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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN Viani Anggi; Joni Tandi; Veronika Veronika
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.294

Abstract

This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.
Hubungan Kadar Natrium Serum dengan Outcome Klinis pada Pasien Cedera Kepala Berat di RSUD Abdul Wahab Sjahranie Samarinda Achmad Rivaldi; Arie Ibrahim; Loly Rotua Dharmanita Siagian
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.296

Abstract

Recently, Traumatic Brain Injury (TBI) has high mortality in the world. In severe TBI, secondary brain injury can occur. ElectrSolyte disorders are the most common in secondary brain insult especially sodium disorders. It remains unclear whether hyponatremia or hypernatremia can cause worse clinical outcome in TBI patients. This study aimed to determine association between serum sodium level with clinical outcome in severe TBI patients at RSUD Abdul Wahab Sjahranie Samarinda. A cross sectional analytical study by taking samples to the patients with diagnosed severe TBI (GCS ≤ 8) which were hospitalized at RSUD Abdul Wahab Sjahranie Samarinda in the period of January-December 2018 that complied inclusion and exclusion criteria. Research variables are sodium serum level and clinical outcome that was assessed by structured interviews for Glasgow Outcome Scale (GOS). The relationship between variables was done using the Fisher's Exact test. A total of 41 severe TBI patients were administered. The characteristics of the sample were the most patients in 20s-40s (46.3%), patients were dominated by male (82.9%) and the most common CT scan characteristic were epidural hematoma (29.3%). The most of patients showed normonatremia in 25 patients (61%), 9 patients (22%) had hypernatremia and 7 patients (17.1%) had hyponatremia. The most clinical outcome on severe TBI patients were worse outcome with 70.7% while good outcome with 29.3%. Statistical result showed there’s no association between serum sodium level (hyponatremia and hypernatremia) with clinical outcome in severe TBI patients with p values, 1.000 and 0.225, respectively. There’s no association between serum sodium level with clinical outcome in severe TBI patients.
TINGKAT KEPUASAN PASIEN RAWAT JALAN TERHADAP PELAYANAN KEFARMASIAN DI INSTALASI FARMASI RUMAH SAKIT MARINIR CILANDAK JAKARTA Jenny Pontoan; Okpri Meila; Yuli Asnanik; Muhammad Azhar Muharam
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.298

Abstract

Measuring the quality dimensions of health service is essential and should be done along with patient satisfaction surveys. The level of patient satisfaction with hospital health services may use the five-dimensional Service Quality (ServQual) method, that is, reliability, responsiveness, assurance, concern and tangible form. The study was conducted to determine the level of outpatient satisfaction with the quality of services provided by The Cilandak Marinir Hospital Pharmacy Installation. The research design is Observational by survey methods, conducted on JKN outpatients, with a total sample of 106 respondents. Inclusion criteria; patients who redeem a prescription at a hospital pharmacy installation at least 2 times; patients who are willing to fill out the questionnaire, sign the questionnaire, and approve the informed consent; patients aged ≥ 15 years. Exclusion criteria are patients who are hospital employees; HIV / AIDS patients. This study was also complemented with data collection permits from the hospital and ethical approval from the ethics research committee of the Universitas Pembangunan Veteran Jakarta. The instrument used is in the form of a questionnaire to measure patient satisfaction about pharmacy services at the pharmacy. The results of the validity test of 0.383-0.950 (components of expectations) and 0.362-0.928 (components of performance) are declared valid. The reliability test results are 0.954-0.961 (expectation component) and 0.951-0.960 (performance component); these results indicate that the questionnaire can be used because all questions are reliable (> 0.60 Cronbach Alpha scores). Data analysis uses the Service Quality method (Service Quality score = Performance - Expectation). A positive score indicates that customer expectations are met so that services on specific dimensions can be perceived as high quality and vice versa. Ideally, the value of the gap between expectations and perceptions is zero. ServQual analysis results based on the gap showed that the most significant value of the gap in the dimensions of reliability -0.18, responsiveness (responsiveness) -0.12, awareness (empathy) -0.08, assurance -0, 07, and tangible form (tangible) -0.03. Based on these results, It can be concluded that pharmaceutical services still need improvement because they still have a negative gap value for the five dimensions.
ISOLASI MIKROBA TANAH YANG BERPOTENSI MENGHASILKAN ANTIMIKROBA Ririn Puspadewi; Rina Anugrah; Afif Abdulbasith; Intan Yunita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.304

