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Cermin Dunia Kedokteran
Published by PT. Kalbe Farma Tbk.
ISSN : 0125913X     EISSN : 25032720     DOI : 10.55175
Core Subject : Health,
Health Professions
Cermin Dunia Kedokteran (CDK) is a Medical Journal published since 1974 and affiliated with PT Kalbe Farma Tbk. CDK is intended to help accommodate scientific publications and help increase and disseminate knowledge related to the development of medical science, pharmacy, and public health. CDK covers the disciplines of medicine, pharmacy, and health with several types of articles, namely: 1. Research 2. Literature review 3. Case report 4. Evidence-based case report (EBCR), systematic review 5. Other scientific articles Based on the SK Kemendikbudristek Nomor 152/E/KPT/2023, CDK has obtained Rank 4 (SINTA 4) for Scientific Journals.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 1,276 Documents
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Potensi Sekretom Mesenchymal Stem Cell untuk Terapi Regeratif Penyakit Paru Fibrosis Kartika, Ronald; Timotius, Kris Herawan
Cermin Dunia Kedokteran Vol 51 No 11 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i11.1270

Abstract

Mesenchymal stem cells (MSC) associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic, and anti-fibrotic properties offers a novel therapeutic approach for fibrosis lung disease. Such therapeutic effects may be attributed to the MSC-secretome, made from free soluble proteins and extracellular vesicles (EVs). This review summarizes some literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome as a high-quality, safe, and effectivemedicinal product.
Gejala Akut Abdomen Terselubung pada Pasien Gagal Jantung Akut: Identifikasi Awal dengan Ultrasonografi Darurat: Laporan Kasus Nugroho, Hari Adityo; Prasetyadjati, Ari; Johan, Willy
Cermin Dunia Kedokteran Vol 52 No 4 (2025): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i4.1274

Abstract

Background: The use of USG (ultrasonography) in the ED (emergency department) has grown rapidly to aid decisions on management. Case: A 71-year-old woman with a history of heart disease, in shock condition, fever for 2 days, and diarrhea was referred with diagnosis of cardiogenic shock. On physical examination there were no signs of an acute abdomen, with suspicion of sepsis. Chest x-ray and urine examination did not find signs of infection. During treatment, consciousness and vital signs worsened; abdominal ultrasound showed signs of acute abdomen which was confirmed by 2-position abdominal x-ray. Discussion: In this case, the final diagnosis was septic shock with cardiogenic shock due to secondary peritonitis due to perforated viscous organ and electrolyte imbalance (mild hyponatremia and hypochloremia), altered mental state and geriatric problem. Surgery was not possible due to the patient’s condition. The patient succumbed on the 2nd day of treatment. Conclusion: Bedside ultrasound examination helps to establish an earlier diagnosis in patients especially with atypical symptoms and may be the key to providing better medical decisions in the ED.
Manifestasi Kelainan Paru pada Lupus Eritematosus Sistemik: Tinjauan Pustaka Apriance, Yessi; Kurniati, Roza; Fauzar
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1277

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a very dynamic course and various clinical manifestations. With respiratory tract involvement in 50%-70% of patients, pulmonary disorders are one of the causes of the high morbidity and mortality in SLE patients. The high mortality in SLE patients with pulmonary disorders contribute to patients' survival with a hazard ratio of 3.13. This article discusses the manifestations of pulmonary disorders in SLE patients.
Dari CLE ke SLE: Laporan Kasus dari Rumah Sakit Setempat: Laporan Kasus Kelvin; Rianto, Louis; Wijayadi, Linda Julianti
Cermin Dunia Kedokteran Vol 52 No 6 (2025): Kesehatan Jiwa
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i6.1281

