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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Characteristics of Aphasia in Ischemic Stroke Patients at a National Brain Center in Indonesia Danardhono, Rasya Hapsari; Saleh, Arman Yurisaldi; Theresa, Ria Maria; Astari, Riezky Valentina
Folia Medica Indonesiana Vol. 59, No. 4
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Highlights: 1. This study was the first study identifying the characteristics of aphasia among ischemic stroke patients during COVID-19 pandemic at a national brain center in Indonesia. 2. This study provides additional data for future studies to conduct a comparison between the pre- and post-pandemic incidence of aphasia. Abstract Different types of aphasia may occur due to lesions in various brain regions following ischemic strokes. Global aphasia was the most prevalent type of aphasia before the COVID-19 pandemic. However, stroke incidence and mortality rose during the pandemic. This study aimed to identify the types, clinical and radiological features, and management of aphasia in ischemic stroke cases during the pandemic. This study was a descriptive study with a cross-sectional design. The total sampling technique was used for the sampling process. The research samples were ischemic stroke subjects with aphasia who were diagnosed between January 1 and December 31, 2021, at the National Brain Center Prof. Dr. dr. Mahar Mardjono Hospital, Jakarta, Indonesia. The statistical analysis was performed using IBM SPSS Statistics for Mac, Version 25.0 (IBM Corp., Armonk, N.Y., USA). The results of this study showed that 162 aphasic subjects had suffered from ischemic strokes. The age range of the subjects was 34–87 years old. The majority of the subjects were male (59.9%) and aged 55–65 years (37.0%). The three most common risk factors were hypertension (90.1%), diabetes mellitus (50.0%), and dyslipidemia (75.9%). Motor aphasia (33.3%) and global aphasia (43.8%) were the most prevalent types of aphasia among the subjects. The parietal lobe was the main location of the causative lesions, as demonstrated by 38 global aphasic subjects and 47 motor aphasic subjects. The therapies administered to the subjects consisted of speech therapy (85.2%), antiplatelet therapy (98.1%), anticoagulants (19.1%), recombinant tissue plasminogen activator (rTPA) (1.2%), and neuroprotectors (3.0%). This study concluded that global aphasia was the most common type of aphasia among ischemic stroke patients during the pandemic, with the parietal lobe as the primary location of the causative lesions.
Clinicopathological Analysis of Postmenopausal Bleeding and Endometrium Hota, Basanta Manjari; Bakshi, Kavitha; Lokam, Geetha; Movva, Naimisha
Folia Medica Indonesiana Vol. 60, No. 1
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Highlights: 1. Malignancies in postmenopausal bleeding are not very common, yet it is necessary to evaluate the etiology and implement appropriate treatment strategies. 2. The findings of this study highlight the need for early detection of benign, premalignant, or malignant cases to provide more effective management, prevent the development of cancer, and improve the prognosis of the condition. Abstract Bleeding from the genital organ after a year of menopause is called postmenopausal bleeding. The causes may be either benign or malignant, originating from genital (uterine or extrauterine) and extragenital sites. About 3% of postmenopausal women suffer from uterine cancer. This present study aimed to analyze the clinical significance of postmenopausal bleeding concerning the source, associated risk factors, and various endometrial pathologies, including malignant and premalignant conditions. This retrospective study was conducted over four years and featured postmenopausal bleeding patients who met the inclusion criteria. Different causes of bleeding were noted and managed. Data collection on the history, clinical examination, blood test, and endometrial biopsy was performed on women with endometrial bleeding. The collected data were analyzed using standard descriptive statistics and presented using frequency tables. A total of 88 women were admitted, of whom 73 (82.95%) had endometrial bleeding and 15 (17.05%) experienced bleeding from other sites. The endometrial bleeding group mostly consisted of women aged >50–60 years (45.20%). Hypertension (26.03%), diabetes (21.91%), obesity (43.83%), and nulliparous (5.48%) were the risk factors present among the patients. The majority of the patients (41.10%) were within five years of menopause. The transvaginal ultrasound findings indicated that 56.16% of the women had an endometrial thickness of >10 mm, while 9.59% had an endometrial thickness of ≤4 mm. Upon histological investigation, endometrial hyperplasia (34.24%), atrophy (38.36%), and cancer (4.11%) were detected. Furthermore, a prevalence of 16.44% was identified as proliferative endometrium, whereas polyps were found in 6.84% of cases. In conclusion, postmenopausal bleeding is mostly benign, but it may raise concerns about the possibility of malignancy, which can be distressing for women. Disregarding the amount and frequency, postmenopausal bleeding requires a thorough evaluation, primarily because adequate management can prevent the progression of many premalignant cases to be endometrial cancer.
