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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Determination of Sun Protection Factor and Antioxidant Properties of Cream Formulation of Kencur (Kaempferia galanga L) and Temu Kunci (Boesenbergia pandurata (Roxb.) Schlecht) Rhizomes Extract Charisma, Shintia Lintang; Rahayu, Wiranti Sri; Wahyuingrum, Retno
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kencur (Kaempferia galanga, L.) rhizome contain ethyl-p-methoxycinnamate (EPMS) which has sunscreen properties. Temu kunci (Boesenbergia pandurata (Roxb) Schlecht) rhizome containsÂ flavonoid and essential oils with oxidant radical scavenging properties. The aimsÂ of this study wereÂ to obtain the optimum physical properties of sunscreen and antioxidant cream and to compare the sun protection factor (SPF) values and antioxidant activity of kencur and temu kunci rhizomes extract before and after formulated.This research used Simplex Latice Design (SLD) model with 2 components of kencur extract and temu kunci extract. Based on the SLD model obtained optimum formula design, then the SPF values and antioxidant activity were studied by UV spectrophotometric method and DPPH method respectively.Based on SLD model obtained optimum formula that containing kencur : temu kunci extract 80%:20% (formula A) and 70%:30% (formula B). The SPF values ofÂ kencur extract, formula A and formula B wereÂ 4.505, 5.024 and 4.511 respectively. Antioxidant activity showed that the IC50 of formula A, formula B, temu kunci extract, BHT and Vitamin E were 109.15 Âµg/ml, 95.23 Âµg/ml, 10.20 Âµg/ml, 22.33 Âµg/ml and 8.78 Âµg/ml respectively.Cream formula A and formula B have optimum physical properties. The SPF value of the optimum formulations were higher than SPF value of kencur extract. Antioxidant activity of that combinations wereÂ lower than temu kunci extract, BHT and Vitamin E.

Formulation and evaluation of erythropoietin-alginate microspheres at different amount of drug Hariyadi, Dewi; Hendradi, Esti; Lailiyah, Khoirotul
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research formulate erythropoietin-alginate microspheres and to evaluate characteristics of erythropoietin-alginate microspheres at different amount of drug using aerosolization. Amount of erythropoietin are 10.000 IU (F1); 20.000 IU (F2); 60.000 IU (F3). The mixture of erythropoietin-alginate was sprayed into CaCl2 and was stirred at 1000 rpm for 30 minutes. Formulas resulted spherical shape of microspheres. The size of microspheres was 2.77 Âµm for F1; 3.89 Âµm for F2; and 4.42 Âµm for F3. The results of swelling index showed that swelling index of microspheres increased by increasing the concentration of erythropoietin. The results were in accordance with the size of the microspheres that increased with increasing concentration of drug. The yields of microspheres obtained were respectively 91.92%; 87.53%; 86.50% for F1, F2 and F3. It can be concluded that the particle size of microspheres, swelling index increased by increasing concentration of erythropoietin. In contrast, yield of microspheres decreased by increasing drug concentration. In conclusion, formula of microspheres were potential in terms of characteristics and may recommend for further in vivo study.Â

Effect of the ethanolic extract of red roselle calyx (Hibiscus sabdariffa L.) on hematocrit, platelets, and erythrocytes in healthy volunteers Siti Setianingsih; Laela Hayu Nurani; Abdul Rohman
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Roselle calyx (Hibiscus sabdariffa L) is widely used as an antioxidant, antihepatotoxic, diuretic, anti-cholesterol, and immunostimulant. Roselle contains anthocyanin and quercetin that have antioxidant activity. This study aimed to determine the effects of the ethanolic extract of roselle calyx on hematocrit, platelets, and erythrocytes in healthy volunteers during the 30-day administration and 15 days after it ceased. This study employed pre- and post-treatment design on 21 healthy volunteers, comprising 11 males and 10 females who fulfilled the inclusion criteria and filled out the informed consent form willingly. Volunteers were provided with roselle capsules for 30 days with a dosage of 500 mg a day taken 10-15 minutes after dinner. The hematologic examination was performed on Day 0, 31, and 45, including the measurement of hematocrit, platelet, and erythrocyte levels using a hematology analyzer. The obtained data were analyzed in SPSS with paired t-test and Wilcoxon test. The results showed that the hematocrit, platelets, and erythrocytes of all male and female volunteers on Day 0, 31, and 45 were within the normal range. The comparison analysis affirmed that there was no significant difference between these three parameters from Day 0 to 31, Day 31 to 45, and Day 0 to 45 (p>0.05). As a conclusion, the administration of the ethanolic extract of roselle calyx with a dosage of one 500mg capsule per day for 30 days did not affect the hematocrit, platelets, and erythrocytes in healthy volunteers. There was also no delayed effect on these three hematological parameters 15 days after the administration stopped.

