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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 257 Documents
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Pengaruh Fraksi Daun Asam Jawa (Tamarindus indica L.) terhadap Fungsi Hati dan Ginjal Tikus Diinduksi Parasetamol Rahimah, Sitti; Awaluddin, Akbar; Wahyuddin, Nurzadrina
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5955

Abstract

Liver and kidneys play a role in the metabolism and excretion of substances that enter the body, they become targets for toxicity from xenobiotics and other chemicals including drugs. Exogenous antioxidants are needed to overcome and prevent oxidative stress. Fraction of tamarind leaf extract (Tamarindus indica L) has antioxidant activity, it has the potential to protect the body from free radicals. This study aimed to determine the effect of giving tamarind leaf fractions on AST, ALT and creatinine levels in rats (Rattus norvegicus) induced with paracetamol. Experimental animals were divided into 4 groups. Group I was given paracetamol induction (negative control), group II was given the ethyl acetate fraction and induced paracetamol, group III was given the n-hexane fraction and induced paracetamol, and group IV was without treatment (positive control). Statistical analysis using One Way Anova test and LSD (Post Hoc) showed that the ethyl acetate fraction was not significantly different (p-value >0.05) with the positive control group and the n-hexane fraction group, but significantly different from the negative control group (p -value
Aktivitas Antiparkinson Ekstrak dan Fraksi Buah Kemukus (Piper cubeba L.) pada Tikus Putih Galur Sprague Dawley Damayanti, Kiki; Anas, Yance; Marlina, Windy; Nabila, Talcha; Irmawati, Putri
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5964

Abstract

Pathophysiologies underlying the Parkinson's disease is oxidative stress, can be treat with antioxidants from natural sources, including Piper cubeba L. Flavonoids are reported as antioxidants. This study aimed to analyse the flavonoids content and antiparkinson activity from the ethanolic extract of cubeb fruits (EECF), ethyl acetate fraction of ethanolic extract of cubeb fruits (EAFEECF), n-hexane fraction of ethanolic extract of cubeb fruits (NHFEECF). This research is an experimental study with a post test only control group design. Eighty four rats were divided into 14 groups. Group 1 is a normal group, group 2-3 are negative controls which were given aquadest and olive oil, respectively. Positive control groups, 4 and 5 were given levodopa 27 mg/kgBW and vitamin E 180 IU/kgBW, respectively. Group 6-14 were given EECF, EAFEECF, and NHFEECF at doses 150, 300, 600 mg/kgBW. Group 2-14 were induced with haloperidol 2 mg/kgBW intraperitoneally 45 minutes after administration of the material tests. The materials are given once a day for 7 days. The length of time the rats can hold on to the rotarod was tested on days 0, 4, 7, 11, 14. The curve showed the data on the survival time of rats on a rotarod versus time, then the AUC0-14 was calculated using the trapezoidal method. The AUC0-14 were analyzed using Mann Whitney test at 95%CI. The flavonoids content were analysed using TLC. The results showed that the EECF, EAFEECF, and NHFEECF contained flavonoids, and antiparkinson activity except for the NHFEECF at doses 150 and 600 mg/kgBW.
Isolasi dan Skrining Aktivitas Antibakteri Fungi Tanah Muara Desa Katialada Gorontalo Lokasi Satu terhadap Staphylococcus aureus Rohmatillah, Wilda Nur; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Pratoko, Dwi Koko; Nugraha, Ari Satia
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5978

