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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Back Matter Volume 9 No 1 Tahun 2019 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 1, FEBRUARI 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Autentikasi Centella asiatica (L.) Urb. (Pegagan) dan Adulterannya Berdasarkan Karakter Makroskopis, Mikroskopis, dan Profil Kimia Maruzy, Anshary; Budiarti, Mery; Subositi, Dyah
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.1830

Abstract

Pegagan or Centella asiatica (L.) Urb. empirically used as medicinal plant and scientifically can be used as antihypertension based on the results of the Jamu Saintification. Raw materials from C. asiatica have the potential to occur adulteration or incorrect use of plants species. There are two species of plants that have the potential to become adulterants of C. asiatica, namely Hydrocotyle verticillata and Merremia emarginata. Thus, the purpose of this study is to authenticate from Pegagan by comparing the macroscopic, microscopic, and chemical profiles of C. asiatica, H. verticillata, and M. emarginata. The method of data collection is done by purposive sampling using form intruments to record macroscopic and microscopic characters, while the chemical profiles are tested using thin layer chromatography methods to determine the content of asiaticosides in both potential adulterants species. The research was conducted at three sampling points: Central Java (Tawangmangu), West Java (Bogor), and East Java (Malang), while for laboratory research activities carried out at B2P2TOOT, Tawangmangu. The results showed macroscopically unique and easy distinguishing characters between C. asiatica and potential adulterant species H. verticillata is a leaf shape, whereas C. asiatica with M. emarginata are leaf-type appearance characters. The character of the simplicia leaf shape between C. asiatica and H. verticillata can be a distinct differentiator characters. Anatomical characters and powder fragments that can be used as a differentiator characters between C. asiatica and H. verticillata are the presence of pith on the stalk and stolon, the type of stomata, and the presence of trichomes. Authentication of simplicia powder of H. verticillata as an adulterant potential of C. asiatica with TLC, can be easily known by the absence of asiaticosides in these simplicia so that H. verticillata cannot be a substitute species for C. asiatica
Kontribusi Kelengkapan Pengisian Formulir Rekonsiliasi Obat terhadap Penggunaan Obat Rasional pada Pasien Rawat Inap di RSU X Bekasi Hasanah, Kurniatul; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.1839

Abstract

Drug reconciliation is needed to get rational treatment therapy. The purpose of this study was to analyze the relationship between the completeness of filling out the form of drug reconciliation and rational drug use at Bekasi X Hospital. The study design used a cross-sectional comparative study to compare between 56 completed drug reconciliation forms and 133 incomplete drug reconciliation forms. Sampling is done in total sampling. The research sample that fulfilled the inclusion criteria was 189 forms (40.6%) of all (466) drug reconciliation forms in November 2015-end April 2016 at X Hospital Bekasi. Data was analyzed using Chi-square test. The results showed that the largest percentage of filling out drug reconciliation forms was incomplete (70.4%), carried out by the pharmacist (56.1%) and not signed by a doctor (63.5%). Percentage of rational drug use by 7.9%, with details: correct diagnosis 53.4%, correct indication 53.4%, correct selection of medicine 33.9%, correct dosage 8.5%, exactly how to administer 37.6%, on time giving 13.8% and correct time giving 14.8%. There is no significant relationship between the completeness of filling out the drug reconciliation form, the types of health workers, the presence/absence of a doctor's signature and rational drug use in inpatients (p> 0.05).Tthere is no significant relationship between the completeness of filling out the reconciliation form and rational drug use in inpatients at Bekasi X Hospital (p> 0.05)
Aktivitas Antioksidan serta Penghambatan HMG CoA dan Lipase dari Kombinasi Ekstrak Daun Binahong-Rimpang Temu Lawak Yunarto, Nanang; Aini, Nurul; Oktoberia, Intan Sari; Sulistyowati, Indah; Kurniatri, Arifayu Addiena
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1930

Abstract

TThe prevalence of dyslipidemia in Indonesia continues to increase. Anredera cordifolia and Curcuma xanthorrhiza are empirically used in the community to overcome dyslipidemia disorders. Flavonoids as the main compounds in A. cordifolia and curcumin in C. xanthorrhiza have potential as antioxidant activity. This study aims to determine the in vitro mechanism of A. cordifolia and C. xanthorrhiza to reduce cholesterol associated with antioxidant activity. The testing was carried out on a combination of ethanol extracts of A. cordifolia leaves with C. xanthorrhiza rhizomes (1:1) and their single extract. The antioxidant activity test was conducted using DPPH method by making serial dilution of samples and ascorbic acid with adding DPPH. The inhibitory activity of HMG CoA and lipase enzymes was carried out enzymatically using ELISA as well as simvastatin as the comparison. The results showed that the highest antioxidant activity is in C. xanthorrhiza extract samples IC50 16.21 ± 1.74 µg/mL, but was less potential compared to ascorbic acid IC50 7,63±0,85 µg/mL. The most potential inhibition of HMG CoA and lipase is in C. xanthorrhiza samples IC50 8.35 ± 0.02 and 22.35 ± 1.26 µg/mL. The combination of A. cordifolia and C. xanthorrhiza (1: 1) is better than A. cordifolia extract but lower than C. xanthorrhiza extract in antioxidant activity as well as the inhibition of HMG CoA reductase and lipase. The result showed a correlation that the higher antioxidant activity, the higher inhibitory of HMG CoA reductase and lipase respectively.
Perdagangan Bebas Produk Farmasi dan Alat Kesehatan serta Kesiapan Memenuhi Persyaratan Cetak Biru Masyarakat Ekonomi ASEAN Prayitno, Lukman; Herman, Max Joseph
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.1966

