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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 750 Documents
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Peningkatan Laju Disolusi Ketoprofen yang Diformulasikan dengan Metode Self Emulsifying Drug Delivery System (SEDDS) Nurul Muhlisah Maddeppungeng; Latifah Rahman
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

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Abstract

After oral administration of the drug, drug dissolution is a requirement for absorption of a drug into the systemic circulation. Based on the classification Biopharmaceutical Classification System (BCS), ketoprofen is included in class II, which has low solubility with good permeability characteristics (effective permeability in humans for ketoprofen 8.70x10-4 cm / s). Self-Emulsifying Drug Delivery System (SEDDS) can improve the bioavailability of drugs that have low solubility with high permeability. Therefore, to increase the dissolution rate, a ketoprofen formulation was carried out using the SEDDS method. Ketoprofen solubility tests were carried out on several types of oil and surfactants, namely corn oil, sunflower oil, soybean oil, oleic acid, tween 80 and span 80 using the method saturation solubility. Three formulas were made containing the active ingredient ketoprofen 50 mg, Tween 80: span 80 (3: 1) as a surfactant with a concentration of 30% (F1), 45% (F2), 60% (F3) and oil as a carrier. The dissolution test results showed that the ketoprofen formulated by the SEDDS method could increase the dissolution rate of ketoprofen, the dissolution percentage of each formula after 1 hour was 62.91% (F1), 78.09% (F2), 100.6% (F3), and 49.95% comparison. Statistical analysis using a completely randomized design showed a significant difference between dissolution rates (F1), (F2) and (F3) with comparators. The ketoprofen formula with surfactant concentration of 60% (F3) showed the highest dissolution rate compared to (F1) and (F2) as well as with comparators.
Identifikasi Senyawa Marker Dominan Ekstrak Daun Sirih Hitam dan Kuantifikasi Berdasarkan Perbedaan Lokasi Tanam: Identification of Dominant Marker Compounds of Black Betel Leaf Extract and Quantification Based on Differences in Planting Locations Fajar Prasetya; M Arifuddin; Arsyik Ibrahim
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.386

Abstract

It has been revealed that the benefits of black betel leaf extract have created an opportunity for the black betel plant to be commercialized. The several benefits of black betel leaf extract are antimicrobial, anti-inflammatory, cytotoxic, and antioxidant. The extraction method uses maceration techniques. Identification of active markers as antimicrobials (Streptococcus mutans, Streptococcus sanguinis, Candida albicans) begins with Bioautography Thin Layer Chromatography (TLC), for isolation from macerated extracts followed by Vacuum Liquid Chromatography Fractionation (KCV), conventional Column Subfraction (KK), Layer Chromatography Thin Preparative (TLC). Quantification of marker compounds using a Thin Layer Chromatography (TLC) Scanner. Samples of black betel leaf (P. betle L. var Nigra) were collected from Samarinda (East Kalimantan), Wonosobo (Central Java), Godean (Yogyakarta), Banyuwangi (East Java) in June 2020. The results of the TLC test for bioautography of 70% ethanol extract and the ethanol fraction of 96% black betel leaf showed that the active spot of ethanol extract 70% for antibacterial activity on Streptococcus mutans Atcc 25175 and Streptococcus sanguinis Atcc 10556 was Rf 0.729 cm, the active spot of the ethanol fraction 96% for the activity of the fungus Candida albicans ATTC 10231; Rf 0.486 cm. Purification using TLC multi eluent with eluent I Hexane: Ethyl Acetate (7: 3) as non polar eluent and eluent II Chloroform: Ethyl Acetate (4: 1) as polar eluent on different TLC plates. The results obtained in the form of a single stain with Rf = 0.4 in eluent I and Rf = 0.73 in eluent II. The results of measuring the levels of the dominant marker compound using a TLC scanner showed that the highest marker compound area was from betel leaf grown in the Godean area (Yogyakarta) with the number 29869.4.
Pengaruh Perbandingan Konsentrasi Polimer terhadap Karakteristik dan Laju Pelepasan Patch Transdermal Nifedipin: The Effect of Comparison Polymer Concentrations on the Characteristics and Release Rate of the Transdermal Nifedipin Patch Nur Azizah Syahrana; Surya Ningsi; Haeria Haeria; Isriany Ismail
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