Physical Condition Comparison between Female Athlete Indoor Hockey of East Java Team and National Team Oemar, Fitry Nachamory; Subagio, Irmantara; Setiawan, Hayuris Kinandita; Rejeki, Purwo Sri
Folia Medica Indonesiana Vol. 57, No. 1
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ABSTRACT The purpose of this research is to describe the physical condition differences between female athletes indoor hockey of East Java Team and National Team. Data sampling is taken from 12 female athletes indoor hockey of PON 2016 with age range 17-28 years old and 12 athletes of indoor hockey of Indonesia's National Team at SEA Games 2017 with age range 19-28 years old for comparison. Physical condition that measured is VO2max to represent endurance, abdominal muscle strength, speed and flexibility. Obtained data is then analyzed using SPSS. VO2max of East Java Team is (39.54±4.18) ml/kg/minute and for National Team is (43.43±7.59) ml/kg/minute (ρ=0.14). For abdominal muscle strength, East Java Team has (41.50±7.01) kg and National Team has (51.83±3.32) kg (ρ=0.00). For Speed, East Java Team has (3.59±0.30) second and National Team has (3.94±0.38) second (ρ=0.51). For Flexibility, East Java Team has (23.75±5.10) cm and National Team has (29.50±4.91) cm (ρ=0.01). From these data we can conclude that East Java Team physical condition is under National Team and it has significant differences at flexibility and abdominal muscle strength. Furthermore, optimal interventions are needed to improve both of those physical conditions. Keywords: hockey, endurance, flexibility, strength, speed
Local Mapping Profile of Mitochondrial DNA (MtDNA)-Loop in Forensic Identification Yudianto, Ahmad; Margaret, Nola
Folia Medica Indonesiana Vol. 54, No. 3
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To prove that mitochondrial DNA damage is not total or partial, as has been found in the preliminary study, studies need to be done to determine the opportunity of successful use of the mitochondrial DNA mini-primer set in an amplicon product below 250 bp. This is important because it can overcome quality problems in degraded DNA, which will complicate the process of DNA forensic identification. This was an observational analytic study with cross sectional design. The study material was DNA from blood and sweat stains taken from abandoned bodies. Samples consisted of 24 pieces of blood and sweat spots. The measurements of mean DNA levels and sample purity used UV-Visible Spectrophotometer, revealing mean DNA in blood samples of 152.89 ± 85.71 µg/ml and sweat samples of 89.19 ± 5.58 µg/ml, and sample purity of DNA and sweat were 1.89 ± 0.71 and 1.69 ± 0.76. Whereas, the result of D-Loop mtDNA: D-Loop I 143bp nt: 16268 -16410 and D-Loop HVS II 126bp nt: 34 -159, indicating blood spots were detected positively >95% and sweat was detected positively in 5%-20%. Results of DNA sequencing from mtDNA of blood spots and sweat spots in 126 bp and 143 bp amplicon revealed nucleotide damage marked with the letter 'N'. In conclusion, mini-primers of mitochondrial DNA in the amplification product mtDNA D-Loop HVS II 126 bp (nt 59-134) and D-Loop HVS I 143 bp (nt 16268- 16410) were effectively used as support for DNA profiling in forensic medicine.
Effect of body mass index (bmi) on mortality and readmission of heart failure patients in cardiovascular outpatient care unit at dr. Soetomo hospital, surabaya Lestari, Sella Rizkita; Andrianto, Andrianto; Nugroho, J
Folia Medica Indonesiana Vol. 52, No. 1
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Obesity is one of risk factors for heart failure in both men and women. Paradoxically, recent studies have shown that high BMIs in heart failure patients were asssociated with better outcomes. This study was aimed to prove the effect of body mass index on mortality and readmission in heart failure patients in cardiovascular outpatient care unit at Dr. Soetomo Surabaya Hospital. The research design was observational analytical study. Subjects consisted of all patients with heart disease in cardiovascular outpatient care unit at Dr. Soetomo Surabaya Hospital that meet the inclusion and exclusion criteria. Through the purposive sampling, 59 patients diagnosed with heart failure were selected. Direct measurements of body weight and height were conducted in February through March 2014 to calculate the BMIs. Based on their BMIs, subjects were then placed into two categories, which were patients with normal and elevated BMIs. Information on deaths and readmissions were gathered in October 2014. The relationship between two variables were then analyzed using Fisher Exact Test. After 8 months of follow up, 5 people (8.5%) died of cardiovascular cause and 7 (11.9%) were re-admitted to the hospital. Among 28 patients with normal BMIs, 3 (10.7%) died and 3 (10.7%) were re-admitted. Among 31 patients with elevated BMIs, 2 (6.5%) died and 4 (12.9%) were re-admitted to the hospital. By using Fisher Exact Test, it was shown that there is no effect of BMI on mortality (p=0.661) and readmission (p=1.000) in heart failure patients.
