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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 906 Documents
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Potensi Metformin sebagai Agen Anti-Kanker Ni Made Dewi Puspita Sari; Muhartono; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.271

Abstract

Metformin is one of the often prescribed anti-diabetic drugs. As an anti-diabetes effect, metformin also becomes anti-cancer. The mechanism of metformin as an anti-cancer through direct and indirect effects. Indirect sugar with loss of glucose levels, effects of hyperinsulinemia, levels of Insulin Growth Factor-1 (IGF-1), and immune responses to cancer cells. A direct effect on AMPK activation stimulation which works molecularly on cancer cells. This makes the metformation is potential as an anti-cancer agent alone or in combination with other chemotherapy agents or radiation.
Perbedaan Keterampilan Komunikasi Antara Mahasiswa Preklinik Dan Klinik Fakultas Kedokteran Universitas Lampung Devi Mutiara Jasmine; Oktafany; Dwita Oktaria
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.273

Abstract

Communication is needed in daily life because communication is important. Communicating means conveying messages from the giver of the message to one or more recipients of the message with or without using a tool. The communicating component is a giver, message, recipient, and media. Communication skills in medical education are taught from the academic stage to the profession stage. Learning effective communication at the academic stage is applied to the tutorial and Clinical Skill Lab (CSL) with simulated patients. While at the profession stage, young doctors have carried out effective communication learning that is directly applied to patients and their families in real terms. This study used a cross sectional design with 66 respondents selected using proportional stratified sampling techniques. The research data was taken from filling out the Interpersonal Communication Competence Scale questionnaire that was developed by Rubin and Martin assessed with 10 indicators of ICCS. Data were analyzed using T test. A total of 66 respondents filled out a questionnaire and the results showed that there were differences in communication skills between preclinical students and clinical at the Faculty of Medicine, University of Lampung with a value of p = 0.002. Thus, the communication skills of preclinical students are lower than those of clinical students with the result of the mean difference being 0.515. There were differences in communication skills between preclinical students and clinical at the Faculty of Medicine, University of Lampung.
Terapi Madu Pada Penderita Ulkus Diabetikum Ayu Ningsih; Susianti; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.275

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by high levels of sugar (hyperglycemia) due to decreased insulin secretion by the pancreas, reduced insulin sensitivity, or both. One complication of DM is diabetic ulcer. Diabetic ulcers occur due to reduced vascular supply of blood vessels at the peripheral end resulting in the absence of oxygen so the tissue becomes necrotic. The importance of wound care is important to prevent the occurrence of fatal complications in the form of amputation in response to Wagner 5 criteria. Treatment of wounds in the form of herbal ingredients such as olive oil, honey and aloe vera has been done. Honey has several ingredients that are useful as antibacterial, anti-inflammatory, autolysis and wound healing. while the important enzymes contained in honey are diastase, invertase, glucose oxidase, peroxidase, and lipase. Antibacterial honey has a mixture of 48% sugar and 15-20% moisture content so that the content makes the bacteria unable to live. Honey can activate plasminogen into plasmin, this plasmin will become a fibrin thread which facilitates blood flow. The high glucose level of honey increases glucolysis which produces an energy source for macrophages.
Pengaruh Asupan Tinggi Fruktosa Terhadap Komplikasi Nefropati Diabetik Pada Penderita Diabetes Mellitus Hanifah Choirunnisa; Waluyo Rudianto; Sutarto
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.276

Abstract

Diabetes mellitus (DM) is a non-communicable disease with a global incidence of 415 million cases in 2015 which has increased 4 times compared to the 1980s in the adult population. The increase in the number of DM in the world in line with the increase in the number of DM in Indonesia in 2018 compared to 2013, which was 1.5%. The increase in the incidence of DM globally causes an increase in various DM complications, one of them is microvascular complications of nephropathy diabetic with an incidence of 20-40%. Increase complication of nephropathy diabetic in people with DM caused by various factors, one of which is an unhealthy lifestyle by consuming a high intake of fructose found in various carbonated soft drinks. Consumption of fructose that is safe for the body no more than 5% of consumption per day. High intake of fructose in carbonated soft drinks increased the greater risk of complications of nephropathy diabetic due to excessive use of ATP in the process of fructose metabolism in the body. The products of fructose metabolism in the body are fructose-1-phosphate and uric acid. Increased fructose-1-phosphate and uric acid will cause hyperglycemia and hyperuricemia which can cause oxidative stress, endothelial dysfunction, and glomerular dysfunction by activating one of the inflammatory mediators inflammatory transcription factors (NF-κB), increasing the production of advanced glycation end products (AGEs) and macrophage activation. Oxidative stress, endothelial dysfunction, and glomerular dysfunction will induce various inflammatory mediators such as cytokines (IL-1, IL-6, IL-18, JAK, STAT and TNF), chemokines (CCL2), and adhesion molecules (ICAM1, VCAM1 ) which causes kidney infiltration of inflammatory cells (monocytes and lymphocytes) which play a role in the pathogenesis of nephropathy diabetic.
Potensi Bit Merah (Beta vulgaris L.) sebagai Nefroprotektor dari Kerusakan Ginjal akibat Radikal Bebas Nabila Shafira; Putu Ristyaning Ayu; Susianti
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.277

