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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Pemanfaatan Pengobat Tradisional oleh Masyarakat Gitawati, Retno
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2836

Abstract

Traditional practitioners Pengobatan Tradisional (Battra) are becoming parts of health care services, and are used to overcome certain health problems in rural areas as well as in urban. However, there is not enough nation wide data of how wide are traditional practices being utilized by the population. Further analysis using the nationwide Riskedas-2007 data is conducted to describe how Battra in Indonesia involved in the population's health care. The analysis is done descriptively, using the cleaned Kesmas (public health) data, ana crosssectional designed with the total sample size of 36.584 respondents. The results showea 1.2% of respondents rely on Battra for inpatient and outpatient services. About 10.1% respondents in West Sulawesi province went to in-patient-serviced (hospitalized) Battra jot their health problems, which is the largest proportion among other Battra utilizations in other provinces. While South Kalimantan is the province with the largest proportion of respondents (4. 7%) went to outpatient services of Battra. Access to the nearest conventional/allopalhic health care services (e.g. public hospital, primary health care, clinics) infuenced the respondent ’s preference for going to Battra The proportion of male respondents who went to Battra is greater than the females, and so the lower educated, and the lower economic status of respondents. More respondents in rural areas went to Battra compared to those in urban.
Karakterisasi Kompleks Inklusi Asam Mefenamat - B-Siklodekstrin yang Dibuat dengan Metode Freeze Drying Setyawan, Dwi; Isadiartuti, Dewi
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2837

Abstract

Characterization of mefenamic acid- ,8-cyclodextrin inclusion complexes by freeze dryin method had been studied. Solid state mefenamic acid - B-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamlc acid, B-cyclodextrin, mefenamic acid - B-cyclodextrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscop (FTIR) , Dijferential Thermal Analyzer (DT/1) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and B-lcyclodextrin. In vitro dissolution rate studies of mefenamic acid, mefenamic acid - B-lcyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid - B-lcyclodextrin inclusion complex showed increasing dissolution rate compared to me?znamic acid - B-cyclodextrin physical mixture and mefenamic acid.
Situasi Pencatatan dan Pelaporan Efek Samping Alat Kesehatan Beresiko di Rumah Sakit Herman, Max J; Raharni, Raharni; Sasanti, Rini
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2840

Abstract

The incidences of adverse effects of medical device used in hospitals either as an allergic reaction, user error or as a device malfimction have been much revealed in mass media up to this moment. In an attempt to develop an assessment and monitoring system of risky medical device in hospitals, a study to explore the medical device adverse eflects in type A, B and C hospitals in four provinces (North Sumatera, DKI Jakarta, West and East Java),including psychiatric, Haji and district hospitals which were selected purposively, was carried out in 2006. Data were collected by interview using questionnaire and focus group discussion as well as direct observation. Study results show that in general the number and kind of medical devices depend on the hospital type and status. Hospital of the A type had more medical devices than type B and C hospitals. Psychiatric hospitals had just several risky medical devices, whereas educational hospitals had many more medical devices. Several adverse effects that were found and ever happened concerning the use of risky medical devices are among others the skin inflammation caused by overdoses in thermodermal therapy, renal inflammation and hematoma following the ultrasonic destruction of renal stone, depigmentation of CT scan operator facial skin and symptoms of anemia in radioisotope and X -ray operator.
Uji Gelagat dan Uji Analgesik Ekstrak Etanol Daun Kembang Sungsang (Gloriosa superba L) pada Hewan Coba Pudjiastuti, Pudjiastuti; Nugroho, Yun Astuti
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2841

