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INDONESIA
Indonesian Journal of Global Health Research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
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Articles 684 Documents
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The Effect of Combining Astaxanthin and Vitamin E on IL-1, IL-6, And CRP Levels Sampurna Sampurna; Rita Kartika Sari; Mutiara Hanif Syafitri; Nafla Aqilah; Saskia Febrian Dwi
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1419

Abstract

Carrageenan-induced inflammation binds to TLR-4, activating the NF-kβ pathway, which attracts macrophages to release proinflammatory cytokines, Interleukin-1 and Interleukin-6, leading to the production of CRP. Astaxanthin and vitamin E have anti-inflammatory effects, but their combined effects are poorly studied. This study examines whether astaxanthin combined with vitamin E reduces IL-6, IL-1, and CRP levels in male Wistar rats induced by carrageenan. This experiment used a post-test-only control-group design with groups: KN (standard feed), KS (1% carrageenan induction), and KP (combination of 0.72 mg/kgBW astaxanthin and 24.1 mg/kgBW vitamin E). ELISA was performed 24 hours after carrageenan induction. Parametric data analysis was performed, followed by a post hoc test. The results showed that IL-1 levels were highest in KS (1.61 pg/mL), followed by KP (0.42 pg/mL) and KN (0.28 pg/mL). Statistical analysis (one-way ANOVA and post hoc tests) identified significant differences among all groups (p<0.05). IL-6 levels decreased in KP (58.67 pg/mL) compared to KS (98.83 pg/mL). CRP levels were highest in KS (2.35 ng/mL), followed by KP (1.01 ng/mL) and KN (0.75 ng/mL), with KS showing a significant increase compared to KN (p<0.05). From these results, it can be concluded that the combination of astaxanthin and vitamin E has an anti-inflammatory effect on IL-6, IL-1, and CRP levels in male Wistar rats induced by carrageenan.
Chronic Infection Contributes to the Risk of Limb Amputation in Patients with Diabetic Ulcers: A Literature Review Wenny Anugraini; Fitri Arofiati; Yanuar Primanda
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1421

Abstract

Diabetic foot ulcers are a chronic complication of diabetes mellitus that often leads to lower extremity amputation and significantly contributes to disability and mortality. Infections, particularly chronic and severe ones, play a significant role in accelerating ulcer progression to amputation, Nevertheless, the synthesis of scientific evidence regarding the contribution of chronic infections as a determinant of amputation is still limited. This literature review aimed to examine the role of chronic infection in the risk of amputation in patients with diabetic foot ulcers. A literature search was conducted on the Scopus, PubMed, and ScienceDirect databases for publications from 2015 to 2025 using keywords related to diabetes mellitus, diabetic foot ulcers, infection, and amputation. Articles were selected based on inclusion and exclusion criteria, 644 articles were identified. After title and abstract screening, followed by full-text review, and critical appraisal using the JBI tools, 10 selected journals were included in the literature synthesis.. The results indicated that moderate to severe infection, osteomyelitis, and pathogen characteristics, particularly Gram-negative and ESBL-producing bacteria, are the main determinants of major amputation. Peripheral artery disease, the severity of ulcers, increased inflammatory parameters, hypoalbuminemia, and certain patient factors also worsen clinical outcomes. It is concluded that chronic infection is a key determinant of amputation in diabetic foot ulcers, making early and aggressive infection prevention and control an essential strategy to reduce amputation rates.
Palliative Care in Patients with Kidney Failure: Bibliometric Analysis Dian Ratri; Erna Rochmawati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1422