Abstract

Introduction: Lupus erythematosus (LE) is a combination of various interrelating autoimmune clinical diseases. Cutaneous lupus erythematosus (CLE) is a spectrum of typical autoimmune skin features of systemic lupus erythematosus (SLE). A good recognition of the typical appearance of this skin lesion (CLE) enables diagnosis and good management of SLE. Case: A 26-year-old female with SLE with acute skin lessions (ACLE) skin lesions. Suspicion of SLE became stronger when the antinuclear antibody (ANA) titer reached 1:3,200. The main therapy is methylprednisolone injection followed by a gradual dose reduction. The patient was treated for 6 days in hospital and all lesions improved. Conclusion: The patient in this case had SLE with 6 clinical domains in the EULAR/ACR 2019 criteria and a total score of 34 (>10). Earlier and more accurate diagnosis of SLE can make therapy more effective, especially if CLE is already present.
LGR-5 sebagai Biomarker pada Kanker Kolorektal: Tinjauan Sistematis Fitur Klinikopatologis dan Nilai Prognostik: Analisis Asaduddin, Aiman Hilmi; Farhania, Roisya Nur; Imani, Namira Putri; Pramaesti, Cindy Ayudia; Sari, Andayani Yuwana
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1282

Abstract

Colorectal cancer (CRC) had the third highest cancer incidence worldwide. Recent researches are targeting specific gene expression as CRC marker. Leucine rich repeat-containing G-protein coupled receptor 5 (LGR5) is one of the genes that regulate tumor metastasis and growth. The aim of this study is to explain the correlation between LGR5, clinical pathology, and prognosis of CRC. This systematic review was arranged using PRISMA for eligible cohort studies and evaluated using Newcastle-Ottawa scale. From 63 articles, 6 articles were selected as eligible articles for data extraction and evaluation. Based on the studies, LGR5 positivity was positively associated with histopathological characteristics, TNM staging, and vascular invasion. Besides, LGR5 expressions in those studies were high and could be positively detected by this marker. LGR5 regulates Wnt/β-catenin signaling pathway promotion in normal colon stem cell. Methylation of Wnt target gene promoter is potent predictor to CRC recurrence thus the expression of LGR5 can be used as CRC marker. LGR5 plays a role as pro-oncogenic factor in colorectal carcinogenesis via prostaglandin E2 and Epidermal Growth Factor signaling. LGR5 induction also could increase cancer cells chemoresistant ability. Thus, LGR5 could determine prognosis of CRC patient and were related to certain clinicopathological features and tumor progressions.
Analisis Perbedaan Mutu Pelayanan Kesehatan Rawat Jalan Berdasarkan Status Akreditasi dengan Metode Service Quality: Hasil Penelitian Hartati, Selvi; Fitriangga, Agus; Raharjo, Widi
Cermin Dunia Kedokteran Vol 51 No 11 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i11.1284

Abstract

Background: To ensure the universal availability of high-quality health care services, the reform of health systems tried not only to improve the coverage of health care but also the overall quality of health care services. Strategies to improve the quality of health care services include the development of a national accreditation system. This study aims to find out the differences in the quality of outpatient health services based on accreditation status. Methods: The study used a cross-sectional design. The population were all outpatients visiting the GS and the KB community health center with inclusion and exclusion criteria. The sample was selected by accidental sampling. Bivariate analysis using the Mann Whitney U test. Results: A significant difference in empathy (p <0.05), but no significant difference in tangibles, reliability, responsiveness, or assurance (p > 0.05). Conclusion: A significant difference in the quality of outpatient health services in ‘paripurna’ (GS) and ‘utama’ (KB) accredited community health centers is only in the quality of empathy.
Hubungan antara Stres Akademik dan Dukungan Sosial Orang Tua dengan Prestasi Akademik Mahasiswa Fakultas Kedokteran Universitas Tanjungpura Angkatan 2020: Hasil Penelitian Sintan, Teofilus; Ita Armyanti; Tejoyuwono, Agustina Arundina Triharja
Cermin Dunia Kedokteran Vol 52 No 6 (2025): Kesehatan Jiwa
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i6.1288

