Pharmaciana: Jurnal Kefarmasian
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
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<![CDATA[The validation of patient knowledge questionnaire for patients with diabetes mellitus and hyperlipidemia ]]>
<![CDATA[Ginanjar Zukhruf Saputri]]>;
<![CDATA[Haafizah Dania]]>;
<![CDATA[Imaniar Noor Faridah]]>;
<![CDATA[Faiza Chusnuni A]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.7508
<![CDATA[Prevalence of Diabetes Mellitus (DM) with Hyperlipidemia increased in Indonesia, where both diseases have a risk of complications towards cardiovascular disease. DM patients with hyperlipidemia require proper management to control blood sugar, total cholesterol and LDL cholesterol. Knowledge is one of the important factors in improving adherence therapy and quality of life of DM-hyperlipidemia patients, especially in controlling blood glucose level and total cholesterol levels. This study aims to develop a patient questionnaire of DM-hyperlipidemia.The study used cross sectional method. Inclusion criteria were patients aged 18 – 70 years old, diagnosed DM-Hyperlipidemia, getting at least 1 oral antidiabetic and oral anti-cholesterol. The questionnaire item of knowledge was developed based on gudeline therapy and previous research reference. Expert validation is done on Doctor who had expert in DM and clinical psychologist. The pilot test was performed on 10 healthy patients and 10 patients of DM-hyperlipidemia who had eligible inclusion criteria. Validation of questionnaire was done on 30 patients of DM-Hyperlipidemia who undergoing therapy at outpatient clinic of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done by interviewing questionnaires in patients. Analysis of data using SPSS with product moment validation test and cronbach alpha to see the reliability of questionnaire.Validation results show there are some invalid items that are in questions 9, 11, 12, 15, 16 and 17, the range of questions about knowledge about hyperlipidemia, medication and general health. Re-validation without invalid item was done and obtained value r> 0.3, with value of Cronbach alpha 0,715.The DM-Hyperlipidemia patient questionnaire was valid and reliable to measure the level of knowledge of DM patients with Dysipidemia.  ]]>
<![CDATA[Reducing ulcerogenic effect of self-nano emulsifying drug delivery system of piroxicam ]]>
<![CDATA[Iis Wahyuningsih]]>;
<![CDATA[Wahyu Widyaningsih]]>;
<![CDATA[Silviana Wulandari]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.11478
<![CDATA[Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory, analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead of SNEDDS. This study uses white rats male strain SD age 2-3 months and weight 100-200 grams of 40 rats. Rats divided into 5 groups. Group I was a normal control group, the test animals were given only water. Group II was a suspending control group treated with a 1% polyvinylpyrrolidone (PVP) solution, group III is a carrier control group treated with SNEDDS carrier which is a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG) 400, group IV was a group of piroxicam drugs suspended with piroxicam 1.08 mg/kg in 1% PVP, group V was treated with SNEDDS piroxicam.Treatment was done for 28 days. After treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were made macroscopically by looking at ulcer scores followed by histopathological observations of tissue. The ulcer score data from each group were analyzed using one-way ANOVAand LSD test. The results showed that the normal control group, 1% PVP suspension and carrier group had a ulcer index of 0.0, 0.0 and 0.0, while the piroxicam suspension group and the SNEDDS group had an ulcer index of 0.88 and 0.0. These results were confirmed by histopathologic results of SNEDDS piroxicam to decrease the effect of pyroxicam ulcerogenic with results in the piroxicam suspension group has ulcer with necrosis by neutrophil infiltration, lymphocytes and mast cells in the mucosal tunica to submucosa. In the SNEDDS piroxicam group there is erosion with necrosis of the mucosal tunica epithelium with infiltration of lymphocytes and mast cells in submucosal tunica. It can be concluded the SNEDDS piroxicam can decrease the ulcerogenic effect.]]>
<![CDATA[Evaluation of adherence, distress and quality of life for type 2 diabetes melitus patients In Puskesmas Wedarijaksa I and Puskesmas Trangkil Kabupaten Pati ]]>
<![CDATA[Dyah Aryani Perwitasari]]>;
<![CDATA[Siti Urbayatun]]>;
<![CDATA[Oni Yulianta Wilisa]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.10573
<![CDATA[Diabetes mellitus is chronic disease that needs the complex and a long term medical treatment. Patient adherence and level of distress can affect patient quality of life. The purposes of this study is to examine patients adherence, distress, and quality of life patients type 2 diabetes mellitus in Kabupaten Pati. This study used cross sectional design and data patients collection techniques were conducted prospective data. The subjects of research were patients with Type 2 diabetes amounted to 126 people. Instruments used in this research is Medication Adherence Respon Scale (MARS) questionnaire to measure patients adherence, Diabetes Distress Scale (DDS) to measure distress, and EQ-5D-5L questionnaire to measure quality of life. Data analysis statistic used Mann Whiney test, and linier regression. This study was