Antifertility activities of srikaya leaves (Annona squamosa L.) ethanol extract against reproduction system : spermatogenesis and quality sperm study Nur Laili Dwi Hidayati; Tita Nopianti; Yuliana Dewi; Yani Suryani
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Has done research about antifertility activities of Srikaya leaves (Annona squamosa L.) ethanol extracts against reproduction system. There are classified into 4 groups: negative control (suspension PGA 1%), I dose (0.00448 g/200 g BW rat), II dose (0.00967 mg/200 g BW rat), and III dose (0.01934 mg/200 g BW rat). Administration of the test preparation is done orally for 48 days. Parameters observed were spermatogenesis and quality of sperm. Spermatogenesis parameters measured were testis index (%), seminiferous tubule diameter (Âµm), the number of spermatogonia and spermatocytes cells. Spermatozoa quality parameters measured were sperm motility, concentration, and morphology. Study parameters were statistically analyzed using ANOVA. The results showed that ethanol extract of Srikaya leaves can lower the index of the testis and seminiferous tubule diameter, decrease the number of spermatogonia and spermatocytes cells significantly. The ethanol extract of Srikaya leaves can reduce sperm motility, concentration, and increasing abnormality significantly.

Isolation, identification, phytochemical screening, and antibacterial activity of Aspergillus sp. MFD-01, an endophytic fungus derived from Mesua ferrea Dwi Hartanti; Risda Yunita Andestia Sinaga; Asmiyenti Djaliasrin Djalil; Retno Wahyuningrum
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

We have successfully isolated and identified endophytic fungi from medicinal plant Mesua ferrea L. grown at Banyumas were for the first time. One of those fungi was MFD-01. In this study, we report the isolation, identification, antibacterial activity, and phytochemical screening of Aspergillus sp. MFD-01. The endophytic fungus was isolated from the leaves of M. ferrea by subsequent inoculation on potato dextrose agar (PDA). The identification was based on its morphology and ITS-DNA sequence. The antibacterial activity was determined by dilution method. The identification of compounds in ethyl acetate extract of it was conducted according to the standart phytochemical screening method. MFD-01 was identified as Aspergillus sp. MFD-01. The ethyl acetate extract of Aspergillus sp. MFD-01 inhibited the growth of both Staphylococcus aureus, and Escherichia coli. At concentration of 1000 ppm, its diameter of inhibitory zone against those bacteria was 10.53 and 11.84, respectively. The extract contained flavonoids, alkaloids, saponins, terpenoids, and tannins, which might responsible for its antibacterial activity against both tested bacteria.

Neuropharmacological Activity of Nut Grass (Cyperus Rotundus L.) Rhizome Fraction Lusi Putri Dwita; Ema Dewanti; Vera Ladeska; Sediarso Sediarso; Adnan Muntashir; Ulfa Safni; Rahma Wulan Sari
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Research in the area of herbal neuropharmacological effects has increased markedly over the past decades. This research was aimed to further investigate neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring hypnotic-siccative and anticonvulsant activities. The exploratory behavior test was performed using Hole Board method while motor coordination was assessed using Rotarod Test. The result showed that the 70% ethanol fraction of Cyperus rotundus rhizome in has significant (p <0,05) neuropharmacological activities. All three fractions tested (ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. Ethanol Cyperus rotundus rhizome fraction could decrease the duration of HLE equal to sodium valproate and potentiated the phenobarbital-induced sleep by decreasing the onset and prolonging the duration of sleep. The highest dose of 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) showed the best anxiolytic activity comparable to diazepam (p> 0.05). In conclusion, Teki ladang (Cyperus rotundus) rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetics drugs.Â

The physical properties and stability of purple yam (Ipomoea batatas (L.) Lam ) lipstick Susmiatun Susmiatun; Anjar mahardian kusuma; Arif Budiman; Indri Hapsari
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The purple yam (Ipomoea batatas (L) Lam) has a useful anthocyanin as a natural dye which safer compare to the synthetic dyes. Anthocyanins have the antioxidant effect that can capture free radicals. The purpose of this study was to assess the effect of purple yam extract in various concentrations on the physical properties and physical stability of lipstick. Lipstick was made in three formulas that is L01, L02, L03. To evaluate the quality of the product, the physical properties, and stability test for purple yam lipsticks were conducted. Physical properties test consisted of organoleptic tests, melting point test, hardness test, homogeneity test, the Pap test, and pH test. Lipstick stability tests were performed by stored lipstick for 30 days at room temperature 25 Â°C, then observed the change of shape, color, and odor during storage. â€œWâ€ a top market leader lipstick in Indonesia was used as a control. Observed data of melting point, strength, and pH of lipstick were analyzed using One Way ANOVA and continued with Tukey. Organoleptic data, homogeneity, topicality and lipstick stability were described descriptively. The results showing no significant differences between lipstick L01, L02, L03 in organoleptic, homogeneity, pH and lipstick physical stability. However, when comparing with W lipstick, there is a significant difference in the melting, hardness and smearing points between L01, L02, L03 lipstick with W lipstick. It was concluded that purple yam extract may influence the physical properties of lipstick in particular melting point and hardness of lipstick. Although it has no effect on the stability of purple yum lipstick.