Abstract

The emergence of antibiotic resistance becomes a barrier in controlling infectious diseases, so it is necessary to find new alternative antibiotics. This study aimed to explore the potential of estuarine soil fungals secondary metabolites isolated from Katialada Village Gorontalo Location One and test their antibacterial activity against Staphylococcus aureus. The antibacterial parameter observed was the percent inhibition of ethyl acetate extracts against Staphylococcus aureus. The estuarine soil samples were cultured in PDA media producing five single fungal isolates differentiated based on color morphology, texture, and shape coded IS2-BTG-4.1.1, IS2-BTG-4.1.2, IS1-BTG-4.2, IS2-BTG4.3.1, and IS2-BTG-4.3.2. Those five samples were fermented using PDB media and the fermented products were extracted with ethyl acetate. The extracts were screened for its compound using a TLC plate and antibacterial testing with a single concentration of 100 g/mL in the microdilution method. The screening results showed that the five ethyl acetate extracts contained terpenoid compounds and code IS2-BTG-4.3.2 also had alkaloids. Based on the antibacterial test results, the five ethyl acetate extracts had growth inhibitory activity on the Staphylococcus aureus, with the percentage showed by IS2-BTG-4.1.1 50,2% ± 14,8%, IS2-BTG-4.1.2 35,6% ± 12,9%, IS1-BTG-4.2 13,0% ± 7,3%, IS2-BTG-4.3.1 13,6% ± 6,0%, and IS2-BTG-4.3.2 by 12,4% ± 9,2%.
Pengaruh Variasi Media Pertumbuhan terhadap Aktivitas Peredaman Radikal Bebas DPPH Ekstrak Kapang Endofit Isolat Cb.D1 Purnamasari, Ayu; Andriyaningsih, Fitri; Pamungkas, Riska Andriani; Septiana, Eris
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6029

Abstract

Endophytic fungi are a source of antioxidant compounds in nature. The low yield of extracts and active compounds produced is one of the limiting factors for using endophytic fungi as a source of natural antioxidant compounds. Modification of growth media is an alternative solution to overcome this problem. This study aimed to determine the effect of media conditions, belonging to carbon and nitrogen sources and different initial pH of fermentation, on the antioxidant through DPPH radical scavenging activity of extract of endophytic fungi Cb.D1 isolated from cinnamon plant leaves. The culture was propagated using Czapek Dox Broth basal liquid medium with agitation speed 120 rpm at room temperature for 14 days. The carbon sources used were glucose, sucrose, and soluble starch. The nitrogen sources were natrium nitrate, ammonium nitrate, and yeast extract. The initial pH conditions used were 5, 7, and 9, and ethyl acetate as the extraction solvent. The results obtained that the variation of nitrogen and carbon sources and also initial pH conditions can increase the yield of extract of endophytic fungi Cb.D1. Glucose, yeast extract, and initial pH at 9 were the best growth media to gain it. The substitution of nitrogen sources and initial pH can increase the DPPH free radical scavenging activity of endophytic fungal extract compared to substitution for carbon sources. The highest activity from the Cb.D1 endophytic fungal extract was obtained from media that contain sucrose and natrium nitrate as a carbon and nitrogen sources and an initial pH of 5. The Variation of growth media of endophytic fungi Cb.D1 affected their extract in DPPH free radical scavenging activity.
Pengembangan Nutrasetikal Es Krim Daun Kelor (Moringa oleifera L.) Ul Haq, Takdir
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6030

Abstract

Moringa plants ranging from fruit, flowers, leaves, skin, seeds, stems to roots have important benefits. One of the most prominent content of moringa is antioxidants, especially in the leaves which contain high antioxidants. Moringa leaves contain antioxidants in the form of interquinones, flavonoids, tannins, steroids, alkaloids, triterpenoids, and saponins. Moringa leaves also contain vitamin C, calcium, B vitamins, iron, vitamin A, potassium and large amounts of protein that are easily digested and absorbed by the body. The use of moringa plants in Indonesia is currently still limited. One of the efforts to increase the utilization of moringa leaves is through the development of nutraceutical products of Moringa Leaf ice cream. This study aims to obtain a nutraceutical formulation of moringa leaf ice cream for and antioxidant activity. This research is an experimental study by conducting experiments to make Moringa Leaf powder by drying at room temperature and used as an additive in ice cream products and measuring antioxidant activity. This study shows that moringa leaf powder can be formulated into nutraceutical ice cream preparations, the antioxidant activity of moringa leaf powder 50 mg and 5% ice cream is classified as weak, moringa leaf powder 100 mg and 150 mg and 10% and 15% ice cream is classified as moderate and the antioxidant activity is moderate. Moringa leaf powder did not change after being formulated into a nutraceutical preparation of moringa leaf ice cream.
Determination of HPLC Chromatogram Profile of Katuk (Breynia androgyna (L.) Chakrab. & N.P.Balakr) Plants from Ristoja's Results using Chemometric Analysis Yunarto, Nanang; Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6040

Abstract

The katuk plant was known as Sauropus androgynous (L.) Merr, but the name is changed to Breynia androgyna (L.) Chakrab. & N.P. Balakr since the publication of Chakrab's & N.P. Balakr in the 2012 Journal of Plant Taxonomists. The content of chemical compounds and secondary metabolites of katuk leaf are strongly influenced by different habitat or location. Therefore, the Center for Research and Development of Medicinal Plants and Traditional Medicines, National Institute of Health Research and Development (NIHRD) has conducted Research on medicinal plants and herbs (RISTOJA) results on 58 samples of katuk plants originating from 7 provinces and used by 13 ethnic groups in Indonesia. This study aims to obtain plant quality based on the description of the High-Performance Liquid Chromatography (HPLC) chromatogram profile, in order to obtain the suitability of the efficacy of medicinal plants with their benefits for the community in an area. Test using HPLC with a gradient mobile phase, mixture of acetonitrile and methanol for 60 minutes. The results of the chromatogram were analyzed chemometrically by using Principal Component Analysis (PCA) data interpretation. PCA results showed that from HPLC chromatograms at 254 nm and 366 nm, each gave 3 different clusters, namely Clusters A, B and C where each cluster has the same chromatogram profile of katuk plants. Cluster A which was identified at a wavelength of 254 nm was the most used cluster by 7 ethnic groups with a total of 28 Katuk samples. Similarly, the chromatogram at a wavelength of 366 nm with the largest cluster is cluster A which is used by 11 ethnic groups with a total of 45 samples of katuk plants. where each cluster had the same chromatogram profile of katuk Plants.
Evaluasi Penggunaan Ramipril dan Candesartan pada Pasien Rawat Inap COVID-19 dengan Komorbid Hipertensi di RSUD Dr. Moewardi Azizah, Deva Yolanda Dwi Nur; Wijayanti, Tri; Cahyo, Lukito Mindi
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6064

Abstract

Hypertension is the most common comorbid in patients infected by COVID-19. Drugs often given for the treatment of hypertension, namely ramipril, and candesartan, are thought to increase the development of COVID-19 because the angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) increase the expression of ACE-2, which is the binding site of SARS-CoV-2. This study aims to analyze the effect of using ramipril and candesartan on healing in hospitalized patients with COVID-19 with hypertension at RSUD dr. Moewardi in 2020. This study was conducted retrospectively. The results were presented descriptively and used medical record data of hospitalized patients with COVID-19 with comorbid hypertension at RSUD dr. Moewardi in 2020. Using ramipril and candesartan affects patient recovery in terms of length of stay (LOS), symptom relief, and RT-PCR test results. Analysis of the research data using SPSS with Spearman correlation test. The Spearman correlation test showed that there was a fairly strong relationship between the use of ramipril and candesartan in patients with COVID-19 with comorbid hypertension on LOS, symptom relief, and RT-PCR test results. The study results show that using ramipril and candesartan can improve the recovery of patients with COVID-19 with comorbid hypertension. ACEI and ARB drugs have not been proven to worsen the patient's condition so their use can be continued.
Pengaruh Variasi Gliseril Monostearat pada Krim Ekstrak Kulit Buah Naga Merah Super (Hylocereus costaricensis) dan Uji Antioksidannya Nugrahaeni, Fitri; Yati, Kori; Sukmara, Sukmara
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6099

Abstract

A Glyceryl monostearate can be used as an emulsifier because it can affect the increase in antioxidant activity. The study aims to determine the effect of fluctuations in the concentration of glyceryl monostearate (GMS) on the physical properties of cream preparations containing 70% ethanol extract from the skin of super red dragon fruit and their antioxidant activity. The research methods carried out experimentally include the manufacture of extracts from super red dragon fruit peel, phytochemical screening using thin layer chromatography, formulations using various concentrations of glyceryl monostearate 8%, 10%, 12% then the physical quality of the cream and antioxidant activity test using the DPPH method. The results of one-way ANOVA for pH, dispersion, adhesion, and viscosity tests showed a p-value of> 0.05, indicating that there was no significant difference. The IC50 results obtained with equations 1, 2, and 3 are 3.69 mg/L, respectively. 3.98mg/L; and 4.78mg/L. Formula 3 is the best formula and estimates the antioxidant activity of Vitamin C, which is a positive control, at a value of 5.83 mg/L. The results of the irritation test showed that none of the formulations caused irritation. The preference test results showed that the respondents liked all the formulas. The conclusion of this study is that increased fluctuations in the concentration of glyceryl monostearate did not affect the physical properties of super red dragon fruit skin extract cream, but did affect its antioxidant activity.
Analisis Efektifitas Biaya Terapi Pengobatan Pasien Diabetes Mellitus Tipe 2 terhadap Kontrol Glukosa Darah Ulfa, Ninik Mas; Fandinata, Selly Septi; Puspitasari, Indra
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6170

