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INDONESIA
Indonesian Journal of Global Health Research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
Arjuna Subject : -
Articles 1,005 Documents
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Vaginal and Labial Graft Urethroplasty in Female Urethral Stricture: A Systematic Review Nur Syifa Fara Wahida Purba; Quranayati Quranayati
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1488

Abstract

Female urethral stricture is considered a relatively uncommon clinical condition, and urethral dilatation has traditionally been the preferred treatment. In recent years, various reconstructive surgical techniques have emerged to provide more definitive management for this challenging group of patients, including the use of grafts in urethroplasty. This study aimed to review the use of vaginal and labial grafts in urethroplasty for female urethral stricture. A systematic review was conducted using PubMed and related databases to identify studies published between 2014 and April 2025. The results were classified according to surgical technique and type of graft used in augmentation urethroplasty. A total of seven studies involving 119 patients were included. The mean follow-up period was 13.55 months for labial grafts and 17.23 months for vaginal wall grafts. Labial grafts demonstrated slightly higher success rates (84%) compared to vaginal grafts (81.73%). In the vaginal graft group, incontinence and recurrence were reported in 17.5% of cases, while failed calibration occurred in 3.8% of patients in the labial graft group. No major donor-site complications were reported. Overall, both graft types provide feasible and safe options for managing female urethral stricture, with labial grafts showing slightly better outcomes.
Effectiveness of Brainstorming-Balanced Health Education in Improving Nutritional Diets in Stunted Toddlers Daratullaila Daratullaila; Agrina Agrina; Erika Erika
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1507

Abstract

Stunting is a chronic nutritional problem that affects children's growth and development due to eating patterns that do not align with balanced nutrition. Mothers, as primary caregivers, play a crucial role, so effective and participatory nursing interventions are essential. This study used Dorothy E. Johnson's Behavioural System Theory as an environmental stimulus that influences behavioural systems. The objective of this study was to analyse the effect of health education using the brainstorming method on balanced nutritional eating patterns in stunted toddlers. This study used a quasi-experimental design with a one-group pretest-post-test approach. The health education intervention was conducted over three weeks through three stages. The Round Robin brainstorming method was used. The study sample consisted of 38 mothers of stunted toddlers, selected using purposive sampling. The measurement tool employed the Food Frequency Questionnaire (FFQ), which underwent validity and reliability tests, showing good content validity and an acceptable reliability coefficient (Cronbach’s alpha = 0.8). The research showed that the majority of children's eating patterns before the brainstorming method were in the poor category (76.3%), and after the intervention, 63.2% of toddlers' eating patterns were in the good category. The Wilcoxon test results indicated a significant effect of health education using the brainstorming method on changes in the dietary patterns of stunted toddlers. Health education using the brainstorming method had a significant effect on improving balanced nutrition in stunted toddlers.
The Effect of Turmeric Leaf (Curcuma Longa L.) Extract on Leptin, Hmg-Coa Levels, and Blood Vessel Histopathology in Hyperlipidemic Rats Induced by A High-Fat Diet and Propylthiouracil: An in Silico and in Vivo Study Melissa Angie; Endy Juli Anto; Jekson Martiar Siahaan
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1510

Abstract

Hyperlipidemia is a major cardiovascular risk factor with increasing global prevalence. Turmeric leaves (Curcuma longa L.) contain bioactive compounds with potential antihyperlipidemic properties through modulation of leptin and HMG-CoA reductase. To analyze the effects of ethanolic turmeric leaf extract on leptin, HMG-CoA levels, and blood vessel histopathology in hyperlipidemic rats using in silico and in vivo approaches. Thirty-six male Wistar rats were divided into six groups: normal control (K1), hyperlipidemia control (K2), simvastatin 0.9 mg/kg BW (K3), and turmeric extract at 300 (K4), 600 (K5), and 1200 mg/kg BW (K6). Hyperlipidemia was induced with high-fat diet and propylthiouracil. In silico molecular docking evaluated compound-protein interactions. Phytochemical screening confirmed five bioactive compound classes. In silico analysis showed rutin with strong binding affinities to leptin (−10.2 kcal/mol) and HMG-CoA reductase (−9.8 kcal/mol). The 300 mg/kg dose significantly improved lipid profiles, reduced aortic wall thickness (192.59±6.99 μm), foam cells (24.17±4.31), and HMG-CoA levels (3.45±0.42 ng/mL) (p<0.001). The 600 mg/kg dose optimally restored leptin (485.67±62.34 pg/mL). Ethanolic turmeric leaf extract exerts significant antihyperlipidemic effects by improving lipid profiles, attenuating atherosclerosis, and modulating leptin and HMG-CoA reductase.
The Relationship between Knowledge and Emergency Response Attitude to the Mount Agung Eruption Disaster Ni Kadek Ayu Purnama Dewi; Ni Made Dewi Wahyunadi; IGA Tresna Wicaksana; Ni Luh Putu Inca Buntari
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1511

