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Medula
Published by Universitas Lampung
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Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 906 Documents
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Penatalaksanaan Holistik Pada Pasien TBC Milier – HIV Seronegatif Annisa Abdillah; Azelia Nusadewiarti
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.284

Abstract

Miliary TBC is a potentially fatal form of TBC. Mortality rates for military TBC occurs higher in adults (25% - 30%) than in children (15% - 20%). Clinical manifestations of patients with miliary tuberculosis in adults are not specific. Therapy is given not only by using drugs, but also the therapy should be focus on the patient or patient-centered and family approach which is done holistically. The study is Case Report. Primary data was obtained through history taking and physical examination by making home visits, filling out family folders, and filling in patient files. Assessment was carried out based on the initial holistic diagnosis, process, and end of the visit quantitatively and qualitatively. Based on holistic diagnosis, the patient complains fever for 6 months, accompanied by night sweats, decrease appetite, nausea, weight loss. The patient is worried that his pain will become increasingly burdensome and life threatening. The patient is a man, 53 years. Patients have fungtional degrees 2 with Milliary TBC – HIV Seronegative, have internal risk factors, such as drinking alcohol and smoking habits, curative treatment patterns, rarely exercise and lack of knowledge about the disease. The intervention and evaluation has been done to the patient and his family members about patient’s illness, medications, lifestyles, obtained changes in the behavior of patients and families. The diagnosis of milliary tuberculosis in this cases is in accordance with the theory and critical appraisal of resent research.
1. Kementrian Kesehatan Republik Indonesia. Pusat data dan informasi tuberkulosis. Jakarta: InfoDATIN; 2018. 2. Sharma SK, Mohan A, Sharma A. Miliary tuberculosis: A new look at an old foe. J Clin Tuberc. 2016; 3(1):13–27. 3. Ray S. Diagnosis and mana Anugerah Indah Sari; Roro Rukmi Windi; Hanna Mutiara
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.285

Abstract

Gross motor development is one of children development which must detect in young age for minimize developmental delayed. Age under 3 is a Golden Period which children brain is rapidly develop. Stimulation is a method that can increase children development. Stimulation in age 0-12 month need for optimizing children development. To know mother charactheristic based on giving gross motor stimulation age 0-12 months old at posyandu in Kelurahan Penengahan Raya Kecamatan Kedaton Bandar Lampung. Design of this observational descriptive to 27 mom who had children 0-12 months old at posyandu in Kelurahan Penengahan Raya Kecamatan Kedaton Bandar lampung. The data were taken in the from primary data from questionnaire to score maternal stimulation. We can get mother age 25-35 yo is 18 people and age <25 yo is 9 people. For job distribution, mother who work as housewife is 23 people, enterpreneur is 2 people and employee is 2 people. For last education distribution, elementary is 1 person, JHS is 10 people, SHS is 14 people and collage is 2 people Conclusion: good gross motor stimulation is given by mother who have 25-35 yo, work as housewife and their last education grade is senior high school.
Hubungan Antara Lama Menderita Diabetes Melitus Tipe 2 Dengan Kejadian Peripheral Arterial Disease Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Kedaton Kota Bandar Lampung Adinda Ayu Lintang S; Hanna Mutiara; Merry Indah Sari; Muhartono; Ryan Falami
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.286

Abstract

Diabetes mellitus is a metabolic disease with characteristics of hyperglycemia occurs due to abnormalities of insulin secretion, insulin function, or both. Diabetes mellitus causes various kinds of complications, one of which is peripheral arterial disease (PAD). PAD is is a condition characterized by atherosclerotic occlusive disease of the lower extremities. The purpose of this study to knowing the relationship between the length of suffering type 2 diabetes mellitus and the incidence of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus in Puskesmas Kedaton Kota Bandar Lampung. This research is correlative analytic with cross sectional approach. The study was conducted November 2017. The population in this study were all patients with DM type 2 who joined prolanis activities at Puskesmas Kedaton of Bandar Lampung city. The number of research samples are 40 respondents with consecutive sampling technique. This results has 17 male and 23 women respondents. The average duration of DM is 9.8 years. Respondents with normal were 52.5%, mild PAD 12.5%, moderate 32.5% and severe 2.5%. Spearman test results of both variables obtained p value of 0.001 and correlation value 0.651. The conclusion is there are relationship between length of suffering type 2 diabetes mellitus and the incidence of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus in Puskesmas Kedaton of Bandar Lampung city.
Peran Albumin Glikat Pada Kontrol Glikemik dan Diagnosis Diabetes Mellitus Sharlene Sabrina; Putu Ristyaning Ayu; Iswandi Darwis
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.287