Abstract

The implementation of the ASEAN Economic Community (AEC) as an Indonesian Government’s strategic step has an impact on economic globalization. The study on pharmaceutical products and medical devices free trade was done using qualitative and quantitative methods. The data were collected from a round table discussion about "Free Trade in Health Goods and Services in ASEAN" which involved the Ministry of Health (MoH), Ministry of Trade (MoT), and National Agency for Drug and Food Control (NADFC). The discussion aimed to obtain information on the readiness to meet the AEC blueprint. Secondary data on export and import of pharmaceutical products and medical devices were obtained from the MoT. The results of the study show that between 2013 and 2017 there were 70-72 product items exported to 9 ASEAN countries with a value much greater than the import. The tariff measure (TM) requirements included the Most Favored Nation (MFN) assessment and regulation of the trade remedy procedure by MoH and MoT. The implementation of ASEAN Common Technical Dossier (ACTD) and Good Manufacturing Practice inspection agreements, Bioequivalence reporting agreements, agreements related to traditional medicines and health supplement have been done by NADFC and industry. The simplification of Certificate of Origin, operation certification procedures and realization of ASEAN self-certification have to be specified. MoH must coordinate with NADFC and MoT in deciding and implementing regulations
Potensi Ekstrak Etanol 96% Daun Salam (Syzigium polyanthum Wight. (Walp.)) terhadap Ekspresi p53 pada Sel Kanker HeLa Cell Lines Hidayati, Wahyu; Sjahid, Landyyun Rahmawan; Ismalasari, Wahyu; Kusmardi, Kusmardi
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.1996

Abstract

Bay leaves (Syzigium polyanthum Wight. (Walp.) have been utilized as one of traditional medicines in Indonesian. However, the potency of the leaves for cancer treatment has not been well-explored. The aim of this study is to determine the expression of p53 tumor suppressor gene after administration of 96% ethanol extract of Bay leaves on HeLa cell lines. This study is begin by making extract using ethanol 96% as a solvent followed by phytochemical screening and extract evaluation of HeLa cells by immunohistochemistry. The observation of p53 protein expression is conducted using the Image J Profiler Plugin software 1.52a version. The H-score data is processed using the One-Way ANNOVA IBM SPSS 20 version program and continued with Post Hoc analysis using the Duncan test. The identification of 96% ethanol extract result showed that bay leaves contain flavonoids, alkaloids, saponins, phenols, terpenoids, and steroids. Based on the Post Hoc test results, the administration of 96% ethanol extract bay leaves with three dose variations (156 µg/ml, 234 µg/ml, 312 µg/ml) and negative control had significant differences, while the high dose (312 µg/ml) had not significant differences to positive control. The result showed that 96% ethanol extract of bay leaves by the dose of 312 ug/ml can inhibit the expression of mutant p53 protein in cervical cancer cells HeLa cell lines.
Efektivitas Formula Krim Tabir Surya Berbahan Aktif Ekstrak Etanol Biji Wali (Brucea javanica L. Merr) Amini, Almira; Hamdin, Candra Dwipayana; Muliasari, Handa; Subaidah, Windah Anugrah
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.2066

Abstract

High intensity of ultraviolet (UV) radiation causes several adverse effect such as erythema, sunburn, pigmentation, early senescence, and skin cancer. These effects can be prevented by using sun protection product. Wali (Brucea javanica L. Merr) is one of natural plants that contain phenol and flavonoid. These compounds are proven to have sunscreen effect. The purposes of this studies are to formulate and evaluate the effectivity of oil-in-water-type sunscreen cream using 1% ethanol extract of Wali seed. The sunscreen cream is developed by using a fusion method and the evaluation of the effectivity is conducted in vivo on the skin of mice (Mus musculus). The formulated sunscreen cream is then tested for its physical properties, including homogenity, pH, spreadability, adhesion, and stability. The effectivity of the formulated cream is also tested by observing the formation of erytema on the skin of mice (Mus musculus). Erythema appearing on the mouse skin is analyzed with ImageJ and SPSS v23 using the one way anova method. The results showed that the ethanol extract of Wali seeds could be formulated into sunscreen cream. Furthermore, the formulated cream was also able to protect the mice skin against the formation of erythema significantly compared to negative controls (p
Ekstrak Etanol Kopi Hijau Arabika (Coffea arabica L.) sebagai Antihiperglikemi pada Mencit (Mus musculus) Hamdani, Irawati; Nurman, Salfauqi
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2122

Abstract

Diabetes mellitus is an excessive level of blood sugar concentration disease. One of the compounds that can moderate the blood sugar level is chlorogenic acid that mostly found in green coffee. This study aims to determine the extract activity of Arabica (Coffea arabica L.) green coffee in decreasing the blood sugar level of mice (Mus musculus) that induced by alloxan monohydrate. The method is True Experimental Laboratories with the analysis of chlorogenic acid levels using a UV-Vis spectrophotometer. The research design is Post Test Control Group Design, using 24 mices that divided into six treatment groups. The groups consist of negative control (distilled water), Dose I (100 mg/kg bw), Dose II (200 mg/kg bw), Dose III (300 mg/kg bw), Dose IV (400 mg/kg bw), and positive control (metformin). Blood sugar levels of the mice is measured at the intervals of 1st day, 7th day, 21st day. The data is analyzed using the SPSS program with normality tests (Kolmogorov-Smirnov), homogeneity tests (Levene Test), and parametric statistical tests (One-Way ANOVA). The data results was normally distributed and homogeneous (P> 0.05) with several pairs of data in the treatment group were significantly different (P> 0.05). The extract of Arabica (Coffea arabica L.) green coffee contained 4.235% chlorogenic acid, could reduced the hyperglycemia mice blood sugar levels by the dose of 10.72% (Dose I); 19.85% (Dose II); 27.20% (Dose III); and 31.60% (Dose IV) with dose IV as the effective dose.
Efektivitas Ekstrak Etanol Daun Durian (Durio zibethinus (Linn.)) sebagai Antihiperurisemia Sonia, Rela; Yusnelti, Yusnelti; Fitrianingsih, Fitrianingsih
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2148

Abstract

Durian (Durio zibethinus Linn.) leaves are known to inhibit the xanthine oxidase enzyme which can reduce uric acid levels in the blood. The purpose of study is to determine the effectiveness of ethanol extracts of durian leaves in reducing uric acid levels in hyperuricemic mice. The mice were induced with chicken’s liver juice 0,2 mL/20 gBW and potassium oxonate 250 mg/kgBW. The animals were mice with uric acid levels above 3,3 mg/dL or 6,2-7,1 mg/dL. The study was used a completely randomized design (CRD) with six treatments and three replications, with three mice in each replications. The treatments group were K+: Allopurinol 10 mg/kgBW; K-: CMC-Na 0.5%; extracts in group P1,P2, P3, P4 are 50; 100; 200; 250 mg/kgBW. The measurements of uric acid levels were performed on day-0, day-6 after induction, and day-15 after administering each group. The data obtained were analyzed by One Way Anova test followed by Duncan's Post Hoc further test. The results showed that durian leaves could reduce uric acid levels in mice blood with the highest percentage reduction was in P2 (100 mg/kgBW) group of 40,53%, followed by P1 (50 mg/kgBW) of 38,68%. The lowest percentage was in the P4 group (250 mg/kgBW) of 22,36%, followed by the P3 group (200 mg/kgBW) of 27,71% and the ED50 value was 61,65 mg/kgBW. In conclusion, ethanol extracts of durian leaves has a significant effect on decreasing total uric acid levels in mice and has potential as an antihyperuricemia agent.
Perbandingan Teknik Aerasi dan Ultrasonikasi Gelasi Ionik Nanopartikel Deksametason Natrium Fosfat Nugroho, Bambang Hernawan; Wardhani, Multi Tri; Suparmi, Suparmi
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2150

Abstract

Alginate, a biocompatible and biodegradable natural polymer, has been widely used as a drug molecular carrier using ionic gelation methods (crosslinking). One of the factors that must be taken into account in its preparation is the mechanical effect. The purpose of this study was to explain the preparation process and the characteristics of the calcium alginate crosslinkers as dexamethasone sodium phosphate carriers with low energy and high energy techniques. Nanosuspension is made in six formulas using 3 techniques: low energy (aeration), high energy (ultrasonication), low and high energy (aeration and ultrasonication) with a fixed concentration of dexamethasone sodium phosphate and sodium alginate, that is 0,2% and 0,1%, with 0,02% and 0,2% of calcium chloride. Determination of particle size, zeta potential, and morphology of nanoparticles using Particle Size Analyzer (PSA) and Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM). Determination of encapsulation efficiency using UV/Vis spectrophotometer and statistical analysis using MANOVA test. Synthesis of nanosuspension using a combination of low and high energy (aeration and ultrasonication) results in the most optimal characteristics with particle size value of 352.90 ± 6.10 nm, homogenized polydispersity index (0,52 ± 0,04), optimal potential zeta -44,40 ± 0,4 mV, the encapsulation efficiency of 49,5 - 74,8% and spherical particle shape. It can be concluded that the preparation using a combination of low and high energy is the most optimal preparation result.

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