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e-Journal Pustaka Kesehatan
Published by Universitas Jember
ISSN : 2355178X     EISSN : 27213218     DOI : -
Core Subject : Health, Science,
e-Journal “Pustaka Kesehatan” merupakan jurnal elektronik ilmiah berISSN (ISSN: 2355-178X) yang menerbitkan artikel hasil penelitian di bidang kesehatan secara umum meliputi: Kedokteran, Kedokteran Gigi, Kesehatan Masyarakat, Farmasi, dan Ilmu Keperawatan. Artikel yang dikirim belum pernah dipublikasikan atau tidak dalam proses penerbitan dalam jurnal ilmiah lain. e-Journal “Pustaka Kesehatan” diterbitkan tiga kali dalam setahun, yaitu bulan Januari, Mei, dan September.
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Articles 621 Documents
Penentuan Kadar Fenol Total pada Ekstrak Daun Tanaman Menggunakan Metode Spektroskopi NIR dan Kemometrik (Determination of Total Phenolic in Leave Extracts Using Spectroscopy NIR and Chemometric) Fracilia Arinda Ratnasari; Lestyo Wulandari; Nia Kristiningrum
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Phenols are group which having one or more hydroxyl groups which attached in aromatic ring and are found in plants. The aim of this research was to study whether NIR and chemometric methods could be used to determine the total phenol content of leave extracts. These methods were compared to UV-Vis spectrophotometry. Phenol was extracted from plant leaves by ultrasonic and maceration. NIR spectral data of selected leave extracts were correlated with total phenol content using chemometric. In this study, the chemometric method that used for quantitative and qualitative analysis were Partial Least Square (PLS) and Linear Discriminant Analysis (LDA), respectively. The PLS R2 calibration was 0.9920369 and RMSEC was 2.0049472. In addition, the R2 of LOOCV and 2-Fold-Cross-Validation were 0.9939401 and 0.9834646, respectively. Furthermore, LDA gave accuracy of 100%. The significance of phenol total that have been measured by NIR and UV-Vis spectrophotometry was evaluated with paired samples T-test and gave no significant difference. In conclusion, total phenol content can be measured using NIR and chemometric methods.   Keywords: phenol, chemometric, LDA, NIR, PLS
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kamboja Putih (Plumeria acuminata) Terhadap Pertumbuhan Streptococcus mutans (Antibacterial Activity Of Etanol Extract Of White Frangipani leaf (Plumeria acuminata) Against The Growth Of Streptococcus mutan Affian Hudatama Putra; Yani Corvianindya Rahayu
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background : Most of caries are caused by Streptococcus mutans. Etanol extract of white frangipani leaf are supposed to inhibit the growth of Streptococcus mutans. This extract contains antibacterial compound such us flavonoid, saponin, tannin, and alkaloid. Purpose : This study was to determine the antibacterial activity of etanol extract of white frangipani leaf in variant concentration on growth of Streptocossus mutans. Method : This study was used well diffusion method with 6 treatment groups. Each petridish were filled BHI-A and inoculated by S. mutans followed by making 6 wells using the borer (diameter 5 mm) and filled 20 µL of white frangipani leaf extract 50%, 25%, 12,5%, 6,25%, povidone iodine as positive control, and aquadest sterile as negative control into the well. Each petridish were incubated at 37ºC for 24 hours. The inhibitory zones were measured by using digital calliper. Results: The result showed that there were inhibitory zones in positive control, extract 50%, and 25% treatment groups and there is no inhibitory zones in negative control, extract 12,5%, and 6,25%. Conclusion: Etanol extract of White frangipani leaf has antibacterial activity against the growth of Streptococcus mutans with minimum inhibitory concentration of 25% . Keywords : Antibacterial activity, Streptococcus mutans, Etanol extract of white frangipani leaf.