Abstract

Diabetes Mellitus or DM is a chronic metabolic syndrome, which is usually characterized by excess glycemic conditions or hyperglycemia. The incidence of diabetes is increasing rapidly in populations in Asia, especially in countries with fairly fast economic growth. At present, there are around 171-194 million people in the world who suffer from diabetes. Fructosamine, glycated albumin and HbA1c are glycate proteins used to evaluate glycemic control in diabetic patients. Albumin glycate (GA) has a much shorter half-life than erythrocytes, so glycemic albumin can reflect glycemic control on a short-term basis (around 2-3 weeks) compared to HbA1c. In addition, GA has faster and greater changes compared to HbA1c, so GA may be more useful for describing glycemic control. The concentration of albumin glycate can be determined in several ways, namely by using the colorimetric method with thiobarbituric acid, the enzymatic method with proteinase and ketamine oxidase, the HPLC chromatography method, and the mass spectrometry method. Several studies have concluded that there is a strong relationship between glycated albumin, HbA1c and fasting blood glucose so that glycated albumin can be used as a glycemic control tool for early detection of diabetes complications, aiding diagnosis of diabetes and assisting in the selection of adequate management for diabetes patients.
Sindrom Serotonin Raisha Rahmani Rizal; Dewi Nur Fiana
Medula Vol 11 No 2 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i2.186

Abstract

Serotonin (SS) syndrome (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in the peripheral (PNS) and central nervous system (CNS). It is characterized by a dose-relevant spectrum of clinical findings associated with levels of free serotonin (5-hydroxytryptamine [5-HT]), or activation of 5-HT receptors (especially the 5-HT1A and 5-HT2A subtypes), which include neuromuscular disorders, autonomic hyperactivity, and altered mental states. Serotonin toxicity begins within a few hours of taking a drug that causes an increase in serotonin. The three classic sets of clinical features are neuromuscular excitation (eg, clonus, hyperreflexia, myoclonus, rigidity), autonomic nervous system excitation (eg, hyperthermia, tachycardia), and altered mental state (eg, agitation, confusion). Although serotonin syndrome rarely causes death, severe cases are medical emergencies that can rapidly lead to multisystem organ failure. Although many drugs have been implicated in serotonin syndrome, life-threatening cases generally occur only when a monoamine oxidase inhibitor is combined with a selective serotonin re-uptake inhibitor. or non-selective. Awareness of Serotonin Syndrome is critical not only in avoiding inadvertently harmful combinations of therapeutic drugs but also in recognizing the clinical picture when it occurs so that treatment can be started immediately. Doctors and nurses should be aware of serotonin syndrome because drugs that can cause it are often used, and intentional overdoses with drugs that can cause serotonin syndrome are seen with increasing frequency. This makes it difficult to detect and doctors can easily mistake serotonin syndrome for antoher diagnose. In this review, the pathophysiology, clinical features, drugs involved and diagnosis of serotonin syndrome are discussed.
PENATALAKSANAAN HOLISTIK PADA PEREMPUAN USIA 73 TAHUN DENGAN SINDROMA METABOLIK Vicki Lusbiyanti Utami; Putu Ristyaning Ayu
Medula Vol 11 No 2 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i2.289

Abstract

Indonesia  dihadapkan  pada banyak masalah  kesehatan, salah satunya yaitu penyakit degeneratif. Penyakit degeneratif merupakan penyakit kronik menahun yang banyak mempengaruhi kualitas hidup serta produktivitas seseorang. Sindrom Metabolik (SM) merupakan kelainan metabolik kompleks.Komponen utama sindrom metabolik adalah obesitas, resistensi insulin, dislipidemia, dan hipertensi.Penyakit seperti hipertensi dan diabetes perlu dikelola secara komprehensif meliputi tatalaksana farmakologis dan non farmakologis.Menerapkan  pendekatan  dokter  keluarga  secara  holistik  dan  komprehensif dalam mendeteksi faktor risiko internal dan eksternal serta menyelesaikan masalah berbasis Evidence Based Medicine yang bersifat family-approached, patient-centered, dan communit oriented. Studi yang dilakukan adalah laporan kasus.Data primer diperoleh melalui anamnesis, pemeriksaan fisik dan kunjungan ke rumah.Data sekunder didapat dari rekam medis pasien.Pasien mengatakan tidak memiliki keluhan apapun.Pasien  mengatakan datang untuk memeriksakan kesehatannya serta membutuhkan surat rujukan ke RS tipe C untuk mendapatkan obat suntik terkait kencing manisnya. Pasien telah menderita kencing manis dan darah tinggi sejak ±7 tahun yang lalu, pasien mengetahui penyakitnya tersebut ketika melakukan skrining sebelum operasi Ca Servix di RSCM.  Pola makan pasien belum dapat dikontrol.Riwayat keluarga pasien yang terkena diabetes mellitus tidak ada, sedangkan riwayat darah tinggi ditemukan juga pada seluruh saudara kandung pasien dan ibu dari pasien serta suami pasien. Penegakan diagnosis dan penatalaksanaan pada pasien ini telah dilakukan secara holistik, patient centered, family approach dan community oriented berdasarkan beberapa teori dan penelitian terkini. Pada proses perubahan perilaku, pasien sudah mencapai tahap trial.
Penerapan Bioteknologi DNA Rekombinan: Pengembangan Vaksinasi COVID-19 Ni Putu Pranita; Rizki Novtarina; Robby Cahyo Nugroho; Rani Himayani; Helmi Ismunandar
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.177

