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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 257 Documents
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Efektivitas Gel Ekstrak Etanol 70% Daun Anggrek Oncidium (Oncidium Aliceara alice) terhadap Penyembuhan Luka Kulit Dorsum Tikus Sprague Dawley Onibala, Michele Liony Maria; Suntadi, Maria Ariska Happy; Wiadji, Jovitta Theachrysilla; Oktaviani, Yustina Wanda Dwi; Gunawan, Yohanes Candra; Widhiastuti, Stefani Santi
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6211

Abstract

Wounds are tissue damage that is generally caused by physical contact. Wound healing is a complex mechanism involving biochemical and biocellular processes. Various therapies can be done to speed up the wound healing process, one of which is treatment using natural ingredients. One of the plants that have the potential to heal wounds is Oncidium Aliceara alice. The purpose of this study was to determine the phytochemical content of Oncidium Aliceara alice and its activity in wound healing when it is formulated in a gel form. This research is experimental research with extraction stages, phytochemical assay, gel formulations, quality test, and wound healing activity tests in animals. The gel formulation was made with various concentrations of Oncidium Aliceara alice extract 2.5%, 5% and 10%. Male Sprague Dawley rats were given an incision wound on the dorsum of the longitudinal axis along 3 cm. Wound care by administering topical Bioplacenton as a positive control, base gel as a negative control, and gel extract concentration variants according to each treatment group. Based on the research, the results of qualitative phytochemical tests showed that the 70% ethanol extract of Oncidium Aliceara alice contains flavonoids (catechins), tannins, steroids, and saponins. The best results were seen on the 7th day of observation for the 10% gel extract treatment group with more perfect signs of wound closure than the bioplacenton treatment.
Validasi Metode Analisis Penetapan Kadar Protein Ekstrak Ikan Gabus dengan Metode Lowry dan Bromocresol Green Suhendi, Andi; Rohman, Abdul; Cahyaningrum, Safira
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6219

Abstract

Snakehead fish is one of the biological resources with high economic value because it contains high albumin levels. Analytical methods for the determination of protein content in snakehead fish are available not been validated. This study aims to obtain a comparison of the accuracy, repeatability, intermediate precision, and linearity between the Lowry and Bromocresol-green methods in determining albumin levels from snakehead fish extracts. This study was performed with the SHIMADZU UV-1280 spectrophotometer at a wavelength of 778 nm for the lowry method and 638 nm for the bromocresol-green method. The results of the study show that all parameters meet the requirements for accepting validation. The results were tested statistically with the independent t-test, the p-value was 0.172 (p> 0.05) the accuracy between the Lowry and Bromocresol-green methods did not have a significant difference, that the Lowry and Bromocresol green methods had the same ability to determine accuracy parameters and precision parameters, the p-value is 0.000 (p
Efek Ekstrak Etanol Daun Kelor terhadap Kadar Kreatinin Serum dan Superoksida Dismutase Tikus Model 5/6 Subtotal Nefrektomi Kuncorojati, Raden Alif; Afifaningrum, Haniy Thri; Swastika, Anis; Afifah, Afifah
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6248

Abstract

Chronic Kidney Disease (CKD) is still a major problem in the health sector in the world, including in Indonesia. One of the main pathomechanisms in CKD is oxidative stress. Superoxide dismutase (SOD) is an enzyme that plays a role in fighting oxidative stress. Oxidative stress can be overcome with antioxidants both from inside the body and from the outside obtained from natural materials. Moringa leaves (Moringa oleifera L.) have the potential to prevent the progressivity of CKD because of their flavonoid content which has an antioxidant effect. This study aimed to analyze the effect of Moringa leaf ethanol extract (MLEE) on serum creatinine and SOD levels in rat model 5/6 subtotal nephrectomy. This research is an experimental study with a post-test only with a control group design. A total of 30 male white rats were randomly divided into 5 groups. Group A: sham control, B: subtotal nephrectomy, C, D, and E: treatment groups with MLEE of 200, 400, and 800 mg/kg BW, respectively. On the 15th day after the administration of extracts or aqua dest, sham surgery was carried out in group A, and 5/6 of subtotal nephrectomy in groups B, C, D, and E continued to administer extracts and aqua dest until the 21st day. A blood sample is taken on the 22nd day after surgery, checked serum creatinine levels and SOD. Data were analyzed using One-way ANOVA. The results showed that there was a significant difference in the average serum creatinine levels (p
Formulation of Instant Granules from Ethanolic Extract of Melinjo Peel (Gnetum gnemon L) Extract as Anti-Hyperuricemia Sari, Diah Permata; Fahriati, Andriyani Rahmah; Maelaningsih, Firdha Senja
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6290

