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Journal Health of Indonesian
Published by Paspama Institute
ISSN : -     EISSN : 29870313     DOI : https://doi.org/10.54209
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health
Journal Health of Indonesian: Journal Health is a peer reviewed and open access journal. The journal facilitates authors to publish scholarly articles in the field of health and provides open access to the public to read abstracts and full papers.Health Care: Health Journal covers all areas of health including nursing, midwifery and public health and accepts original articles, case reports and review articles. Articles submitted to the journal will be screened by the editors and decide whether the article will be sent to reviewers or not.
Arjuna Subject : Umum - Umum
Articles 31 Documents
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The Impact of Climate Change on Area-Based Disease Management Sipra Barutu
Journal Health of Indonesian Vol. 3 No. 01 (2025): Journal Health of Indonesian, January 2025
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v3i01.107

Abstract

Climate change has become one of the major challenges in area-based disease management. This article investigates the impact of climate change on the dynamics and strategies of area-based disease management. We use historical climate data and climate change models to analyze its impact on disease spread, and explore adaptation and mitigation that can be applied in the context of area-based disease management. The results of this study indicate that climate change has affected the geographical distribution of diseases, seasonality of spread, and prevalence rates. In addition, this article also provides insights into strategic steps that can be taken to strengthen area-based disease management in the face of climate change challenges.
Biorhythm Analysis Of The Analgesic Effect Of Paracetamol In Inpatients With COVID-19 At The Hospital Yuneka Saristiana; Fendy Prasetyawan; Adiyansyah Lukman Hakim; Althaf Rajahala B Sinun; Deo Rudita Febrian Waly
Journal Health of Indonesian Vol. 2 No. 01 (2024): Journal Health of Indonesian, january 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i01.109

Abstract

The global COVID-19 pandemic has posed unprecedented challenges to global health, impacting healthcare institutions worldwide. Dr. Soedomo Regional General Hospital in Trenggalek has been actively involved in treating COVID-19 patients, emphasizing the need for improved care standards and effective symptom management. Paracetamol, a commonly used medication, is a key focus in this endeavor. This study investigates the chronopharmacology of paracetamol in COVID-19 patients, emphasizing the importance of timing in therapeutic interventions. The research, conducted at Dr. Soedomo Regional General Hospital, involves 100 COVID-19 patients undergoing paracetamol therapy. The analysis includes demographic data, paracetamol administration at different times, and the resulting body temperature changes. The findings reveal that the body's response to paracetamol varies significantly depending on the time of administration. Notably, at 4:00 PM, a more pronounced decrease in body temperature is observed, suggesting a heightened effectiveness of therapy. This phenomenon is attributed to the body's circadian rhythm, influencing physiological functions over a 24-hour period. This study lays the groundwork for the "right time, right dose" concept in clinical practice. Considering the circadian rhythm is essential in designing personalized and effective treatment protocols, aiming for optimal outcomes. Despite limitations, including a small sample size, this research provides valuable insights into the circadian aspects of drug efficacy, paving the way for more tailored treatment approaches.
Descriptive Analysis the Analgesic Activity of Chloroform Fraction from Acorus Calamus L. Leaf Extract on Male White Mice (Mus Musculus) Induced by Acetic Acid Fendy Prasetyawan; Yuneka Saristiana; Ibrahim Fadlannul Haq; Ibrahim Irsyadul Ibad; Ibrahim Iskandar Alfaris
Journal Health of Indonesian Vol. 2 No. 01 (2024): Journal Health of Indonesian, january 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i01.110