Abstract

Disaster emergency response is a rapid action to mitigate the impact of a disaster. Therefore, community emergency response is crucial in reducing risk. This requires knowledge and training to enable the community to act appropriately and effectively when a disaster occurs. To determine the relationship between community knowledge and emergency response attitudes regarding the Mount Agung eruption in Tunas Sari Hamlet, Karangasem Regency. This study used a quantitative, correlative analytical approach with a cross-sectional approach, with a sample of 350 respondents selected using a purposive sampling technique. Data collection used a knowledge questionnaire and an attitude questionnaire. The questionnaire for the variables of the level of knowledge and attitudes of the community towards evacuation routes was compiled by researchers based on relevant theories and indicators, then a content validity test (face validity) was carried out through expert judgment by two expert lecturers. Data analysis was descriptive. The Kolmogorov-Smirnov normality test indicated that the data were not normally distributed, therefore the Spearman's Rho test was used. The majority of respondents had good knowledge (67.1%) and moderate emergency response attitudes (64.6%). The Spearman's Rho test showed a significant relationship between knowledge and emergency response attitudes (p<0.001) with a correlation coefficient of r=0.326, indicating a positive relationship with weak strength. Increased disaster education, training, and routine simulations are recommended to strengthen the community's emergency response skills.
A Comparison of Spiritual Therapy and Relaxation on Anxiety Levels in Preoperative Patients: A Scoping Review Ika Dwi Purwaningsih; Titih Huriah
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1519

Abstract

Surgical procedures can cause stress and anxiety in most preoperative patients. Spiritual therapy and relaxation therapy can be alternative therapy to reduce preoperative anxiety. This study aims to critically analyze and compare scientific evidence regarding the effectiveness of spiritual therapy and relaxation on preoperative patient anxiety levels. The method used in this study was a scoping review of research articles with a randomized controlled trial (RCT) design. Article quality assessment was carried out using the Critical Appraisal Skills Program (CASP) instrument. The reviewed articles focus on spiritual therapy interventions (prayer, hypnosis, healing touch) and relaxation in preoperative patients. Based on the results obtained, it was found that most articles showed that spiritual therapy and relaxation were effective in significantly reducing preoperative anxiety levels. Therefore, it can be concluded that spiritual therapy and relaxation are proven effective in reducing preoperative patient anxiety. This integration can be recommended to improve the quality of care and patient safety.
The Effect of Intralesional Propolis on Transforming Growth Factor-β (TGF-β) Expression in Tendon Healing: An Experimental Study in a Wistar Rat Model of Partial Achilles Tendon Rupture Luthfi Walikram; Nino Nasution; Andriandi Andriandi
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1524

Abstract

Transforming growth factor-beta (TGF-β) regulates tendon repair, but dysregulated expression contributes to fibrosis. Propolis contains flavonoids and phenolics with immunomodulatory activity and may influence TGF-β signaling. This study evaluated intralesional propolis on TGF-β expression in a Wistar rat partial Achilles rupture model. A true experimental post-test only control group design was used. Male Wistar rats underwent standardized partial Achilles transection (30–40% thickness) and were randomized to: 50% propolis 0.1 mL intralesional (n=9), 0.9% NaCl 0.1 mL (n=9), or no injection (n=9). On day 35, tendons were harvested for immunohistochemistry using an IHC World–based scoring (H-score 0–300) assessed in ≥5 high-power fields by two independent raters. Interobserver agreement was moderate (κ=0.444, p<0.001). TGF-β H-score categories differed significantly among groups (Kruskal–Wallis p<0.001). The propolis group shifted toward higher expression: 88.9% (8/9) were 101–200 and 11.1% (1/9) were 51–100, whereas both comparator groups clustered at 0–50 (44.4%) and 51–100 (55.6%), with none ≥101. Intralesional 50% propolis increased TGF-β immunohistochemical expression at day 35 after partial Achilles rupture, suggesting enhanced regenerative signaling during tendon healing. Further studies should assess dose–response effects and biomechanical outcomes in vivo.
Comparison of Combined Perineural Injection and Oral Mecobalamin with Oral Mecobalamin Therapy on Sensory Symptom Improvement in Patients with Carpal Tunnel Syndrome Diah Andini; Masita Masita; Henry Sugiharto; Erial Bahar
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1526

Abstract

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of combined perineural injection and oral mecobalamin compared with oral mecobalamin alone on sensory symptom improvement in CTS patients. This was a comparative interventional study conducted in patients with mild to moderate CTS at Dr. Mohammad Hoesin General Hospital, Palembang. Subjects were divided into two groups: a combination therapy group (perineural injection plus oral mecobalamin) and an oral mecobalamin group. Sensory symptoms were assessed using the Visual Analog Scale (VAS) at baseline, week 2, and week 4. Between-group and within-group comparisons were analyzed using t-tests, while mixed ANOVA was used to evaluate the effects of time and treatment group. Multivariate analysis was performed to identify factors independently associated with sensory symptom improvement. A total of 30 CTS patients were included in this study. There were no significant differences in baseline demographic and clinical characteristics between groups. Mixed ANOVA analysis demonstrated a significant time effect (p < 0.001) and a significant time group interaction, indicating a faster pattern of sensory symptom improvement (VAS score reduction) in the combination group. Multivariate analysis showed that combination therapy, sex, and occupation were independently associated with sensory symptom improvement, with occupation being the most dominant factor. The combination of perineural injection and oral mecobalamin is more effective in accelerating and enhancing sensory symptom improvement compared with oral mecobalamin therapy alone in patients with mild to moderate CTS.
Histological Description of Skeletal Muscles of Wistar Rats Given Nephelium Lappaceum Extract Lukman Fajar Setyawan; Elvin Clara Angmalisang; Sonny John Ruddy Kalangi
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1529

