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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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KEMAMPUAN PENGHAMBATAN RADIKAL BEBAS HAND SANITIZER EKSTRAK METANOL DAUN SEPAT(Mitragynaspeciosa) Rakhmadhan Niah; Novia Ariani
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.314

Abstract

Leaves Sepat (Mitragynaspeciosa) is a plant of Kalimantan. These plants are often used traditionally to reduce blood sugar and antibacterial. The effectiveness is related with strong antioxidant activity in flavonoid compounds. Flavonoid compounds work through the mechanism of capturing free radicals, reducing oxidative stress. The purpose of this study was to measure the percentage of free radical inhibition in the hand sanitizer of methanol extract of leaves Sepat (Mitragynaspeciosa). Sample extraction by maceration method using methanol. Qualitative analysis of chemical compounds with certain eluents using Thin Layer Chromatography (TLC). The antioxidant activity test using the DPPH immersion method (1,1-Diphenyl-2-picryl Hidrazil) measured absorption at a wavelength of 517 nm. The largest percentage of free radical inhibition was obtained in a hand sanitizer concentration of 80 ppm, which is 51.07 ppm.
PERBANDINGAN FISIK FORMULA LIPSTIK DENGAN BASIS LEMAK TENGKAWANG (ILLIPE BUTTER) DAN LEMAK COKLAT (COCOA BUTTER) Husnul Warnida; Yullia Sukawaty; Fazri Wisnu Ardhita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.322

Abstract

Illipe butter and cacao butter have alike physical characteristic. Hence, illipe butter is one of CBS (cacao butter substitute) in food industry. The studi aims to compare the physical properties of illipe butter based lipstick with cacao butter based lipstick. Illipe butter in the study is a vegetable fat from the nut of Shorae mecistopteryx, it has a melting point of 29 ° C. The study was conducted at Pharmaceutical Technology Laboratory of Stikes Samarinda. Lipstick bases consist of illipe butter, cacao butter, carnauba wax, beeswax, lanolin and castor oil. Physical evaluation of lipstick includes homogeneity test, pH test, meting point test, hardness test, patch test, and sensory evaluation. The results showed that all lipstick formulas were homogeneous, stable, and no discoloration during 14 days. The average pH of all lipstick formulas is 5.9. Melting point of illipe buteer based lipstick is 58-59 ° C and 59-60° on cocoa butter based lipstick. Illipe butter brown fat base. Hardness level of illipe butter based lipstick is 433-833 grams, while cocoa butter based lipstick has a hardness level more than 1000 grams. Panelists in sensory evaluation preferred illipe butter based lipstick.
PENGARUH PENAMBAHAN AMILUM GEWANG (Corypha utan Lamarck) SECARA INTRAGRANULAR DAN EKSTRAGRANULAR TERHADAP SIFAT FISIK TABLET PARACETAMOL DENGAN METODE GRANULASI BASAH Maria Hilaria; Devi Ristian Octavia
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.323

Abstract

Gewang (Corypha utan Lamk) is a member of a palm tree that grows wild in most parts of Indonesia. The gewang plant is rich in starch which is thought to be used as an additional ingredient in making Paracetamol tablets with wet granulation methods. This study aims to determine the effect of starch supplementation on the physical properties of Paracetamol tablets. This research is a type of experimental research. Tablets are made in three formulas based on variations in the ratio of starch gewang intragranular and extragranular. Comparison of three formulas intragranular and extragranular, namely: FI (100%: 0%), FII (75%: 25%), FIII (0%: 100%). Tablets are made in wet granulation method with starch binder. Homogeneous dry granules then tested for physical properties of granules include: flow time, stationary angle, and tapping. Furthermore, pressing and tablets obtained were tested for the physical and chemical properties of tablets including weight uniformity and hardness. Statistical analysis of the physical quality of tablets was carried out by the Kolmogorov-Smirnov data normality test, followed by the dendan One Way Anova. The results showed that the use of starch gewang intragranular, extragranular and intragranular and extragranular combinations affected the physical properties of tablets. The method of adding extragranular starch starch to formula 3 produced tablets with effective tablet fragility, which was to meet the physical properties of tablets.
UJI EFEKTIVITAS TABIR SURYA (IN VITRO) EKSTRAK ETANOL DAUN UBI JALAR Ungu (Ipomoea Batatas (L.)) Varietas Antin-3 DARI DUA METODE PENGERINGAN DAUN YANG BERBEDA Damaranie Dipahayu; Djamilah Arifiyana
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.324