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by blood glucose levels exceeding normal. The length of therapy in DM patients causes the large amount of treatment costs incurred, although in Indonesia BPJS insurance is used but this puts the burden of health financing on the Indonesian government, so there is a need for an analysis of costs associated with therapeutic outcomes. The purpose of this study was to analyze the Cost Effectiveness of Type 2 DM patients in a hospital in the South Surabaya area. The method used is observation, with retrospective observation on type 2 DM patients in outpatient internal polyclinics for the period April – December 2021. The results obtained were 30 patients who routinely controlled 2, 3, 4, 5, 6, 7, 8 and 9 months, receiving single therapy or a combination of antidiabetic drugs. In this study, a cost and effectiveness analysis was carried out with the measurement of therapeutic outcomes, namely pre-post GDP and pre-post GD2PP. The conclusion of this study were 30 female patients (100%), age > 45 years 24 people (80%). The effectiveness of sulfonylurea single therapy is 50% with an ACER of between Rp. 4,392.48 – Rp. 18,686.86 routine control 2, 3 and 9 months. For the treatment of 2 combinations of Thiazolidinediones + Insulin has an effectiveness value of 100% with ACER Rp. 42,490.08 routine control 6 months. While the 3 combinations that have a 100% effectiveness value are the combination of Sulfonylurea + Thiazolidinedione + Biguanide with an ACER price of Rp. 6,668.4 routine follow-up for 3 months. In 3 combinations of oral antidiabetic with insulin (Insulin + Sulfonylurea + Thiazolidioine + alpha glucosidase inhibitor) has a 100% effectiveness value, the ACER price is Rp. 36,082.36 routine control 7 months.
Pengembangan dan Validasi Metode Bioanalisis Trimetoprim dalam Sampel Plasma dan Urin Manusia Simulasi Menggunakan KCKT-PDA Notario, Dion; Amelia, Jessica; Della, Genoveva
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6189

Abstract

To monitor trimethoprim levels (TMP) in humans, a validated, simple, and cost-efficient analytical method is needed to be applied regularly. However, most of the methods used to establish TMP levels in urine and plasma use complex instrumentation. Therefore, in this study, a simpler High-Performance Liquid Chromatography-based (HPLC) method was developed. The separation was carried out using a GIST® C18 column (150 × 4.6 mm, 5 μm) at a temperature of 35°C which was fed by a mobile phase in the form of an acetic acid solution pH 2.5: acetonitrile (87:13, v / v) at a speed of 1.4 ml/min. Detection was performed with Photodiode Array Detector (PDA) at wavelengths of 254 nm and 243 nm to quantify TMP in urine and plasma samples respectively. The preparation of urine and plasma sequentially was carried out by the liquid-liquid extraction (ECC) method using ethyl acetate and the protein precipitation using acetonitrile. This method proved to be selective, linear (R=0.997), accurate with %error ≤ 10.29% at LLOQ level and above LLOQ value %error ≤ 10.45%, precision with %RSD ≤ 11.79% at LLOQ level and %RSD ≤ 10.82% above LLOQ. In addition, this method is quite sensitive for pharmacokinetic studies in the urine and monitoring of TMP levels in the blood with LLOQ 5 mg/L in both urine and plasma. The stability of trimethoprim in solution, urine, and plasma was conducted to ensure storage time. The developed method is proven to be valid and can be applied in pharmacokinetic studies and monitoring of trimethoprim drug levels in urine and plasma.

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