Abstract

Pain management is a critical aspect of pharmaceutical research, and Acorus calamus L., commonly known as jeringau, has garnered attention for its potential analgesic properties. This study focuses on evaluating the analgesic activity of the chloroform fraction from ethanol extract of jeringau leaves (Acorus calamus L.) on male white mice induced by acetic acid. Chronic and acute pain significantly impacts individuals' quality of life, emphasizing the need for effective and safe analgesic alternatives. While Acorus calamus leaf extract has shown pharmacological potential, especially the chloroform fraction, a dedicated investigation into its analgesic effects on animal models is lacking. Male white mice, recognized for their reproducible and measurable responses to painful stimuli, serve as relevant subjects in this study. The population of 25 mice, aged 2-3 months and weighing 20-30 grams, is divided into 5 treatment groups, including negative and positive controls. The study employs three dosages of the chloroform fraction, administered orally, with observations made on writhing behavior following intraperitoneal injection of 0.5% acetic acid. Statistical analysis will evaluate significant differences between treatment groups, providing insights into the analgesic potential. Results indicate that Dosage III (44.8 mg/40g BW) exhibits the highest analgesic efficacy at 73.99%, showcasing a dose-dependent response. The mechanism involves flavonoids inhibiting the cyclooxygenase enzyme, aligning with established analgesic actions. Ibuprofen, the positive control, and jeringau leaf extract demonstrate analgesic effects, reinforcing traditional knowledge. This research contributes to scientific understanding, establishing a foundation for further exploration.
Optimizing COVID-19 Therapy: Analysis of Prescription Profiles in Non-Comorbid Inpatients to Enhance Treatment Strategies and Clinical Outcomes Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Ilhawa Zahra
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study explores the clinical characteristics, treatment patterns, and outcomes of COVID-19 inpatients without comorbidities, aiming to contribute valuable insights to the management of the disease. Through meticulous data collection from medical records of 468 confirmed COVID-19 patients admitted to Gambiran Regional General Hospital between April and June 2020, 36 patients meeting inclusion criteria were identified. The research findings reveal a higher incidence of COVID-19 among males and a prevalent age group of 31-40 years. Notably, elderly individuals and those with underlying health conditions face a greater risk of severe outcomes, underscoring the importance of tailored interventions for vulnerable populations. The study highlights a diverse treatment approach, with a significant proportion of patients receiving supplements to bolster immune function. Antiviral medications like Favipiravir are also utilized to inhibit viral replication, although definitive treatment for COVID-19 remains elusive. Antibiotics play a crucial role in preventing bacterial respiratory infections, while supportive medications help alleviate symptoms commonly associated with the disease. Importantly, the findings emphasize the multifaceted nature of COVID-19 management and the need for targeted interventions to optimize patient outcomes. By elucidating the therapeutic landscape and clinical course of COVID-19 inpatients without comorbidities, this study contributes to the growing body of knowledge surrounding the disease. These insights can inform clinical decision-making, resource allocation, and public health strategies aimed at combating the ongoing pandemic.
Assessment of the Effectiveness of Centella asiatica Ethanol Extract in Alleviating Diarrhea in Castor Oil-Induced White Mice: A Pharmacological Approach Yuneka Sarisitiana; Fendy Prasetyawan; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Ivan Junius Mesak
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

