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Nanang Yunarto
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Optimasi Formula Pasta Gigi Kombinasi Ekstrak Rimpang Temu Kunci dan Sereh dengan CMC-Na dan Carbomer sebagai Bahan Pengikat Menggunakan Metode Simplex Lattice Design Hati, Anita Kumala; Dyahariesti, Niken; Yuswantina, Richa
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.2317

Abstract

Comercial toothpaste contain fluoride to prevent dental caries. The usage of fluoride in large quantities may cause irreversible enamel fluorosis, brittle bones, brittle teeth, premature aging, spontaneous abortion, and carcinogenic. Objective this experiment is knowing the extract concentration of finger roots and lemongrass which is equivalent to positive control and then performed optimization of toothpaste preparation formula with different concentrations of CMC-Na and carbomer with pH and viscosity parameters using the Simple Lattice Design method. The antibacterial test of lemongrass extract, finger roots and its combination with a concentration of 5% against Streptococcus mutans bacteria, showed the average diameter of the largest clear zone: finger roots extract was 11.167±0.288mm; combination of lemongrass extract:finger roots extract (1:2) was 10.83±0.288mm; combination of lemongrass extract: finger roots (2:1) was 10,067±1,006mm; lemongrass extract was 9.33±0.751mm; The combination of lemongrass extract:finger roots extract (1:1) was 9,133±0,321mm.. Post Hoc test results shows comparable to positive controls were 5% finger roots extracts, combination of lemongrass:finger roots 1:2 combination, and 2:1 combination. The optimum formula was obtained using the SLD method with a combination of 0.900% CMC-Na and 1,100% carbomer as a binding agent. The optimum pH formula of toothpaste was 7,613±0,076 and Viscosity 2,43,104cps±2571,640. The paired t-test pH obtained p-value 0.222 and the viscosity obtained p-value 0.934. The experimental results were not significantly different from the results predicted by the software simply latex design. The 5% finger roots extract can be developed into an herbal toothpaste with binding agent CMC-Na and a carbomer ratio of 0,9:1,1.
Karakteristik Minuman Probiotik Sari Ubi Kayu dari Kultur Bakteri Lactobacillus acidophilus dan Streptococcus thermophilus Yulia, Nunung; Wibowo, Adi; Kosasih, Eva Dania
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2488

Abstract

Functional foods are food that consumed, as usual, has a physiological effect and can reduce the effect of chronic disease. One of them is probiotic beverages. Probiotic beverages that have been widely known overtime was produced by a dairy house. This product could have been expensive due to the cost of raw materials. The alternative raw material such as the use of extracted cassava juice may reduce the price of the final product. The aims of this research were to study the effects of culture comparison between characteristics of the probiotic beverage from cassava juice, and get the best culture comparison that produces the best probiotic characteristics of the lactic beverage fermentation from cassava juice. This research applied qualitative experiment method in Lactobacillus acidophilus and Streptococcus thermophiles as an inoculum evaluated. Serial in culture ratio respectively 20:50; 30:50; 40:50; and 50:50. The observed research were pH value, viscosity, total lactic acid bacteria (LAB) and activities test against bacteria Escherichia coli. The result showed that the best culture comparison qualified as probiotics criteria was 50:50. It was having pH value 4,1; viscosity 0,706 g/mL; total LAB 2,1x106 cfu/mL and activity bacteria Escherichia coli was 5,3 mm.
Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin Lestari, Febia Arien; Hajrin, Wahida; Hanifa, Nisa Isneni
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2496

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.
Efek Iritasi Sabun Mandi Batang Mengandung Susu Produk Usaha Kecil Menengah di Kota Cimahi Vikasari, Suci Nar; Hermanto, Faizal; Simatupang, Elivas; Sutjiatmo, Afifah Bambang; Sutarna, Titta Hartyana; Puspadewi, Ririn; Rachmawan, Lucky; Haq, Fahmy Ahsanul
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2592

Abstract

One of the ways to increase profit in small and medium business (UKM) in Cimahi is by diversifying its products, through manufacturing of bar soap derived from cow's milk from UKM. The requirement of bath soap is proper acidity (pH) level, otherwise it will make the skin dry, itchy or even increase irritation. Therefore, this in vivo non-clinical irritation evaluation is conducted to evaluate the effects of bar soap produced by UKM in Cimahi according to the guidelines in rat test animals. The animals is divided into five groups and exposed to soap for four hours. Five soap samples is obtained from UKM in Cipageran area, Cimahi. Observations is made at the hours of 1, 4, 24, 48, and 72 hours after exposure and is continued for 14 days. The measured parameters is erythema and edema, and the primary irritation index. The results showed that bar soap containing cow milk produced by UKM in Cimahi did not cause erythema and edema. Primary irritation index of all bath soap samples was 0.0 . It can be concluded that soap bars containing cow's milk produced by Cimahi City UKM including into the category of very mild irritation (negligigle).
Preparation of Curcumin-Liposomes using pH-Driven Method to Enhance Stability and Encapsulation Efficiency Sekaringtyas, Fransiska Christydira; Purwajanti, Suwasmi; Mardliyati, Etik; Ningsih, Sri
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2728