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Abstract

Nifedipine is a dihydropyridine anti-hypertensive drug as a calcium channel blocker with low oral biovaibility and a short half-life resulting in frequent repeated daily use of the drug when given orally in conventional dosage forms. The matrix system transdermal patch is an option that allows controlled delivery of the drug through the skin and provides patient comfort. The purpose of this study was to determine the effect of polymer deposition on the material and the in-vitro release rate of nifedipine transdermal patches with the polymer ratio of Ethyl Cellulose (EC) and Hydroxy Propyl Methyl Cellulose (HPMC) used, namely F1 (7:3), F2 (8:2) and F3 (9:1). The results of the nifedipine patch test on organoleptic examination are round, characteristic odor, yellow color and smooth surface texture. In vitro release showed that the best polymer was found in Formula 2 EC: HPMC (8:2) with good characteristics and the highest flux value was 1.307 (µg.cm-2 min-1).
Efektivitas Ekstrak Daun Bidara (Zizipus Mauritiana L.) pada Kulit Akibat luka Bakar dalam Berbagai Varian Konsentrasi Ekstrak Terhadap Hewan Uji Kelinci (Oryctolagus cuniculus L.): Effectiveness of Bidara Leaf Extract (Zizipus Mauritiana L.) on Skin Due to Burns in Various Variants of Extract Concentration Against Rabbit (Oryctolagus cuniculus L.) Test Animals Samsidar Usman; Firawati Firawati; Zulkifli Zulkifli
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.392

Abstract

Tumbuhan Bidara merupakan salah satu obat tradisional yang banyak digunakan secara empiris di masyarakat. Olehnya itu perlu dilakukan penelitian fitokimia dalam mendapatkan informasi ilmiah tentang kandungan senyawa aktif dalam tumbuhan tersebut. Tujuan penelitian ini adalah untuk mengidentifikasi senyawa aktif dan menganalisis efektivitas ekstrak daun Bidara (Zizipus Mauritiana L.) dalam meregenerasi sel kulit akibat luka bakar dalam berbagai variasi konsentrasi. Skrining fitokimia merupakan proses identifikasi senyawa kimia yang terdapat pada tumbuhan, meliputi senyawa alkaloid, flavanoid, tannin dan saponin. Berdasarkan hasil skrining diketahui bahwa ekstrak daun Bidara positif mengandung senyawa metabolit sekunder yaitu alkaloid, flavanoid, tannin dan saponin. Uji efektivitas ekstrak daun Bidara merupakan suatu penelitian eksperimental yang dilakukan dengan menggunakan hewan uji kelinci dengan indikator luka bakar yang terdiri dari diameter luka dan persentase penyembuhan luka bakar. Hasil yang diperoleh pada masing-masing kelompok perlakuan dianalisis dengan menggunakan tekhnik uji beda ANOVA (rancangan Tuckey HSD). Berdasarkan uji ANOVA diperoleh nilai tidak signifikan 0,812 pada hari ke-7 , signifikan 0,025 pada hari ke-14, dan signifikan 0,008. pada hari ke- 21.
Pengaruh Konsumsi Pisang Ambon (Musa paradisiaca) terhadap Penurunan Tekanan Darah Penderita Hipertensi di Puskesmas Bontang Selatan: Effect of Ambon Banana (Musa paradisiaca) Consumption on Decreasing Blood Pressure of Hypertension Patients in Bontang Selatan Health Center Muhammad Rizky Ramadhan; Yuliana Rahmah Retnaningrum; Yudanti Riastiti; Yadi Yadi; Hadi Irawiraman
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.394