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Abstract

This study investigated the potential anti-diarrheal effects of ethanol extract from Centella asiatica leaves using a castor oil-induced diarrhea model in mice. The extract, obtained from Centella asiatica leaves, was administered orally to mice at various doses. Parameters including the frequency, duration, and onset of diarrhea were measured and compared with control groups. Results indicated a dose-dependent reduction in diarrhea frequency and duration in treated mice. Higher doses of Centella asiatica ethanol leaf extract demonstrated efficacy comparable to loperamide, a standard anti-diarrheal drug. Histopathological analysis further revealed protective effects on intestinal tissue integrity, suggesting a potential mechanism of action for the observed anti-diarrheal activity. These findings underscore the potential of Centella asiatica ethanol leaf extract as a natural alternative for managing diarrhea. The study contributes to the growing body of evidence supporting the traditional use of Centella asiatica in folk medicine for gastrointestinal ailments. However, further research is warranted to elucidate the underlying mechanisms of action responsible for its anti-diarrheal effects and to conduct clinical trials for human validation. In conclusion, this research highlights the significance of exploring natural remedies derived from medicinal plants like Centella asiatica for combating gastrointestinal disorders. The study underscores the potential of Centella asiatica ethanol leaf extract as a therapeutic agent for managing diarrhea and improving public health outcomes.
Unveiling the Mysteries of Pharmacoreincarnation: A Study on the Spiritual and Metaphysical Dimensions of Using Psychoactive Drugs for Accessing Past Life Memories Fendy Prasetyawan; Nanda Ardianto; Yuneka Saristiana; Wahyu Ariawan; Faisal Akhmal Muslikh; Yunita Dian Permatasari
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research delves into the multifaceted realm of psychoactive drugs, spirituality, and the exploration of past life memories, known as "pharmacoreincarnation." Psychoactive substances like psilocybin, LSD, and DMT have gained attention for their profound alterations in consciousness and subjective experiences, often described as mystical or spiritual. Belief in reincarnation persists globally, fueled by anecdotal testimonials and cultural traditions. The study aims to explore pharmacoreincarnation through a comprehensive literature review and interdisciplinary perspective. Academic databases such as PubMed, PsycINFO, Scopus, and Google Scholar will be utilized to access relevant articles published in English within the last two decades. Thematic analysis will identify recurring themes and patterns across the literature, synthesizing findings to develop a coherent understanding of pharmacoreincarnation. The methodology involves systematic literature search, screening, and review processes to extract pertinent information aligned with the research objective. The synthesized findings will be organized into logical sections within the literature review, ensuring clarity and rigor. Peer review and revision will validate the quality and accuracy of the review before finalization. The study anticipates contributing significantly to knowledge on pharmacoreincarnation and its implications for consciousness studies, spirituality, and therapeutic practices. By embracing an interdisciplinary approach, it aims to unravel the underlying mechanisms of such experiences and their broader implications for personal identity and reality.
Patterns of Antihypertensive Medication Utilization Among Hypertensive Patients: A Review of Single-Therapy Practices in Outpatient Primary Healthcare Centers Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Chandra Arifin; Abd Rofiq; Elsa Mahardika Putri; Anis Akhwan Dhafin
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.115

Abstract

Hypertension, often referred to as "The Silent Disease," presents a significant global health challenge due to its asymptomatic nature and association with severe cardiovascular complications. Effective management of hypertension primarily relies on the administration of antihypertensive drugs, either as monotherapy or combination therapy. This study investigates the utilization patterns of single antihypertensive drugs among hypertensive patients in the outpatient setting of Puskesmas "X" in Solo City. Utilizing a retrospective approach, data from patient medical records were analyzed to examine drug usage patterns and patient responses to therapy. Results revealed a noteworthy preference for combination therapy, with approximately 64.18% of patients opting for this approach. Combination therapy strategies were favored due to their additive and synergistic effects, potential for reducing side effects, and enhanced blood pressure control. Specifically, amlodipine from the calcium channel blocker (CCB) group emerged as the most commonly prescribed single antihypertensive drug, while the combination of amlodipine with candesartan from the angiotensin receptor blocker (ARB) group was the predominant combination therapy. These findings align with previous research, emphasizing the significance of combination therapies in hypertension management..
Chronopharmacological Insights: Enhancing Acetaminophen Administration Timing for Inpatient COVID-19 Management Fendy Prasetyawan; Yuneka Saristiana; Anis Akwan Dhafin; Okky Intan Mawarni; Asrizal Azis; Ema Tri Wulan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.116