Abstract

Curcumin, a hydrophobic polyphenol, derived from turmeric, has numerous pharmacological activities, including hepatoprotective, antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic. However, the therapeutic efficacy of curcumin is limited due to its poor oral bioavailability and high susceptibility to degradation. The poor oral bioavailability of curcumin has been attributed to its poor aqueous solubility and extensive first past metabolism. Curcumin dissolves in alkaline conditions but it is highly unstable undergoing rapid hydrolytic degradation in neutral or alkaline condition. To solve these problems, liposome-based encapsulation technology is applied to improve the bioavailability of curcumin. The existing method to prepare curcumin-liposome, thin-film method, is complex and usually required the use of organic solvents. In this study, pH-driven method, an organic solvent-free and easily encapsulation technique utilizing the pH-dependent solubility of curcumin was proposed to improve the stability and bioavailability. Curcumin-liposomes were prepared using phospholipon 90 H and soya lecithin as phospholipid sources. The characterizations of curcumin-liposomes include particle size, microstructure, encapsulation efficiency, infrared spectra, salt stability and storage stability. The particle size measured was 77.85 ± 0.39 nm. It was found that curcumin-liposomes prepared by the pH-driven method was stable during storage for 30 days and gave encapsulation efficiency of 60.71 ± 0.20%, higher as compared to the ones prepared by thin-film method. In conclusion, pH-driven is a promising method for the preparation of curcumin-liposomes to enhance stability and encapsulation efficiency
Front Matter Volume 10 No 1 Tahun 2020 Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Back Matter Volume 10 No 1 Tahun 2020 Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Analisis Kuantitatif Artemisinin dari Ekstrak Metanol Tanaman Artemisia Annua L. Menggunakan Densitometer Isnawati, Ani; Gitawati, Retno
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2833

Abstract

Artemisinin is the best antimalaria for chloroquine resistant P. falciparum recommended by WHO in a combination therapy. Artemisinin is isolated from Artemisia annua L (family: Asteraceae) that can grow as it should be in Indonesia and has cult1'vated by BPTO Tawangmangu in order to self-provide for raw material antimalarial. One of the important analysis is method for measuring artemisinin concentration in extract. The method should be more rapid, accurate, and suitable with the instruments available. Measuring analysis are used to determine cultivated result and to analyze cost benefit raw material malaria medicine. The method will also be validated for accuracy, precision, selectivity, sensitivity and linearity. It is found that maximum wave length of artemisinin is 366 nm with TLC-densitometiy validated method, shown a good linearity, a coeficient of corelation of 0.99976, a detection limit of 0.028 mg/mL, and a quantitative limit of 0.094 mg/mL. Artemisinin concentration obtained from methanol extract is 0. 221% with a recovery concentration of 1 01,08%.
Kajian Toksikologi dan Penanggulangan Senjata Kimia Raini, Mariana
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2834

Abstract

A chemical weapon is defined as a substance that is intended for use in military and non- military operations to kill, seriously injure or otherwise incapacitate people, or to harm or destroy their habitat or economy. Chemical weapons can be made by toxic chemicals reaction. Chemical weapons misused may lead to terror, injury, death and environmental damage The Chemical Weapons Convention (CWC) is an arms control agreement which outlaws the production, stockpiling and use of chemical weapons. C WC is the Convention on the Prohibition of the Development, Production, Stoclqoiling and Use of Chemical Weapons and on their Destruction. This article describe how to idenlijji chemical weapons, sign and symptom of their toxicity, impact and the chemical weapons convention, in order to handle and control chemical weapons release.
Karakterisasi dan Toksisitas Akut pada Minyak Buah Merah Widowati, Lucie; Pudjiastuti, Pudjiastuti; Mudahar, Harfia
Jurnal Kefarmasian Indonesia VOLUME 1, NOMOR 1, 2009
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v1i1.2835

Abstract

Buah Merah (Pandanus conoideus Lam), is an endemic plant from Papua and its surrounding. Oil of buah merah known and claimed for cancer, HIV/AIDS, lung tuberculosis, diabetic and decreased blood cholesterol treatment. Since buah merah oil widlly is used in communities, safety test is needed. There were no toxic effects as abnormal behavior or mortality in rats, even using in high dose of 5 ml/200g body weight or approximately 9.4 times of human dose (1 x HD = 30 ml). Due to this situation, the acute toxicity has been done by Biomedical and Pharmaceutical Research and Development Center, at 2006. The result showed that qualitative test based on chemical group compounds, triterpenoid, phenol and steroid have been found clearly. Basically the oil is not toxic for single dose. Since there ‘s no mortality, the LD;0 will be considered as pseudo LD50, that means that doses of 5 ml/200g body weight of Wistar rat is safe for utilization, or the safety dose for human will bein a very large range.

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