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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 7 Documents
 1 
Search results for , issue "Vol. 22 No. 2 (2025): September 2025" : 7 Documents clear
Identification of Volatile Compounds in Lemon, Local Lemon and Lime Peel Extract Using Gas Chromatography – Mass Spectrometer Ihsan Pratama, Muhammad; Yulianis, Yulianis; Sanuddin, Mukhlis
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.19749

Abstract

Orange peel is one of the main sources of essential oil. Lemon orange can also be found in an area of Jambi City, commonly referred to as local lemon, but the shape and characteristics differ slightly from common lemons. The identification results of local lemon peels indicate that these oranges are a cross between lemons and limes (Citrus medica × Citrus aurantifolia). This study aims to analyze and determine the differences in the components of the peels of lemon, local lemon, and lime using gas chromatography–mass spectrometer (GC-MS). The contribution of this research lies in providing scientific data on the chemical composition of local lemon peels, which have not been widely studied, thereby offering potential applications for the development of natural products, essential oil industries, and local biodiversity utilization. This research was conducted by extracting the peels from lemons, local lemons, and limes using acetone as a solvent. The extracts were then analyzed for their components using GC-MS. The GC-MS analysis of acetone extracts from lemon, local lemon, and lime peels revealed 19 compounds in each sample. Four compounds were found to be common across all three samples, namely 2-pentanone, 4-hydroxy-4-methyl; β-bisabolene; bis (2-ethylhexyl) phthalate; and 2H-1-Benzopyran-2-one, 5,7-dimethoxy. Meanwhile, 15 other compounds showed different contents, indicating that the hybrid nature of local lemons influenced their chemical composition. These findings highlight the unique characteristics of local lemon peels and their potential as a valuable source of bioactive compounds.
Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Evaluation of Antibiotic Use in the Inpatient Internal Medicine Ward at RSUD Ulin Banjarmasin Nata Asi, Seva Bela; Aryzki, Saftia; Anggoro Mukti, Yusuf; Yuwindry, Iwan
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29559

Abstract

The misuse of antibiotics is a significant concern due to the potential for developing resistance, which poses a growing global health threat. In the United States, antibiotic-resistant infections impact two million individuals annually, leading to 23,000 deaths. In Indonesian hospitals, antibiotic prescription rates are high, ranging from 44-97%, with 30-80% of these prescriptions being inappropriate. This study aims to evaluate the use of antibiotics in the internal medicine inpatient ward at Ulin Hospital, Banjarmasin, both quantitatively and qualitatively, using the ATC/DDD and Gyssens methods. A descriptive observational study was conducted using retrospective data collected from January to December 2023. The analysis included prescription data from inpatients in the internal medicine ward. Several antibiotics were identified, including Ceftriaxone, Azithromycin, Levofloxacin, Moxifloxacin, Cefixime, and Cefotaxime. The total DDD value was found to be 118.69 DDD/100 inpatient days. The DU 90% analysis showed the following usage rates: Ceftriaxone (oral) 52.51%, Azithromycin (parenteral) 60.55%, Levofloxacin (oral) 68.10%, Moxifloxacin (parenteral) 75.21%, Cefixime (parenteral) 81.02%, and Cefotaxime (oral) 86.09%. Ceftriaxone was the most frequently used antibiotic, with 39 patients receiving appropriate prescriptions (category 0) according to the Gyssens method. In conclusion, Ceftriaxone was the most commonly used antibiotic, representing 36.90% of prescriptions. The evaluation using the ATC/DDD method yielded a total DDD/100 inpatient days value of 118.69, while the Gyssens method indicated that 33.33% of prescriptions were appropriate.
Bioinformatics Analysis to Identify Therapeutic Targets of Artocarpus altilis Compounds in Breast Cancer Therapy Farid, Muhammad; Dewi, Fitria Puspita; Ramadhania, Widya Aryana; Rastrani, Ardestya; Rahma, Adinda Aulia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31075

Abstract

Breast cancer remains the most prevalent malignancy among women worldwide, with approximately 2.3 million new cases and 685,000 deaths reported in 2020. Despite advances in surgery, chemotherapy, radiotherapy, endocrine, and targeted therapies, these treatments are often limited by severe side effects and resistance mechanisms. Artocarpus altilis a medicinal plant rich in flavonoids and other bioactive compounds, has been traditionally utilized in various therapeutic contexts and is increasingly recognized for its anticancer potential. This study aimed to systematically identify the molecular targets and signaling pathways associated with A. Artocarpus altilis in breast cancer using a network pharmacology approach, thereby providing novel insights into its therapeutic relevance. The in-silico analysis integrated compound screening, drug-likeness evaluation, target protein prediction, protein–protein interaction mapping, Gene Ontology enrichment, and KEGG pathway analysis. Among 14 candidate compounds, three exhibited poor pharmacokinetic properties based on Lipinski’s Rule of Five. A total of 16 breast cancer-related protein targets were identified, with Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor 1 Receptor (IGF1R) emerging as the most significant hubs. Functional enrichment revealed that these targets participate in critical oncogenic pathways, including PI3K/Akt, MAPK, and JAK/STAT signaling, which are strongly associated with cell proliferation, migration, and metastasis. The findings highlight the central role of EGFR and IGF1R in mediating the pharmacological effects of A. Artocarpus altilis suggesting its potential as a complementary therapeutic candidate in breast cancer management. While this study provides a systematic bioinformatics-based framework for elucidating the molecular mechanisms of A. Artocarpus altilis, further experimental validation in vitro and in vivo is essential to confirm its efficacy and safety.
Optimization of Halal Capsule Shell Combination of Amylopectin of Cassava (Manihot esculenta) Pell and Caragenan of Euchema cottoni Pratiwi, Arika Putri; Nur Hazlia, Syarifah; Hartinah Yulianto, Siti; Shifa Syururin, Wakhidatus; Marfu'ah, Nurul
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29640