Abstract

Melinjo (Gnetum gnemon L) is extensively found in Indonesia, and all of its components are highly employed, with the fruit being the most commonly used. However, melinjo fruit can induce hyperuricemia if ingested excessively since it contains purines, which can raise uric acid levels. Several investigations have found that melinjo peel can lower uric acid levels in experimental rats in vivo. As a result, the goal of this study is to create and evaluate immediate granule formulations of melinjo peel extract. Plant determination, standardization of specified parameters, standardization of non-specific parameters, formulation, and physical and chemical assessment of instant granules of melinjo peel extract are all steps of the technique. This study employed two instant granule formulations of melinjo peel extract FI and FII with varying PVP concentrations (1g FI and 3g FII). Flow time testing, angle of repose testing, compressibility index testing, water content testing, and dissolving time testing were all part of the physical examination of instant granules. The chemical evaluation took the form of a UV-Vis spectrophotometer study of total flavonoid levels in instant extracts and granules. The FI and FII instant granule formulas had a yellow color, the flow time test results were in a good category (44 g/s and 81 g/s), the angle of repose test results was in the very good flow properties category (19° and 16°), the compressibility test results, the water content test, and the dissolving time test were performed in triplo, in 0, 7th, and 14th day, and the results were in a good category. In conclusion, the physical features of instant granules of FI and FII melinjo peel extracts fulfilled the requirements for all test parameters and had a high possibility to be produced as anti hyperuricemia preparations.
Pengaruh Pemberian Kombinasi Ekstrak Etanol Piper crocatum dan Ekstrak Akuades Elaeocarpus ganitrus pada Kadar Gula Tikus Lestari, Apriani; Kiromah, Naelaz Zukruf Wakhidatul; Fitriyati, Laeli
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6298

Abstract

Diabetes mellitus is a disease characterized by hyperglycemia. Antidiabetic research using natural ingredients has been carried out a lot, one of which is by utilizing red betel leaves and granite leaves. Combining two plants must be done to increase the antihyperglycemic effect and reduce the toxic effects. This study aimed to obtain the most effective dose variations in combinations of plants that are safer and have better results so that they can be used as alternative treatments. The blood sugar levels were measured in vivo on white Wistar rats induced with streptozotocin using a glucometer. The results showed that a single extract of red betel leaf (100 mg/kg BW) and a single extract of granite leaf (100 mg/kg BW) had a percentage decrease in blood sugar levels of 27% and 10%, respectively. While the combination of extracts with a ratio of 100:100, 50:50, 100:50, and 50:100 mg/kg BW has a decrease in blood sugar levels of 50%, 42%, 33%, and 19% after 21 days of observation. The study also showed that the positive control of 0.036 mg glimepiride caused a 36% decrease in sugar levels. Statistical analysis proved that the effect of reducing blood sugar levels on days 0 to 21 differed for each treatment group with a p-value of 0.05. The study concluded that the combination of red betel leaf extract and granite leaf extract was more effective on blood sugar levels than the single extract of each plant in white male Wistar rats. The percentage reduction in blood sugar levels of the combination extract with a dose ratio of 50:50 mg/kg BW and 100:100 mg/kg resulted in better antidiabetic activity than the positive control glimepiride. The combination ratio of 100:100 mg/kg BW extract had the best antidiabetic activity compared to the other extract treatment groups.
Maja Fruit (Crescentia cujete L.) Potential as a Laxative in Mice Teodhora, Teodhora; Manalu, Rosario Trijuliamos; Kusuma, Ika Maruya; Azizah, Shandy
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6300

Abstract

Constipation is a digestive disorder that anyone with symptoms of complex, uneven, and irregular bowel movements commonly experiences. This study aims to determine the laxative effect of maja extract (Crescentia cujete L.) on male white mice (Mus musculus) induced by loperamide. This fruit has been reported to be used as an analgesic, anti-inflammatory, and for digestive system disorders. The method used to test laxative activity is the intestinal transit method. Parameters observed included stool weight, defecation frequency, feces consistency, and not passage length in the intestine of mice. The extract was administered orally at a dose of 125 mg/kg BW, 250 mg/kg BW and 500 mg/kg BW; as a comparison, a negative control (CMC Na) and a positive control (docusate sodium) were used.  Phytochemical screening of maja extract contains alkaloids, flavonoids, tannins, and saponins. The best results were obtained maja fruit can provide a therapeutic laxative effect through the molecular mechanism of secondary metabolites in loperamide-induced test animals.
Formulation and Evaluation of Gummy Candy from the Extract of Jathropa Leaf (Jatropha curcas L.) Aulia, Gina; Sayyidah, Sayyidah; Fadhilah, Humaira; Ismaya, Nurwulan Adi; Indah, Fenita Purnama Sari
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6429