Pengaruh Diaphragmatic Breathing Exercise terhadap Fungsi Pernapasan (RR dan APE) pada Lansia di UPT PSLU Kabupaten Jember (The Effect of Diaphragmatic Breathing Exercise on Respiration Function (RR and PEFR) in Elderly at UPT PSLU Jember Regency) Santi Dwi Pangestuti; Murtaqib Murtaqib; Nur Widayati
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Oxygenation is human major basic need for maintaining body cell metabolism, survival and activities of various body organs. Respiratory system and cardiovascular system change throughout the aging process. Decreased respiratory function will affect the fulfillment of the needs of oxygenation in the elderly. Diaphragmatic breathing exercise is one of methods to maintain and improve respiratory functions in the elderly. This research aimed to determine the effect of diaphragmatic breathing exercise on respiratory functions (RR and PEFR) in the elderly. This research is a pre-experimental research with one group pretest and posttest design. Sampling technique used purposive sampling with 14 elderly given intervention of diaphragmatic breathing exercise once a day for 14 days. The collection of data was by observation, that is, by measuring the value of RR and APE before and after diaphragmatic breathing exercise. Data analysis used dependent t-test with α=5%. The research results of statistical calculation indicated p value of 0.000 (p
Efektivitas Perasan Daun Kemangi (Ocimum basilicum) dibanding Larutan Pembersih Gigi Tiruan Effervescent sebagai Pembersih Gigi Tiruan Resin Akrilik terhadap Pertumbuhan Candida albicans Sherlika Puspita Sari; Achmad Gunadi; Dewi Kristiana
Pustaka Kesehatan Vol 7 No 2 (2019): Volume 7 No. 2, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i2.19127

Abstract

The heat cured acrylic resin is common used as denture base material, but its microporosity can affect the cleanliness of the denture base lead to accumulation of plaque and food waste, and further increase the number of Candida albicans and cause denture stomatitis. There are 2 type of cleaning agents; natural cleaning agents, such as basil and chemical cleaning agents, for example effervescent artificial cleaning tablets. This study compared the effectiveness of basil leaves squeeze and effervescent denture cleaning solutions in soaking heat cured acrylic resin plates on the growth of C. albicans. There were 24 of 10x10x1 mm acrylic resin plates divided into 6 treatment groups. The acrylic resin plate was soaked in the basil leaves squeeze and effervescent denture cleaning solutions. Measurement of C. albicans absorbance used a spectrophotometer, then calculated the total of C. albicans using the formula. Data was analyzed using the One Way ANOVA test. The analysis showed that there are significant differences on the growth inhibition of C. albicans between treatment groups (p <0.005). The effervescent denture cleansing solution has a better antifungal effectiveness than the basil leaves
Efek Hepatoprotektif Ekstrak Etanol Brokoli (Brassica oleracea L. var. italica) terhadap Kerusakan Histologis Sel Hati Tikus Wistar yang Diinduksi DMBA (Hepatoprotective Effect of Ethanolic Extract of Broccoli (Brassica oleracea L. var. italica) on the Histologically Damage of Wistar Rats Liver Cell Induced by DMBA) Muhtar Ady Kusuma; Elly Nurus Sakinah; Rosita Dewi
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

DMBA (7,12-Dimethylbenz(α)antracene) is one of Polycyclic Aromatic Hydrocarbon’s form that is abundant on air pollution, i.e. automobile exhaust, cigarette smoke, and wood stoves. DMBA is metabolized in liver result in DMBA-DE. DMBA-DE is a free radical compound that has hepatotoxic effect. Broccoli contains flavonoid that has antioxidant effect. It can stabilize DMBA-DE radical compound. This research was conducted to investigate the hepatoprotective effect of ethanolic extract of broccoli on the damage of rat’s liver cells induced by DMBA. This research used 30 white male rats that was divided into 6 groups: normal control (aquadest), positive control (DMBA) and the treatment groups(using brocolli ethanolic extract with dose : 250, 500, 1000, and 2000 mg/kgBB). The treatment was given for 7 days followed by single-dose DMBA 15 mg/kgBB induction in the 8th day. Histological appearance of liver cells were examined on the 12th day. Data were analyzed by using Kruskal Wallis test followed by Mann Whitney. The result showed that there was a significant difference among the groups with p<0.05. In conclusion, there were some differences of hepatoprotective effect of broccoli ethanolic extract on the histologically damage of rats liver cells induced by DMBA. Keywords: ethanolic extract of broccoli, DMBA, histopathology, hepatoprotective
Perbedaan OHI-S DMF-T dan def-t Pada Siswa Sekolah Dasar Berdasarkan Letak Geografis Di Kabupaten Situbondo (Difference Of OHI-S And DMF-T On Elementary School Students Based On Geographical Location In Situbondo) Oktavilia Dwi Wina; Niken Probosari; Sulistiyani .
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background the level of dental health and a person's mouth can be seen on high and low scores OHI-S, DMFT and def-t. OHI-S (Oral Hygiene Index Simplified) is an idea of the level of cleanliness of teeth and the mouth of a person. DMF-T index is a measurement of permanent tooth caries and def-t in first gear.  Health Profile Data Situbondo in 2010 shows thepercentage of caries rate 77,37% in the ages of pre  school and primary school students (primary school), it can be influenced by one's situation and environmental conditions such as geographical location. The purpose of this research is to know the difference in OHI-S, DMF-T and def-t on elementary school students based on geographical location in Situbondo that coastal areas, lowlands and the hills. This research is research observational analytic with cross sectional approach methods and techniques of sampling this research is purposive sampling so as to get the number of samples of the 450 students. At each of the elementary schools in three districts will be examination of OHI-S, DMF-T and def-t to specify OHI-S index, DMF-T and-t def. Data analysis using different test Kruskal-Wallis and Mann-Whitney. The results of this research show that the value of OHI-S students in coastal areas that is 49% better than any other area. The average DMF-T students in coastal areas 0,56; lowlands 0,97 and the hills 1,20. Average def-t in coastal areas 1,20; lowlands 1,61 and the hills 1,32. The conclusion is no difference in the value of  OHI-S and DMF-T while the value of the def-t there is no distinction. The advice is need for further research based on the classification of age so that the average difference is seen more clearly visible.   Keywords::def-t, DMF-T, Elementary School, Geographical location, OHI-S.  
Optimasi Konsentrasi Span 80 dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida-kitosan (Optimization of Span 80 Concentration and Stiring Time on The Preparation of Metformin Hydrochloride-Chitosan Microspheres ) Christyn Novita S; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6614

Abstract

Metformin hydrochloride (MH) has been used as first line for type 2 diabetes mellitus treatment. However, it has relatively low bioavailability, short half-life and could cause gastrointestinal side effects, therefore it is appropriately prepared as microspheres. Microspheres is micro particle which is between 1-1,000 µm in size. Many factors affected the result of microspheres preparation, such as surfactant concentration and stirring time. This research was aimed to find the best composition of span 80 concentration and stirring time to produce MH-chitosan (CH) microspheres with the highest entrapment efficiency (EE) using factorial design optimization. MH was used as active substance, CH as polymer, span 80 as surfactant and non-aqueous solvent evaporation method was chosen for microspheres preparation technique. The optimized formula 2 % span 80 and 2 hours stirring time gained 86.803 ± 0.544 % EE, 24.571 ± 0.157 % drug loading, and 88.220 ± 0.137 % yield. The microspheres had a relatively smooth, bright surface, and spherical structure. The average particle’s size was 161.2 ± 1.743 μm. FTIR analysis indicated that there were no changes in the spesific functional clusters of MH as an active substance. Keywords: metfomin-hydrocloride-chitosan microspheres, non-aquoeous solvent evaporation, factorial design, span 80 concentration, stirring time.