Abstract

Palliative care for patients with kidney failure is increasingly recognized as an important approach to improving quality of life through symptom control, psychosocial and spiritual support, and strengthening shared decision-making, yet the global knowledge landscape remains fragmented and incompletely mapped. Mapping publication performance, geographic distribution of country contributions, and the dynamics of research themes related to palliative care in kidney failure patients through bibliometric analysis. A bibliometric study was conducted using the Scopus database spanning the last 10 years. The search strategy combined the keywords palliative care and kidney failure. From 4,730 initial findings, a gradual narrowing was performed to obtain 2,397 documents meeting the criteria, consisting of 1,974 research articles and 423 review articles. Descriptive analysis was used for annual publication trends and country contributions, while VOSviewer version 1.6.18 was used to map keyword co-occurrence, overlay maps, and density maps. Keyword mapping places demographic and clinical terms as central nodes, with primary clusters reflecting acute conditions and severity indicators including acute kidney injury and respiratory infectious complications, chronic kidney disease and dialysis therapy clusters linked to themes of palliative care, terminal care, quality of life, psychology, and conservative care, and geriatric clusters and service outcomes such as hospitalization, comorbidities, risk factors, length of stay, and mortality. The overlay map demonstrates a shift in themes from patient support and quality of life to a stronger focus on clinical outcomes, comorbidities, and infectious and respiratory contexts in the more recent period, while the density map highlights the largest hotspots in the elderly population and the kidney disorder theme networked with hospitalization outcomes.Palliative care research in patients with kidney failure is dominated by clinical themes and service outcomes, while patient-centered themes such as quality of life, psychology, and terminal and conservative care emerge as important but relatively less prominent. Strengthening studies measuring meaningful outcomes for patients and caregivers, standardizing terminology and reporting, and multicenter collaboration across countries are needed to reduce contextual bias and enhance global relevance.
Social Skills Training as a Psychosocial Intervention to Improve Social Functioning in Schizophrenia: A Literature Review Suhermi Suhermi; Amin Samiasih; Muhammad Fatkhul Mubin; Vivi Yosafianti; Ratih Sri Wardani
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.1423

Abstract

Social functioning is an individual's ability to interact adaptively, perform social roles, and engage in social activities in accordance with prevailing norms. In patients with schizophrenia, social functioning often declines due to cognitive, affective, and motivational impairments that accompany the course of the illness. This systematic review aims to evaluate the effectiveness of Social Skills Training interventions in improving various aspects of social functioning, including communication skills, social interaction, social roles, and participation in social activities. This review follows the PRISMA-2020 guidelines. A systematic search was conducted on the Scopus, PubMed, ProQuest, ScienceDirect, and EBSCO databases for English-language studies published between 2021 and 2025. A combination of keywords was used to form the search string, including “Social Skill Training” OR “SST” AND “Social functioning” OR “interpersonal functioning” OR “social performance” AND “Schizophrenia”. Boolean operators ‘AND’ and “OR” were used to narrow the resultsQuality assessment was conducted independently using the Joanna Briggs Institute (JBI) checklist. The synthesis of the five research articles analyzed showed that Social Skills Training (SST) had a positive impact on improving the social functioning of schizophrenia patients in various service contexts and patient characteristics. The studies reviewed consisted of two studies with a Randomized Controlled Trial (RCT) design and three quasi-experimental studies, with sample sizes varying from small to medium. All studies reported an increase in social functioning after the provision of SST intervention, either as a single intervention or in combination with standard therapy. Social Skills Training (SST) has been proven effective in improving the social functioning of schizophrenia patients, including communication skills, social interaction, social roles, and participation in social activities.
Nurse Management and Leadership Practices in Hospitals: A Systematic Review Ayu Trisnadewi; Elsye Maria Rosa
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1424