dominated by female patients 78.6%. The mean age of DMT2 patients was 54.49 ± 6.19 years. The average value of adherence (MARS) was 21.33 ± 2.90 including in moderate adherence. The mean total of DDS score was 1,56±0,42 including not distress level and the highest is the emotional burden domain. The mean value of EQ5D5L index was 0.729 ± 0.161. The results showed a significant association (p <0.05) between patient characteristics age and duration of sick with adherence. There were significant association (p <0.05) between age to physician distress, gender with emotional, marital status with emotional and interpersonal distress, duration of sick to physician distress and management therapy distress. Marital status and income had significant relationship to quality of life. Emotional burden domain had significant relationship to quality of life. Multivariate analysis showed that the relationship of adherence and distress by the emotional burden to quality of life. This study concluded the significant relationship between adherence, distress and quality of life.]]>
<![CDATA[Formulation and evaluation of erythropoietin-alginate microspheres at different amount of drug ]]>
<![CDATA[Dewi Hariyadi]]>;
<![CDATA[Esti Hendradi]]>;
<![CDATA[Khoirotul Lailiyah]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.9203
<![CDATA[This research formulate erythropoietin-alginate microspheres and to evaluate characteristics of erythropoietin-alginate microspheres at different amount of drug using aerosolization. Amount of erythropoietin are 10.000 IU (F1); 20.000 IU (F2); 60.000 IU (F3). The mixture of erythropoietin-alginate was sprayed into CaCl2 and was stirred at 1000 rpm for 30 minutes. Formulas resulted spherical shape of microspheres. The size of microspheres was 2.77 µm for F1; 3.89 µm for F2; and 4.42 µm for F3. The results of swelling index showed that swelling index of microspheres increased by increasing the concentration of erythropoietin. The results were in accordance with the size of the microspheres that increased with increasing concentration of drug. The yields of microspheres obtained were respectively 91.92%; 87.53%; 86.50% for F1, F2 and F3. It can be concluded that the particle size of microspheres, swelling index increased by increasing concentration of erythropoietin. In contrast, yield of microspheres decreased by increasing drug concentration. In conclusion, formula of microspheres were potential in terms of characteristics and may recommend for further in vivo study. ]]>
<![CDATA[Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation ]]>
<![CDATA[Rise Desnita]]>;
<![CDATA[Sri Luliana]]>;
<![CDATA[Zainab Kasim]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.7696
<![CDATA[Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.]]>
<![CDATA[Evaluation of erythropoietin therapy in hemodialysis patients at PKU Muhammadiyah Hospital Yogyakarta ]]>
<![CDATA[Adnan Adnan]]>;
<![CDATA[Haafizah Dania]]>;
<![CDATA[Woro Supadmi]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.7725
<![CDATA[Most of the patients with end-stage renal disease who undergo hemodialysis receive erythropoietin (EPO) therapy for anemia treatment. Anemia with EPO deficiency is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve anemia and quality of life of patients. This analytic observational study was conducted in a cross-sectional design. It aimed to identify the difference in red blood cell profiles, namely hemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), and quality of life of CKD patients on EPO and non-EPO therapy at PKU Muhammadiyah Hospital in Yogyakarta. The inclusion criteria were PGK ICD N18.9 outpatients who received hemodialysis therapy at this hospital and were literate, able to understand the questionnaire, and willing to be a respondent. The results showed that there was no significant difference (p>0,05) between the red blood cells (Hb, MCV, MCH, MCHC) of the EPO and non-EPO therapy groups. The correlation between the EPO and the quality of life of patients in all of the KDQOL domains was p> 0.05. Aside from the insignificant difference between the EPO and non-EPO therapy groups, the research concluded that there was no correlation between either the EPO or the non-EPO therapy with the quality of life of hemodialysis patients.]]>
<![CDATA[Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae ]]>
<![CDATA[Patonah Hasimun]]>;
<![CDATA[Agus Sulaeman]]>;
<![CDATA[Hendra Mahakam Putra]]>;
<![CDATA[Heni Lindasari]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.9430
<![CDATA[Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme activity and lipid peroxidation. This study was conducted by 2 methods including assay of HMG CoA reductase inhibition and lipid peroxidation test. The study was performed by in vitro method, using 20% rat liver homogenate. The inhibition of HMG CoA reductase enzyme was done by reacting liver homogenate, HMG CoA substrate, which added the Zingiberaceae extract compared with simvastatin as standard drug. The absorbance of the mixture was measured by a Microlab 300 spectrophotometer at a 340 nm wavelength. Lipid peroxidation assay was induced by the FeSO4.7H2O solution. The absorbance value measured using a spectrophotometer at a 532 nm wavelength. Lipid peroxidation inhibition was characterized by absorbance of the test extract, compared with the control group. The obtained data was calculated as percent of inhibition and was used to calculate IC50 extract test. The results showed that the 10 ethanolic extracts of Zingiberaceae rhizomes have activity as enzyme inhibitor HMG-CoA reductase with IC50 value range 65.8±4.1 – 203.3±15.2 ppm, and inhibition of lipid peroxidation with IC50 value range 13.5±5.0 – 219.6±4.3 ppm. This study can be concluded that the Zingiberaceae rhizomes have potential role as antihyperlipidemic agents through inhibition of HMG CoA reductase enzyme activity and preventing lipid peroxidation.]]>