Abstract

Hyperglycemia is a condition characterized by elevated blood sugar levels, which can trigger oxidative stress and cause cellular damage, including to skeletal muscle cells. The antioxidant content in rambutan leaf extract can lower blood sugar levels. This study aims to determine the histological features of skeletal muscle of Wistar rats given rambutan leaf extract after alloxan induction. Method: This study used a laboratory experimental design with a post-test only control group design. A total of 20 Wistar rats were randomly divided into four groups: a negative control group, a positive control group, and treatment groups administered rambutan leaf extract at doses of 25 mg/kg body weight and 50 mg/kg body weight. Data were collected through blood glucose level measurements, examination of histopathological specimens of skeletal muscle stained with hematoxylin and eosin (H&E), and measurements of muscle fiber diameter. The data were analyzed descriptively by comparing histological findings, blood glucose levels, and mean muscle fiber diameters across groups. Group A experienced a decrease in the average diameter of muscle fibers to 49.06 mm (longitudinal) and 70.45 mm (transverse) accompanied by morphological changes in the form of wavy skeletal muscle fibers. Group B showed improvements in muscle fiber structure with an average diameter approaching normal, namely 59.35 mm (longitudinal) and 91.35 mm (transverse). Group C saw an increase in the average diameter of muscle fibers to 100.97 mm (longitudinal) and 130.21 mm (transverse) indicating a tissue protective effect. Group D showed an average diameter of muscle fibers of 29.47 mm (longitudinal) and 54.34 mm (transverse) accompanied by wavy skeletal muscle fibers. Administration of rambutan leaf extract at a dose of 25 mg/kgBW to Wistar rats increased the average diameter of skeletal muscle fibers and maintained the basic structure of skeletal muscle tissue. Administration of rambutan leaf extract at a dose of 50 mg/kgBW showed wavy skeletal muscle fibers and a decrease in the average diameter of skeletal muscle fibers.
Perianal Herpes Zoster with Diabetes Mellitus: A Rare Case Report Kelvin Kelvin; Cayadi Sidarta Antonius
Indonesian Journal of Global Health Research Vol. 8 No. 4 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i4.1530

Abstract

Herpes zoster (HZ) is caused by the reactivation of latent varicella-zoster virus and most commonly affects the thoracic and trigeminal dermatomes. Involvement of the sacral dermatomes, particularly with perianal extension, is rare and can mimic various anorectal disorders, leading to delayed diagnosis in elderly patients with comorbidities. In this case report, herpes zoster in the perianal area significantly disrupted the patient's daily activities, requiring prompt diagnosis and management. A 78-year-old female presented with blisters accompanied by pain, burning, and tingling in the left buttock area extending to the anus. The dermatologic findings included multiple vesicles to bullae on an erythematous base containing clear fluid in a zosteriform arrangement, discrete to confluent, crusted form. A Tzanck test revealed multinucleated giant cells. The primary therapy consisted of oral acyclovir and mupirocin ointment. Herpes zoster involving the sacral to perianal dermatomes (S2-S4) can cause various functional complications, including neuritis characterized by sensory and motor deficits, which can affect the patient's daily activities. Antiviral treatment within the first 72 hours can help minimize complications. Pain should be controlled to prevent worsening the patient's quality of life. Early diagnosis and treatment, along with vaccination, can reduce morbidity and prevent complications, especially disruption of daily activities in patients with perianal HZ.
Early Encounters: Understanding Early Onset Drug Misuse among Youth Mutia Rahmah; Annisa Intan Sulistyani
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1541

Abstract

Adolescents experience a transition from childhood dependence to adult independence, which is often accompanied by a search for identity, exploration of the social environment, and increased curiosity about new things, including risky behavior, namely drug abuse. Based on data obtained at the preliminary study stage at the BNN Banjarbaru City, two junior high schools were found with the most significant number of students who had ever abused drugs. This study aims to determine the description of drug abuse and determine the relationship between respondent characteristics and drug abuse in adolescents. This study employed a quantitative descriptive approach using a cross-sectional design conducted at SMP “X” in Banjarbaru City.  Results: The Simple Random Sampling technique was used, and 70 students were obtained as respondents. The instruments used were demographic questionnaires and ASSIST Young 10-14 and ASSIST Young 15-17. Data analysis was carried out univariately and bivariately (chi-square). There was a significant relationship between age and tobacco (p-value = .036) and alcohol ((p-value = .040). There was no relationship between gender and tobacco (p-value = 0.153) and alcohol ((p-value = 0.363). Prevention and intervention programs should pay special attention to the dangers of tobacco/vaping and alcohol, target adolescents to reduce moderate and high risks, and prevent initiation of use in non-risk groups.

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