Abstract

Gelatin, a primary material for capsule shells, is predominantly sourced from pigs, raising significant concerns regarding its halal status for Muslim consumers. Therefore, identifying halal and sustainable alternatives to gelatin is crucial for the pharmaceutical industry. This study aimed to formulate and evaluate halal capsule shell preparations combining amylopectin from cassava (Manihot esculenta) peel starch and carrageenan from Euchema cottoni. The research utilized an experimental quantitative design with five formulations (F1–F5) based on varying amylopectin: carrageenan concentrations, namely 0.5%:3% (F1), 1%:3% (F2), 1.5%:3% (F3), 0%:3% (F4), and 3%:0% (F5). The capsule shells were assessed through specification tests, water content, ash content, and disintegration time. Data were analyzed using one-way ANOVA in SPSS version 26.0 at a 95% confidence level. The results showed that all formulations met the standards for water content (20–60%), ash content (<5%), and disintegration time (<30 minutes) based on PT. Kapsulindo Indonesia and the Indonesian Pharmacopoeia. However, none of the formulations fully met the specifications for capsule body diameter, cap diameter, and total length, primarily due to manual molding limitations. Among the five formulations, F3 demonstrated the closest conformity to standard physical parameters. Statistical analysis indicated that variations in the concentration of cassava peel starch and Euchema cottoni carrageenan significantly influenced capsule shell specifications, moisture content, and disintegration time (p<0.05), while having no significant effect on ash content (p>0.05). In conclusion, the combination of cassava peel amylopectin and Euchema cottoni carrageenan shows promising potential as a halal and eco-friendly alternative to gelatin-based capsule shells. Further optimization using automated molding systems is recommended to achieve standardized dimensions for commercial application.
Association between Hormonal Contraceptive Use and Hypertension Risk among Reproductive-Age Women: A Cross-sectional Study at Cileungsi Public Health Center, Indonesia Nafara Maharani Itamy, Defa; Rahmi, Eldiza Puji; Luthfiyani Citra Pradana, Dhigna; Farida Muti, Annisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31400

Abstract

Hypertension remains a major public health problem that may be influenced by hormonal contraceptive use, particularly oral and injectable methods commonly used by women of reproductive age. These contraceptives have raised concerns about their potential impact on blood pressure regulation. This study aimed to investigate the association between hormonal contraceptive use and the occurrence of hypertension among women of reproductive age at the Cileungsi Public Health Centre, Bogor Regency, Indonesia. A cross-sectional study was conducted in 2024 using retrospectively collected medical record data of all hormonal contraceptive users at the facility. Total sampling was applied, and data on contraceptive type, duration of use, age, parity, and the most recent blood pressure readings were analyzed. The chi-square test was employed to examine associations between hormonal contraceptive characteristics and hypertension, with a significance level set at p < 0.05. The results revealed a significant association between contraceptive type and hypertension (p = 0.01, OR = 0.27), showing that users of oral contraceptive pills were more likely to develop hypertension than injectable users. Duration of use (p = 0.03, OR = 3.06), age (p = 0.04, OR = 0.12), and parity (p = 0.01, OR = 0.21) were also significantly associated with hypertension. Women aged ≥45 years, those with longer contraceptive use, and multiparous users exhibited a higher risk of elevated blood pressure. These findings highlight that both contraceptive-related and demographic factors contribute to hypertension risk among hormonal contraceptive users. Regular blood pressure monitoring and individualized counseling are essential, especially for oral and long-term users. This study contributes local evidence supporting safer contraceptive practices and cardiovascular risk management within primary healthcare settings.
Estimating the Economic Value and Determining Factors of Unused Medicines Among Households in Cibarusah District, Bekasi Regency Rozak, Abdul; Priyanto, Priyanto; Khaira Rusdi, Numlil
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.31418

Abstract

The accumulation of unused and expired medicines in households poses significant economic, health, and environmental challenges. This study aimed to estimate the economic value of unused medicines and identify factors contributing to their accumulation among households in the Cibarusah District, Bekasi Regency, Indonesia. A cross-sectional survey was conducted from May to June 2025 involving 354 households selected using a convenience sampling approach. Data were collected through structured, face-to-face interviews with validated questionnaires and analyzed descriptively using Microsoft Excel 2021 and SPSS version 29. Results showed that 71.5% of households stored unused medicines, representing an estimated total economic value of IDR 25,271,179, or an average loss of IDR 99,886 per household. Expired medicines accounted for 28.5% of all stored items, with a mean value of IDR 114,897 per household. Analgesics, antipyretics, nonsteroidal anti-inflammatory drugs (NSAIDs), and antigout agents were the most frequently stored drug classes (20.1%), followed by gastrointestinal medicines (15.2%). The primary reasons for medicine accumulation were recovery from illness (70.9%), drug ineffectiveness (15.8%), and expiration (28.5%). Most respondents were female (67.2%), aged 36–55 years, and had completed secondary education. When extrapolated to all 32,515 households in Cibarusah District, the potential economic loss due to unused medicines reached approximately IDR 1.18 billion. This study highlights the substantial economic burden associated with household medicine storage and the need for improved public awareness of rational medicine use. Strengthening educational programs, involving community pharmacists in household medicine management, and establishing structured medicine take-back systems are essential to reduce pharmaceutical waste and its economic impact. These findings contribute valuable local evidence to support national strategies for promoting sustainable and responsible medicine use in Indonesia.

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