<![CDATA[The potentiation effect of Bawang Dayak (Sisyrinchium palmifolium L.) extract on T47D cell growth inhibition after 5-fluorouracil treatment ]]>
<![CDATA[Azizah Yuniarti]]>;
<![CDATA[Elza Sundhani]]>;
<![CDATA[Nunuk Aries Nurulita]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.9480
<![CDATA[5-Fluorouracil (5-FU) is chemotherapy agents that used in breast cancer treatment that has toxic effects such as myelotoxicity. its effectiveness relatively low. Bawang Dayak has been widely empirically used as a breast cancer treatment. This study's aims were to determine the sensitivity of 5-FU against T47D cells, as single and its combination with EBD, to determine apoptotic induction, and the inhibitory effect of T47D cell cycle. The cytotoxic assay was using the MTT method with the concetration of 5-FU (0-600μg / mL) and EBD (0-250μg / mL). Apoptotic induction analysis were determined by PI/annexin V. Both of apoptotic and cell cycle analysis was performed by flowcytometry. The results of the 5-FU and EBD cytotoxic test on T47D cells obtained IC50 274μg/mL and 75μg/mL, respectively. The combination of 5-FU and EBD has a mild to strong synergistic effect (CI 0.829 and 0.779). its ombined treatment induced apoptosis in T47D cells by 21.33%. Combination of these combinations caused cell accumulation in G0-G1 phase of 57.11%, greater than control (41.20%). Provision of 5-FU and EBD combination treatments causes disturbance and damage to cells that cause cell cycle arrest in the G0-G1 phase and can not proceed to the next phase. The combination of 5-fluorouracil and EBD has a synergistic effect as breast cancer co-chemotherapy is able to induce apoptosis against T47D cells by triggering cell accumulation in G0-G1 phase. The extract of Bawang Dayak has a high potential to be developed as co-chemotherapy in breast cancer.]]>
<![CDATA[The effect of concentration variation of ethanolic extract from potato peels (Solanum tuberosum L.) on the physical properties and antibacterial activity of gels against Propionibacterium acnes ]]>
<![CDATA[Dewi Rashati]]>;
<![CDATA[Mikhania Cristiningtyas Eryani]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.8395
<![CDATA[Gel is a semisolid dosage form that consumers prefer because of its cool sensation. This research aimed to identify the effect of different concentrations of ethanolic extract from potato peels on the physical properties and the antibacterial activities of the resultant gels against Propionibacterium acnes. The gel was prepared with three formulas using a variety of potato peel concentrations, namely 50%, 60% and 70%. Its physical properties were analyzed based on organoleptic observation, homogeneity, pH, and spreadability. The results showed that the ethanolic extract of potato peels affected the color and viscosity of the gel. However, no effects were detected on shape, smell, pH, and spreadability. All formulas showed strong inhibitory capacity against Propionibacterium acnes.]]>
<![CDATA[Anti Inflammatory And Anti Bacterial Activity Of Sumbawa Oil ]]>
<![CDATA[Taufan Hari Sugara]]>;
<![CDATA[Baiq Nurbaety]]>
<![CDATA[ Pharmaciana Vol 8, No 2 (2018): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
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DOI: 10.12928/pharmaciana.v8i2.8010
<![CDATA[Sumbawa oil is a traditional ingredient that known as local wisdom of the island society of Sumbawa. It is believed to treat wounds, sprains, rheumatism, thrush and toothache. This study aims to determine the the effectiveness of anti-inflammatory and antibacterial activity of sumbawa oil products based on the types of raw materials and its phytochemical compounds. There are 3 stages in this research, consists of collecting various trademark of sumbawa oil product, determining type of raw material and analysis of phytochemical compound, followed by pharmacological activity test (Anti-inflammatory and antibacterial). Anti-inflammatory test was performed by observing the decrease of percentage inflammation of 21 white rats in 7 groups of egg white injection treatment. Antibacterial test using TSA method by observing the inhibition zone against S. aureus and E. coli bacteria. The results showed that Sumbawa oil products are known to contain secondary metabolite compounds of saponins, Triterpenoids, steroids and Flavonoids. All samples of Sumbawa oil products showed anti-inflammatory activity based on a decrease in the percentage of inflammation in the white rats leg for 6 hours of observation. Sumbawa oil also shows antibacterial activity in the strong category and has a wide spectrum because it can inhibit the growth of gram positive and negative bacteria each of 11,83-14,67 mm and 10,67-12,33 mm. This study concluded that Sumbawa oil was shown to have antiinflamatory and antibacterial activity even though its value was still lower than standard drug.]]>