Abstract

ABSTRAKHipertensi adalah peningkatan tekanan darah yang disebabkan peningkatan curah jantung dan resistensi perifer pembuluh darah. Hipertensi dapat diobati dengan obat-obatan dan konsumsi buah serta sayur terutama buah yang mengandung kalium seperti pisang ambon. Penelitian ini bertujuan untuk mengetahui pengaruh konsumsi pisang ambon dalam membantu terapi penurunan tekanan darah pada penderita hipertensi di wilayah kerja Puskesmas Bontang Selatan. Metode yang digunakan adalah quasy experimental dengan desain non-equivalent control group. Sampel pada penelitian ini sebanyak 15 penderita hipertensi yang memenuhi kriteria inklusi. Analisis data menggunakan uji Paired T-Test, Wilcoxon Signed Ranks Test, Mann-Whitney dan Kruskal-Wallis. Hasil analisis univariat menunjukkan rata-rata tekanan darah kelompok kontrol sebelum perlakuan 152/92 mmHg dan setelah perlakuan 149,33/92 mmHg dibandingkan rata-rata tekanan darah kelompok perlakuan sebelum perlakuan 152/88,67 mmHg dan setelah perlakuan 137,33/84 mmHg. Hasil analisis bivariat menunjukkan tidak terdapat pengaruh variabel kelompok kontrol pada tekanan darah sistolik ataupun diastolik penderita hipertensi di Puskesmas Bontang Selatan serta terdapat pengaruh variabel kelompok perlakuan pada tekanan darah sistolik ataupun diastolik penderita hipertensi di Puskesmas Bontang Selatan. Kata Kunci: Hipertensi, Pisang ambon ABSTRACTHypertension is an increase in blood pressure caused by increased cardiac bulk and peripheral resistance of blood vessels. Hypertension can be treated with medications and consumption of fruits and vegetables, especially potassium-containing fruits such as ambon bananas. This study aims to find out the influence of banana consumption in helping blood pressure reduction therapy in hypertension patients in the working area of Puskesmas Bontang Selatan. The method used is quasy experimental with non-equivalent control group design. Samples in this study as many as 15 hypertension patients who met the inclusion criteria. Data analysis using Paired T-Test, Wilcoxon Signed Ranks Test, Mann-Whitney and Kruskal-Wallis. Univariate analysis results showed the average blood pressure of the control group before treatment was 152/92 mmHg and after treatment 149.33/92 mmHg compared to the average blood pressure of the treatment group before treatment of 152/88.67 mmHg and after treatment of 137.33/84 mmHg. The results of bivariate analysis showed that there was no influence of variable control group on systolic or diastolic blood pressure of hypertension patients in South Bontang Health Center and there was a variable influence of treatment group on systolic or diastolic blood pressure of hypertension patients at the South Bontang Health Center. Keywords: Hypertension, Ambon banana
Formulasi dan Uji Efektivitas Salep Ekstrak Etanol Daun Dewa (Gynura segetum L) terhadap Penyembuhan Luka Bakar pada Tikus Putih (Rattus norvegicus): Formulation and Testing the Effectiveness of God's Leaves Ethanol Extract (Gynura segetum L) to Healing Burnes in White Rats (Rattus norvegicus) Indah Indah; Nur Azizah Syahrana; Marwati Marwati
Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

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Abstract

Tujuan penelitian ini adalah untuk mengetahui efektivitas salep ekstrak etanol daun dewa (Gynura segetum L) dan pada konsentrasi berapa yang efektif mempercepat proses penyembuhan luka bakar derajat II. Ekstrak dibuat dengan metode meserasi menggunakan etanol 96%. Penelitian ini menggunakan hewan uji tikus putih (Rattus novergicus) yang dibagi menjadi 5 kelompok yaitu salep ekstrak daun dewa 1%, 3%, 5%, kontrol negatif basis salep dan kontrol positif salep Mebo®. Pembuatan luka bakar derajat II menggunakan metode lempeng logam. Hasil analisis statistik uji menggunakan One Way ANOVA dan Tukey menunjukan hasil antar kelompok berbeda secara signifikan. Berdasarkan literatur, luka bakar derajat II dapat dapat sembuh selama 21 hari. Namun, pada salep ekstrak daun dewa 1% dan 3 % luka bakar sembuh pada hari ke 19 dan luka bakar yang paling cepat sembuh adalah pada pemberian salep ekstrak 5% karena pada hari ke 21 luka sudah tertutup.
Pengaruh Tempat Tumbuh dan Profil Kandungan Kimia Minyak Atsiri dari Rimpang Jahe Merah (Zingiber officinalle Linn. Var rubrum): Influence of Growth Sites and the Chemical Content Profile of Essential Oils from Red Ginger Rhizome (Zingiber officinalle Linn. Var rubrum) Marwati Marwati; Burhanuddin Taebe; Alfrida Tandilolo; Syamsu Nur
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.396