Abstract

Introduction: First-year medical faculty students are one of the populations that often experience academic stress. Academic stress can affect academic achievement. Parents’ social support will make their children able to undergo lectures and show good academic achievement. This research aims to determine the relationship between academic stress and parents’ social support on academic achievement among Medicine Faculty students, Tanjungpura University batch 2020. Methods: A cross-sectional observational analytical study. There search population was Medicine Faculty students, Tanjungpura University batch 2020. The research sample was 239 people, chosen by simple random sampling technique. Data was obtained from filling in personal data, student academic stress scale (SASS) questionnaire, parents’ social support questionnaire, and cumulative grade point average. Bivariate analysis used the Spearman correlation test. Results: The result of the correlation test for academic stress and academic achievement was p=0,146; r=0,094; and the correlation test for parents’ social support and academic achievement was p=0,016; r=0,156. Conclusion: There is an insignificant positive relationship between academic stress and academic achievement and a significant positive relationship between parents’ social support and academic achievement.
N-butylphthalide: Neuroprotektor untuk Stroke Iskemik Clement, Lyon
Cermin Dunia Kedokteran Vol 52 No 1 (2025): Obstetri & Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i1.1290

Abstract

Stroke, especially ischemic stroke, is still one of the most prioritized health problems in Indonesia with an enormous burden and cost. The main strategy to treat ischemic stroke, which is reperfusion therapy by thrombolytic therapy or thrombectomy, has various challenges in its practices, especially regarding the recommended time window due to facility and infrastructure limitations. N-butylphthalide (NBP) is a neuroprotector with the potential ability to improve cerebral microcirculation, protect the blood-brain barrier, protect neurons from apoptosis, induce neurogenesis, and maintain neuron survivability in the condition of ischemic stroke based on preclinical studies. Clinically, NBP showed benefits mainly in improving post-stroke disability. NBP is a promising neuroprotector for better clinical outcomes.
Hubungan Perilaku Konsumsi Makanan Cepat Saji terhadap Tingkat Keparahan Akne Vulgaris pada Mahasiswa Laki-Laki: Hasil Penelitian Santosa, Mariani; Anastasia, Cindy; Lonah; Yuliana; Yantho, Erwin; Budiyanti, Ecie
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1291

Abstract

Introduction: Acne vulgaris has the highest prevalent skin disease in the world, with food is one of the most common triggers in adolescents. Availability of fast food has influenced young adults eating pattern. This study aims to determine the relationship between frequency of fast food consumption and severity of acne vulgaris in male students. Methods: This cross-sectional study was conducted on 129 male students. Frequency of fast food consumption and severity of acne vulgaris was measured using a modified FFQ questionnaire and GAGS score. Data were processed with STATA and analyzed using Chi-square. Results: The result showed that 65.89% male students often consumed fast food and the majority of respondents experienced mild acne vulgaris (55.81%). There was a significant relationship between frequency of fast food consumption and severity of acne vulgaris (p=0.020). Conclusion: The results of this study suggest a significant relationship between frequency of fast food consumption and severity of acne vulgaris among male students.
Pengaruh ASI Eksklusif, Berat Badan Lahir Rendah, dan Tinggi Badan Ibu terhadap Kejadian Stunting pada Anak di Bawah Usia 2 Tahun di Kabupaten Tapin, Indonesia: Hasil Penelitian Riza, Ade
Cermin Dunia Kedokteran Vol 52 No 1 (2025): Obstetri & Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i1.1292

Abstract

Background: Stunting affects intergenerational linear growth; short mothers are preceded by stunted childhood and will give birth to babies with low birth weight (LBW). Exclusive breastfeeding is known as one of the factors to prevent stunting. This study was conducted to see the effect of exclusive breastfeeding, history of low birth weight, and mother’s height on the incidence of stunting among below-two-year-old children in Tapin district. Method: Cross-sectional with a bivariate Chi-Square analysis test with odds ratio to assess the risk. Result: The results showed that the incidence of stunting was associated with the mother’s height (p=0.002, OR 8.325, 95% CI 2.117–32.741). Exclusive breastfeeding and low birth weight were not associated with the incidence of stunting (p=0.751, OR 1.303, 95%CI 0.454-3.738 for exclusive breastfeeding and p=0.201, OR 2.222, 95%CI 0.849–5.818 for LBW). Conclusion: Mother’s height affects the incidence of stunting in below-two-year-old children in Tapin district. 

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