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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
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PENATALAKSANAAN HOLISTIK PENYAKIT CAMPAK PADA BALITA USIA 3 TAHUN DENGAN RIWAYAT BELUM IMUNISASI CAMPAK DAN TINGKAT PENGETAHUAN KELUARGA MINIMAL MELALUI PENDEKATAN KEDOKTERAN KELUARGA DI WILAYAH KERJA PUSKESMAS SUKARAJA Umroh, Afidatul; Mayasari, Diana
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.924

Abstract

Measles is a highly contagious disease. Measles is an important cause of child death worldwide. Groups of children of pre-school age and elementary school age are vulnerable to contracting measles because they have weak immune systems. Measles can cause immune amnesia which will affect the immune system, making sufferers susceptible to other diseases or complications. This indicates that holistic and comprehensive patient care is an important matter through the role of the family doctor. The purpose of writing this article is to identify internal, external risk factors and clinical problems found in patients, apply a holistic and comprehensive family doctor approach according to the problems found in patients, and carry out evidence-based medicine management that is family-approach, patient-centered and community oriented. The study is a case report. Primary data were obtained through history taking, physical examination and home visits. The assessment is based on a holistic diagnosis from the beginning, process and end by means of in-depth interviews, observations and patient filling sheets. Patient An. H, 3 years old, has had a continuous fever since 6 days ago, accompanied by a cold cough. On the fourth day of fever, reddish spots appear, starting behind the ears and then spreading to the face, neck, chest, stomach and arms, accompanied by red and watery conjunctiva of the eyes. Neighbor's children experienced the same complaint. The patient has not received measles immunization.
PENATALAKSANAAN HOLISTIK PADA PASEN DIABETES MELITUS TIPE 1 TIDAK TERKONTROL PADA REMAJA USIA 17 TAHUN DI PUSKESMAS NATAR MELALUI PENDEKATAN KEDOKTERAN KELUARGA Aulia Dita Maurizka; Mayasari, Diana
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.925

Abstract

Type 1 diabetes mellitus (DMT1) is a lifelong chronic disorder of glucose homeostasis characterized by autoimmune destruction of insulin-producing pancreatic beta cells, which progressively leads to insulin deficiency and results in hyperglycemia. This disease causes chronic complications that require ongoing treatment management and education for patients and their families. Uncontrolled disease will cause various metabolic complications, macrovascular and microvascular disorders that cause a decrease in the quality and life expectancy of the patient. The purpose of writing this article is to applying the principles of a holistic and comprehensive family doctor approach in detecting internal and external risk factors and solving EBM (Evidence Based Medicine) problems that are family approach and patient centered. This study is a descriptive study of case reports. Primary data were obtained through autoanamnesis and alloanamnesis, physical examination and home visits. Secondary data obtained from the patient's medical record. Patient An.J, aged 17 years, complained of feeling weak and tingling in his legs. The patient has a history of type 1 diabetes on insulin treatment. Patient complaints do not recur and can return to normal activities. Clinically the patient was diagnosed with type 1 diabetes mellitus and diabetic neuropathy. Internal risks are family history of DM, lack of knowledge about type 1 diabetes, high calorie and sugar diet behavior, smoking habits, and alcohol consumption and rarely exercise. External risk with a lack of family knowledge about diabetes mellitus, its triggers and complications faced by the patient. Furthermore, holistic management is carried out, namely non-medical management and mentose medicine with intervention using poster media. In the evaluation, the results obtained in the form of a better understanding of the disease and changes in behavior that have an impact on improving the quality of life. Holistic management with a family medicine approach is needed for patients with type 1 diabetes mellitus with complications of DM neuropathy to identify problems in various aspects in order to support the success of therapy and change patient behavior so as to prevent aggravation of complications.
SUPLEMENTASI EKSTRAK DAUN KELOR (Moringa oleifera L.) TERHADAP ANEMIA DEFISIENSI BESI: ARTIKEL REVIEW Satria, Dzakiyyah Shoofina Jasmine; Triyandi, Ramadhan; Iqbal, Muhammad; Andrifianie, Femmy
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.929

Abstract

Iron is an important component of hemoglobin. The function of iron, which is as a source of energy for muscles so that it can affect physical endurance and the ability to work in adolescents. Iron deficiency can lead to hematological disorders of anemia. Anemia is a body condition in which the number of red blood cells and oxygen transport capacity is insufficient to meet the physiological needs of the body. Moringa leaves can be used as a substitute for iron tablets, because Moringa leaf powder contains 28 mg of iron. The method used in this writing, is literature review by collecting several research articles. This literature source search uses literature research sources in the form of google scholar and Pubmed. The inclusion criteria from the search, namely research articles using Indonesian and English, articles published within the last 10 years (2013-2023), and discussing the topic of moringa oleifera and anemia. The results of this literature search can be concluded that Moringa oleifera supplementation significantly increases serum iron levels.
Penerapan DNA Rekombinan Dalam Terapi Gen Ardandi, Rofi Yoga; Nurhaliza, Suci; Poty, Pitha Maykania; Sha, Nindy Putri; Rahmanisa, Soraya
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.930

Abstract

Recombinant DNA technology is the fusion of genetic material from two different sources. Recombinant DNA refers to combining genetic material from two different sources to create a new organism or to produce a specific protein. The main purpose of genetic recombination is to produce more evolved and adapted organisms, as well as develop biotechnology strategies, such as recombinant protein production. This technology is applied in clinical and medicine such as vaccines. Recombinant vaccines are made by utilizing recombinant DNA technology, which is a gene cloning technique that is modified to produce the specific protein product sought. Gene cloning is a procedure by which foreign DNA or genes are inserted into a host cell using a vector. Gene cloning involves the insertion of a gene of interest into a vector, resulting in the creation of recombinant DNA that can replicate within the host cell, an example being the SARS-CoV-2 DNA vaccine. Oncolytic virus, Gendicine, Modified Virus Ankara (MVA) are recombinant DNA technologies for cancer therapy. The advantages of this therapy are its ability to form new combinations of genetic material by insertion of molecules; DNA recombination technology allows the production of large quantities of certain protein molecules, which can be used in the manufacture of drugs; the production of therapeutic substances by strains of organisms can be achieved through the use of recombinant DNA technology; drugs that have unique properties that are difficult or impossible to obtain through traditional approaches can be made through DNA recombination; and DNA recombination plays an important role in drug manufacturing by facilitating the synthesis of therapeutic molecules important for human health. The disadvantages are that it has a negative impact on the environment, requires strict supervision to ensure safety and security, and ethical controversies. This technology has many benefits, but it is necessary to consider some of the disadvantages and adverse effects that can be caused.
Anemia Fanconi : Review Article Syaka, Muthiiah Khodista; Panjaitan, Vania Christy M; Gerliandi, Egi Oktarian; Dewi, Meidiana Kartika
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.931

Abstract

Fanconi anemia (AF) is a rare, multisystem genetic disorder that affects various physiological aspects, especially the bone marrow, and increases the risk of cancer, such as acute myeloid leukemia (AML) and head and neck cancer. This disease is caused by mutations in 23 genes of the FA/BRCA DNA repair pathway. This article presents the results of a literature study on FA, with a focus on etiology, pathophysiology, molecular pathology, diagnosis, risk factors, clinical symptoms, and management. Through literature study methods, the author collected information from national and international journal sources between 2012 and 2021. The etiology of FA involves mutations in 23 FA genes, with variations in carrier frequency depending on ethnic group. The pathophysiology of FA is related to the inability of cells to repair damaged DNA interstrand crosslinks (ICLs), which can lead to bone marrow failure. Molecular pathology involves the function of the FA/BRCA repair pathway and its impact on the genome. Diagnosis of FA requires clinical evaluation, molecular analysis, and bone marrow examination. Risk factors involve genetic aspects and specific carrier frequencies in ethnic populations. Clinical symptoms of FA involve anemia, infection, and somatic manifestations. Management of FA depends on the severity, with hematopoietic stem cell transplantation (HSCT) being the primary choice. HSCT from matched, nonmatched, or haploidentical donors has provided increasingly better results. This study underscores the importance of early diagnosis of FA to improve prognosis. Although HSCT is the primary treatment option, careful consideration of risks and benefits must be taken. The results of this literature study provide in-depth insight into FA, supporting appropriate monitoring and management efforts for individuals with this condition.
Potensi Senyawa Alami dalam Polifenol dengan Mekanismenya untuk Melawan Kanker Mesensy, Natasya; Putri, Giska Tri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.933

Abstract

Globally, cancer is the leading cause of death because its pathophysiology includes multifactorial components. In general, various things mediate its development, such as genetic mutations, toxin intake, radiation exposure, unhealthy food, and work pressure. To increase the chance of cure from cancer and the possibility of survival, early detection, and appropriate treatment are needed. In the last decade, the high content of bioactive compounds contained in nutraceutical components has been considered as a complement in food, food supplements, and medicines. The medicines here include appropriate treatment to fight cancer without worrying about anticancer side effects that can cause adverse responses. Compounds in nutraceuticals are natural bioactive ingredients that have anticancer properties, which can kill cells that have metastasized or have become cancerous without being toxic to surrounding normal cells. This effect is proven when these natural bioactive compounds are contained in conventional medicine and show that nutraceutical supplementation contributes to the success of cancer treatment as an anticancer. This review examines the current knowledge from various literature regarding several natural bioactive extracts that contain certain polyphenolic compounds. The activity of this compound can be seen from the inhibition of cell proliferation, anti-inflammatory action, and antioxidant activity. Therefore, nutraceutical supplementation can be recommended along with conventional treatment to obtain a better therapeutic response in cancer patients.
PERAN KOMPONEN BIOAKTIF DALAM SENYAWA ALAMI UNTUK TATALAKSANA HEPATITIS Aulia Berliana; Graharti, Risti
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.934

Abstract

Hepatitis virus infection is a global public health threat that causes substantial liver-related morbidity and mortality. Hepatitis is a liver infection that causes inflammation, causing swelling of the liver. This liver infection has various variants, all of which are detrimental to human health. In recent times, natural compounds have become popular to be developed as antiviral drugs to fight viral infections. These natural compounds can come from plant extraction or a combination of animal and plant extraction. Several of these compounds have shown significant effectiveness in their mechanism as antivirals against the hepatitis virus due to the presence of bioactive components in them. The mechanism of action of this bioactive component is demonstrated by disrupting the virus life cycle, replication, release, and interaction with the host. This literature study will explain strategies for treating hepatitis with these natural compounds. Recent research shows that bioactive components such as phenylpropanoids, flavonoids, xanthones, anthraquinones, terpenoids, alkaloids, and aromatics have antiviral activity against hepatitis. Therefore, based on a literature review of the latest research that reveals clinical trials of these bioactive components, this natural compound can be used as a potential treatment alternative in the management of hepatitis in the future.
Faktor-Faktor yang Mempengaruhi Derajat Kecacatan Kusta Fauziani, Andra Nabila; Anggraini, Dwi Indria; Hanriko, Rizki; Sibero, Hendra Tarigan
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.936

Abstract

Morbus Hansen, also known as leprosy, is an infectious disease that is chronic or chronic. This disease is caused by the acid-fast bacillus (BTA) Mycobacterium leprae which is obligate intracellular. This disease can attack various body systems, including the peripheral nervous system, skin, mucosa, upper respiratory tract, reticuloendothelial system, eyes, muscles and bones. Based on WHO data for 2021, globally there were 133,781 cases of leprosy, with Indonesia ranking third highest in the world with 10,976 new cases after India and Brazil. Leprosy that is not treated properly can cause disability. There are two types of disability in leprosy, namely primary and secondary disability. Primary disability is caused directly by the Mycobacterium leprae bacteria, while secondary disability is a disorder that arises because the primary disability is not treated properly. The level of disability in leprosy is classified based on symptoms of damage to the eyes, hands and feet with levels 0, 1 and 2. Factors that influence the degree of disability in leprosy are grouped into demographic factors, internal factors and external factors. Demographic factors include age, gender, socio-economic status, occupation, and education level. Internal factors include the type of leprosy, length of suffering, number of nerves affected, and leprosy reaction. External factors include compliance with taking medication, delays in treatment, and self-care.
Faktor-faktor yang Mempengaruhi Keberhasilan Terapi Pasien Kusta Sagia, Nabilla Alsa; Anggraini, Dwi Indria; Wulan, Anggraeni Janar; Sibero, Hendra Tarigan
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.937

Abstract

Leprosy is a chronic granulomatous infectious disease caused by the obligate intracellular bacterium Mycobacterium leprae (M. leprae). This disease comes from the Latin word "lepros" which means scale. M. Leprae bacteria enter the human body through 2 main routes, namely through the skin and the upper respiratory tract. Leprosy bacilli enter the human body through direct contact with the skin or nasal mucosa originating from droplets. Bacteria from droplets will survive for 2 days in a dry environment, even up to 10 days in a humid environment and low temperatures. The success of therapy for Morbus Hansen patients is expressed by RFT (Release from Treatment). RFT can be stated after the dose is fulfilled without having to undergo laboratory examination. PB (paucibacillary) patients who have received 6 doses (blister) of treatment within 6-9 months are declared RFT, without having to undergo a laboratory examination. MB (multibacillary) patients who have received 12 doses (blister) of MDT treatment within 12-18 months are declared RFT, without having to undergo a laboratory examination. The factors that play a role in the success of therapy for leprosy patients are age, gender, education, employment, knowledge, compliance with taking medication, and family support.
Hubungan Determinan Sosial Kesehatan dengan Infeksi Toksoplasma gondii Jasmine, Almaina Puteri; Mutiara, Hanna; Suwandi, Jhons Fatriyadi; Putri, Giska Tri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.938

Abstract

Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis. The high rate of toxoplasmosis infection in the Lampung region reaches 88.23%. Typically, toxoplasmosis presents no symptoms but can pose serious problems for individuals with compromised immune systems or pregnant women. The purpose of this study is to identify the relationship between social health determinant factors such as age, gender, educational level, occupation, and residence address with the incidence of T. gondii infection among patients at Dr. H. Abdul Moeloek Hospital. The aim is to identify individuals at risk of toxoplasmosis infection early so prevention can be done immediately. This study is an analitic quantitative research with a cross-sectional design. The study population consists of patients at Dr. H. Abdul Moeloek Hospital who have been screened for toxoplasmosis from 2017 to 2023, with a sample size of 93 samples. A total of 67 samples were tested positive for toxoplasmosis, while 26 samples tested negative with the sampling technique using total sampling. Data were collected from patients medical records and were analyzed by univariate and bivariate analysis using Chi-square method. The results indicate a relationship between age (p 0.002), gender (p <0.001), and educational level (p <0.001) with the incidence of Toxoplasma gondii infection among patients at Dr. H. Abdul Moeloek Hospital from 2017 to 2023.

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