Abstract

Nurse management and leadership play a critical role in shaping nurses’ work environments, patient safety, and organizational performance in hospital settings. In recent years, there has been a growing shift from traditional hierarchical management toward more relational and clinically oriented leadership practices. However, empirical evidence regarding dominant leadership styles, associated outcomes, and remaining research gaps remains dispersed across the literature. This systematic review aimed to synthesize existing evidence on nurse management and leadership practices in hospital settings, with a focus on dominant leadership styles, reported outcomes, and identified research gaps. A systematic review was conducted following the PRISMA 2020 guidelines. Literature searches were performed in PubMed/MEDLINE, Scopus, and CINAHL databases. A total of 524 articles were initially identified. After removal of duplicates and screening of titles and abstracts, 45 articles were assessed for full-text eligibility. Ten studies met all inclusion criteria and were included in the final synthesis. Data were analyzed using a narrative thematic approach. The synthesis revealed three main themes. First, transformational leadership emerged as the most frequently examined leadership style in nurse management, with increasing attention to clinical leadership among bedside nurses. Second, leadership practices were associated with nurse-related outcomes (work engagement, reduced burnout, and job performance), patient-related outcomes (quality of care, patient safety, and satisfaction), and organizational outcomes (innovative work behavior and reduced counterproductive behaviors). Third, several research gaps were identified, including the predominance of cross-sectional designs, reliance on self-reported measures, limited multicultural perspectives, and insufficient evidence on the long-term impact of leadership during and after healthcare crises such as the COVID-19 pandemic. Evidence from this systematic review indicates that relational and transformational leadership practices are consistently associated with positive outcomes for nurses, patients, and healthcare organizations in hospital settings. Strengthening leadership development and advancing longitudinal and intervention-based research are essential to better understand causal mechanisms and support sustainable improvements in nursing management and leadership.
Risk Factors of Dental Caries in Primary School Children: A Systematic Literature Review Zita Aprillia; Mohammad Zen Rahfiludin; Henry Setyawan Susanto; Syamsulhuda Budi Mustofa
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1433

Abstract

Dental caries is a chronic infectious disease with a high prevalence in elementary school-aged children (6–12 years) globally. This condition is influenced by the complex interaction of various determinants of health. This study aims to identify and synthesize the dominant risk factors for the occurrence of dental caries in elementary school-age children based on the latest scientific evidence. Systematic review was conducted following the PRISMA 2020 guidelines. A comprehensive literature search was conducted on the Scopus and PubMed databases for English-language articles published in the time range November 2022 to November 2025. Inclusion criteria include cross-sectional, cohort, case-control studies that analyze caries risk factors in elementary school-aged children of 6–12 years. Of the 1,422 articles identified from three databases, 11 studies met the eligibility criteria and were included in the final analysis. The main risk factors are categorized into behavioral and lifestyle aspects, socio-demographic, and socioeconomic. The findings suggest that high-sugar diet behaviors (sugary snacks and soft drinks) and poor oral hygiene (rarely brushing and not using dental floss) were the dominant factors. Socio-demographically, low parental education levels, low socioeconomic status, and male gender have a significant association with an increased risk of caries. In addition, the presence of dental plaque and tooth morphology (deep gaps) are important biological determinants. Dental caries in elementary school children is multifactorial, but lifestyle factors related to diet and oral hygiene, as well as family socioeconomic background are the main determinants. Effective prevention strategies require a holistic approach that focuses on modifying children's behavior and improving parental education.  
Effectiveness of Video-Based Preoperative Education on Reducing Anxiety Levels in Patients Undergoing Surgery: A Literature Review Siti Suryani Asmara; Yanuar Primanda; Fitri Arofiati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1434

Abstract

Preoperative anxiety is a psychological response frequently experienced by patients prior to surgical procedures and can have negative impacts on physiological conditions, anesthetic requirements, and the postoperative recovery process. Video-based preoperative education is considered an innovative approach that is potentially more effective than conventional educational methods. This literature review aims to analyze the effectiveness of video-based preoperative education on reducing anxiety levels in patients undergoing surgical procedures. This study utilized a literature review design with a systematic article search conducted on PubMed, Scopus, and ScienceDirect databases. The included articles were quantitative studies with randomized controlled trial and quasi-experimental designs published between 2020–2025. Out of 1,487 articles, 11 articles that met the inclusion criteria were analyzed narratively. The review results indicated that all studies reported a significant reduction in preoperative anxiety levels in groups receiving video-based education compared to conventional education or no intervention. Video education was proven to improve understanding, a sense of security, and the psychological readiness of patients before surgery. Video-based preoperative education is effective in reducing patient anxiety levels and has the potential to be integrated into standard preoperative care.
Analysis of Determinant Factors on Patient Satisfaction in the Emergency Department Rima Faradila; Indasah Indasah; Nurwijayanti Nurwijayanti; Farida Farida
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1441