Abstract

Zingiber officinalle Linn. Var rubrum is a typical Indonesian plant that contains lots of essential oils. Essential oils are secondary metabolites of the terpenes which are synthesized through the mevalonic acid pathway. Essential oils in the health sector are used as antiseptic, anti-inflammatory, analgesic and sedative. This study aims to isolation and identification the ratio of the redrhizome ginger essential oil compounds based on the growing location, which were taken from Enrekang and Maros districts.The extraction of essential oils was carried out using the water vapor distillation method, and the essential oils obtained were identified using a GC-MS Spectrophotometer. The results showed that the essential oil of red ginger root from Maros had a yield percentage of 3.8% and 2.7% from Enrekang. Identification of essential oil compounds from the two regions using GC-MC is that eucalyptol, linalyl acetate,1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol, dan citral, eugenol, geranyl acetat, dan citonellol.
Hubungan Usia Menarche, Status Gizi, Stres dan Kadar Hemoglobin Terhadap Kejadian Dismenorea Primer pada Mahasiswi Fakultas Kedokteran, Universitas Mulawarman: Relationship between Menarche Age, Nutritional Status, Stress, and Hemoglobin Levels on the Incidence of Primary Dysmenorrhea in Students of Faculty of Medicine, University of Mulawarman Safira Nuraini; Yasmin Sabina Sa'diah; Evi Fitriany
Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i3.398

Abstract

ABSTRACT Primary dysmenorrhea is a condition of cramping pain in the lower abdomen which could affect the back or inner thigh occuring just before or during menstruation without any gynaecological problems. The study was conducted to find out the assosiation between age at menarche, nutritional status, stress, hemoglobin level and primary dysmenorrhea. Analytical observational study with cross sectional design was used. The population were female students of the Medical Faculty of Mulawarman University. A total of 87 samples was took with purposive sampling technique. The data collection was carried out using WaLIDD score questionnaire, DASS 42 questionnaire, direct measurement of body weight, height, and hemoglobin level. The data was analysed with univariate and bivariate analysis by Pearson Chi-Square and Fisher’s Exact Test. The result showed that most of the respondents had moderate primary dysmenorrhea (51,7%), normal age at menarche (47,1%), overweight nutritional status (35,6%), moderate stress (35,6%) and normal hemoglobin level (66,7%). It was concluded that there was a relationship between primary dysmenorrhea with menarche (p=0,016), nutritional status (p=0,042) and stress (p=0,035), but there was no relationship with hemoglobin level (p=0,055). Keywords: Primary dysmenorrhea, menarche, nutritional status, stress, hemoglobin level ABSTRAK Dismenorea primer adalah kondisi nyeri atau kram perut bagian bawah tanpa adanya masalah ginekologi yang dapat menjalar ke punggung atau paha bagian dalam dan terjadi sebelum atau selama menstruasi. Tujuan penelitian ini untuk mengetahui hubungan usia menarche, status gizi, stres dan kadar hemoglobin terhadap kejadian dismenorea primer. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Populasi penelitian adalah seluruh mahasiswi Fakultas Kedokteran Universitas Mulawarman angkatan 2018-2019, didapatkan sampel sebanyak 87 orang menggunakan teknik purposive sampling. Data dikumpulkan dengan cara pengisian kuesioner WaLIDD score, Depression Anxiety Stress Scale (DASS) 42, pengukuran langsung berat badan, tinggi badan dan kadar hemoglobin. Analisis data dilakukan univariat dan bivariat menggunakan uji Pearson Chi-Square dan Fisher’s Exact Test. Hasil penelitian didapatkan responden paling banyak mengalami dismenorea primer sedang (51,7%), usia menarche kategori normal (47,1%), status gizi overweight (35,6%), stres tingkat sedang (35,6%) dan kadar hemoglobin (Hb) normal (66,7%). Ada hubungan antara usia menarche (p=0,016), status gizi (p=0,042) dan stres (p=0,035), tetapi tidak ada hubungan kadar Hb (p=0,055) dengan kejadian dismenorea primer. Kata kunci: Dismenorea primer, usia menarche, status gizi, stres, kadar hemoglobin
Review: Pengaruh Faktor Risiko Terhadap Induksi Persalinan: Review: The Effect of Risk Factors on Induction of Labor Esmaya R. A. Adaniyah; Endang Sawitri; Erwin Ginting
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i6.401