Abstract

The global COVID-19 pandemic has posed unprecedented challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek, which is involved in the management of COVID-19 patients, has witnessed a long journey in responding to and treating individuals infected with the SARS-CoV-2 virus. The use of acetaminophen has been a primary focus in efforts to improve standards of care and understanding symptom management in COVID-19 patients. Chronopharmacological analysis of acetaminophen use in COVID-19 patients at Dr. Soedomo Hospital aims to provide insight into how the timing of drug administration can affect therapeutic responses. There is evidence that the body's circadian rhythm can influence the metabolism and pharmacological effects of drugs, but this perspective has not been fully explored in the context of COVID-19. This study involved an analytical observational approach with a Cross-Sectional design and retrospective data collection method from the medical records of COVID-19 patients treated at Dr. Soedomo Regional Hospital in Trenggalek District. The results of the study showed that acetaminophen therapy at 16.00 WIB resulted in a more significant reduction in body temperature compared to other times. A deeper understanding of the body's circadian rhythm can help optimize the benefits of therapy and reduce potential side effects. Although there are limitations to this study, these results provide a basis for the development of more targeted and personalized treatment strategies. The clinical implications of this research can help in determining the optimal timing for administering therapy to achieve desired effects in COVID-19 patients.
Strategizing Antiviral Medication Usage for Chronic Kidney Disease Patients with SARS-CoV-2: Insights from Inpatient Pharmacy Practices at Hospital Settings Yuneka Saristiana; Leny Witaning Kusumati; Neni Probosiwi; Tsamrotul Ilmi; Nur Fahma Laili; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.120

Abstract

The emergence of the SARS-CoV-2 virus in 2020 led to the onset of the COVID-19 pandemic, posing significant challenges globally. As of December 19, 2021, the worldwide confirmed cases surpassed 273 million, with a devastating death toll exceeding 5.3 million. Indonesia reported its first case on March 2, 2020, and has since faced escalating numbers, necessitating urgent attention.Chronic kidney disease (CKD) has emerged as a commonly occurring comorbidity among COVID-19 patients, drawing attention due to the vulnerability of CKD patients to medical complications. Understanding the use of antiviral drugs in CKD patients with COVID-19 is essential, considering the risks of drug toxicity and interactions. This study aims to investigate the frequency of antiviral drug usage in COVID-19 patients with CKD, providing insights into treatment strategies and guiding medical practitioners. Conducted at Dr. Soedomo Trenggalek Regional Hospital, the research utilizes a cross-sectional, non-experimental design and purposive sampling method. Data collection involves patients' medical records, focusing on demographics, antiviral drug usage, disease severity, treatment duration, mortality rates, and potential side effects. The demographic analysis reveals that the majority of COVID-19 patients with CKD are aged 50 and above, with males comprising 74% of the cohort. Age and gender influence disease severity, with older individuals and males at higher risk. Antiviral drug usage predominantly includes favipiravir (64%) and remdesivir (36%), underscoring their importance in treatment protocols. Decisions regarding antiviral therapy in CKD patients with COVID-19 require careful consideration of benefits, risks, and patient characteristics.
Type II Diabetes Mellitus And Anti-Diabetic Therapy Patterns In Hospital X, Central Java Okky Intan Mawarni; Anak Agung Indah Krisnadewi; Elsa Mahardika Putri; Anis Akhwan Dhafin; Fendy Prasetyawan
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.121

Abstract

Type 2 DM can be a risk factor for arteriosclerotic cardiovascular disease complications (coronary heart disease, stroke, and peripheral arterial disease), heart failure, chronic renal failure, and cardiovascular risk. This cross-sectional study was conducted on 100 type 2 diabetic patients who were prescribed anti-diabetic therapy. The prescription pattern was analyzed and adherence to treatment guidelines was done by comparing with the 2021 PERKENI guidelines. The results of the distribution of the characteristics of T2DM respondents at X Hospital 2022 were mostly aged> 45 years as much as 87%, the most gender was male as much as 54%, the most comorbidities were 97% of respondents, the most treatment pattern was monotherapy as much as 64%, the highest number of drugs received by patients was 81% with criteria> 5 drugs.

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