Hemoglobin A1c (Hba1c) is Strongly Correlated with Mean Corpuscular Volume Among Type 2 Diabetes Mellitus (T2dm) Patients Admitted in a Tertiary Hospital in East Java, Indonesia Salim, Yusuf; Kalanjati, Viskasari P.; Prajitno, Jongky H.; Melbiarta, Rezy R.
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely. • MCV levels could mirror health indicator in adult T2DM patients. Abstract: HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312; p<0.001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.
Front Matter Vol. 56, No. 3 September (2020) Matter, Front
Folia Medica Indonesiana Vol. 56, No. 3
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Back Matter Vol.58 No.4 December 2022 Indonesiana, Folia Medica
Folia Medica Indonesiana Vol. 58, No. 4
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Back Matter Vol.58 No.4 December 2022
Case report: secondary laparoscopic assissted transanal endorectal pull-through. A pre-eliminary study Barmadisatrio, Barmadisatrio; Hariono, Hariono
Folia Medica Indonesiana Vol. 52, No. 1
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The definitive treatment for Hirschsprung's disease is pullthrough procedure, that can be done through conventional pullthrough approach or through minimal invasive approach. The benefit of minimal invasive technique compared to conventinal open procedure is shorter time to oral intake, shorter length of stay, and less postoperative pain. Secondary LATEP is a minimal invasive pull through technique in patients with preexisting colostomy. Primary pullthrough sometimes cannot be done because limitation of health facilities, uneven distribution of pediatric surgeons throughout the country and late diagnosis of Hirschsprung's Disease. In dr Soetomo Hospital Surabaya, 7 secondary LATEP procedures were done in January to August 2014. The age range was 6 months to 8 years old. All patients survived, 1 patient had stenosis of anastomotic site 2 weeks postoperative, 3 had enterocolitis, 3 with no complication. Secondary LATEP is a minimal invasive approach for Hirschsprung's Disease that can be adjusted with Indonesia's social and economic condition, where most population was distant from an adequate health facility. As there is high incidence of malnutrition, enterocolitis and also the distance from appropriate health services, stoma formation is the first thing that can be done before definitive treatment.Secondary LATEP has never been done in Indonesia, and we still need more data and research to evaluate the benefit and disadvantage of this approach compared to conventional or minimal invasive primary pull through. In conclusion, secondary LATEP is an appropriate pullthrough alternative for Hirschsprung's Disease and applicable in Indonesia, considering the social and economy condition. Further study must be done to develop this method.
The Effect of Methylmercury Exposure on Astrocyte of Cerebellar Cortex of White Rats (Rattus novergicus) Sugianto, Paulus; Pardede, Sabrina Melisa; Widjaja, Ngakan Made Rai; Widjiati, Widjiati
Folia Medica Indonesiana Vol. 55, No. 2
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The aim of this research was to investigate the effect of different dose methylmercury (II) chloride on astrocyte in cerebellar cortex of white rat (Rattus norvegicus) exposed. This study used randomized control design using 15 adult female Wistar rats weight 180-200 g of body weight. Before treatment the white rats was adapted in a week, then randomly divided into 3 groups each consist of 5 rats. P0 as control were given 0.5 ml aquades, P1 and P2 were given 0.1 and 0.2 mg/kg/day respectively. All groups were given treatment per oral in 30 days with sonde. The data was analyzed by ANOVA, Duncan's multiple range (Duncan's Multiple Range Test). White rats exposed by methylmercury (II) chloride, had a significant differences in the percentage of necrotic astrocyte (p<0.05). Methylmercury chloride exposure increases the number of necrotic astrocytes on white rat.

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