Abstract

Abstract Induction of labor has become one of the most common interventions in modern obstetrics, with an increasing number of pregnant women worldwide that received labor induction interventions to deliver their babies. Labor induction was influenced by several risk factors. This systematic review study aimed to evaluate the influence of risk factors against induction of labor. Searches were performed by searching articles using electronic databases or search engine i.e Pubmed, Clinical Key, Google Scholar, Research Gate, or Science Direct that were limited to studies published between 2015 and 2020 in English and Indonesian Language. 270 studies was found and 48 studies were selected based on the inclusion criteria. The results of this systematic reviews showed that maternal age was not affecting labor induction in 71.1% of the studies evaluated, parity was affecting labor induction in 90% of the studies, body mass index was affecting labor induction in 66.7% of the studies, and Bishop Score was affecting labor induction in 90.3% of the studies. It can be concluded that maternal age was not affecting induction of labor, but labor induction were influenced by parity, body mass index and Bishop score in the majority of the included studies. Abstrak Induksi persalinan telah menjadi salah satu intervensi yang paling umum dalam kebidanan modern, dimana semakin banyak wanita hamil di seluruh dunia yang menerima intervensi induksi persalinan untuk melahirkan bayi mereka. Induksi persalinan dipengaruhi oleh beberapa faktor risiko. Systematic review ini bertujuan untuk mengevaluasi bagaimana pengaruh faktor risiko terhadap induksi persalinan. Systematic review ini dilakukan dengan pencarian studi pada database atau search engine yang dapat diakses seperti Pubmed, Clinical Key, Google Scholar, Research Gate, atau Science Direct, dan dibatasi terbitan tahun 2015-2020 dalam Bahasa Indonesia dan Bahasa Inggris. Hasil pencarian diperoleh sebanyak 270 studi dan tersisa 48 studi yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan usia maternal tidak mempengaruhi induksi persalinan pada 71,1% hasil studi, jumlah paritas mempengaruhi induksi persalinan pada 90 % hasil studi, indeks massa tubuh mempengaruhi induksi persalinan pada 66,7% hasil studi, dan skor Bishop mempengaruhi induksi persalinan pada 90,3% hasil studi. Disimpulkan bahwa usia maternal tidak mempengaruhi induksi persalinan, tetapi jumlah paritas, indeks massa tubuh dan skor Bishop mempengaruhi induksi persalinan pada sebagian besar studi yang diinklusi
Review: Perbandingan Beberapa Ekstrak Kulit Buah sebagai Anti-hiperpigmentasi: Review: Comparison of Fruit Skin Extract as Anti-hyperpigmentation Kianmaswati Nurdzul Allgisna; Siti Hindun; Nopi Rantika
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.403

Abstract

Hiperpigmentasi adalah istilah yang sering digunakan untuk menggambarkan kondisi di mana pigmentasi tidak rata di area kulit. Salah satu perawatan yang paling direkomendasikan untuk hiperpigmentasi adalah menggunakan hidrokuinon. Tetapi alternatif lain seperti bahan-bahan alami juga mendapatkan popularitas sebagai alternatif produk pencerah kulit yang baru meninjau studi klinis dengan menentukan perbandingan ekstrak kulit buah yang memiliki kemampuan terbaik untuk menghambat proses melanogenesis. Metode yang digunakan yaitu dengan pencarian data secara sistematis dengan database PubMed, NCBI dan SCOPUS yang dilakukan pada bulan Oktober 2020 yang menggunakan berbagai nama bahan, "IC50" dan "Anti - hiperpigmentasi". Diharapkan terbentuknya tinjauan literatur untuk mengungkapkan ekstrak mana yang memiliki kemampuan terbaik dalam menghambat proses melanogenesis. Ekstrak kulit jeruk, kulit apel, kulit pepaya, kulit pisang, dan terutama kulit delima yang memiliki aktivitas anti-tirosinase yang kuat dan dapat digunakan sebagai agen pemutih kulit.

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