Abstract

UV solar radiation intensively caused damage to human skin. Purple sweet potato leaves (Ipomoea batatas (L.)) contain a high anthocyanin component which has a chromophore group with conjugated double bonds, thus absorbing electromagnetic radiation in UV and Visible wavelength, so it can be used as a natural source of sunscreen. The aim of this research was conducted to determine the SPF value of ethanolic extract of purple sweet potato leaves (Ipomoea batatas (L.)) Antin-3 variety from two different drying methods namely freeze-drying for 48 hours (EFD) and oven for 24 hours (EOV). The results of this study indicate that Antin-3 leaf extract (EFD) at a concentration (ppm) 900; 700; 500; 300; 100 respectively are SPF 30; 25; 17; 11 and 4, while (EOV) respectively are SPF 13; 10; 7; 4 and 1. Effectivity sunscreen represented as SPF values, above 15 were categorized as ultra protection; between 8 and 15 as maximal protection; between 6 and 8 as extra protection; between 2 and 4 as minimal protection. From the results of this study, it can be concluded that the method of freeze-drying even though it requires a longer time and costs more expensive than the oven method but provides protection for sunscreen 2.5 times higher.
POTENSI INTERAKSI ANTAR OBAT PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE-2 DENGAN KOMORBIDITAS HIPERTENSI Liniati Geografi; Octaviana Maria Simbolon
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.331

Abstract

Type 2 diabetes mellitus (insulin-dependent diabetes or adult-onset diabetes) is a condition caused by the ineffective use of insulin in the human body. This disease is also often accompanied by hypertension, where these comorbidities can spur severe cardiovascular complications such as heart attacks, strokes and kidney failure. Hospitalised diabetic patients with comorbid hypertension, have the potential to experience drug-related problems / Drug-Related Problems (DRPs), especially Drug-Drug Interactions (DDIs) due to a combination of therapies during the treatment period. The results obtained from the data tracking of 52 patients showed that 21 patients (40%) had the potential to experience DDIs. The types of potential DDI found in this study had 71 kinds variation with 124 events, 5% were major and 95% were moderate. The prevalence of potential interactions between drugs is quite high and varied. Inpatient monitoring of the risk is essential to avoid potential dangers inflicts on patients.
POTENSI DAUN MANGROVE (Rhizopora mucronata) SEBAGAI ANTIDIABETES Usman Sain; Dinda Noor Sukma; Bena Septariama Simatupang
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.332

Abstract

Rhizopora mucronate is a typical mangrove plant that easly found on the coast of Muara Badak Beach, Kutai Kartanegara Regency, East Borneo, Indonesia. The purpose of this research is to know the activity of active compound from mangrove Rhizopora mucronate leaves that have the potencial as antidiabetic. Samples of R. mucronata mangrove leaves were taken at Muara Badak beach region. Leaf samples that have been dried, are extracted by maceration using methanol solvent and followed by a partition extraction process using n-hexane solvent. The methanol and n-hexane extracts from R.mucronata mangrove leaves were obtained, followed by phytochemical tests (alkaloid, flavonoid, steroid, terpenoid, phenolic compounds, tannin, and saponin) qualitatively. Then the antidiabetic activity was tested using an oral glucose tolerance test method. Phytochemical test results of methanol and n-hexane extracts of R.mucronata mangrove leaves are positive contained group compounds; alkaloids, flavonoids, tannins and phenolics. The percentage decrease in blood glucose levels of mice for positive control (Glibenclamide 0.05 mg / kgBB) was 21.81%, methanol extract for group III (dose 62.5 mg / kgBB) 67.86%, Group IV (dose 125 mg / kgBB) 58.74% and Group V (group V (dose 62.5 mg / kgBW) 67.86%, Group IV (dose 125 mg / kgBW) 58.74% and Group V (group V (dose 62.5 mg / kgBW) dose 250 mg / kg) 36.72%. Then the percentage decrease in blood glucose levels of mice for n-hexane extract; Positive control was 11.60%, Group III (dose 62.5 mg / kgBW) was 20.1%, Group IV (dose 125 mg / kgBW) 7.83% and Group V (dose 250 mg / kgBW) 42.7%. The methanol extract of R.mucronata mangrove leaves at a dose of 62.5 mg / kgBB has the best antidiabetic activity. Whereas n-hexane extract has the best antidiabetic activity at a dose of 250 mg / kgBW. Thus the methanol and n-hexane extract of Rhizopora mucronata mangrove leaves has the potential as an antidiabetic.
IDENTIFIKASI PENGARUH TAKARAN BAHAN DASAR TERHADAP KUALITAS MIE BASAH BERDASARKAN DAYA SERAP AIR DAN METODE DOE Anis Siti Nurrohkayati; Binyamin Binyamin; Muhammad Khairul
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.333