Abstract

Every human being is born with a pair of kidneys located retroperitoneal in the body cavity. Kidney is an organ that filters blood and gets rid of the body’s metabolic waste. In addition, kidneys also play an important role in the excretion of drugs from the body, thus making it vulnerable to damage due to drugs and free radicals. in small amounts, free radicals can be converted into a non-toxic compound through the defence mechanism of endogenous antioxidants. However, when exposed to large amounts of free radicals, there will be an imbalance between the antioxidants produced and the antioxidants needed by the body. Overtime, the body will run out of antioxidants and free radicals will accumulate in the body. These free radicals wil form a covalent bond with the cell in the body especially in the proximal convoluted tubules of the kidneys and cause damage to the kidneys. This mechanism is called oxidative stress. Decreased kidney function can be assessed through blood urea and creatinine examination. Beetroot (Beta vulgaris L.) is a root plant that is generally used as vegetables. Beetroot is one of vegetables with the highest antioxidants content. Several studies have shown that beetroot extract has activity as a nephroprotector due to its abundant exogenous antioxidant contents. The antioxidant that are found in beetroots are flavonoids, betacyanins, betaxantins, ascorbic acidz, and carotenoids.
Efek Aloe vera dalam Menurunkan Risiko Penyakit Stroke Angwen Rial Huga; Anggraeni Janar Wulan; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.278

Abstract

Stroke is a non communicable disease whose prevalence is increasing in Indonesia. The results of the Riset Kesehatan Dasar (Riskesdas) in 2018 showed that an increase in the prevalence of stroke from 7% (in 2013) to 10.9% with the highest proportion was in East Kalimantan (14.7%) and the lowest proportion was in the Papua region (4.1%). The increased prevalence is related to unhealthy lifestyles. Besides that hypercholesterolemia (high cholesterol levels in the blood) is also a risk factor for stroke which if not handled properly will lead to atherosclerotic plaque formation in blood vessels. This plaque can block the flow of blood that carries oxygen to the brain so that it can cause a stroke. One type of plant in Indonesia that has benefits in lowering cholesterol levels is Aloe vera. There are many ingridients of Aloe vera such as amino acids, salicylic acids, anthraquinons, enzymes, magnesiums, zincs, minerals, vitamins (A, C, E), lignins, saponins, phytosterols, monosaccharides, and polysaccharides (glucomannans and acemannans). Based on several studies, Aloe vera can reduce blood cholesterol levels with saponins, phytosterols, and glucomannans compound that have a direct role in lowering cholesterol levels. Saponin will inhibit the absorption of cholesterol in the gastrointestinal tract and increase its excretion, phytosterols will bind cholesterol and prevent cholesterol from being absorbed by the gastrointestinal tract, whereas glucomannan which is fiber will absorb water and inhibit the process of recycling bile salts so that only a few will return to the liver and more excreted through feces. Reduced blood cholesterol levels due to Aloe vera will have a good effect on atherosclerotic plaque so as to reduce the risk of stroke.
Relationship Of Family Factor Againts The Development Of Children Age 4-6 Years Old In Padang Manis Village Wonosobo District Tanggamus Regency Andrian Reza Saputra; Dian Isti angraini; Tri Umiana Soleha
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.279