Abstract

The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.
Pengaruh Pemberian Buah Mengkudu (Morinda citrifolia) Terhadap Penyakit Dislipidemia Chania Forcepta; Khairun Nisa; Dian Isti Anggraini
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.188

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by an increase in the lipid fraction in the blood. Dyslipidemia is an important problem because it is a major risk factor for heart disease. The cause of dyslipidemia is caused by disruption of lipid metabolism due to the interaction of genetic and environmental factors. An alternative treatment for dyslipidemia is to use noni (Morinda citrifolia) fruit which contains xeronin, proxeronin, ascorbic acid, linoleic acid, β-carotene, flavonoids and caprylit acid. Compounds that are thought to lower cholesterol are flavonoids. The flavonoid compounds in noni inhibit HMG-CoA reductase so that total cholesterol and LDL will decrease. Noni fruit can also be useful as an antioxidant, anti-inflammatory, antinociceptive, anti-cancer, anti-diabetes and anti-hypertension. Consumption of noni fruit must be careful with gastritis sufferers because noni is acidic. With antidiabetic drugs hypoglycemia and hypotension can occur, because they can reduce blood glucose and potassium levels. The color of urine can be pink to brownish red. May interact with ACE inhibitor drugs, angiotensin II receptor antagonists, potassium-sparing diuretics. May reduce the effect of immunosuppressant drugs.
Sistem Saraf Pusat dan Perifer Syalwa Meutia Syalwa Meutia; nurul utami; Rani Himayani; selvi rahmawati
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.189

Abstract

The structure of the central nervous system consists of the cerebrum, cerebellum, and spinal cord which are located in the cranial cavity and vertebral canal. The primary functional unit of the neural network is nerve cells (neurons) which function to form and transmit information in the form of electrical impulses and supporting cells (neuroglia) which are located around neurons and are more numerous than neurons. The parts of a neuron include the cell body (soma or perikaryon), dendrites and axons. Based on the number of dendrites and axons, neurons are classified into multipolar, bipolar and pseudounipolar neurons. Neuroglia consist of astrocytes, oligodendrocytes, microglia, and ependymal cells. Neuroglia play a role in providing a conducive microenvironment for the activity of neurons. The peripheral nervous system is a nervous system that connects all parts of the body with the central nervous system, this system consists of nervous tissue located outside the brain and spinal cord (spinal cord) such as the skin and other senses, the peripheral nervous system consists of cells Nerve cells group together to form ganglia, nerve fibers, and nerve end bodies
Bacillary Dysentery jefri irawan; Meilisa Hidayah Putri; Rani Himayani; Ratna Dewi Puspita Sari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.211

Abstract

Gastrointestinal infection due to amoeba is one of the causes of diarrhea which appears to be a public health problem with a high incidence in the community. Bacillary dysentery/shigellosis has become a major cause of morbidity and mortality in children in developing countries, and is also an important cause of morbidity in industrialized countries. Shigella sp. is a diarrheal pathogen that is closely related to Escherichia coli. The pathogen was named by Kiyoshi Shiga, who in 1898 identified the most virulent strain of shigella, Shigella dysenteriae, as the causative agent of shigellosis. Shigella spp. is a Gram-negative bacillus from the family Enterobacteriaceae. Therefore, the aim of this literature review is to further review the management of bacillary dysentery. Shigellae is transmitted by the faecal-oral route or through ingestion of contaminated food and water. This research is a literature review involving as many as 10 library sources with the keywords used, namely 'management and shigellosis' with the year published between 2012 - 2021. Abstracts and full text of the journal are read and examined, then an analysis of the contents contained in the research objectives is carried out and research results/findings. Results. Various studies have shown over the last few decades, Shigella spp. have undergone mutations, developing mechanisms to damage cell processes in the gastrointestinal tract. Therefore, innovative methods and appropriate management are needed to prevent antibiotic resistance in the treatment of shigellosis.

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