Abstract

The soil is one of the habitats for microorganisms, in one gram soil there are millions of microorganism. Population microorganism per gram the rich soil of covering bacteria, actinomycetes, fungi, algae and protozoa. Garden having the potential to do exploration of isolation microorganisms. This is because land contains many organic compounds and minerals that is one ecosystem fertile to life and growth microorganisms. Whenever a microorganisms have proven produce substance antimicrobe so organisms of its potential as producer antibiotics. Material research the land, taken from the soil Faculty of Pharmacy Plant Garden of UNJANI, we did dilution and cultivated in a media potato dextrose broth. The isolate from medium broth was cultivating in a media potato dextrose agar, to obtained isolates single. Isolates obtained seen features macroscopic and microscopic. The results obtained isolates isolation two of the four isolates that can give inhibition to Escherichia coli but does not inhibition to Staphylococcus aureus. Keywords: isolation, microbe, soil
IDENTIFIKASI DAN PENETAPAN KADAR SENYAWA TANIN PADA EKSTRAK DAUN BIDURI (Calotropis gigantea) METODE SPEKTROFOTOMETRI UV-VIS Yuska Noviyanty; Hepiyansori Hepiyansori; Yudan Agustian
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.307

Abstract

Calotropis gigantea (Biduri) are plants that are widely used as herbal medicines by the community. Calotropis gigantea (Biduri) is used as a medicine for coughing, hives, medication for toothache, medicine for ear pain, epilepsy, wounds, sprains and diarrhea. The chemical content of Calotropis gigantea (Biduri) is in the form of glycosides, saponins, alkaloids, flavonoids, and tannins. The purpose of this study was to determine the presence or absence of tannin compounds and levels of tannin compounds in Calotropis gigantea (Biduri). The identification test used FeCl3 and gelatin reagent. Extraction was carried out by maceration using ethanol 96% solvent. Determination of tannin levels of. Calotropis gigantea (Biduri) by Uv-vis spectrophotometry method. The results of the identification test showed that Calotropis gigantea (Biduri) positively contained tannins with FeCl3 resulting in a blackish green color and gelatin causing deposits. The results of the average level of tannins in biduri leaf extract Calotropis gigantea (Biduri) at a concentration of 100 ppm of 1.16 µg / ml, a concentration of 200 ppm of 3.53 μg / ml and a concentration of 300 ppm of 7.12 μg / ml.
UJI FITOKIMIA DAN ANTIOKSIDAN EKSTRAK ETANOL PROPOLIS LEBAH KELULUT (Tetragonula iridipennis) DARI SAMARINDA KALIMANTAN TIMUR Binti Khairunnisa; Enih Rosamah; Harlinda Kuspradini; Irawan Wijaya Kusuma; Sukemi Sukemi; Nataniel Tandirogang; Enos Tangke Arung
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.309

Abstract

The study aims to identify the secondary metabolite compounds contained in the ethanol extract Propolis Tetragonula Iridipennis and determine the antioxidant activity. Propolis is extracted from the beehive of Kelulut (Tetragonula Iridipennis) with a method of maceration of ethanol 96% produce a yield of 66.73%. Propolis extract contains alkaloid compounds, flavonoids, triterpenoids, tannins and carbohydrates. Propolis extract tested its antioxidant activity using the DPPH method (1.1-diphenyl-2-picrylhydrazyl) with a wavelength of 514 nm. Results showed a percentage of propolis extract free radicals 59% in concentrations of 100 ppm with IC50 33.74 ppm so that propolis extract is potentially as an antioxidant.
PERBEDAAN KEPATUHAN MINUM OBAT PADA PASIEN YANG BARU TERDIAGNOSA DAN SUDAH LAMA TERDIAGNOSA PENYAKIT DIABETES MELITUS TIPE 2 Selly Septi Fandinata; Rizky Darmawan
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.310

Abstract

Diabetes mellitus is a chronic disease caused by insufficient insulin effectively. Compliance medication in patients diabetes mellitus is important to achieve treatment goals and effective to prevent complications in diabetes mellitus. The duration of suffering from DM is one of the factors that influences medication adherence. The purpose of this study is to compare the differences in adherence to taking medication between patients who have just been diagnosed with diabetes mellitus type II. Questionnaire instrument 4 indicators of compliance (right dose, right frequency, right interval, right time). Analysis statistical of the Mann-Whitney test. Total of 10 new patients and 20 old patients were diagnosed. The results study is patient to be compliant with right dose adherence 8 new patients (80%), 19 old patients (95%). Right frequency adherence 9 new patients (80%), 19 old patients (95%). Timely compliance 7 new patients (70%), 16 old patients (80%). Right interval adherence 4 new patients (40%), 13 old patients (65%). The results of data analysis showed p-value = 0.076> 0.05 there was no significant difference in adherence to taking medication between old patients and new patients with diabetes mellitus type II.
HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN OUTCOME STROKE PADA PASIEN DENGAN DAN TANPA INTRACRANIAL LARGE ARTERY STENOSIS Dedi Sutia; Syarif Indra; Andi Fadilah Yusran Putri; Firstisa Nuzulia K
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.311

Abstract

Blood pressure in acute onset of ischemic stroke usually increase in patients with intracranial artery stenosis. The aim of increasing blood pressure in this situation is to maintain cerebral autoregulation, meanwhile increased blood pressure in acute onset of ischemic stroke is associated with poor clinical outcomes. This study aims to determine the association between systolic blood pressure and stroke outcomes in patients with and without intracranial large artery stenosis which will help the clinician to determine the prognosis in acute ischemic stroke patients. This study used a cross-sectional design. The population of this study was ischemic stroke patients with or without intracranial arterial stenosis based on the results of transcranial doppler ultrasonography in the neurology department of RSUP Dr. M. Djamil Padang from January 2018 - July 2018. P-value <0.05 was considered statistically significant. In 25 subjects, there were 9 males (36%) and 16 females (64%) based on the gender category.There was a significant difference in systolic blood pressure in both groups (p=0.035). There was no significant difference in MRS values in both groups (p=0.480). There was no significant difference between systolic blood pressure and MRS values in patients with intracranial large artery stenosis (p=0.579) and patients without intracranial large artery stenosis (p=0.481). There was no association between systolic blood pressure and stroke outcome in patients with and without intracranial large artery stenosis.
PENETAPAN KADAR TOTAL FLAVONOID EKSTRAK ETANOL KACANG MERAH (Phaseolus vulgaris L.) SECARA SPEKTROFOTOMETRI VISIBEL Novena Yety Lindawati; Sabilla Hudzaifah Ma'ruf
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.312

Abstract

Red kidney bean is one of the string beans that contain highest-fiber with a concentration 26.3 gram/100 gram substance. Red kidney bean contains flavonoid tannin steroid/triterpenoid and coumarin. The Flavonoid in red kidney bean has anti-diabetes activity. This research aims to determine total flavonoid content in the red kidney bean extract. Extraction is done using the maceration method with 70% ethanol solvent. The extract which is got is used for qualitative and quantitative analysis. Quercetin used as a standard solution. The qualitative analysis of flavonoid using TLC, Wilstater Cyanidin by forming a red complex and NaOH by a forming yellow complex. The Quantitative analysis was using colorimetry method with reagent AlCl3 to form complexes between AlCl3 and keto groups. Quantitative analysis continued with Visible Spectrophotometry on a wavelength of 430.0 nm and operating time at the 27th minute. The results of the qualitative test showed that the extract was positive flavonoids. The average concentrations of total flavonoids were 0,4733% extract with a variation coefficient value of 1,2%.
KARAKTERISTIK FISIK SEDIAAN FOOT SANITIZER SPRAY KOMBINASI EKSTRAK BIJI KOPI (Coffea) DAN RIMPANG JAHE (Zingiber officinale) DENGAN VARISASI KECEPATAN DAN WAKTU PENGADUKAN Wilda Amananti; Aldi Budi Riyanta
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.313

Abstract

Foot odor is a common body odor problem. The smell of feet makes oneself and people around uncomfortable, the smell of feet can be eliminated by washing the foot using soap, using a tabun powder. However, the foot wash using soap or powder is assessed less practical. Footsanitizer Spray is a new innovation of foot odor relievers that are practical and efficient use. Stirring process will affect product quality especially particle size distribution. So in this study aims to assess the effect of speed and time stirring of physical characteristics of the preparation of the foot sanitizer spray. In this research has been done variation of speed and stirring time, variation of stirring speed is done by varying the stirring speed at 300 rpm, 500 rpm and 700 rpm. Variation in stirring time is done by varying the stirring time for 1 hour, 2 hours and 3 hours. From the results of this research can be concluded that coffee beans extract and ginger rhizome can be used as a spray footsanitizer. And the greater the speed of the mixing form of the Footsanitizer spray the more cloudy and the viscosity value and type weight is getting bigger. The longer the stirring also leads to greater viscosity and density values.

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