Daya Inhibisi Korosi Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) terhadap Kawat Thermal NiTi Ortodonti (Corrosion Inhibition of Starfruit Leaves Extract (Averrhoa bilimbi L.) on Thermal NiTi Orthodontic Wire) Irdian Devi Saputri; Rudy Joelijanto; Leliana Sandra Devi Ade Putri Putri
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Orthodontic wire can corrode in oral cavity. Corrosion can affect human body and feature of orthodontic wire. One way to reduce corrosion rate is using inhibitor. Natural ingredients extract inhibitor is usually preferred because it’s not harmful to environment. One of natural ingredients that can be used is starfruit leaves. This study was aimed to determine the corrosion inhibition of starfruit leaves extract on Thermal NiTi orthodontic wire. This study was an experimental laboratory research. Samples was 12 Thermal NiTi orthodontic wire which had been prepared and then divided into control group, 600 ppm group and 1000 ppm group. Then samples were measured by using a potentiostat. Results of Kruskal Wallis test and Mann-Whitney test showed a significant difference between groups. The conclusion from this research was there were starfruit leaves extract have corrosion inhibition on thermal NiTi orthodontic wire. Keyword: corrosion inhibiton, starfruit leaf extract, thermal NiTi orthodontic wire
Uji Daya Hambat Ekstrak Metanol Daun Ungu (Graptophillum pictum (L.) Griff) terhadap Pertumbuhan Bakteri Saluran Akar Gigi (Inhibition Test of Purple Leaf (Graptophillum pictum (L.) Griff) Methanol Extract toward Root Canal Bacteria's Growth) Resti Ayu Indriana; Pudji Astuti; Atik Kurniawati
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background: Root canal bacteria in necrotizing pulp are dominated by polymicrobial bacterial colonization. Bacteria control were performed by using antribacterial irrigation. Purple leaf methanol extract contains triterpenoids, alkaloids, flavonoids, glycosides, saponins, and tanins which are to own antibacterial capability. Objective: To determine a wide range of consentrations, the minimal concentration of purple leaf methanol extract which able to inhibit the growth of root canal bacteria, and how much is the concentration of the purple leaf methanol extract which is equivalent to 2.6% sodium hypochlorite. Methods: The method was used well diffusion. Antibacterial test was indicated by the existance of the inhibition zone around the well hole. Total samples used were 56 samples for  each 7 group treatment, which are concentration 100%, 50%, 25%, 12,5%, 6,25% of purple leaf methanol extract, 2.6% of sodium hypochlorite, and sterile water. The results of the study was then tested by the statistical parametric one way ANOVA and LSD. Results and Conclusion: The concentration of purple leaf methanol extract which ables to inhibit the growth of root canal bacteria is 12,5%, 25%, 50%, and 100% also the minimum concentration is 12,5%, and the concentration of purple leaf methanol extract which is equivalent to 2.6% of sodium hypochlorite is concentration of 25%.Keywords: Antibacterial, Root Canal Bacteria, Purple Leaf Methanol Extract, Graptophillum pictum (L.) Griff
Pengaruh Ekstrak Bangle (Zingiber cassumunar Roxb.) terhadap Kadar TNF-ɑ pada Mencit yang Diinfeksi Plasmodium berghei Pungky Setya Arini; Wiwien Sugih Utami; Erma Sulistyaningsih
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Malaria is an infectious disease caused by Plasmodium spp. Death in malaria is resulting from the parasite’s resistance to malaria drugs and immune system problem. This study was conducted to determine the immunostimulant activity of bangle extract (Zingiber cassumunar Roxb.) in mice infected with Plasmodium berghei. Mice were divided into 5 groups; negative control group [K(-)], positive control group [K(+)] and 3 treatment groups (P1, P2, P3). All groups except K(-) were infected with P. berghei, P1 was treated with Bangle ethanolic extract 0,904 mg/gBW, P2 was given with Bangle ethanolic extract 0,904 mg/gBW and artemisinin 0,0364 mg/gBW, P3 was treated with artemisinin 0,0364 mg/gBW. After 4 days treatment, blood TNF-α from intracardial was measured. The result showed that TNF-α of P1, P2, P3, K(+) and K(-) were 77,46 ± 33,96 ρg/ml, 55,08 ± 15,19 ρg/ml, 85,56 ± 22,43 ρg/ml, 102,81 ± 61,76 ρg/ml, 41,29 ± 2,28 ρg/ml, respectively. The Mann-Whitney test showed p value ≥ 0,05. In conclusion, Zingiber cassumunar Roxb. extract had no effect on TNF-α of P. berghei-infected mice. Keywords: immunostimulant, Zingiber cassumunar Roxb, TNF-α