Determination of sun protection factor and antioxidant properties of cream formulation of kencur (Kaempferia galanga L) and temu kunci (Boesenbergia pandurata (Roxb.) Schlecht) rhizomes extract Shintia Lintang Charisma; Wiranti Sri Rahayu; Retno Wahyuingrum
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kencur (Kaempferia galanga, L.) rhizome contain ethyl-p-methoxycinnamate (EPMS) which has sunscreen properties. Temu kunci (Boesenbergia pandurata (Roxb) Schlecht) rhizome contains flavonoid and essential oils with radical scavenging properties. The aims of this study were to obtain the optimum physical properties of sunscreen and antioxidant cream and to compare the sun protection factor (SPF) values and antioxidant activity of kencur and temu kunci rhizomes extract before and after formulated. This research used Simplex Latice Design (SLD) model with 2 components of kencur extract and temu kunci extract. Based on the SLD model obtained optimum formula design, then the SPF values and antioxidant activity were studied by UV spectrophotometric method and DPPH method respectively. Based on SLD model obtained optimum formula that containing kencur : temu kunci extract 80%:20% (formula A) and 70%:30% (formula B). The SPF values of kencur extract, formula A and formula B were 4.505, 5.024 and 4.511 respectively. Antioxidant activity showed that the IC50 of formula A, formula B, temu kunci extract, BHT and Vitamin E were 109.15 Î¼g/mL, 95.23 Î¼g/mL, 10.20 Î¼g/mL, 22.33 Î¼g/mL and 8.78 Î¼g/mL respectively. Cream formula A and formula B have optimum physical properties. The SPF value of the optimum formulations were higher than SPF value of kencur extract. Antioxidant activity of that combinations were lower than temu kunci extract, BHT and Vitamin E.

Antibacterial activity of dialkyl-aginate biosurfactant cream againts Staphylococcus aureus an Pseudomonas aerugynosa Kintoko Kintoko; Nining Sugihartini; Benazir Evita Rukaya
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dialkyl-alginate biosurfactant is an amphifilik rhamnolipid biosurfactant that has the potential to be developed into an antibacterial agent. The purpose of this study was to prove that the biosurfactant of dialkyl alginate both before and after creams has antibacterial activity especially against Staphylococcus aureus and Pseudomonas aeruginosa. Test of antibacterial activity of biosurfactant dialkyl alginate at concentrations of 5%, 10% and 20% to Staphylococcus aureus and Pseudomonas aeruginosa using Hammond, et al (2011) modified quantitative method. EnbaticÂ® 1% is used as a positive control and sterile aquadest as a negative control. Determination of antibacterial activity of dialkyl alginate biosurfactant followed by analysis of leakage of protein and nucleic acids using UV-vis Spectrophotometry and leakage of Ca2 + and K + metal ions using Atomic Absorption Spetrophotometry (AAS). The most active concentration was formulated into cream and then performed physical evaluation (organoleptic, pH, adhesion, spreading and viscosity) and tested antibacterial activity using the well method. The test results showed that the biosurfactants of dialkyl-alginate before and after the cream was treated as antibacterial activity. The concentration of 10% was the most active concentration having activity which did not differ significantly to positive control with p value of 0,05

In silico study of the active compounds in bitter melon (Momordica charantia L) as antidiabetic medication Ruswanto Ruswanto; Richa Mardianingrum; Tresna Lestari; Tita Nofianti; Lilis Tuslinah; Dudi Nurmalik
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antidiabetic are many drugs available in the market, but most medications have side effects that are relatively high and cause toxicity, so it needs tobe develoved search of new drug compounds were more potent drugs with side effects as low. Various research have shown that bitter melon (Momordica charantia L) has an effect antidiabetic. But it is not known specifically as antidiabetic compounds that act on bitter melon (Momordica charantia L). This study was conducted to predict the active compounds of bitter melon (Momordica charantia L)potent as antidiabetic in silico, through the molecular docking, Drug scan, PreADMET and molecular dinamics simulation. The results of the 26 active compound bitter melon (Momordica charantia L) obtained one potential compounds that are active against nuclear reseptor RORÎ± that is goyaglikosida-h and more potent than Rosiglitazon

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA