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Jurnal Widya Medika
Published by Universitas Katolik Widya Mandala Surabaya
ISSN : 23380373     EISSN : 26232723     DOI : https://doi.org/10.33508/jwm
Core Subject : Health,
Medicine & Pharmacology
Jurnal Widya Medika is the official publication media of Widya Mandala Surabaya Catholic University, Faculty of Medicine. Jurnal Widya Medika publishes original research articles, case reports, and literature reviews from scientists of various medical education and research institutions, including select scientific works from medical students. All articles published had undergone plagiarism checks, editorial review by the editorial board, and peer review by experts from their respective fields in order to maintain the high standard of articles published in Jurnal Widya Medika.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 184 Documents
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THE CORRELATION OF LEFT VENTRICULAR MECHANICAL DISPERSION AND LEFT VENTRICULAR EJECTION FRACTION WITH QT DISPERSION IN END-STAGE RENAL DISEASE PATIENTS ON HEMODIALYSIS BEFORE AND AFTER DIALYSIS Harry Pribadi; Agnes Lucia Panda; Benny Mulyanto Setiadi
JURNAL WIDYA MEDIKA Vol. 8 No. 2 (2022): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i2.4152

Abstract

Background: Ventricular arrhythmias (VA) is common in dialytic patients. Left Ventricular Mechanical Dispersion (LVMD) could provide an inhomogeneous of left ventricular myocardium contraction lead to VA. Reduced Left Ventricular Ejection Fraction (LVEF) and QT Dispersion (QTd) are well-known VA predictors in dialytic patients. This study aimed to determine the relationship between LVMD and LVEF on QT dispersion in ESRD patients before and after dialysis. Methods: This cross-sectional study was conducted in November 2021 - February 2022. All study subjects who met the inclusion criteria underwent history taking and physical examination including age, sex, body weight, body height, electrocardiography, echocardiography, and routine laboratory studies. Results: Among 43 subjects, 24 (55.8%) were male, with mean age of 51,14±11,6 was conducted in this study. The most common comorbidities were hypertension (79%) and diabetes mellitus (44.19%). Pre-dialysis LVMD mean was 28.99±15.98 ms and significantly decrease to 24.16±15.77 ms after dialysis (p
HYPOGLYCEMIC, ANTI-INFLAMMATORY EFFECT OF PORANG (AMORPHOPHALLUS ONCHOPYLLUS) ON ALLOXAN-INDUCED DIABETIC RATS Young, Andre; Novita, Bernadette Dian; Ricardo, Evan; Dewi, I.G.A.P.D; Amadeo, Jovan; Dewi, Sianty; Tahalele, Paul
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4173

Abstract

Introduction: Iles-iles / Porang is a tuber-producing plant that is commonly found in Indonesia. One of the most sought after content from Porang is Glucomannan. One of Porang’s health benefit is related to the effect of lowering blood glucose levels because it can prevent glucose absorption. These benefit is interesting to study because there has been no research linking the use of Porang to reduce inflammatory process in hyperglycmic conditions. Purpose: This study aims to analyze the anti-inflammatory, anti-oxidant and hypoglycemis effects of Glucomannan from Porang (Amorphophallus onchophyllus) extract in experimental animals. Method: The research design was a true experimental post-test only control group with random sampling to determine 5 white rats into the normal group, positive control group, negative control group and treatment 1, 2 and 3. The positive control group received Acarbose therapy thile the negative control group received carboxy-methyl-cellulose (CMC) therapy. This study used Porang extract (Amorphophallus onchophyllus) with concentrations of 200, 400 and 800 mg/Kg in hyperglycemic white rats that had been induced by Aloxan. The study was conducte for 50 days and then blood and serum samples were taken to assess the effect of hypoglycemia, anti-inflammatory and anti-oxidant using blood glucose, Malondialdehyde and C-reactiveprotein (CRP) measurement. Result and Discussion: The results showed no significant difference between the groups of rats receiving Porang extract and the positive and negative control groups. However, the MDA levels after 50 days of intervention between the negative control group and the therapy with doses of 200, 400 and 800 mg/Kg showed significant differences. Similarly found for blood glucose levels after intervention between negative control group and the 200 and 400 mg/Kg therapy group. This results may be caused by the type of Porang used, the form of the Porang and the concentration level of the Porang extract. Conclusion: Porang with the type of Amorphophallus onchophyllus can’t be used directly, but requires further processing to obtain the active substance Glucomannan.
CORRELATION OF SERUM ZINC LEVELS WITH SEVERITY AND DISEASE ACTIVITY IN VITILIGO PATIENTS AT SANJIWANI GIANYAR HOSPITAL Sayu Widiawati; Made Budiani; Pradnya Iswara
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4230

Abstract

Vitiligo is autoimmune disease, characterized by well defined milky-white macule, caused by destruction of melanocyte selectively. Management of vitiligo is still challenging due to the pathogenesis is not yet fully understood, and vitiligo can caused significant psychological distress to the patients. Several studies reveal the role of zinc as an important element in the prevention and treatment of vitiligo based on zinc's function as an antiapoptotic, as a bull against free radicals, and as an important element in melanogenesis by stimulating cell mediated immunity activity, zinc and alpha melanocyte stimulating hormone. We conducted an analytical cross-sectional study that aims to determine the correlation between plasma zinc levels and the severity of vitiligo using the VASI score and vitiligo disease activity calculated based on the VIDA score. The results showed that there was a strong negative correlation between serum zinc levels and the VASI score, with a correlation coefficient or r = -0.668 and p
THROUGH A MICROSCOPIC LENS: SKIN MICROBIOME AS THE CONFEDERATE IN ATOPIC DERMATITIS Catharina Clarissa Ursia; Patricia Dian Putri
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4265

Abstract

Reciprocity between skin microbiome and the host underlies the occurrence, exacerbation, and severity of atopic dermatitis (AD). However, the role of skin microbiome in the pathogenesis of AD is yet to be depicted. This review highlights the host–microbiome interactions which relies on barrier status, microbiome composition, and microbe–microbe interactions. A microbiome shift, with abundance of S. aureus and lower microbial diversity, compromises the skin barrier function. It goes to show that epidermal barrier defect depletes the protective commensal skin bacteria and demonstrate how dysbiosis of the skin microbiome can lead to AD.
IMPACT OF DIABETES MELLITUS AS A COMORBIDITY OF COVID-19 PATIENTS TREATED AT PANTI NIRMALA MALANG: REVIEWED FROM COAGULATION PARAMETERS Winarko Luminturahardjo; Hustorio Aliongko Simamora; Evan Kurniawan Gianto
JURNAL WIDYA MEDIKA Vol. 8 No. 2 (2022): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i2.4321

Abstract

Background: Treatment of COVID-19 patients with comorbid like diabetes mellitus as more consequences such as greater mortality risk and prolonged hospitalization. One of the reasons is caused by a hypercoagulable state. Aim: To prove the difference in coagulation parameters of platelet count, C-Reactive Protein, and D-dimer between Covid-19 patients with diabetes comorbidity and without diabetes, and to analyze the correlation between coagulation parameters with the stage of pneumonia caused by Covid19. Methods: The design is a cross-sectional study. The sample was collected from patients registered whose hospitalized in an isolation ward at Panti Nirmala Hospital Malang from April to October 2021. Coagulation parameters (platelet counts, C-reactive protein (CRP), and D-dimer level) were measured from 134 patients, divided between 40 patients with diabetes mellitus and 94 patients without diabetes mellitus. Statistical analysis was performed by software SPSS 24, the version year 2016. Results: Among 134 COVID-19 patients who had diabetes and no diabetes comorbidity, there are results: no significant difference in average platelet counts between the two groups (p=0.763), and the difference in C-reactive protein is significant between the two groups (p=0.076), and the difference of D-dimer level is not significant between them (p=0.593). There is a positive correlation between CRP and D-dimer level with the stage of COVID19 pneumonia (r=0.000 and r=0.134), and on the other hand, there is a negative correlation between platelet counts with the stage of pneumonia (r=-0.126). Conclusion: COVID-19 patients hospitalized with diabetes mellitus tend to have more severe conditions marked by a higher level of coagulation parameters and correlate with the severity of pneumonia.
SARS-COV-2 (COVID-19) EXAMINATION USES ANTIGEN SWAB FOR COMPANY’S EMPLOYEES IN SURABAYA ON JULY – AUGUST 2021 Lukas Slamet Riadi; Yudhiakuari Sincihu; Mulya Dinata; Vincentius Diamantino Supit; Juanita Harrisa; Putri Lisdiyanti
JURNAL WIDYA MEDIKA Vol. 8 No. 2 (2022): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i2.4322

Abstract

Background of the problem: Since 2020, all the countries in the world has been rocked by Covid-19 (Sars-Cov-2) pandemic. Since July 2021, Indonesia became Covid-19 epicentrum with the highest mortality 2.048 people in the world on 10th August 2021. Covid-19 supporting diagnosis checkup uses RT-PCR and Antigen rapid test, this was based on the Indonesian Health Minister instruction about the uses of antigen test for 2019 Corona Virus Disease checkup. Method: This research uses cross sectional, retrospective analytic study by seeing the data that was taken from SARS-Cov-2 antigen rapid test from some location of companies in Surabaya. The swab data is from Sentra Medika Clinic Surabaya by using nasopharyngeal and nasal antigen SARS-CoV-2 rapid test kit (immunochromatography method). Result: The main data of labor’s characteristics is 6033 people. The highest number was on July to August 2021 on the age range of 30-39 years old (39,70%), meanwhile at the age of 60-69 years old is 0,45%. In the case of Covid-19 virus infection, the highest number of positive antigen was at the age range of 30-39 years old was 64 people (41,30%), whereas 2 people (1,30%) were at the age range of 60-69 years old. At the age more than 60, the number of case is not many but the statistic analytic result shows that age influences P0,05 (P 0,260) Covid-19 Antigen swab test result. The case spike happened on July 2021, 153 people were positive of Antigen swab test: 141 people were men (92,16%) and 12 people were women (7,84%). On August 2021, 2 men were positive (100%). Conclusion: The result of the research in July 2021 shows that the highest numbers of labor are at the age of 30-39 years old. The risk of Covid-19 infection mostly at men. Whereas Covid-19 infection risk is at the age of 60-69 years old are in small amount. Age influences the result of Covid-19 Antigen swab test. Meanwhile, gender does not influence the result of Covid-19 Antigen swab test.
GRAVES DISEASE Prettysun Ang Mellow
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4510

Abstract

Graves' disease is one of the most common autoimmune diseases. The disease is named after the scientist Robert James Graves, who first described it in the 19th century as a syndrome with an enlarged and overactive thyroid gland (hyperthyroidism due to circulating autoantibodies), rapid heart rate, and eye abnormalities. graves’ disease is the most common cause of hyperthyroidism and affects more women than men. Graves’ disease can appear at any age, but it most commonly appears for the first time between the ages of 20 and 40. Factor is a predisposition that is more dominant than environmental factors. There are circulating autoantibodies produced by B lymphocytes induced by autoreactive T lymphocytes that recognize thyrotropin-stimulating hormone (TSH) receptors in thyroid tissue as self-antigens. These autoantibodies are also known as TSH receptor antibodies (TSH-R Ab), thyrotropin stimulating antibodies (TSI), or thyrotropin receptor antibodies (TRAb). TRAb acts like TSH to cause thyroid hyperplasia (diffuse goitre), increased synthesis, and excessive and uncontrolled secretion of thyroid hormones (T4: tetraiodothyronine T4 and T3: triiodothyronine T3). Investigations to confirm Graves’ disease show elevated thyroid hormones (T4 and T3) with very low TSH and increased TRAb. On thyroid ultrasound, the majority of patients have a hypervascular and hypoechoic diffusely enlarged thyroid gland. The treatment for graves’ disease is to reduce the synthesis of thyroid hormones using anti-thyroid drugs, or to reduce the amount of thyroid tissue with radioactive iodine (RAI) or total thyroidectomy. Methimazole is the first-choice antithyroid drug with good effectiveness and safety. Although the recurrence rate after stopping the drug is still quite high
REPORTING THE DETECTION RESULT OF SARS-CoV-2 ANTIBODY RAPID TEST OF COMPANY’S EMPLOYEES IN SURABAYA AND PASURUAN, INDONESIA Mulya Dinata; Angelina Tulus; Evelyn Ongkodjodjo; Lukas Slamet Rihadi; Dewa Ayu Liona Dewi; Gabrielle Tjipta Joewana; Nurlita Wulansari
JURNAL WIDYA MEDIKA Vol. 9 No. 1 (2023): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i1.4631

Abstract

Background: Coronavirus (CoV) is a large family of viruses that causes illnesses ranging from mild to severe symptoms. Coronavirus Disease (Covid-19) is a new type of virus that has never been indentified in humans before. Methods: All antibody test methods and RT-PCR tests have an optimum time window in the incubation period or infection of a person. The antibody test method cannot be used as an early detection tool for people who are still on the first day of the incubation process. IgG and IgM antibody levels are still low on the first day of infection, even though the number of viral particles is very high at the beginning. Result: Sars-Cov-2 (Covid-19) antibody examination sample was taken from Main Clinic of Sentra Medika Surabaya, from May to August 2020, with the age range of 18-65 old amounted to 1015 people. The number of samples with the age range of 40-49 is 404 people (39,90%), Production Department has 773 samples of people (76,16%), the number of security samples is 39 people (3,84%), and others have 109 samples of people (10,74%). The number of male samples is 666 people (65,62%) more than female 349 people (34,38%). Positive Covid-19 Antibody examination results for Office Department are IgM 3 people, IgG 3 people, and the total numbers are 6 people (21%). Positive Covid-19 Antibody examination results for the production department are IgM 14 people, IgG 1 person. So, the total numbers are 17 people (59%). The most positive Covid-19 antibody examination result is the production department namely 59% and including positive results for IgM and IgG. The condition above the production department has the most frequent because of the condition of employees including some companies which had overtime work or 2 shifts. Conclusion: The highest number of Positive Covid-19 antibody examination result. The most department is the production department. The age range of 50-59 years old has a small number. At the time of being infected with Covid-19, IgG and IgM are negative, it needs time to get a positive examination result of IgG or IgM or both. The antibody examination method cannot be used as an early detection tool for Covid-19.
CHEST RONTGEN FINDINGS IN CHRONIC KIDNEY DISEASE PATIENT WITH CONGESTIVE HEART FAILURE: A CASE REPORT Evita Zevanya; Sudharmadji Sudharmadji
JURNAL WIDYA MEDIKA Vol. 9 No. 2 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i2.4898

Abstract

Chronic kidney disease is persistent abnormality or damage in kidney structure or function for more than 3 months. Prevalence of CKD is around 10 – 14% in general population and affects around more than 800 million individuals worldwide. Patients with CKD have higher risk of cardiovascular disease and synergistic pathological effects can speed up worsening of diseases. Radiology examination is one of the test that can be used to evaluate kidney and heart structural damage. The aim of this paper is to report chest rontgen findings in a man aged 54 years old with CKD with HF in 3 serials imaging result. Patient admitted to hospital caused by shortness of breath. Patient has history of hypertension, diabetes mellitus type 2, CKD stage V, and congestive heart failure. From physical examination, oxygen saturation was 97%, blood pressure was 154/115 mmHg, and extremity edema was found. Chest rontgen impression was bronchitis, dextra pleural effusion, and normal cardiac size. He got oxygen, Furosemide, Nicardipine, Aspirin, Irbesartan, Amlodipine, Calcium carbonate, and hemodialysis as therapies. After be hospitalized 2 days, patient’s condition was better, and therapy was continued outpatient. Chest rontgen examination result a year ago showed pulmonary edema, bilateral pleural effusion, and cardiomegaly with shortness of breath as major symptom. Chest rontgen examination result 6 months ago showed bronchopneumonia and cardiomegaly with fever, cough, nausea, and loss of appetite. In conclusion, most of CKD patients particularly in late stage have cardiovascular disease and radiology examination is important to detect and evaluate structural cardiac abnormality in CKD patients. Keyword: Chest rontgen, chronic kidney disease, congestive heart failure.
THE USE OF BASEL SCORE IN EARLY DETECTION OF CORONARY LESION SEVERITY IN NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND UNSTABLE ANGINA PECTORIS Andrew Eka Pramudita Sunardi; Dewi Utari Djafar; Edmond Leonard Jim; Fima Lanra Fredrik Gerald Langi
JURNAL WIDYA MEDIKA Vol. 9 No. 2 (2023): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v9i2.5060

Abstract

Early diagnosis of cardiac ischemia is crucial for effective management of acute myocardial infarction. The BASEL (Better Analysis of ST-segment Elevations and Depressions in a 12-leads-ECG) score has been shown to provide additional diagnostic value to the established electrocardiographic (ECG) criteria. This study aimed to evaluate the use of BASEL score to determine the severity of coronary lesions in patients with non-ST segment elevation acute coronary syndrome. This study used a cross-sectional approach and was conducted from January 2021 to January 2022. From a total of 90 subjects, more than three-quarters were male, while the mean age was 60.3 years. The median BASEL score was 2.3 (1–4.2). GRACE 2.0 score had a mean of 97.3±26. The SYNTAX I score had a mean of 25±15.6, the SYNTAX II – PCI median score was 34.5 (25.9-42.4), and the SYNTAX II-CABG mean score was 23.4±11.9. The BASEL score showed a significant association with the SYNTAX I score both in univariate 2.60 (2.60-3.59), p

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