability, product consistency, and techno-economic validation remain major barriers. Biomass composition strongly influences yield, crystallinity, morphology, thermal stability, and dispersibility. Therefore, future nanocellulose production should be designed through feedstock-specific, application-oriented, and environmentally responsible process integration.
Metal-Organic Frameworks for Targeted Cancer Drug Delivery: A Systematic Review of Stimuli-Responsive Platforms and Therapeutic Performance Rizal Irfandi
Hayyan Journal Vol. 3 No. 2 (2026): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i2.5289

Abstract

Metal-Organic Frameworks (MOFs) have gained increasing attention as promising nanocarriers for targeted cancer drug delivery due to their high surface area, tunable porosity, adjustable chemical structure, and capacity for controlled drug release. Conventional chemotherapy often faces limitations such as systemic toxicity, poor tumor selectivity, low bioavailability, and damage to healthy tissues. Stimuli-responsive MOFs enable drug release in response to specific tumor microenvironment conditions, including acidic pH, redox imbalance, enzyme overexpression, hypoxia, or external triggers such as light and temperature. This systematic review synthesizes 30 selected studies, focusing on MOF types, therapeutic cargo, stimuli-responsive mechanisms, cancer models, and reported therapeutic outcomes. Findings show that ZIF-8, UiO-66, MIL-series, and related MOF platforms are widely investigated, with doxorubicin and other anticancer drugs frequently used. pH-responsive and redox-responsive systems dominate, while multifunctional MOFs combining chemotherapy with photothermal or photodynamic therapy show strong potential. Clinical translation remains limited due to unresolved concerns regarding long-term biosafety, biodegradation, pharmacokinetics, immune response, reproducibility, and scalability. Stimuli-responsive MOFs represent a promising direction for precision cancer therapy, but further in vivo validation and translational studies are required
Computational Design and Pharmacokinetic Profiling of Novel Fe(II)-Peptide Complex Rizal Irfandi
Hayyan Journal Vol. 3 No. 1 (2026): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v3i1.5302

Abstract

Metal-peptide complexes represent a promising avenue in medicinal chemistry due to their unique coordination and biological properties. This study aimed to design and evaluate a Fe(II)-proline-arginine-dipeptide complex as a potential therapeutic agent. Computational modeling constructed the ligand and optimized the coordination geometry with Fe(II) and two chloride ligands, forming a stable distorted tetrahedral structure. 1H- and 13C-NMR spectra confirmed preservation of the dipeptide framework. Physicochemical assessment revealed a molecular weight of 396.056 g/mol, low LogP of 0.21947, balanced hydrogen-bond donors and acceptors, and a polar surface area of 139.047 Ų, supporting oral drug-likeness. ADMET analysis predicted moderate intestinal absorption (38.444%), low CNS penetration, minimal CYP enzyme interaction, and moderate clearance (1.11 log mL/min/kg). Toxicity prediction indicated no AMES mutagenicity, hepatotoxicity, or hERG inhibition, with an oral rat LD50 of 2.174 mol/kg. These results demonstrate that the Fe(II)-proline-arginine-dipeptide complex possesses structural stability, favorable pharmacokinetic behavior, and a broad safety profile, highlighting its potential as a therapeutic candidate. The study provides a framework for integrating peptide ligand design with metal coordination and in silico pharmacokinetic evaluation, suggesting avenues for experimental validation and future drug development.

Page 10 of 11 | Total Record : 101

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