Abstract

Gloriosa superba L belongs to the Colchiceae family. These vine plants reach 2.5 m in height and can grow at 400 in above sea level. The leaves contain chemical compounds such as alkaloid colchisin, glorisin and triterpen which possess analgesic properties. Many studies have been conducted in the tubers of such plants but scientific information on the eflicacy the leaves as analgesic have not thus far been published. Therefore, in this work a study wa conducted to test behavior and analgesic efiicacy of compounds in the Gloria superba L. leaves extracted with ethanol. The results showed the influence on the central nervous system and analgesic eflecls at doses of extract for 2 mg/100g body weight of mice and it's no significant diflerent with asetosal (p< 0, 05).
Efek Daun Dewa (Gynura pseudo-china Aug D.C.) terhadap Peningkatan Trombosit Tikus Putih yang Diinduksi Hidroksi Urea Winarno, M. Wien; Suciati, Yesi; Sediarso, H.
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2842

Abstract

Daun dewa (Gynura pseudo-china Aug. DC), empirically used as anti-inflammation, anti-diare, anti-tumor, and anti-fungus Additionally, it also used to prevent blood vessel contriction, and stimulate the immune system. The leaf flom Daun Dewa empirically used to dengue fever treatment. In this study, 25 white rats Wistar strain were used which is divided into 5 groups J I) control group, 2) study group, which is divedid into 3 doses (100 mg, 200 mg, 400 mg/200g body weight) and 3) the normal control group (without induced). Hydroxy urea dose 27 mg/200 g body weight 2 times a day for induced. The treatment given 8 days dividing and every 2 days once done taking 0,5 ml of blood via the tail vein. Result showed ethanol leaf extract of Daun dewa dose 100 mg, 200 mg, and 400 mg/ 200 g body weight increase thrombocyte. Incease thrombocyte going on forth day afier the test dose, and the sixth day amount thrombocyte have reached normal.
Pengembangan dan Potensi Pala (Myristica fragransi) Alegantina, Sukmayati; Mutiatikum, D.
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2843

Abstract

History has shown that Indonesia is the greatest producer of nutmeg since XV century. In fact, about 60 % of the world supply of nutmeg is produce in Indonesia, where nutmegs are commonly used as both spices and food. Beside, a few use it as an oil and balsam. In other counties, nutmeg is used as material for trimiristin production, which is a main substance of myristic acid and alcohol in cosmetic industry. Data have shown that Indonesian ’s export of nutmeg to USA is rally high, especially for the nutmeg ‘s production. The price of trimiristin is relatively high when synthesized from myristic acid and alcohol. Therefore, the development of new techniques for the isolaton of timiristin from nutmeg may decrease the production costs. Furthermore, trimiristin production can be hugely increased, due to the large quantity of nutmeg produced in Indonesia.
Pengaruh Meniran (Phyllanthus niruri L) Terhadap Patogenesis lnfeksi Salmonella Sunarno, Sunarno
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 2, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i2.2844

Abstract

Typhoid/paratyphoid disease is a major problem in Indonesia. Management of therapy including the use of immunomodulator must be developed continuously. In this case Phyllanthus niruri L is immunomodulator that has been usefitl to increase the animal and human immunity. The purpose of this stun) was to know the influence of Phyllanthus niruri L on the Salmonella infection focusing on spleen bacterial colonies. The experiment was designed with post test-only control group to 18 Bab/C Mice infected by Salmonella typhimurium divided into one control group and two experimental groups which hmie given Phyllanthus niruri L of 3x 0.125 mg/day (P1) and 3x 0.25 mg/day (P2) orally. Statistical analysis was used Oneway ANOVA test. The research result showed that treatmen P1 had significant influence to decrease spleen bacterial colonies compared to control group.
Kandungan Fenolik dan Flavonoid Total Daun Macaranga hispida (Blume) Mull. Arg sebagai Kandidat Obat Antidiabetes Megawati, Megawati; Fajriah, Sofa; Supriadi, Edi; Widiyarti, Galuh
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.2846

Abstract

Diabetes Mellitus (DM) is one of the non communicable diseases (NCDs) with the largest number of deaths in the world. The Macaranga hispida (Blume) Mull. Arg is a source of phenolic compounds. Phenolic is grouped as polyphenols group that widely functioned as antidiabetic. The α-glucosidase enzyme plays a role in the forming of glycoproteins and glycolipids. The α-glucosidase enzyme can be used for antidiabetic activity assay because of its capability on breaking down carbohydrate into glucose in the human small intestine. This study aimed to determine phenolic content, total flavonoid content, and antidiabetic activity of M. hispida leaves extract and its fraction. The extract and fraction were tested for the phenolic levels using Folin-Ciocalteau method, the total flavonoid using alumunium chloride method, and the antidiabetic activity using α-glukosidase method. The yield of methanolic extract of the Macaranga hispida was 10.23%. Phenolic content of the ethyl acetate fraction from the methanolic extract was 8.411 mg, equivalent to gallic acid/100 mg extract. Total flavonoid content was 6.14 ± 0.31b/b μg/mL. Antidiabetic activity assay of the extract and the fractions of Macaranga hispida resulted the highest antidiabetic activity (IC50) was in the ethyl acetate fraction with IC50 value 21.91 μg / mL.
Efek Mutagenik Ekstrak Etanol Daun Kembang Sungsang (Gloriosa superba L.) Sundari, Dian; Pudjiastuti, Pudjiastuti
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 3, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i3.2848

Abstract

Eflicacy of a plant can be caused by chemical compounds contain, on the other hand can cause toxic eflects. Toxic ejfects of chemicals can be defined as the potential of chemicals to poison the bodies of people who are exposed kembang sungsang (Gloriosa superba Linn.) including Colchicaceae families. Plants used empirically for treatment of Gout, diuretic, rheumatism, etc. Mutagenicity is a test to determine the possibility of compounds are mutagens. To see if these plants have the effect of mutagens, mutagenicity tests performed 70% ethanol extract of the leaves Kembang sungsang. Mutagenicity studies conducted by the Ames method using five test bacterial strains that have been transferred are.‘ Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 and Escherichia colt WP2uvrA with and without metabolic activator S-9. The dose tested was 125, Z50, 500, 1000, and 2000 ul /plate. As a negative control was DMSO solution of 100 ul /plate. The results showed that the mutagenic test 70% ethanol extract of leaves Kembang sztngsang. with the addition aktivator without the addition of S-9 did not have the eflect of mutagens.
Gambaran Kualitas Air Minum Di Jabodetabek Tahun 2007-2009 Alegantina, Sukmayati; Isnawati, Ani; Raini, Mariana
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 3, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i3.2849

Abstract

The greater the public awareness of health can be ascertained from the number of people who determined the water used for drinking water. Water determination is one of the programs in Pharmacy and Chemistry Laboratory in Center for Biomedic and Pharmacy. Ministry of Health. Water sample is determined chemically and physically based on the parameter requirements by the Regulation of Ministry of Health (Permenkes) No 907/Menkes/SK/V11/2002. The design of the study is cross-sectional, the samples are waters from Jakarta, Depok, Tangerang, Bekasi (Jabodetabek), and outside Jabodetabek. The water samples are obtained from people who requested to determine their drinking water during period 2007- 2008. The amount of the water samples are 1668. Water determination is done both physically and chemically. Physical water determinations are including odor, TDS (total of dissolved solids), flavour, temperature, turbidity, and colour. Chemical water determinations are Nitrit, Fer-rum, hardness, Chloride, Manganese, pH, Sulfate, Sulfide, and organic substances. Based on the results, the result shows that 27,5% of water determinations are not recommended to drink because it contained high concentration of Manganese /7,6 91), Ferrum (7,2 %), turbidity (2,4%) and colour (2,5 %). The ratio of the samples which is not recomended to drink towards total sample in one area of Tangerang is 52.0%. Based on sampling water depth >100 m, the ratio of the samples which is not recomended to drink towards the total sample that collectedfrom the depth >100 m sample is 64.2%.

Page 6 of 27 | Total Record : 269

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