Abstract

Wet noodles are one of the foods that are favored by all people, especially in Indonesia. Wet noodles are made from basic ingredients of wheat flour or wheat flour. So far there have been many innovations of wet noodles with basic ingredients apart from wheat flour. The difference in the basic ingredients and additional ingredients can affect the quality of the noodles. However, it is not yet known whether the effect of the quality of the wet noodles is influenced by the type of flour used, the amount of the basic ingredients, or whether there is an effect of the extracts of other ingredients on the quality of the wet noodles. This is the reason for this research. Thus, this study aims to determine the types and differences in the use of basic ingredients in making wet noodles that can affect the quality of wet noodles. Measurement parameters used are by calculating the level of water absorption. The combination of wheat flour, cassava flour, and seaweed were used in this study. Calculation analysis is performed using the Taguchi method. The Taguchi method is the methodology in the world of Engineering which can be used as a method to measure or improve the quality of a product, as well as minimize costs. Wet noodle making experiments were conducted according to the Taguchi Design of Experiments (DOE) method. The repetition of the experiment was carried out eight times according to the orthogonal array (OA) matrix used. There are 5 control factors and 3 noise factors that are used in this study. Control factors are wheat flour, cassava flour, eggs, salt, and seaweed. Meanwhile, the noise factor is a lot of water, a long time to rest dough, and a long time to steam. ANOVA analysis and mean effect were carried out to find out which factors had the most significant influence on the quality of the noodles.
EFEKTIVITAS EDUKASI VIDEO UNTUK KELENGKAPAN PENJELASAN CARA PENGGUNAAN INHALER OLEH MAHASISWA APOTEKER Amelia Lorensia; Rifaatul Laila Mahmudah; Ema Arifatul Masruroh; Navaul Setiya Ningrum
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.340

Abstract

Pharmacists are one of the health workers who play a role in providing information related to explanations of how to use inhaler preparations to asthma patients. This study aims to determine the effectiveness of providing educational videos on how to use several types of inhalers (MDI, MDI with spacers, Diskus®, and Bodyaler® given to pharmacist students. This research is a pre-post design (experimental) study. Sampling was conducted using the method non random sampling using purposive technique, normality test using Shapiro-Wilk and continued.From the results of the data obtained, each assessment verbally (as explained by the subject) and motoric assessment (as demonstrated by the subject) is seen from the pre- and post-intervention Comparing the completeness of explanations both verbally and motorically, showing significant differences compared to before education, with P values ​​for MDI (P (0,000) ≤0.05), MDI with spacers (P (0,000) ≤0.05) Diskus® (P (0,000) ≤0.05), and Turbuhaler® (P (0,000) ,00.05), therefore video education has proven to be effective in increasing student proficiency. self-pharmacist to explain how to use inhalers.
OPTIMASI VARIASI KONSENTRASI LIPID TERHADAP KARAKTERISTIK FISIK SOLID LIPID NANOPARTICLE (SLN) GLIBENKLAMID Nurul Arfiyanti Yusuf; Rahmad Aksa; Fisa Juniawan Cahyono
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.341

Abstract

Glibenclamide is a sulfonylurea drug compound used as oral antidiabetic. Solid Lipid Nanoparticles (SLN) are alternative carrier systems that can be used to increase the bioavailability of drugs with low solubility. The purpose of this study was to determine the effect of lipid concentration on the efficiency of Solid Lipid Nanoparticle (SLN) entrapment efficiency of glibenclamide, to determine the optimum concentration of lipids which had the best Solid Lipid Nanoparticle (SLN) efficiency parameter values ​​of glibenclamide. This study varied between glyceryl monostearate and oleic acid as a lipid phase made in 12 formulas. The method of making solid lipid nanoparticles used by the solvent emulsion / evaporation method. The results of the study showed that the concentration variations between oleic acid lipids and glyceryl monostearate had a significant effect on percent entrapment efficiency in glibenclamide Solid Lipid Nanoparticle (SLN) preparations. The optimal formula is a formula with 1% oleic acid and 9% glyceryl monostearate which has particle size of 294.6 nm with a PI value (polydispersity index) of 0.465 .
PENGUKURAN KINERJA INSTALASI FARMASI RUMAH SAKIT DAERAH LIUN KENDAGE TAHUNA BERDASARKAN PERSPEKTIF CUSTOMER DAN LEARNING AND GROWTH Gayatri Citraningtyas; Deby Afriani Mpila; Mariana Gagola
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.342

Abstract

This recent day hospital facing a competitive competition, and high expectation of health services from public. Thus the hospital have to fix and improve public health services quality. There was a need to evaluate Pharmacy Installation performance, if the hospital already work in line with the vision, mission, and goal of the organization. The objectives of this research was to performance measurement of Pharmacy Installation at RSD Liun Kendage Tahuna using balanced scorecard (BSC) method from customer perspective and learning and growth perspective. Research design used in this study was descriptive evaluation with prospective data collection. Qualitative data was a inteview with head of Pharmacy Installation, although quantitative data were an observation, questionnaire and administration report. The result of performance measurement from customer perspective showed Ikj value were -0,43 (negative index), which means there were a gap between the reality and expectation on health services that delivered. Patient growth level increased from 92,3 % in 2016; 94,5% in 2017; and 95,3% in 2018. Performance measurement from learning and growth perspective showed average value 2,85 for employee spirit (high category), and productivity were 78,64% (good category). The conclusion were Pharmacy Installation of RSD Liun Kendage Tahuna already showed a good performance, although there were a need to make an improvement on customer satisfaction.

Page 17 of 33 | Total Record : 326

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