Abstract

The family is the first environment that is introduced to the children. The family is the first subject that matter to be a factor of developmental deviation. This study’s aim to determine the relationship between Family Factors and children developmental in age 4-6 years old. Total samples of 52 family in Padang Manis village who selected with total sampling technique. Inclusion criteria is a family and child 4-6 year old who is willing to be a respondent. The results showed that there was a significant correlation between family income and children development with p = 0,003 (p <0,05). There was a significant correlation between parenting system and children development with p value = 0,034 (p <0,05). There was a significant relationship between parent educational background and children development with p = 0,001 (p <0,05). There was a significant relationship between the number of siblings and the development of children with a value of p = 0.001 (p <0.05). Result showed there is a relationship of family factors to the development of children in age 4-6 years old in the Padang Manis village Wonosobo district Tanggamus regency.
Pengaruh Jintan Hitam (Nigella sativa) Terhadap Sindrom Metabolik Pada Wanita Menopause Diwanti Aulia Hasanah; Sutarto; Putu Ristyaning Ayu; Selvi Rahmawati
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.281

Abstract

Menopause is permanently cessation of menstruation for at least 12 months in women with a median age of 51 years. The incidence of chronic diseases will be increased in menopause women, so that it affects their quality of life. Changes in estrogen levels during menopause are associated with an increase in body fat. This is an alarm sign for women's health because it causes an increase in blood pressure, insulin resistance and dyslipidemia. These changes can contribute to an increased risk of metabolic syndrome in menopausal women. Black cumin plant is a spice plant belonging to the Ranunculaceae family and grows in various regions of the world. Black cumin seeds and oils are usually used as traditional medicine for various diseases. The main bioactive substance in black cumin, thymoquinone, has a major influence in improving metabolic syndrome in menopausal women, especially in controlling lipid and blood sugar profiles. The mechanism of hypolipidemic action of N. sativa based on research caused by an increase in the regulation of LDL molecules through receptor-mediated endocytosis, and several other mechanisms. The hypoglycemic effect of N. sativa is by maintaining the integrity of pancreatic β cells, causing an increase in insulin levels.
Efektivitas Dari Tanaman Zodia (Evodia Suaveolens) Sebagai Insektisida Nabati Nyamuk Aedes aegypti Penyebab Demam Berdarah Anniza Agustina; Betta Kurniawan; M. Yusran
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.282

Abstract

Dengue Hemorrhagic Fever (DHF) is a problem of one infectious disease in the community. Dengue virus infection through Aedes aegypti mosquito bites to humans as a vector. Eradication of vectors using insecticides must be environmentally friendly and safe for the ecosystem. Vegetable insecticide was chosen because it is easy to obtain and friendly to the environment. Zodia plants have been widely used by the people, especially the people of Papua as an anti-mosquito. Because of the content of evodiamine, rutaecarpine, and linalool, a-pinene is very effective as a mosquito repellent. Three ways of working plant-based insecticides work, namely: contact poison, gas poison and stomach poison. Research by calculating the average number of mosquitoes - the number of mosquitoes perched on the probandus arm with a concentration of 5%, 10%, 15%, 20%, 25%, 30% proves that the concentration of 25% has a longer protective power of 4 hours with an average of an average of 91%. Other studies say that the concentration of Zodia leaves can last five hours with a concentration of 60% even though it has only 48% protective power. The addition of a fragrant aroma that is fixative can increase protective power. This zodia plant contains linalool (46%) and a-pinene (13.26%). Linalool in zodia leaf essential oils have active ingredients such as evodiamine and rutaceacarpine which have a bitter taste and distinctive aroma.
Evaluasi Radiologis Pneumotoraks Spontan Sekunder pada Pasien dengan Tuberkulosis Paru Kasus Relaps Pertiwi Permata Putri; Tantri Dwi Kaniya
Medula Vol 9 No 2 (2019): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i2.283

Abstract

Pneumothorax is one of emergency case which needs to be immidiately treated. Spontaneus secondary pneumothorax (SSP) is one type of pneumothorax with history of pulmonary disease. Pulmonary tuberculosis (TB) is the most common etiology of SSP. Estimated incidence rate of SSP caused by pulmonary TB is 0,6-1,4%. Diagnosis can be made by history-taking and physical examination, but other examination like radiology imaging is important to evaluate and follow-up the patient so that an appropriate and optimum management can be given. A 31 years old male complained breathlessness since 3 days before hospitalized with history of pulmonary TB 8 years ago and had completed all of the drug regiment. in this last 1 month, patient experienced dry cough, sub-febrile fever, malaise, and frequently sweating at night without activity. Radiological finding on the day of admission: pleural white line and avascular hiperluscent, conclusion: pneumothorax dextra. Chest radiograph after water-sealed drainage showed improvement, early-detection of complication, and ensure the position of the drain.

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