Abstract

Patient satisfaction is a crucial indicator of healthcare quality, particularly in the Emergency Department (ED), where services must be rapid, accurate, and compassionate. This study aimed to analyze determinant factors influencing patient satisfaction in the Emergency Department of Bhayangkara Hospital Tulungagung. A quantitative cross-sectional design was applied to 110 ED patients selected through systematic random sampling. Data were collected from November 24–30, 2025, using a SERVQUAL-based questionnaire measuring responsiveness, assurance, tangibles, empathy, reliability, and response time. Instrument testing showed that all items were valid (r count > 0.413) and reliable (Cronbach’s Alpha > 0.70). Data analysis using Spearman’s rho correlation and logistic regression revealed that all service quality dimensions were positively and significantly associated with patient satisfaction (p < 0.05). Responsiveness had the strongest correlation (r = 0.748), followed by empathy (r = 0.710). Logistic regression identified empathy as the most dominant determinant (β = 0.458). These findings indicate that empathetic care and interpersonal interactions play a central role in improving patient satisfaction in the ED.
Application Distal Leg Massage in Diabetes Mellitus Patient Post Lumbar Surgery with Peripheral Arterial Disease: Case Report Natamia Kyrieleison Habeahan; H. Kosim; Atlastieka Praptiwi
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1443

Abstract

Postoperative lumbar surgery patients with diabetes mellitus are at risk of developing complex neurovascular disorders. Neurological deficits caused by lumbar nerve compression or diabetic neuropathy often result in numbness and tingling in the distal limbs, while impaired peripheral circulation related to diabetes mellitus can delay tissue healing. Distal limb massage is a non-pharmacological intervention that may help improve blood circulation and support peripheral nerve function recovery. To determine the effect of distal limb massage on improving peripheral circulation in post-lumbar surgery patients with diabetes mellitus and peripheral arterial disease (PAD). This descriptive case report with a nursing care approach was conducted from September 13 to 16, 2025, in Room UBK 2 of Welas Asih Hospital. A 46-year-old woman with a lumbar abscess and diabetes mellitus received distal limb massage twice daily for three days (30 minutes/session). Peripheral circulation was assessed using Ankle-Brachial Index (ABI) and plantar temperature before and after intervention and analyzed descriptively. After the intervention, the Ankle-Brachial Index (ABI) increased in the right leg from 1.04 to 1.08 and in the left leg from 0.75 to 0.82. In addition, the average plantar temperature increased by 0.3–0.5°C, indicating improved peripheral perfusion. Distal limb massage demonstrated potential effectiveness in improving peripheral circulation, as reflected by increased ABI values and plantar temperature, and may help reduce numbness and tingling in post-lumbar surgery patients with diabetes mellitus and PAD.
Analysis of the Relationship Between Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Red Blood Cell Distribution Width (RDW) With Colorectal Cancer Staging Mei Vrayanti F.S; Jelita Siregar; Adi Muradi Muhar
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1449

Abstract

This study aimed to examine the relationship between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) with colorectal cancer (CRC) staging. Colorectal cancer is one of the most prevalent malignancies worldwide and a leading cause of cancer-related mortality, particularly in Indonesia. Inflammation plays an important role in cancer progression, and systemic inflammatory markers such as NLR, PLR, and RDW are considered practical, accessible, and cost-effective indicators for assessing disease severity and prognosis. An observational analytic study with a cross-sectional design was conducted at H. Adam Malik General Hospital, Medan, from November 2024 to January 2025. A total of 56 newly diagnosed CRC patients who had not undergone surgery or chemotherapy were enrolled using consecutive sampling. Blood samples were analyzed using a Sysmex XN-1500 hematology analyzer. Statistical analyses included independent t tests, Mann–Whitney tests, Spearman correlation, and receiver operating characteristic (ROC) analysis. The results demonstrated a significant difference in PLR values between early- and advanced-stage CRC (p = 0.003), with a moderate positive correlation between PLR and cancer stage (r = 0.297, p = 0.026). RDW showed a weak but statistically significant correlation with CRC stage (r = 0.284, p = 0.034). In contrast, NLR did not show a statistically significant correlation with CRC staging (p = 0.109). These findings suggest that PLR and RDW are promising, simple, and inexpensive inflammatory biomarkers that may assist in the preoperative staging of colorectal cancer, whereas NLR alone may not be a reliable predictor of CRC stage.

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