Abstract

People are becoming more interested in nutraceutical preparations to maintain health as the world's health problems worsen. Jatropha curcas leaves (Jatropha curcas L.) have anthelmintic properties due to tannin compounds that act as anti-worms. This study aims to produce jelly candy preparations from Jatropha curcas leaves and evaluate these preparations. There are two stages of research: raw material preparation and verification, and jelly candy formulation. This study showed that the best concentration of Jatropha leaf extract was Formula 2. Based on the phytochemical test, there were alkaloids in the Jatropha leaf extract.  The pH value of gummy candies preparations of castor leaf extract, weight uniformity test, passed the moisture content test because they met the requirements for a wide range of dosage values. Meanwhile, the Hedonic Test results show that Formula 2 is the most preferred by children. So, based on the evaluation and hedonic test results, Formula 2 is the best preparation for jelly candy from jatropha leaves.
Evaluation of the Use of Antibiotics in the COVID-19 Ward at A North Jakarta Hospital Arrang, Sherly Tandi; Buntoro, Leonardo; Notario, Dion
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6539

Abstract

The misuse of antibiotics can lead to antibiotic drug resistance, which can increase morbidity and mortality. In order to stop the emergence of antibiotic drug resistance, the WHO recommends routinely assessing the usage of antibiotics. When the COVID-19 epidemic broke out, antibiotic consumption significantly increased compared to the prior year. The panic buying phenomenon also appeared during the COVID-19 pandemic. As a result of this circumstance, medications like antibiotics become rare. The abuse of antibiotics during the COVID-19 pandemic may have contributed to the spread of antibiotic resistance more frequently. This study was conducted to evaluate and describe the use of antibiotic drugs in COVID-19 ward patients at a North Jakarta regional hospital for the period April 2020 – April 2021. This study was an observational study design. The Gyssens method and the Anatomical Therapeutic Chemical/Defined Daily Doses (ATC/DDD) methodology, respectively, evaluate the effectiveness of antibiotic use on a quantitative and qualitative level. There were 24 different types of antibiotics used, and 161 respondents all met the criterion for inclusion. The most widely used antibiotic was azithromycin, with a DDD/100 patient days value of 25.15. According to Gyssen’s evaluation, 92.6% of antibiotic usage was rational and 7.4% was irrational.
In Silico Study and Pharmacokinetics Prediction of ɛ-Viniferin Compound as Anticancer Drug Candidate Dewi, I Gusti Ayu Intan Puspita; Yuda, Putu Era Sandhi Kusuma; Rahadi, I Wayan Surya
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6556

Abstract

The ɛ-Viniferin (ɛ-VNF) is a resveratrol dimer found in grapes (Vitis vinifera) which is thought to have anticarcinogenic activity. Breast cancer is one of the biggest causes of mortality in women. Current conventional chemotherapy can give negative side effects for cancer patients. Therefore, exploration to find an alternative modality is required. HER2 (Human Epidermal Growth Factor Receptor 2) and CDK6 (Cyclin Dependent Kinase 6) are two proteins that play an important role in breast cancer cell proliferation and differentiation. This study aimed to determine the potential of ɛ-VNF in inhibiting HER2 and CDK6 by molecular docking study. This research was conducted in silico using AutoDockTools v1.5.7 software. The results were validated with PyMOL and visualized in Discovery Studio Visualizer software to see the amino acid residues generated. Prediction of pharmacokinetics and toxicity profiles of the compound were performed with SwissADME and ADMETLab web tools. The results showed that ɛ-VNF was able to bind to HER2 and CDK6 receptors with binding energies of -10,45 kcal/mol and -7,56 kcal/mol, respectively. In silico pharmacokinetics and toxicity studies showed that ɛ-VNF fulfills Lipinski’s Rule of Five and has the potential to be used as a drug candidate. Overall, the results of this study indicate that ɛ-VNF has the potential to be further investigated and developed as an anticancer drug candidate through inhibition of HER2 and CDK6 receptors.
Formulation of Serum Using a Combination of Tamanu Oil and Tea Tree Oil as Antiacne Ermawati, Dian; Cahyani, Pradina Zustrian; Shahnaz, Ifa; Juniarty, Amelya; Mahardhika, Chandra Leony; Chasanah, Uswatun
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6570

Abstract

Acne is a chronic inflammation of the skin caused by bacteria. Tamanu oil contains neoflavonoids and tea tree oil contains terpenes-4-ol, both of which have good antibacterial agents. The combination of Tamanu oil and tea tree oil will produce a preparation synergistic in inhibiting bacterial growth. This study was to determine the best formula for serum preparations with good characteristics and stability against bacteria without irritating the skin. Serum formulation in three different concentrations of Tamanu oil is 0.5%, 0.75%, and 1%, each combined with 2% tea tree oil. Then the characteristics test (organoleptic, homogeneity, viscosity, dispersibility, and pH), stability test (organoleptic, homogenous, and pH) using cyclic temperature stress testing, and antibacterial test against Staphylococcus aureus and Propionibacterium acnes using well-diffusion method and irritation test using Hen’s egg test chorioallantoic membrane (HET-CAM) were carried out. The results showed that the overall viscosity, spreadability, and pH matched the specification, were stable, and had no irritation effect. Serum formulation containing Tamanu oil 1% and tea tree oil 2% is the best antibacterial activity which zones inhibition of 12.5 mm on Propionibacterium acnes and 11.6 mm on Staphylococcus aureus.

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